Tom Hemming Karlsen's publications

Publications by Tom Hemming Karlsen

57 publications found

Publications in press

1. Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE et al.
   Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
   J Hepatol (in press)
   PubMed 22521342
2. Metzger J, Negm AA, Plentz RR, Weismüller TJ, Wedemeyer J, Karlsen TH, Dakna M, Mullen W, Mischak H, Manns MP, Lankisch TO
   Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders
   Gut (in press)
   PubMed 22580416
3. Næss S, Shiryaev A, Hov JR, Franke A, Karlsen TH
   Genetics in primary sclerosing cholangitis
   Clin Res Hepatol Gastroenterol (in press)
   PubMed 22554879
4. Srivastava B, Mells GF, Cordell HJ, Muriithi A, Brown M, Ellinghaus E, Franke A, Consortium UP, Karlsen TH, Sandford RN, Alexander GJ, Chapman RW, Rushbrook SM, Melum E
   Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis
   Scand J Gastroenterol (in press)
   PubMed 22554193

Publications 2012

1. Fosby B, Karlsen TH, Melum E (2012)
   Recurrence and rejection in liver transplantation for primary sclerosing cholangitis
   World J Gastroenterol, 18 (1), 1-15
   PubMed 22228965

Publications 2011

1. Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C et al. (2011)
   Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
   Nat Genet, 43 (3), 246-52
   PubMed 21297633
2. Folseraas T, Karlsen TH (2011)
   To MMP or not to MMP: a role for matrix metalloproteinase 3 in primary sclerosing cholangitis?
   Liver Int, 31 (6), 751-4
   PubMed 21645205
3. Folseraas T, Melum E, Franke A, Karlsen TH (2011)
   Genetics in primary sclerosing cholangitis
   Best Pract Res Clin Gastroenterol, 25 (6), 713-26
   PubMed 22117637
4. Friman S, Foss A, Isoniemi H, Olausson M, Höckerstedt K, Yamamoto S, Karlsen TH, Rizell M, Ericzon BG (2011)
   Liver transplantation for cholangiocarcinoma: selection is essential for acceptable results
   Scand J Gastroenterol, 46 (3), 370-5
   PubMed 21073376
5. Hov JR, Keitel V, Schrumpf E, Häussinger D, Karlsen TH (2011)
   TGR5 sequence variation in primary sclerosing cholangitis
   Dig Dis, 29 (1), 78-84
   PubMed 21691110
6. Hov JR, Kosmoliaptsis V, Traherne JA, Olsson M, Boberg KM, Bergquist A, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH (2011)
   Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis
   Hepatology, 53 (6), 1967-76
   PubMed 21413052
7. Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismüller TJ, Wedemeyer J, Schramm C, Sterneck M, Günther R, Braun F et al. (2011)
   Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
   Hepatology, 53 (6), 1977-85
   PubMed 21425313
8. Karlsen TH, Kaser A (2011)
   Deciphering the genetic predisposition to primary sclerosing cholangitis
   Semin Liver Dis, 31 (2), 188-207
   PubMed 21538284
9. Karlsen TH, Lazaridis KN (2011)
   At the end of the beginning. Foreword
   Semin Liver Dis, 31 (2), 111-3
   PubMed 21538278
10. Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M et al. (2011)
    Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
    Nat Genet, 43 (1), 17-9
    PubMed 21151127

