Publications 2023

Andresen H, Pérez-Ternero C, Robinson J, Dickey DM, Hobbs AJ, Potter LR, Levy FO, Cataliotti A, Moltzau LR (2023)
Novel enhancers of guanylyl cyclase-A activity acting via allosteric modulation
Br J Pharmacol, 180 (24), 3254-3270
DOI 10.1111/bph.16203, PubMed 37522273

Publications 2022

Calamera G, Moltzau LR, Levy FO, Andressen KW (2022)
Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
Int J Mol Sci, 23 (4)
DOI 10.3390/ijms23042145, PubMed 35216259

Manfra O, Calamera G, Froese A, Arunthavarajah D, Surdo NC, Meier S, Melleby AO, Aasrum M, Aronsen JM, Nikolaev VO, Zaccolo M, Moltzau LR, Levy FO, Andressen KW (2022)
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors
Cardiovasc Res, 118 (6), 1506-1519
DOI 10.1093/cvr/cvab167, PubMed 33970224

Publications 2019

Calamera G, Li D, Ulsund AH, Kim JJ, Neely OC, Moltzau LR, Bjørnerem M, Paterson D, Kim C, Levy FO, Andressen KW (2019)
FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
Commun Biol, 2, 394
DOI 10.1038/s42003-019-0641-x, PubMed 31701023

Cosson MV, Hiis HG, Moltzau LR, Levy FO, Krobert KA (2019)
Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β₁-adrenoceptor-mediated inotropic response
J Mol Cell Cardiol, 131, 132-145
DOI 10.1016/j.yjmcc.2019.04.017, PubMed 31009605

Publications 2017

Ahamed M, Vermeulen K, Schnekenburger M, Moltzau LR, Levy FO, Marton J, Froeyen M, Olberg DE, Diederich M, Bormans G (2017)
Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers
Lett. Drug Des. Discov., 14 (7), 787-797
DOI 10.2174/1570180813666161101152943

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO, Moltzau LR (2017)
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur J Pharmacol, 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014, PubMed 28697992

Todd Milne G, on behalf of the Ironwood team, Sandner P, Lincoln KA, Harrison PC, Chen H, Wang H, Clifford H, Qian HS, Wong D, Sarko C, Fryer R, Richman J, Reinhart GA, Boustany CM, Pullen SS, Andresen H, Moltzau LR, Cataliotti A, Levy FO, Lukowski R, Frankenreiter S, Friebe A, Calamaras T, Baumgartner R et al. (2017)
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017
BMC Pharmacol Toxicol, 18 (Suppl 1), 64
DOI 10.1186/s40360-017-0170-5, PubMed 29035170

Publications 2016

Eikemo H, Moltzau LR, Hussain RI, Nguyen CH, Qvigstad E, Levy FO, Skomedal T, Osnes JB (2016)
CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes
Biochem Biophys Res Commun, 471 (1), 219-25
DOI 10.1016/j.bbrc.2016.01.132, PubMed 26809094

Eikemo H, Moltzau LR, Nguyen CHT, Levy FO, Skomedal T, Osnes JB (2016)
CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes
Biochem Biophys Res Commun, 477 (1), 14-19
DOI 10.1016/j.bbrc.2016.05.138, PubMed 27237977

Publications 2014

Brudeli B, Navaratnarajah M, Andressen KW, Manfra O, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2014)
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists
Bioorg Med Chem Lett, 24 (18), 4598-4602
DOI 10.1016/j.bmcl.2014.06.083, PubMed 25149506

Moltzau LR, Aronsen JM, Meier S, Skogestad J, Ørstavik Ø, Lothe GB, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle
J Pharmacol Exp Ther, 350 (3), 681-90
DOI 10.1124/jpet.114.214882, PubMed 25022512

Moltzau LR, Meier S, Aronsen JM, Afzal F, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium
Naunyn Schmiedebergs Arch Pharmacol, 387 (5), 407-17
DOI 10.1007/s00210-013-0953-1, PubMed 24424715

Publications 2013

Brudeli B, Andressen KW, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2013)
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists
Bioorg Med Chem, 21 (22), 7134-45
DOI 10.1016/j.bmc.2013.09.004, PubMed 24113240

Brudeli B, Moltzau LR, Nguyen CH, Andressen KW, Nilsen NO, Levy FO, Klaveness J (2013)
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist
Eur J Med Chem, 64, 629-37
DOI 10.1016/j.ejmech.2013.03.060, PubMed 23711770

Moltzau LR, Aronsen JM, Meier S, Nguyen CH, Hougen K, Ørstavik Ø, Sjaastad I, Christensen G, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2013)
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium
Br J Pharmacol, 170 (2), 366-79
DOI 10.1111/bph.12282, PubMed 23808942

Publications 2012

Brattelid T, Qvigstad E, Moltzau LR, Bekkevold SV, Sandnes DL, Birkeland JA, Skomedal T, Osnes JB, Sjaastad I, Levy FO (2012)
The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure
PLoS One, 7 (9), e45489
DOI 10.1371/journal.pone.0045489, PubMed 23029047

Publications 2011

Afzal F, Aronsen JM, Moltzau LR, Sjaastad I, Levy FO, Skomedal T, Osnes JB, Qvigstad E (2011)
Differential regulation of β2 -adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle
Br J Pharmacol, 162 (1), 54-71
DOI 10.1111/j.1476-5381.2010.00890.x, PubMed 21133887

Afzal F, Qvigstad E, Aronsen JM, Moltzau LR, Sjaastad I, Skomedal T, Osnes JB, Levy FO (2011)
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle
Naunyn Schmiedebergs Arch Pharmacol, 384 (6), 543-53
DOI 10.1007/s00210-011-0670-6, PubMed 21901315

Berrade L, Aisa B, Ramirez MJ, Galiano S, Guccione S, Moltzau LR, Levy FO, Nicoletti F, Battaglia G, Molinaro G, Aldana I, Monge A, Perez-Silanes S (2011)
Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action
J Med Chem, 54 (8), 3086-90
DOI 10.1021/jm2000773, PubMed 21469694

Publications 2010

Brudeli B, Moltzau LR, Andressen KW, Krobert KA, Klaveness J, Levy FO (2010)
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists
Bioorg Med Chem, 18 (24), 8600-13
DOI 10.1016/j.bmc.2010.10.011, PubMed 21075638

Publications 2009

Qvigstad E, Moltzau LR, Aronsen JM, Nguyen CH, Hougen K, Sjaastad I, Levy FO, Skomedal T, Osnes JB (2009)
Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition
Cardiovasc Res, 85 (4), 763-72
DOI 10.1093/cvr/cvp364, PubMed 19900965

Publications 2008

Kloster MM, Hafte TT, Moltzau LR, Naderi EH, Dahle MK, Skålhegg BS, Gaudernack G, Levy FO, Naderi S, Blomhoff HK (2008)
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase
Cell Signal, 20 (6), 1169-78
DOI 10.1016/j.cellsig.2008.02.007, PubMed 18406106

Publications 2005

Moltzau LR (2005)
Novel serotonin receptor ligands: pharmacological characterisation of new 5-HT₄ receptor ligands and clonig of the 5-HT₁E and the 5-HT₂A receptor in the process to test new ligands
L.R. Moltzau, Oslo, 128 s.
BIBSYS 052191435