Publications

Publications published since 2003 or in press from OUS - Laboratory for genome repair and regulation

64 publications found

Publications in press

1. Zheng G, Dahl JA, Niu Y, Fu Y, Klungland A, Yang YG, He C
   Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases
   RNA Biol, 10 (6) (in press)
   PubMed 23619745

Publications 2013

1. Furu K, Klungland A (2013)
   Tzfp represses the androgen receptor in mouse testis
   PLoS One, 8 (4), e62314
   PubMed 23634227
2. Herrmann D, Dahl JA, Lucas-Hahn A, Collas P, Niemann H (2013)
   Histone modifications and mRNA expression in the inner cell mass and trophectoderm of bovine blastocysts
   Epigenetics, 8 (3), 281-9
   PubMed 23406883
3. Jonson I, Ougland R, Larsen E (2013)
   DNA Repair Mechanisms in Huntington's Disease
   Mol Neurobiol, 47 (3), 1093-102
   PubMed 23361256
4. Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG (2013)
   ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
   Nat Commun, 4, 1832
   PubMed 23673617
5. Solberg A, Robertson AB, Aronsen JM, Rognmo O, Sjaastad I, Wisløff U, Klungland A (2013)
   Deletion of mouse Alkbh7 leads to obesity
   J Mol Cell Biol, 5 (3), 194-203
   PubMed 23572141
6. Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE et al. (2013)
   ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
   Mol Cell, 49 (1), 18-29
   PubMed 23177736

Publications 2012

1. Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD (2012)
   DNA repair is indispensable for survival after acute inflammation
   J Clin Invest, 122 (7), 2680-9
   PubMed 22684101
2. Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH (2012)
   Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells
   Cell Oncol (Dordr), 35 (3), 217-27
   PubMed 22700320
3. Kleppa L, Mari PO, Larsen E, Lien GF, Godon C, Theil AF, Nesse GJ, Wiksen H, Vermeulen W, Giglia-Mari G, Klungland A (2012)
   Kinetics of endogenous mouse FEN1 in base excision repair
   Nucleic Acids Res, 40 (18), 9044-59
   PubMed 22810208
4. Larsen E, Rise J, Lund KE (2012)
   The relationship between snus use and smoking cognitions
   Addict Res Theory, 20 (6), 447-455
   PubMed 23204990
5. Meza TJ, Moen MN, Vågbø CB, Krokan HE, Klungland A, Grini PE, Falnes PØ (2012)
   The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage
   Nucleic Acids Res, 40 (14), 6620-31
   PubMed 22532610
6. Møllersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveterås L, Bjølgerud A, Wilson DM, Bjørås M, Klungland A (2012)
   Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
   Hum Mol Genet, 21 (22), 4939-47
   PubMed 22914735
7. Nordstrand LM, Furu K, Paulsen J, Rognes T, Klungland A (2012)
   Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes
   Nucleic Acids Res, 40 (21), 10950-63
   PubMed 22965116
8. Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E (2012)
   ALKBH1 is a histone H2A dioxygenase involved in neural differentiation
   Stem Cells, 30 (12), 2672-82
   PubMed 22961808
9. Robertson AB, Dahl JA, Ougland R, Klungland A (2012)
   Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads
   Nat Protoc, 7 (2), 340-50
   PubMed 22281869