Publications 2010

1. Bowlus CL, Li CS, Karlsen TH, Lie BA, Selmi C (2010)
   Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations
   Liver Transpl, 16 (11), 1324-30
   PubMed 21031548
2. Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Belouchi M, Fournier H, Reinhard C, Ding J, Li Y, Tejasvi T, Gudjonsson J, Stoll SW, Voorhees JJ, Lambert S, Weidinger S, Eberlein B, Kunz M, Rahman P, Gladman DD, Gieger C, Wichmann HE, Karlsen TH, Mayr G et al. (2010)
   Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
   Nat Genet, 42 (11), 991-5
   PubMed 20953188
3. Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH, IBSEN study group, Krawczak M et al. (2010)
   Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
   Nat Genet, 42 (4), 292-4
   PubMed 20228798
4. Hollenbach JA, Meenagh A, Sleator C, Alaez C, Bengoche M, Canossi A, Contreras G, Creary L, Evseeva I, Gorodezky C, Hardie RA, Karlsen TH, Lie B, Luo M, Martinetti M, Navarette C, de Oliveira DC, Ozzella G, Pasi A, Pavlova E, Pinto S, Porto LC, Santos P, Slavcev A, Srinak D et al. (2010)
   Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA
   Tissue Antigens, 76 (1), 9-17
   PubMed 20331834
5. Holm K, Melum E, Franke A, Karlsen TH (2010)
   SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
   BMC Bioinformatics, 11, 600
   PubMed 21167019
6. Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH et al. (2010)
   Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
   PLoS One, 5 (8), e12403
   PubMed 20811628
7. Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P (2010)
   Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C
   J Hepatol, 52 (5), 712-7
   PubMed 20347497
8. Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P et al. (2010)
   Genome-wide association analysis in primary sclerosing cholangitis
   Gastroenterology, 138 (3), 1102-11
   PubMed 19944697
9. Karlsen TH, Hov JR (2010)
   Genetics of cholestatic liver disease in 2010
   Curr Opin Gastroenterol, 26 (3), 251-8
   PubMed 20042859
10. Karlsen TH, Melum E, Franke A (2010)
    The utility of genome-wide association studies in hepatology
    Hepatology, 51 (5), 1833-42
    PubMed 20232293
11. Karlsen TH, Schrumpf E, Boberg KM (2010)
    Update on primary sclerosing cholangitis
    Dig Liver Dis, 42 (6), 390-400
    PubMed 20172772
12. Karlsen TH, Schrumpf E, Boberg KM (2010)
    Primary sclerosing cholangitis
    Best Pract Res Clin Gastroenterol, 24 (5), 655-66
    PubMed 20955968
13. Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF (2010)
    Association to the Glypican-5 gene in multiple sclerosis
    J Neuroimmunol, 226 (1-2), 194-7
    PubMed 20692050
14. Melum E, May S, Schilhabel MB, Thomsen I, Karlsen TH, Rosenstiel P, Schreiber S, Franke A (2010)
    SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region
    Hum Mutat, 31 (7), 875-85
    PubMed 20506538

Publications 2009

1. Forsbring M, Vik ES, Dalhus B, Karlsen TH, Bergquist A, Schrumpf E, Bjørås M, Boberg KM, Alseth I (2009)
   Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
   Carcinogenesis, 30 (7), 1147-54
   PubMed 19443904
2. Karlsen TH (2009)
   Genome-wide association studies reach hepatology
   J Hepatol, 50 (6), 1278-80
   PubMed 19395112
3. Lorentzen AR, Karlsen TH, Olsson M, Smestad C, Mero IL, Woldseth B, Sun JY, Senitzer D, Celius EG, Thorsby E, Spurkland A, Lie BA, Harbo HF (2009)
   Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
   Ann Neurol, 65 (6), 658-66
   PubMed 19630074
4. Melum E, Franke A, Karlsen TH (2009)
   Genome-wide association studies--a summary for the clinical gastroenterologist
   World J Gastroenterol, 15 (43), 5377-96
   PubMed 19916168
5. Scholz T, Karlsen TH, Sanengen T, Schrumpf E, Line PD, Boberg KM, Jörgensen PF, Fosby B, Bentdal O, Ostensen AB, Osnes S, Riddervold F, Haugaa H, Hausken J, Bergmann JB, Foss S, Björo K, Foss A, Levertransplantasjonsgruppen ved Oslo universitetssykehus, Rikshospitalet (2009)
   [Liver transplantation in Norway through 25 years]
   Tidsskr Nor Laegeforen, 129 (24), 2587-92
   PubMed 20029553
6. Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, Karlsen TH, Boberg KM, Bergquist A, Kunz M, Witte T, Gross WL, Epplen JT, Alarcón-Riquelme ME, Schreiber S, Ibrahim SM (2009)
   Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases
   Genes Immun, 10 (6), 601-5
   PubMed 19387457

Publications 2008

1. Eike MC, Nordang GB, Karlsen TH, Boberg KM, Vatn MH, IBSEN study group, Dahl-Jørgensen K, Rønningen KS, Joner G, Flatø B, Bergquist A, Thorsby E, Førre O, Kvien TK, Undlien DE, Lie BA (2008)
   The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases
   Ann Rheum Dis, 67 (9), 1287-91
   PubMed 18065500
2. Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S (2008)
   Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
   Nat Genet, 40 (6), 713-5
   PubMed 18438405
3. Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, IBSEN study group, Mathew CG et al. (2008)
   Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
   Nat Genet, 40 (11), 1319-23
   PubMed 18836448
4. Hov JR, Boberg KM, Karlsen TH (2008)
   Autoantibodies in primary sclerosing cholangitis
   World J Gastroenterol, 14 (24), 3781-91
   PubMed 18609700
5. Karlsen TH, Schrumpf E, Boberg KM (2008)
   Gallbladder polyps in primary sclerosing cholangitis: not so benign
   Curr Opin Gastroenterol, 24 (3), 395-9
   PubMed 18408471
6. Melum E, Buch S, Schafmayer C, Kalthoff H, Tepel J, Schreiber S, Karlsen TH, Hampe J (2008)
   Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma
   Int J Cancer, 123 (1), 241-2
   PubMed 18398827
7. Melum E, Karlsen TH, Bergquist A, Schrumpf E, Boberg KM (2008)
   An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis
   Am J Gastroenterol, 103 (4), 1045; author reply 1045-6
   PubMed 18397431
8. Melum E, Karlsen TH, Schrumpf E, Bergquist A, Thorsby E, Boberg KM, Lie BA (2008)
   Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms
   Hepatology, 47 (1), 90-6
   PubMed 18023027

