|Position:||Senior scientist, Dr. rer. nat.|
|Phone:||+47 2278 1736|
Biomarker discovery and medical biostatistics in cancer research with special interest in malignant peripheral nerve sheath tumors and colorectal cancer. Drug discovery and functional studies in cancer models. Immunohistochemical protein expression analyses using tissue microarrays.
2001: Ph.D. (Dr.rer.nat.) – Biophysical Chemistry, Technical University Berlin, Germany.
Kolberg M (2001)
Generation and Characterization of Free and Metal Associated Amino Acid Radicals in Ribonucleotide Reductase Using EPR Techniques.
Doctoral dissertation, Fakultät II - Technische Universität Berlin.
Kolberg M (1997)
Fraksjonering og karakterisering av proteinkomponenter i alkenmonooksygenase fra Mycobacterium E3.
Cand. scient. thesis, University of Oslo
2001-2005 Post doctoral fellowship, Department of Molecular Biosciences, University of Oslo.
Other international lab experience:
1994-2004 Annual visits to the Department of Biophysics (Astrid Gräslund-lab), Stockholm University, Sweden, for EPR experiments
1998-2004 Annual visits to the Department of Molecular Biology (Britt-Marie Sjöberg-lab), Stockholm University, Sweden, for site-directed mutagenesis and protein overexpression
1999 Short visit to the Department of Microbiology (Thomas Eitinger-lab), Humbolt University, Berlin, Germany, for protein overexpression under anaerobic conditions
2002-2003 Two visits to the Department of Chemistry (Gary Brudvig-lab), Yale University, New Haven, USA, for saturation recovery EPR-analyses
2002-2004 Annual visits to the High Magnetic Field Laboratory (LNCMI-G) (Anne-Laure Barra-lab), CNRS, Grenoble, France, for high field EPR experiments
2002-2004 Annual visits to the European Synchrotron Radiation Facilities, Grenoble, France, for X-ray crystallography
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Clin Cancer Res, 21 (16), 3759-70
Connexins in colorectal cancer pathogenesis
Int J Cancer, 137 (1), 1-11
The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation
J Biol Chem, 287 (19), 15851-61
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
Int J Cancer, 131 (3), 570-81
Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors
J Surg Oncol, 104 (7), 792-7
Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
J Transl Med, 6, 13
A new tyrosyl radical on Phe208 as ligand to the diiron center in Escherichia coli ribonucleotide reductase, mutant R2-Y122H. Combined x-ray diffraction and EPR/ENDOR studies
J Biol Chem, 280 (12), 11233-46
The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase
J Inorg Biochem, 99 (6), 1320-8
A comparative reactivity study of microperoxidases based on hemin, mesohemin and deuterohemin
J Inorg Biochem, 99 (3), 852-63
The use of multi-frequency EPR techniques to identify the radicals produced in irradiated beta-blockers
Free Radic Res, 38 (1), 59-66
Structure, function, and mechanism of ribonucleotide reductases
Biochim Biophys Acta, 1699 (1-2), 1-34
Crystal structural studies of changes in the native dinuclear iron center of ribonucleotide reductase protein R2 from mouse
J Biol Chem, 279 (45), 46794-801
Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data
Proc Natl Acad Sci U S A, 100 (6), 3209-14
Protein thiyl radicals directly observed by EPR spectroscopy
Arch Biochem Biophys, 403 (1), 141-4
Generation and electron paramagnetic resonance spin trapping detection of thiyl radicals in model proteins and in the R1 subunit of Escherichia coli ribonucleotide reductase
Arch Biochem Biophys, 397 (1), 57-68