Author network for Tom Hemming Karlsen by COREMINE medical

Publications in press

Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismüller TJ, Schramm C, Wittig M, Bergquist A, Björnsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK et al.
Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Hepatology (in press)
PubMed 22821403

Ellinghaus D, Zhang H, Zeissig S, Lipinski S, Till A, Jiang T, Stade B, Bromberg Y, Ellinghaus E, Keller A, Rivas MA, Skieceviciene J, Doncheva NT, Liu X, Liu Q, Jiang F, Forster M, Mayr G, Albrecht M, Hasler R, Boehm BO, Goodall J, Berzuini CR, Lee J, Andersen V et al.
Association Between Variants of PRDM1 and NDP52 and Crohns Disease, Based on Exome Sequencing and Functional Studies
Gastroenterology (in press)
PubMed 23624108

Hirschfield GM, Chapman RW, Karlsen TH, Lammert F, Lazaridis KN, Mason AL
The Genetics of Complex Cholestatic Disorders
Gastroenterology (in press)
PubMed 23583734

Karlsen TH, Boberg KM
Update on primary sclerosing cholangitis
J Hepatol (in press)
PubMed 23603668

Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S et al.
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nat Genet (in press)
PubMed 23603763

Publications 2013

Friedrich K, Rupp C, Hov JR, Steinebrunner N, Weiss KH, Stiehl A, Brune M, Schaefer PK, Schemmer P, Sauer P, Schirmacher P, Runz H, Karlsen TH, Stremmel W, Gotthardt DN (2013)
A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis
PLoS One, 8 (3), e58734
PubMed 23505555

Jørgensen KK, Lindström L, Cvancarova M, Karlsen TH, Castedal M, Friman S, Schrumpf E, Foss A, Isoniemi H, Nordin A, Holte K, Rasmussen A, Bergquist A, Vatn MH, Boberg KM (2013)
Immunosuppression after liver transplantation for primary sclerosing cholangitis influences activity of inflammatory bowel disease
Clin Gastroenterol Hepatol, 11 (5), 517-23
PubMed 23333218

Metzger J, Negm AA, Plentz RR, Weismüller TJ, Wedemeyer J, Karlsen TH, Dakna M, Mullen W, Mischak H, Manns MP, Lankisch TO (2013)
Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders
Gut, 62 (1), 122-30
PubMed 22580416

Publications 2012

Andresen K, Boberg KM, Vedeld HM, Honne H, Hektoen M, Wadsworth CA, Clausen OP, Karlsen TH, Foss A, Mathisen O, Schrumpf E, Lothe RA, Lind GE (2012)
Novel target genes and a valid biomarker panel identified for cholangiocarcinoma
Epigenetics, 7 (11), 1249-57
PubMed 22983262

Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE et al. (2012)
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J Hepatol, 57 (2), 366-75
PubMed 22521342

Fosby B, Karlsen TH, Melum E (2012)
Recurrence and rejection in liver transplantation for primary sclerosing cholangitis
World J Gastroenterol, 18 (1), 1-15
PubMed 22228965

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V et al. (2012)
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature, 491 (7422), 119-24
PubMed 23128233

Karlsen TH (2012)
A lecture on the genetics of primary sclerosing cholangitis
Dig Dis, 30 Suppl 1, 32-8
PubMed 23075866

Næss S, Shiryaev A, Hov JR, Franke A, Karlsen TH (2012)
Genetics in primary sclerosing cholangitis
Clin Res Hepatol Gastroenterol, 36 (4), 325-33
PubMed 22554879

Srivastava B, Mells GF, Cordell HJ, Muriithi A, Brown M, Ellinghaus E, Franke A, Consortium UP, Karlsen TH, Sandford RN, Alexander GJ, Chapman RW, Rushbrook SM, Melum E (2012)
Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis
Scand J Gastroenterol, 47 (7), 820-6
PubMed 22554193

Publications 2011

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C et al. (2011)
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Nat Genet, 43 (3), 246-52
PubMed 21297633

Folseraas T, Karlsen TH (2011)
To MMP or not to MMP: a role for matrix metalloproteinase 3 in primary sclerosing cholangitis?
Liver Int, 31 (6), 751-4
PubMed 21645205

Folseraas T, Melum E, Franke A, Karlsen TH (2011)
Genetics in primary sclerosing cholangitis
Best Pract Res Clin Gastroenterol, 25 (6), 713-26
PubMed 22117637

Friman S, Foss A, Isoniemi H, Olausson M, Höckerstedt K, Yamamoto S, Karlsen TH, Rizell M, Ericzon BG (2011)
Liver transplantation for cholangiocarcinoma: selection is essential for acceptable results
Scand J Gastroenterol, 46 (3), 370-5
PubMed 21073376

Hov JR, Keitel V, Schrumpf E, Häussinger D, Karlsen TH (2011)
TGR5 sequence variation in primary sclerosing cholangitis
Dig Dis, 29 (1), 78-84
PubMed 21691110