Publications 2011

1. Fusser M, Nesse GJ, Khobta A, Xia N, Li H, Klungland A, Epe B (2011)
   Spontaneous mutagenesis in Csb(m/m)Ogg1?(/)? mice is attenuated by dietary resveratrol
   Carcinogenesis, 32 (1), 80-5
   PubMed 21062970
2. Haj-Yasein NN, Jensen V, Vindedal GF, Gundersen GA, Klungland A, Ottersen OP, Hvalby O, Nagelhus EA (2011)
   Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10)
   Glia, 59 (11), 1635-42
   PubMed 21748805
3. Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare Ø, Laake P, Klungland A, Thorén AE, Burkhardt JM, Ottersen OP, Nagelhus EA (2011)
   Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
   Proc Natl Acad Sci U S A, 108 (43), 17815-20
   PubMed 21990350
4. Kasper M, Jaks V, Are A, Bergström Å, Schwäger A, Svärd J, Teglund S, Barker N, Toftgård R (2011)
   Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
   Proc Natl Acad Sci U S A, 108 (10), 4099-104
   PubMed 21321199
5. Lauritzen KH, Cheng C, Wiksen H, Bergersen LH, Klungland A (2011)
   Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses
   DNA Repair (Amst), 10 (6), 639-53
   PubMed 21550321
6. Lauritzen KH, Dalhus B, Storm JF, Bjørås M, Klungland A (2011)
   Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond
   Mech Ageing Dev, 132 (8-9), 424-8
   PubMed 21354441
7. Moen MN, Knævelsrud I, Haugland GT, Grøsvik K, Birkeland NK, Klungland A, Bjelland S (2011)
   Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair
   J Bacteriol, 193 (17), 4495-508
   PubMed 21665970
8. Robertson AB, Dahl JA, Vågbø CB, Tripathi P, Krokan HE, Klungland A (2011)
   A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
   Nucleic Acids Res, 39 (8), e55
   PubMed 21300643
9. Robertson J, Robertson AB, Klungland A (2011)
   The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression
   Biochem Biophys Res Commun, 411 (1), 40-3
   PubMed 21703242
10. Strømme P, Dobrenis K, Sillitoe RV, Gulinello M, Ali NF, Davidson C, Micsenyi MC, Stephney G, Ellevog L, Klungland A, Walkley SU (2011)
    X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction
    Brain, 134 (Pt 11), 3369-83
    PubMed 21964919
11. Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Rangroo Thrane V, Enger R, Haj-Yasein NN, Skare Ø, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA (2011)
    Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema
    Proc Natl Acad Sci U S A, 108 (2), 846-51
    PubMed 21187412
12. van den Born E, Vågbø CB, Songe-Møller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PØ (2011)
    ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
    Nat Commun, 2, 172
    PubMed 21285950

Publications 2010

1. Dahl JA, Reiner AH, Klungland A, Wakayama T, Collas P (2010)
   Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos
   PLoS One, 5 (2), e9150
   PubMed 20161773
2. Knævelsrud I, Moen MN, Grøsvik K, Haugland GT, Birkeland NK, Klungland A, Leiros I, Bjelland S (2010)
   The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement
   J Bacteriol, 192 (21), 5755-66
   PubMed 20453094
3. Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH, Klungland A (2010)
   Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior
   Mol Cell Biol, 30 (6), 1357-67
   PubMed 20065039
4. Møllersen L, Rowe AD, Larsen E, Rognes T, Klungland A (2010)
   Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice
   PLoS Genet, 6 (12), e1001242
   PubMed 21170307
5. Nordstrand LM, Svärd J, Larsen E, Nilsen A, Ougland R, Furu K, Lien GF, Rognes T, Namekawa SH, Lee JT, Klungland A (2010)
   Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects
   PLoS One, 5 (11), e13827
   PubMed 21072209
6. Songe-Møller L, van den Born E, Leihne V, Vågbø CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PØ, Klungland A (2010)
   Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding
   Mol Cell Biol, 30 (7), 1814-27
   PubMed 20123966

Publications 2009

1. Robertson AB, Klungland A, Rognes T, Leiros I (2009)
   DNA repair in mammalian cells: Base excision repair: the long and short of it
   Cell Mol Life Sci, 66 (6), 981-93
   PubMed 19153658
2. van den Born E, Bekkelund A, Moen MN, Omelchenko MV, Klungland A, Falnes PØ (2009)
   Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
   Nucleic Acids Res, 37 (21), 7124-36
   PubMed 19786499

Publications 2008

1. Larsen E, Kleppa L, Meza TJ, Meza-Zepeda LA, Rada C, Castellanos CG, Lien GF, Nesse GJ, Neuberger MS, Laerdahl JK, William Doughty R, Klungland A (2008)
   Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants
   Cancer Res, 68 (12), 4571-9
   PubMed 18559501
2. Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PØ, Klungland A (2008)
   AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA
   Cancer Res, 68 (11), 4142-9
   PubMed 18519673
3. Saxowsky TT, Meadows KL, Klungland A, Doetsch PW (2008)
   8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells
   Proc Natl Acad Sci U S A, 105 (48), 18877-82
   PubMed 19020090

