Research projects

Our aim is to model human diseases using induced pluripotent stem cells (iPSC).

Currently we are working on reprogramming cells from patients suffering from Huntington disease to iPSC. Also, we are in the process of reprogramming fibroblasts from patients with different genetic imprinting disorders. Furthermore, by using embryonic stem cells derived from knockout animals lacking enzymes involved in epigenetic regulation, we try to elucidate mechanisms regulating pluripotency and self-renewal.

We do have a close collaboration with professor Arne Klungland (the National Hospital, Oslo, Norway), professor Jennie Lee (Harvard Medical School, Boston, USA) and professor Mary Donohoe (Weill Cornell Medical College, New York, USA).