
| Ragnhild A. Lothe | |
| Position: | Professor, Head of Department |
| Phone: | +47 2278 1728 |
| Email: | |
Department of Cancer Prevention, Institute for Cancer Research
Oslo University Hospital, Oslo, Norway
Areas of research
I. Developmental biology of solid tumors. Molecular mechanisms underlying the development of colorectal cancer, testicular cancer and malignant peripheral nerve sheath tumors.
II. Translational research relevant for these three diseases.
Biosketch
Current positions
Head of Dept. of Cancer Prevention, Norwegian Radium Hospital, Rikshospitalet (RR).
Professor at the Department of Molecular Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo (U of Oslo).
Vice-director of CoE: Centre for Cancer Biomedicine, Faculty of Medicine, U of Oslo.
Academic degrees
1981: B.Sc. (Cand. Mag.)- Biology, Chemistry, Mathematics, Faculty of Mathematics and Natural Sciences, University (U) of Bergen
1983: M.Sc. (Cand. Scient.) – Biology, Faculty of Mathematics and Natural Sciences, U of Oslo.
1992: Ph.D. (Dr.philos) – Medicine, Faculty of Medicine, U of Oslo. Suppressor genes involved in tumorigenesis of colon and testis. A molecular and cytogenetic study. ISBN 82-7633-018-5
Hospital assignments
Scientific advisor (20% position) in molecular diagnostics, Dept. Pathology (1993-2000), and Dept. Cancer Genetics (2001), The Norwegian Radium Hospital (NRH).
Scientific activity
Publications in: cancer- genetics and epigenetics, molecular- pathology and oncology
Research group part of
- Centre of excellence: Cancer Biomedicine
- Centre for research based innovation: stem cell based tumor therapy
Supervision
Awards and honors
2003 The Ragnar Mørk legacy prize
2007 Elected member of the Norwegian Academy of Science and Letters
2007 King Olav the Vth Cancer Research Prize
2007 Medinnova idea prize
Ongoing tasks
Chair of the research council of the Norwegian Cancer Society
Editor-in-Chief: Critical Reviews in Oncogenesis (www.begellhouse.com).
Member of the Research Council for the Rikshospitalet and the U of Oslo (second elected period).
Member of the Comprehensive Cancer Centre Advisory Board for RR.
Member of the Commision of Forensic Medicine, appointed by the Norwegian Ministry of Justice and the Police.
Chair of the board, the Norwegian Centre of Molecular Medicine (NCMM, U of Oslo) with EMBL partnership.
Board member in Oslo Cancer Cluster
Author network for Ragnhild A. Lothe by COREMINE medical
Publications in press
ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
Gut (in press)
PubMed 22213796
Oncogenicity of the developmental transcription factor Sox9
Cancer Res (in press)
PubMed 22246670
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
Int J Cancer (in press)
PubMed 21866551
The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer
Int J Cancer (in press)
PubMed 22173985
Publications 2012
FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
Genes Chromosomes Cancer, 51 (3), 240-9
PubMed 22081504
Publications 2011
Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumors
Endocr Relat Cancer, 18 (6), C31-4
PubMed 21868474
The testicular germ cell tumour transcriptome
Int J Androl, 34 (4 Pt 2), e133-50; discussion e150-1
PubMed 21651573
Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma
Amino Acids, 41 (4), 875-84
PubMed 20191297
TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers
Epigenetics, 6 (9), 1120-1130
PubMed 21847011
Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
PLoS One, 6 (9), e24419
PubMed 21909432
Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
Mol Cancer, 10, 85
PubMed 21777459
SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
Oncogene, 30 (37), 3967-78
PubMed 21499309
Fusion gene microarray reveals cancer type-specificity among fusion genes
Genes Chromosomes Cancer, 50 (5), 348-57
PubMed 21305644
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines
BMC Cancer, 11, 211:1-11
PubMed 21624110
Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
PLoS One, 6 (7), e22317
PubMed 21814574
DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer
Epigenetics, 6 (5), 602-9
PubMed 21406965
Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors
J Surg Oncol, 104 (7), 792-7
PubMed 21547915
Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
Genome Med, 3 (5), 32
PubMed 21619627
CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
Genes Immun, 12 (8), 653-62
PubMed 21716316
Publications 2010
Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
Mol Cancer, 9, 100
PubMed 20459617
DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset
