Publications
Publications published since 2003 or in press from OUS - Laboratory for genome repair and regulation
64 publications found
Publications in press
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Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases
RNA Biol, 10 (6) (in press)
PubMed 23619745
Publications 2013
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Tzfp represses the androgen receptor in mouse testis
PLoS One, 8 (4), e62314
PubMed 23634227 -
Histone modifications and mRNA expression in the inner cell mass and trophectoderm of bovine blastocysts
Epigenetics, 8 (3), 281-9
PubMed 23406883 -
DNA Repair Mechanisms in Huntington's Disease
Mol Neurobiol, 47 (3), 1093-102
PubMed 23361256 -
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
Nat Commun, 4, 1832
PubMed 23673617 -
Deletion of mouse Alkbh7 leads to obesity
J Mol Cell Biol, 5 (3), 194-203
PubMed 23572141 -
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
Mol Cell, 49 (1), 18-29
PubMed 23177736
Publications 2012
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DNA repair is indispensable for survival after acute inflammation
J Clin Invest, 122 (7), 2680-9
PubMed 22684101 -
Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells
Cell Oncol (Dordr), 35 (3), 217-27
PubMed 22700320 -
Kinetics of endogenous mouse FEN1 in base excision repair
Nucleic Acids Res, 40 (18), 9044-59
PubMed 22810208 -
The relationship between snus use and smoking cognitions
Addict Res Theory, 20 (6), 447-455
PubMed 23204990 -
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage
Nucleic Acids Res, 40 (14), 6620-31
PubMed 22532610 -
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
Hum Mol Genet, 21 (22), 4939-47
PubMed 22914735 -
Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes
Nucleic Acids Res, 40 (21), 10950-63
PubMed 22965116 -
ALKBH1 is a histone H2A dioxygenase involved in neural differentiation
Stem Cells, 30 (12), 2672-82
PubMed 22961808 -
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads
Nat Protoc, 7 (2), 340-50
PubMed 22281869
Publications 2011
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Spontaneous mutagenesis in Csb(m/m)Ogg1?(/)? mice is attenuated by dietary resveratrol
Carcinogenesis, 32 (1), 80-5
PubMed 21062970 -
Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10)
Glia, 59 (11), 1635-42
PubMed 21748805 -
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
Proc Natl Acad Sci U S A, 108 (43), 17815-20
PubMed 21990350 -
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
Proc Natl Acad Sci U S A, 108 (10), 4099-104
PubMed 21321199 -
Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses
DNA Repair (Amst), 10 (6), 639-53
PubMed 21550321 -
Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond
Mech Ageing Dev, 132 (8-9), 424-8
PubMed 21354441 -
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair
J Bacteriol, 193 (17), 4495-508
PubMed 21665970 -
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
Nucleic Acids Res, 39 (8), e55
PubMed 21300643 -
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression
Biochem Biophys Res Commun, 411 (1), 40-3
PubMed 21703242 -
X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction
Brain, 134 (Pt 11), 3369-83
PubMed 21964919 -
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema
Proc Natl Acad Sci U S A, 108 (2), 846-51
PubMed 21187412 -
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
Nat Commun, 2, 172
PubMed 21285950
Publications 2010
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Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos
PLoS One, 5 (2), e9150
PubMed 20161773 -
The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement
J Bacteriol, 192 (21), 5755-66
PubMed 20453094 -
Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior
Mol Cell Biol, 30 (6), 1357-67
PubMed 20065039 -
Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice
PLoS Genet, 6 (12), e1001242
PubMed 21170307 -
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects
PLoS One, 5 (11), e13827
PubMed 21072209 -
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding
Mol Cell Biol, 30 (7), 1814-27
PubMed 20123966
Publications 2009
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DNA repair in mammalian cells: Base excision repair: the long and short of it
Cell Mol Life Sci, 66 (6), 981-93
PubMed 19153658 -
Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
Nucleic Acids Res, 37 (21), 7124-36
PubMed 19786499
Publications 2008
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Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants
Cancer Res, 68 (12), 4571-9
PubMed 18559501 -
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA
Cancer Res, 68 (11), 4142-9
PubMed 18519673 -
8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells
Proc Natl Acad Sci U S A, 105 (48), 18877-82
PubMed 19020090
Publications 2007
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Repair of methyl lesions in DNA and RNA by oxidative demethylation
Neuroscience, 145 (4), 1222-32
PubMed 17175108 -
A novel splice site mutation in the Cockayne syndrome group A gene in two siblings with Cockayne syndrome
Neuroscience, 145 (4), 1397-406
PubMed 17084038 -
[Nobel Prize for genetic modification]
Tidsskr Nor Laegeforen, 127 (23), 3054
PubMed 18049491 -
Oxidative damage to purines in DNA: role of mammalian Ogg1
DNA Repair (Amst), 6 (4), 481-8
PubMed 17127104 -
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Nature, 447 (7143), 447-52
PubMed 17450122 -
Organ and cell specificity of base excision repair mutants in mice
Mutat Res, 614 (1-2), 56-68
PubMed 16765995 -
Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA
EMBO J, 26 (8), 2206-17
PubMed 17396151 -
Genome instability and DNA damage accumulation in gene-targeted mice
Neuroscience, 145 (4), 1309-17
PubMed 17218062 -
Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol
FEMS Yeast Res, 7 (6), 848-59
PubMed 17506834 -
Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
Free Radic Res, 41 (2), 172-81
PubMed 17364943 -
Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice
Oncogene, 26 (27), 4044-8
PubMed 17213818
Publications 2006
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Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice
Oncogene, 25 (17), 2425-32
PubMed 16369492 -
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
EMBO J, 25 (10), 2189-98
PubMed 16642038 -
Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse
Helicobacter, 11 (5), 494-505
PubMed 16961812
Publications 2005
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Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo
Nucleic Acids Res, 33 (15), 4704-10
PubMed 16113241 -
Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice
Int J Biochem Cell Biol, 37 (6), 1331-6
PubMed 15778095
Publications 2004
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Urinary excretion of DNA repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species
Free Radic Biol Med, 37 (9), 1449-54
PubMed 15454284 -
Transcription activities at 8-oxoG lesions in DNA
DNA Repair (Amst), 3 (11), 1457-68
PubMed 15380101 -
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
Mol Cell, 16 (1), 107-16
PubMed 15469826 -
Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine
Free Radic Res, 38 (11), 1201-5
PubMed 15621697
Publications 2003
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Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
DNA Repair (Amst), 2 (6), 707-18
PubMed 12767349 -
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
Mol Cell Biol, 23 (15), 5346-53
PubMed 12861020 -
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
Nucleic Acids Res, 31 (14), 3893-900
PubMed 12853604 -
Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide
DNA Repair (Amst), 2 (7), 809-17
PubMed 12826281 -
Better late than never for repair of miscoding lesions within a transcribed template
Mol Cell, 12 (4), 799-800
PubMed 14580331




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