Anita Langerød's project group
TP53 and somatic genetics of breast cancer
Our research is focused on understanding the genomics of breast cancer, and in particular the role of TP53 and associated molecular networks. TP53 is a key regulator of many critical cellular processes and the gene is affected by mutation in breast cancer subtypes with poor prognosis. By integrating cancer genome profiling with single gene analysis in large series of patient samples, we aim to search for diagnostic, prognostic and predictive biomarkers of breast cancer.
Current projects and funding sources:
- Elucidating the TP53 network in breast cancer (Helse Sør-Øst)
- Breast Cancer Somatic Genetics Study (BASIS; EU FP7)
Contact information:
Department of Genetics, Institute for Cancer Research, Oslo University Hospital - Radiumhospitalet, Montebello, 0310 Oslo, Norway. Phone: +47 22 78 13 76, Fax: +47 22 78 13 95, Switchboard: +47 22 93 40 00. Email: anita.langerod@rr-research.no
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Jan 17, 2012
Latest publictions
Anita Langerød
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
Cell, 148 (1-2), 244-58
PubMed 22265415
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups
Breast Cancer Res Treat, 130 (2), 599-608
PubMed 21667122
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Nat Genet, 43 (7), 621-9
PubMed 21642992
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