PLoS One, 5 (11), e13978
PubMed 21103049
Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
J Clin Oncol, 28 (9), 1573-82
PubMed 20159821
Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors
J Carcinog, 9, 1
PubMed 20411023
Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
Clin Cancer Res, 16 (23), 5842-51
PubMed 20975101
UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
Autophagy, 6 (7), 863-70
PubMed 20724836
Genomic aberrations in borderline ovarian tumors
J Transl Med, 8, 21
PubMed 20184781
Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
Genes Chromosomes Cancer, 49 (11), 1046-53
PubMed 20725991
Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin
BMC Cancer, 10, 587
PubMed 20979647
Publications 2009
TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours
Mol Cell Endocrinol, 306 (1-2), 75-80
PubMed 19041365
Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours
J Pathol, 217 (5), 693-701
PubMed 19142971
Autophagy in tumour suppression and promotion
Mol Oncol, 3 (4), 366-75
PubMed 19559660
Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
Neuro Oncol, 11 (5), 514-28
PubMed 19182148
Novel Mutations of the Suppressor Gene PTEN in Colorectal Carcinomas Stratified by Microsatellite Instability- and TP53 Mutation- Status (vol 29, pg E252, 2008)
Hum. Mutat., 30 (6), 1023
Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology
Pharmacogenet Genomics, 19 (10), 751-9
PubMed 19741569
Tumor spreading to the contralateral ovary in bilateral ovarian carcinoma is a late event in clonal evolution
J Oncol, 2010, 646340
PubMed 19759843
Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
Genes Chromosomes Cancer, 48 (2), 184-93
PubMed 18973136
Large scale genomic instability as an additive prognostic marker in early prostate cancer
Cell Oncol, 31 (4), 251-9
PubMed 19633362
A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
Mol Cancer, 8, 5
PubMed 19152679
Publications 2008
RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A
Neoplasia, 10 (7), 680-6, 2 p following 686
PubMed 18592002
Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
Mol Cancer, 7, 94
PubMed 19117505
Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status
Hum Mutat, 29 (11), E252-62
PubMed 18781614
Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
J Transl Med, 6, 13
PubMed 18346269
Publications 2007
Improved gene expression signature of testicular carcinoma in situ
Int J Androl, 30 (4), 292-302; discussion 303
PubMed 17488342
Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers
Mol Cancer, 6, 12
PubMed 17274819
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
Mol Cancer, 6, 2
PubMed 17201907
DNA hypermethylation of MAL: a promising diagnostic biomarker for colorectal tumors
Gastroenterology, 132 (4), 1631-2; author reply 1632
PubMed 17408629
The epigenome of testicular germ cell tumors
APMIS, 115 (10), 1147-60
PubMed 18042148
Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study
J Transl Med, 5, 70
PubMed 18162130
Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors
J Clin Oncol, 25 (6), 708-14
PubMed 17228018
Slip slidin' away: a duodecennial review of targeted genes in mismatch repair deficient colorectal cancer
Crit Rev Oncog, 13 (3), 229-57
PubMed 18298386
The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers
Epigenetics, 2 (4), 237-43
PubMed 18281782
DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets
Mol Cancer, 6, 45
PubMed 17623056
Publications 2006
The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes
Genes Chromosomes Cancer, 45 (1), 31-41
PubMed 16145679
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study
Ann Oncol, 17 (5), 842-7
PubMed 16524972
ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
Cell Oncol, 28 (5-6), 259-72
PubMed 17167179
Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)
J Pathol, 210 (4), 441-9
PubMed 17029216
To the Readers and Future Authors of Critical Reviews in Oncogenesis
Critical Reviews in Oncogenesis, 12 (1-2), 1-2
PublikaID 27
Statistical dissection of genetic pathways involved in prostate carcinogenesis
Genes Chromosomes Cancer, 45 (2), 154-63
PubMed 16235241
Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas
Mol Cancer, 5, 33
PubMed 16952311
8q gain is an independent predictor of poor survival in diagnostic needle biopsies from prostate cancer suspects
Clin Cancer Res, 12 (13), 3961-70
PubMed 16818693
Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes
Cell Oncol, 28 (5-6), 315-26
PubMed 17167184
Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours
J Pathol, 209 (4), 492-500
PubMed 16721726
Publications 2005
Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
J Neuropathol Exp Neurol, 64 (1), 74-81
PubMed 15715087
Adenomas and follicular carcinomas of the thyroid display two major patterns of chromosomal changes
J Pathol, 206 (3), 305-11
PubMed 15852498
Identification of two molecular groups of seminomas by using expression and tissue microarrays
Clin Cancer Res, 11 (16), 5722-9
PubMed 16115909
TP53 mutations are associated with a particular pattern of genomic imbalances in breast carcinomas
J Pathol, 207 (1), 14-9
PubMed 16007576
The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation
Mol Cancer, 4 (1), 8
PubMed 15691383
Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development
Cancer Res, 65 (13), 5588-98
PubMed 15994931
Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis
Methods Mol Biol, 291, 207-16
PubMed 15502225
Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability
Neoplasia, 7 (2), 99-108
PubMed 15802015
Publications 2004
Genome characteristics of primary carcinomas, local recurrences, carcinomatoses, and liver metastases from colorectal cancer patients
Mol Cancer, 3, 6
PubMed 14977426
Evaluation of genomic changes in a large series of malignant ovarian germ cell tumors--relation to clinicopathologic variables
Cancer Genet Cytogenet, 155 (1), 25-32
PubMed 15527899
Genome signatures of colon carcinoma cell lines
Cancer Genet Cytogenet, 155 (2), 119-31
PubMed 15571797
A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines
Mol Cancer, 3, 28
PubMed 15476557
Ethnic variation in the prevalence of AZF deletions in testicular cancer
Mutat Res, 554 (1-2), 45-51
PubMed 15450403
Genomic analysis of prostate carcinoma specimens obtained via ultrasound-guided needle biopsy may be of use in preoperative decision-making
Cancer, 101 (8), 1786-93
PubMed 15386312
Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis
Br J Cancer, 91 (4), 775-82
PubMed 15266323
Publications 2003
Molecular cytogenetic characterization of desmoid tumors
Cancer Genet Cytogenet, 146 (1), 1-7
PubMed 14499689
Genetic profiling of colorectal cancer liver metastases by combined comparative genomic hybridization and G-banding analysis
Genes Chromosomes Cancer, 36 (2), 189-97
PubMed 12508247
Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients
J Clin Oncol, 21 (5), 820-9
PubMed 12610180
Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation
Oncogene, 22 (34), 5358-61
PubMed 12917637
Genome profiles of bilateral dysgerminomas, a unilateral gonadoblastoma, and a metastasis from a 46, XY phenotypic female
Hum Pathol, 34 (9), 946-9
PubMed 14562293
Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors
Cancer Genet Cytogenet, 147 (1), 1-8
PubMed 14580764
Genetic and protein markers related to in situ growth and multiplicity in small sporadic colorectal adenomas
Scand J Gastroenterol, 38 (3), 298-306
PubMed 12737446
Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays
Neoplasia, 5 (5), 397-404
PubMed 14670177
Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome
J Clin Oncol, 21 (24), 4586-91
PubMed 14673046
NKX3.1 expression is lost in testicular germ cell tumors
Am J Pathol, 163 (6), 2149-54
PubMed 14633588
The testicular germ cell tumour genome
APMIS, 111 (1), 136-50; discussion 50-1
PubMed 12752254
WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas
Gastroenterology, 124 (1), 270-1
PubMed 12512062
Publications 2002
Genome profiling of breast cancer cells selected against in vitro shows copy number changes
Genes Chromosomes Cancer, 33 (3), 304-9
PubMed 11807988
Alterations of the fragile histidine triad gene, FHIT, and its encoded products contribute to testicular germ cell tumorigenesis
Cancer Res, 62 (2), 512-7
PubMed 11809703
Genome profiles of familial/bilateral and sporadic testicular germ cell tumors
Genes Chromosomes Cancer, 34 (2), 168-74
PubMed 11979550
The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas
Cancer Epidemiol Biomarkers Prev, 11 (12), 1684-8
PubMed 12496062
Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis
Br J Cancer, 87 (7), 756-62
PubMed 12232760
APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status
Scand J Gastroenterol, 37 (10), 1184-93
PubMed 12408524
New insights into testicular germ cell tumorigenesis from gene expression profiling
Cancer Res, 62 (8), 2359-64
PubMed 11956097
Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors
Oncogene, 21 (24), 3909-16
PubMed 12032829
Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer
Oncogene, 21 (57), 8878-84
PubMed 12483540
Publications 2001
Assessments of clonal composition of colorectal adenomas by FISH analysis of chromosomes 1, 7, 13 and 20