Publications 2007

1. Falnes PØ, Klungland A, Alseth I (2007)
   Repair of methyl lesions in DNA and RNA by oxidative demethylation
   Neuroscience, 145 (4), 1222-32
   PubMed 17175108
2. Kleppa L, Kanavin ØJ, Klungland A, Strømme P (2007)
   A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome
   Neuroscience, 145 (4), 1397-406
   PubMed 17084038
3. Klungland A, Andersson KB (2007)
   [Nobel Prize for genetic modification]
   Tidsskr Nor Laegeforen, 127 (23), 3054
   PubMed 18049491
4. Klungland A, Bjelland S (2007)
   Oxidative damage to purines in DNA: role of mammalian Ogg1
   DNA Repair (Amst), 6 (4), 481-8
   PubMed 17127104
5. Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT (2007)
   OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
   Nature, 447 (7143), 447-52
   PubMed 17450122
6. Larsen E, Meza TJ, Kleppa L, Klungland A (2007)
   Organ and cell specificity of base excision repair mutants in mice
   Mutat Res, 614 (1-2), 56-68
   PubMed 16765995
7. Leiros I, Nabong MP, Grøsvik K, Ringvoll J, Haugland GT, Uldal L, Reite K, Olsbu IK, Knaevelsrud I, Moe E, Andersen OA, Birkeland NK, Ruoff P, Klungland A, Bjelland S (2007)
   Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA
   EMBO J, 26 (8), 2206-17
   PubMed 17396151
8. Nordstrand LM, Ringvoll J, Larsen E, Klungland A (2007)
   Genome instability and DNA damage accumulation in gene-targeted mice
   Neuroscience, 145 (4), 1309-17
   PubMed 17218062
9. Ringvoll J, Uldal L, Roed MA, Reite K, Baynton K, Klungland A, Eide L (2007)
   Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol
   FEMS Yeast Res, 7 (6), 848-59
   PubMed 17506834
10. Risom L, Dybdahl M, Møller P, Wallin H, Haug T, Vogel U, Klungland A, Loft S (2007)
    Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
    Free Radic Res, 41 (2), 172-81
    PubMed 17364943
11. Trapp C, Reite K, Klungland A, Epe B (2007)
    Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice
    Oncogene, 26 (27), 4044-8
    PubMed 17213818

Publications 2006

1. Larsen E, Reite K, Nesse G, Gran C, Seeberg E, Klungland A (2006)
   Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice
   Oncogene, 25 (17), 2425-32
   PubMed 16369492
2. Ringvoll J, Nordstrand LM, Vågbø CB, Talstad V, Reite K, Aas PA, Lauritzen KH, Liabakk NB, Bjørk A, Doughty RW, Falnes PØ, Krokan HE, Klungland A (2006)
   Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
   EMBO J, 25 (10), 2189-98
   PubMed 16642038
3. Touati E, Michel V, Thiberge JM, Avé P, Huerre M, Bourgade F, Klungland A, Labigne A (2006)
   Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse
   Helicobacter, 11 (5), 494-505
   PubMed 16961812

Publications 2005

1. Holen T, Moe SE, Sørbø JG, Meza TJ, Ottersen OP, Klungland A (2005)
   Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo
   Nucleic Acids Res, 33 (15), 4704-10
   PubMed 16113241
2. Rozalski R, Siomek A, Gackowski D, Foksinski M, Gran C, Klungland A, Olinski R (2005)
   Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice
   Int J Biochem Cell Biol, 37 (6), 1331-6
   PubMed 15778095

Publications 2004

1. Foksinski M, Rozalski R, Guz J, Ruszkowska B, Sztukowska P, Piwowarski M, Klungland A, Olinski R (2004)
   Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species
   Free Radic Biol Med, 37 (9), 1449-54
   PubMed 15454284
2. Larsen E, Kwon K, Coin F, Egly JM, Klungland A (2004)
   Transcription activities at 8-oxoG lesions in DNA
   DNA Repair (Amst), 3 (11), 1457-68
   PubMed 15380101
3. Ougland R, Zhang CM, Liiv A, Johansen RF, Seeberg E, Hou YM, Remme J, Falnes PØ (2004)
   AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
   Mol Cell, 16 (1), 107-16
   PubMed 15469826
4. Rozalski R, Siomek A, Gackowski D, Foksinski M, Gran C, Klungland A, Olinski R (2004)
   Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine
   Free Radic Res, 38 (11), 1201-5
   PubMed 15621697

Publications 2003

1. Dantzer F, Bjørås M, Luna L, Klungland A, Seeberg E (2003)
   Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
   DNA Repair (Amst), 2 (6), 707-18
   PubMed 12767349
2. Larsen E, Gran C, Saether BE, Seeberg E, Klungland A (2003)
   Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
   Mol Cell Biol, 23 (15), 5346-53
   PubMed 12861020
3. Moe A, Ringvoll J, Nordstrand LM, Eide L, Bjørås M, Seeberg E, Rognes T, Klungland A (2003)
   Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
   Nucleic Acids Res, 31 (14), 3893-900
   PubMed 12853604
4. Rogers PA, Eide L, Klungland A, Ding H (2003)
   Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide
   DNA Repair (Amst), 2 (7), 809-17
   PubMed 12826281
5. Seeberg E, Klungland A (2003)
   Better late than never for repair of miscoding lesions within a transcribed template
   Mol Cell, 12 (4), 799-800
   PubMed 14580331