High dose therapy and stem cell research
Strategy since 1987
High dose therapy with stem cell support (HDT) in cancer has been performed at NRH since 1987. At that time, an institutional strategy for HDT was founded. It was decided to focus on malignant lymphomas with an unfavourable clinical course. As a part of the strategy a research project was undertaken for the removal of contaminating lymphoma B-cells from the harvested cell suspensions from the bone marrow. A clinically scaled purging project was developed in order to remove contaminating B- and T- lymphoma cells by means immunomagnetic beads conjugated with monoclonal antibodies directed towards various B- or T- cell antigen determinants on the lymphoma cells.
Thus, the initial project had two aims:
- The clinical outcome after HDT in malignant lymphoma.
- The effect of purging with immunomagnetic beads with regard to clinical relapse and possible negative effects on engraftment of the bone marraow.
During the 1990’s, the program has been expanded to comprise relapsed Hodgkin’s lymphomas, transformed follicular lymphomas and mantle cell lymphomas, as adjuvant treatment in localized poor prognoses breast cancer, small cell lung cancer, Ewing sarcomas, osteosarcomas and testicular cancer. Many of these studies have been undertaken in national or international multicentre cooperation in order to obtain consensus about the clinical benefit of HDT.