Int J Cancer, 92 (6), 816-23
PubMed 11351301
Gender difference for mismatch repair deficiency in human colorectal cancer
Gastroenterology, 121 (4), 1026-7
PubMed 11665694
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
Int J Cancer, 92 (3), 441-50
PubMed 11291084
Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors
Genes Chromosomes Cancer, 30 (2), 202-6
PubMed 11135438
A germline E-cadherin mutation in a family with gastric and colon cancer
Int J Mol Med, 8 (4), 439-43
PubMed 11562785
Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA
Cancer Genet Cytogenet, 127 (1), 64-70
PubMed 11408068
Familial/bilateral and sporadic testicular germ cell tumors show frequent genetic changes at loci with suggestive linkage evidence
Neoplasia, 3 (3), 196-203
PubMed 11494113
Evaluation of breast cancer polyclonality by combined chromosome banding and comparative genomic hybridization analysis
Neoplasia, 3 (3), 204-14
PubMed 11494114
WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability
Gastroenterology, 121 (6), 1275-80
PubMed 11729105
Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas
Scand J Gastroenterol, 36 (12), 1327-31
PubMed 11761025
Publications 2000
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
Oncogene, 19 (1), 164-8
PubMed 10644993
Primary cervical carcinomas show 2 common regions of deletion at 3P, 1 within the FHIT gene: evaluation of allelic imbalance at FHIT, RB1 and TP53 in relation to survival
Int J Cancer, 88 (2), 217-22
PubMed 11004671
DNA copy number changes in malignant ovarian germ cell tumors
Cancer Res, 60 (11), 3025-30
PubMed 10850452
High frequency of clonal chromosome abnormalities in prostatic neoplasms sampled by prostatectomy or ultrasound-guided needle biopsy
Genes Chromosomes Cancer, 28 (2), 211-9
PubMed 10825006
Evaluation of 1p losses in primary carcinomas, local recurrences and peripheral metastases from colorectal cancer patients
Neoplasia, 2 (6), 514-22
PubMed 11228544
Publications 1999
Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway
Genes Chromosomes Cancer, 26 (2), 151-60
PubMed 10469453
Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability
Oncogene, 18 (48), 6806-9
PubMed 10597289
Publications 1998
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors
Cancer Res, 58 (10), 2087-90
PubMed 9605748
Allelic imbalance and cytogenetic deletion of 1p in colorectal adenomas: a target region identified between DIS199 and DIS234
Genes Chromosomes Cancer, 21 (3), 185-94
PubMed 9523193
TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival
Clin Cancer Res, 4 (1), 203-10
PubMed 9516972
[Molecular biology. Basis for increased understanding of diseases and improved diagnostics]
Tidsskr Nor Laegeforen, 118 (11), 1681
PubMed 9621751
Association of p53 accumulation with TP53 mutations, loss of heterozygosity at 17p13, and DNA ploidy status in 273 colorectal carcinomas
Diagn Mol Pathol, 7 (4), 215-23
PubMed 9917132
Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype
Mol Pathol, 51 (5), 254-61
PubMed 10193519
[Tumor suppressors--genes and proteins]
Tidsskr Nor Laegeforen, 118 (12), 1887-92
PubMed 9638059
The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer
Cancer Res, 58 (14), 2923-4
PubMed 9679946
Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites
Genes Chromosomes Cancer, 21 (2), 101-7
PubMed 9491320
Publications 1997
Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors
Int J Cancer, 74 (6), 664-9
PubMed 9421366
Comparison of genetic changes in frozen biopsies and microdissected archival material from the same colorectal liver metastases
Diagn Mol Pathol, 6 (6), 318-25
PubMed 9559291
Microsatellite instability in cervical and endometrial carcinomas
Int J Cancer, 70 (5), 499-501
PubMed 9052745
Microsatellite instability in human solid tumors
Mol Med Today, 3 (2), 61-8
PubMed 9060003
Benign and malignant thyroid lesions show instability at microsatellite loci
Eur J Cancer, 33 (2), 293-6
PubMed 9135503
Publications 1996
Gain of 17q24-qter detected by comparative genomic hybridization in malignant tumors from patients with von Recklinghausen's neurofibromatosis
Cancer Res, 56 (20), 4778-81
PubMed 8840998
Allelotype profiles of local recurrences and distant metastases from colorectal-cancer patients
Int J Cancer, 69 (6), 452-6
PubMed 8980246
Publications 1995
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas
Hum Mol Genet, 4 (11), 2065-72
PubMed 8589682
P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo
Br J Cancer, 72 (2), 307-11
PubMed 7640210
