Research projects

Organization of respiratory complexes during disease and stress

We are currently investigating the mode of supercomplex assembly in different cellular system.

1. In collaboration with the institute of microbiology, we are evaluating the mitochondrial supercomplex organization in cytomegalovirus-infected cells.

2. During apoptosis, mitochondria play essential role in both initiation and execution of the cell death scenario. Our focus on mitochondrial supercomplexes aim to evaluate the impact of supercomplexes in the sensitivity towards apoptosis.

3. Supercomplexes alteration is associated to disease. We have found mitochondrial alteration in fibroblasts from a mouse model of Cockayne Syndrome.

Modulation of mitochondrial function during neuronal differentiation

In this project, we are exploring the maturation of mitochondria during differentiation from neural stem cell to differentiated neurons and astrocytes. In addition, we are investigating the impact of mtDNA integrity on the differentiation process.

Intramitochondrial organization of mtDNA

Mitochondrial DNA resides in the matrix side of mitochondria, and there are increasing number of non-DNA related proteins being found to be associated to mtDNA. Among these proteins, are several key metabolic proteins, such as subunit of the branched-chain ketoacid dehydrogenase (E2), and infer a molecular link between mtDNA and metabolic regulation.We are currently investigating this relationship.

Characterization of mitochondrial parameters important for learning and memory

In collaboration with Dr. Gro Amdam at UMB, we are analysing mitochondrial parameters that are associated with cognitive function in Honey Bees (Apis Mellifera  carnica). The project involves evaluation of cognitive testing of bees. The learning capacity is correlated with alteration in mtDNA integrity in bee brain. We have succeeded in establishing methods for analysis of mtDNA damage, mtDNA concentration and mitochondrial gene expression.