Publications 2007

1. Franke A, Rosenstiel P, Balschun T, Von Kampen O, Schreiber S, Sina C, Hampe J, Karlsen TH, Vatn MH, IBSEN Study Group, Solberg C (2007)
   No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample
   Gastroenterology, 132 (5), 2080-1
   PubMed 17484912
2. Karlsen TH, Boberg KM, Olsson M, Sun JY, Senitzer D, Bergquist A, Schrumpf E, Thorsby E, Lie BA (2007)
   Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
   J Hepatol, 46 (5), 899-906
   PubMed 17383044
3. Karlsen TH, Boberg KM, Vatn M, Bergquist A, Hampe J, Schrumpf E, Thorsby E, Schreiber S, Lie BA, IBSEN Study Group (2007)
   Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis
   Genes Immun, 8 (3), 275-8
   PubMed 17301827
4. Karlsen TH, Hampe J, Wiencke K, Schrumpf E, Thorsby E, Lie BA, Broomé U, Schreiber S, Boberg KM (2007)
   Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis
   Am J Gastroenterol, 102 (1), 115-21
   PubMed 17100974
5. Karlsen TH, Schrumpf E, Boberg KM (2007)
   Genetic epidemiology of primary sclerosing cholangitis
   World J Gastroenterol, 13 (41), 5421-31
   PubMed 17907284
6. Wiencke K, Karlsen TH, Boberg KM, Thorsby E, Schrumpf E, Lie BA, Spurkland A (2007)
   Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes
   Tissue Antigens, 69 (2), 161-9
   PubMed 17257319

Publications 2006

1. Bowlus CL, Karlsen TH, Broomé U, Thorsby E, Vatn M, Schrumpf E, Lie BA, Boberg KM (2006)
   Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis
   J Hepatol, 45 (5), 704-10
   PubMed 16750586
2. Franke A, Ruether A, Wedemeyer N, Karlsen TH, Nebel A, Schreiber S (2006)
   No association between the functional CARD4 insertion/deletion polymorphism and inflammatory bowel diseases in the German population
   Gut, 55 (11), 1679-80
   PubMed 17047129
3. Karlsen TH, Lie BA, Frey Frøslie K, Thorsby E, Broomé U, Schrumpf E, Boberg KM (2006)
   Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis
   Gastroenterology, 131 (3), 781-7
   PubMed 16952547
4. Melum E, Karlsen TH, Broomé U, Thorsby E, Schrumpf E, Boberg KM, Lie BA (2006)
   The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients
   Tissue Antigens, 68 (1), 78-81
   PubMed 16774544

Publications 2004

1. Laerum H, Karlsen TH, Faxvaag A (2004)
   Use of and attitudes to a hospital information system by medical secretaries, nurses and physicians deprived of the paper-based medical record: a case report
   BMC Med Inform Decis Mak, 4, 18
   PubMed 15488150

Publications 2003

1. Karlsen TH, Sommerfelt H, Klomstad S, Andersen PK, Strand TA, Ulvik RJ, Ahrén C, Grewal HM (2003)
   Intestinal and systemic immune responses to an oral cholera toxoid B subunit whole-cell vaccine administered during zinc supplementation
   Infect Immun, 71 (7), 3909-13
   PubMed 12819076
2. Laerum H, Karlsen TH, Faxvaag A (2003)
   Effects of scanning and eliminating paper-based medical records on hospital physicians' clinical work practice
   J Am Med Inform Assoc, 10 (6), 588-95
   PubMed 12925550

Publications 2000

1. Grewal HM, Karlsen TH, Vetvik H, Ahrén C, Gjessing HK, Sommerfelt H, Haneberg B (2000)
   Measurement of specific IgA in faecal extracts and intestinal lavage fluid for monitoring of mucosal immune responses
   J Immunol Methods, 239 (1-2), 53-62
   PubMed 10821947