Deletion of 1p loci and microsatellite instability in colorectal polyps
Genes Chromosomes Cancer, 14 (3), 182-8
PubMed 8589034
[Early diagnosis of colorectal tumors]
Tidsskr Nor Laegeforen, 115 (26), 3231-2
PubMed 7482447
Molecular genetic changes in human male germ cell tumors
Lab Invest, 73 (5), 606-14
PubMed 7474934
Alterations at chromosome 17 loci in peripheral nerve sheath tumors
J Neuropathol Exp Neurol, 54 (1), 65-73
PubMed 7815081
Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile
Int J Cancer, 64 (1), 32-6
PubMed 7665246
Publications 1994
Association studies of a polymorphism in the Wilms' tumor 1 locus in Norwegian patients with testicular cancer
Int J Cancer, 58 (4), 523-6
PubMed 8056449
Publications 1993
P53 expression is associated with a high-degree of tumor DNA aneuploidy and incidence of p53 gene mutation, and is localized to the aneuploid component in colorectal carcinomas
Int J Oncol, 3 (2), 305-12
PubMed 21573365
No germline TP53 mutations detected in familial and bilateral testicular cancer
Genes Chromosomes Cancer, 6 (2), 92-7
PubMed 7680893
Frequent loss of 11p13 and 11p15 loci in male germ cell tumours
Genes Chromosomes Cancer, 7 (2), 96-101
PubMed 7687459
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history
Cancer Res, 53 (24), 5849-52
PubMed 8261392
Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1)
Pathol Res Pract, 189 (4), 465-71; discussion 471-4
PubMed 8351250
The TP53 tumour suppressor gene in colorectal carcinomas. I. Genetic alterations on chromosome 17
Br J Cancer, 67 (1), 88-92
PubMed 8094008
The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinicopathological variables
Br J Cancer, 67 (1), 93-8
PubMed 8427784
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome
Cancer Res, 53 (24), 5853-5
PubMed 8261393
K-ras oncogene codon 12 point mutations in testicular cancer
Environ Health Perspect, 101 Suppl 3, 185-7
PubMed 8143614
Publications 1992
No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung
Genes Chromosomes Cancer, 5 (2), 97-103
PubMed 1381957
Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors
J Natl Cancer Inst, 84 (14), 1100-8
PubMed 1619684
High resolution chromosome banding in search of germ line mutations applied on testicular cancer patients
Cancer Genet Cytogenet, 59 (1), 62-7
PubMed 1555193
Chromosome 12 in human testicular cancer: dosage changes and their parental origin
Cancer Genet Cytogenet, 64 (1), 21-6
PubMed 1458445
Constitutional ring chromosomes and tumour suppressor genes
J Med Genet, 29 (12), 879-82
PubMed 1336057
Publications 1991
Chromosome 13 alterations in osteosarcoma cell lines derived from a patient with previous retinoblastoma
Cancer Genet Cytogenet, 57 (1), 31-40
PubMed 1684533
Genetic alterations within the retinoblastoma locus in colorectal carcinomas. Relation to DNA ploidy pattern studied by flow cytometric analysis
Br J Cancer, 64 (3), 475-80
PubMed 1911187
Altered dosage of the sex chromosomes in human testicular cancer: a molecular genetic study
Int J Cancer, 47 (4), 518-22
PubMed 1995482
Publications 1990
Human pepsinogen A (PGA): an informative gene complex located at 11q13
Hum Genet, 84 (3), 293-5
PubMed 1968039
2ND NON-GERM CELL MALIGNANCIES AFTER RADIOTHERAPY OF TESTICULAR CANCER WITH OR WITHOUT CHEMOTHERAPY
Br. J. Cancer, 61 (4), 639-643
Second non-germ cell malignancies after radiotherapy of testicular cancer with or without chemotherapy
Br J Cancer, 61 (4), 639-43
PubMed 2109999
High-resolution karyotypes of eighteen Norwegian polyposis patients
Cancer Genet Cytogenet, 47 (1), 69-72
PubMed 2162732
Publications 1989
[The polyposis project]
Nord Med, 104 (1), 12-5
PubMed 2536147
Loss of 3p or 11p alleles is associated with testicular cancer tumors
Genomics, 5 (1), 134-8
PubMed 2767683
Publications 1988
[The polyposis project]
Tidsskr Nor Laegeforen, 108 (29), 2465-8
PubMed 2905084
VNTR (variable number of tandem repeats) markers show loss of chromosome 17p sequences in human colorectal carcinomas
Cytogenet Cell Genet, 48 (3), 167-9
PubMed 2906851
Publications 1987
The Kidd (JK) blood group locus assigned to chromosome 18 by close linkage to a DNA-RFLP
Hum Genet, 77 (3), 205-9
PubMed 2890568
Loss of one chromosome #13 during development of a polyposis tumor
Cancer Genet Cytogenet, 28 (2), 335-42
PubMed 2887278
Publications 1986
Very close linkage between D2S1 and ACP1 on chromosome 2p
Ann Hum Genet, 50 (Pt 4), 361-7
PubMed 3481680
Publications 1985
Stainer and Scholte's pertussis medium with an alternative buffer
J Biol Stand, 13 (2), 129-34
PubMed 2860114




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