Hov JR, Kosmoliaptsis V, Traherne JA, Olsson M, Boberg KM, Bergquist A, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH (2011)
Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis
Hepatology, 53 (6), 1967-76
PubMed 21413052

Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismüller TJ, Wedemeyer J, Schramm C, Sterneck M, Günther R, Braun F et al. (2011)
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
Hepatology, 53 (6), 1977-85
PubMed 21425313

Karlsen TH, Kaser A (2011)
Deciphering the genetic predisposition to primary sclerosing cholangitis
Semin Liver Dis, 31 (2), 188-207
PubMed 21538284

Karlsen TH, Lazaridis KN (2011)
At the end of the beginning. Foreword
Semin Liver Dis, 31 (2), 111-3
PubMed 21538278

Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M et al. (2011)
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nat Genet, 43 (1), 17-9
PubMed 21151127

Publications 2010

Bowlus CL, Li CS, Karlsen TH, Lie BA, Selmi C (2010)
Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations
Liver Transpl, 16 (11), 1324-30
PubMed 21031548

Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Belouchi M, Fournier H, Reinhard C, Ding J, Li Y, Tejasvi T, Gudjonsson J, Stoll SW, Voorhees JJ, Lambert S, Weidinger S, Eberlein B, Kunz M, Rahman P, Gladman DD, Gieger C, Wichmann HE, Karlsen TH, Mayr G et al. (2010)
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
Nat Genet, 42 (11), 991-5
PubMed 20953188

Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH, IBSEN study group, Krawczak M et al. (2010)
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
Nat Genet, 42 (4), 292-4
PubMed 20228798

Hollenbach JA, Meenagh A, Sleator C, Alaez C, Bengoche M, Canossi A, Contreras G, Creary L, Evseeva I, Gorodezky C, Hardie RA, Karlsen TH, Lie B, Luo M, Martinetti M, Navarette C, de Oliveira DC, Ozzella G, Pasi A, Pavlova E, Pinto S, Porto LC, Santos P, Slavcev A, Srinak D et al. (2010)
Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA
Tissue Antigens, 76 (1), 9-17
PubMed 20331834

Holm K, Melum E, Franke A, Karlsen TH (2010)
SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
BMC Bioinformatics, 11, 600
PubMed 21167019

Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH et al. (2010)
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
PLoS One, 5 (8), e12403
PubMed 20811628

Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P (2010)
Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C
J Hepatol, 52 (5), 712-7
PubMed 20347497

Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P et al. (2010)
Genome-wide association analysis in primary sclerosing cholangitis
Gastroenterology, 138 (3), 1102-11
PubMed 19944697

Karlsen TH, Hov JR (2010)
Genetics of cholestatic liver disease in 2010
Curr Opin Gastroenterol, 26 (3), 251-8
PubMed 20042859

Karlsen TH, Melum E, Franke A (2010)
The utility of genome-wide association studies in hepatology
Hepatology, 51 (5), 1833-42
PubMed 20232293

Karlsen TH, Schrumpf E, Boberg KM (2010)
Update on primary sclerosing cholangitis
Dig Liver Dis, 42 (6), 390-400
PubMed 20172772

Karlsen TH, Schrumpf E, Boberg KM (2010)
Primary sclerosing cholangitis
Best Pract Res Clin Gastroenterol, 24 (5), 655-66
PubMed 20955968

Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF (2010)
Association to the Glypican-5 gene in multiple sclerosis
J Neuroimmunol, 226 (1-2), 194-7
PubMed 20692050

Melum E, May S, Schilhabel MB, Thomsen I, Karlsen TH, Rosenstiel P, Schreiber S, Franke A (2010)
SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region
Hum Mutat, 31 (7), 875-85
PubMed 20506538

Publications 2009

Forsbring M, Vik ES, Dalhus B, Karlsen TH, Bergquist A, Schrumpf E, Bjørås M, Boberg KM, Alseth I (2009)
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
Carcinogenesis, 30 (7), 1147-54
PubMed 19443904

Karlsen TH (2009)
Genome-wide association studies reach hepatology
J Hepatol, 50 (6), 1278-80
PubMed 19395112

Lorentzen AR, Karlsen TH, Olsson M, Smestad C, Mero IL, Woldseth B, Sun JY, Senitzer D, Celius EG, Thorsby E, Spurkland A, Lie BA, Harbo HF (2009)
Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
Ann Neurol, 65 (6), 658-66
PubMed 19630074

Melum E, Franke A, Karlsen TH (2009)
Genome-wide association studies--a summary for the clinical gastroenterologist
World J Gastroenterol, 15 (43), 5377-96
PubMed 19916168

Scholz T, Karlsen TH, Sanengen T, Schrumpf E, Line PD, Boberg KM, Jörgensen PF, Fosby B, Bentdal O, Ostensen AB, Osnes S, Riddervold F, Haugaa H, Hausken J, Bergmann JB, Foss S, Björo K, Foss A, Levertransplantasjonsgruppen ved Oslo universitetssykehus, Rikshospitalet (2009)
[Liver transplantation in Norway through 25 years]
Tidsskr Nor Laegeforen, 129 (24), 2587-92
PubMed 20029553

Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, Karlsen TH, Boberg KM, Bergquist A, Kunz M, Witte T, Gross WL, Epplen JT, Alarcón-Riquelme ME, Schreiber S, Ibrahim SM (2009)
Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases
Genes Immun, 10 (6), 601-5
PubMed 19387457

Publications 2008

Eike MC, Nordang GB, Karlsen TH, Boberg KM, Vatn MH, IBSEN study group, Dahl-Jørgensen K, Rønningen KS, Joner G, Flatø B, Bergquist A, Thorsby E, Førre O, Kvien TK, Undlien DE, Lie BA (2008)
The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases
Ann Rheum Dis, 67 (9), 1287-91
PubMed 18065500

Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S (2008)
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Nat Genet, 40 (6), 713-5
PubMed 18438405

Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, IBSEN study group, Mathew CG et al. (2008)
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Nat Genet, 40 (11), 1319-23
PubMed 18836448

Hov JR, Boberg KM, Karlsen TH (2008)
Autoantibodies in primary sclerosing cholangitis
World J Gastroenterol, 14 (24), 3781-91
PubMed 18609700

Karlsen TH, Schrumpf E, Boberg KM (2008)
Gallbladder polyps in primary sclerosing cholangitis: not so benign
Curr Opin Gastroenterol, 24 (3), 395-9
PubMed 18408471

Melum E, Buch S, Schafmayer C, Kalthoff H, Tepel J, Schreiber S, Karlsen TH, Hampe J (2008)
Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma
Int J Cancer, 123 (1), 241-2
PubMed 18398827

Melum E, Karlsen TH, Bergquist A, Schrumpf E, Boberg KM (2008)
An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis
Am J Gastroenterol, 103 (4), 1045; author reply 1045-6
PubMed 18397431

Melum E, Karlsen TH, Schrumpf E, Bergquist A, Thorsby E, Boberg KM, Lie BA (2008)
Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms
Hepatology, 47 (1), 90-6
PubMed 18023027

Publications 2007

Franke A, Rosenstiel P, Balschun T, Von Kampen O, Schreiber S, Sina C, Hampe J, Karlsen TH, Vatn MH, IBSEN Study Group, Solberg C (2007)
No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample
Gastroenterology, 132 (5), 2080-1
PubMed 17484912

Karlsen TH, Boberg KM, Olsson M, Sun JY, Senitzer D, Bergquist A, Schrumpf E, Thorsby E, Lie BA (2007)
Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
J Hepatol, 46 (5), 899-906
PubMed 17383044

Karlsen TH, Boberg KM, Vatn M, Bergquist A, Hampe J, Schrumpf E, Thorsby E, Schreiber S, Lie BA, IBSEN Study Group (2007)
Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis
Genes Immun, 8 (3), 275-8
PubMed 17301827

Karlsen TH, Hampe J, Wiencke K, Schrumpf E, Thorsby E, Lie BA, Broomé U, Schreiber S, Boberg KM (2007)
Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis
Am J Gastroenterol, 102 (1), 115-21
PubMed 17100974

Karlsen TH, Schrumpf E, Boberg KM (2007)
Genetic epidemiology of primary sclerosing cholangitis
World J Gastroenterol, 13 (41), 5421-31
PubMed 17907284

Wiencke K, Karlsen TH, Boberg KM, Thorsby E, Schrumpf E, Lie BA, Spurkland A (2007)
Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes
Tissue Antigens, 69 (2), 161-9
PubMed 17257319

Publications 2006

Bowlus CL, Karlsen TH, Broomé U, Thorsby E, Vatn M, Schrumpf E, Lie BA, Boberg KM (2006)
Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis
J Hepatol, 45 (5), 704-10
PubMed 16750586

Franke A, Ruether A, Wedemeyer N, Karlsen TH, Nebel A, Schreiber S (2006)
No association between the functional CARD4 insertion/deletion polymorphism and inflammatory bowel diseases in the German population
Gut, 55 (11), 1679-80
PubMed 17047129

Karlsen TH, Lie BA, Frey Frøslie K, Thorsby E, Broomé U, Schrumpf E, Boberg KM (2006)
Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis
Gastroenterology, 131 (3), 781-7
PubMed 16952547

Melum E, Karlsen TH, Broomé U, Thorsby E, Schrumpf E, Boberg KM, Lie BA (2006)
The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients
Tissue Antigens, 68 (1), 78-81
PubMed 16774544

Publications 2004

Laerum H, Karlsen TH, Faxvaag A (2004)
Use of and attitudes to a hospital information system by medical secretaries, nurses and physicians deprived of the paper-based medical record: a case report
BMC Med Inform Decis Mak, 4, 18
PubMed 15488150

Publications 2003

Karlsen TH, Sommerfelt H, Klomstad S, Andersen PK, Strand TA, Ulvik RJ, Ahrén C, Grewal HM (2003)
Intestinal and systemic immune responses to an oral cholera toxoid B subunit whole-cell vaccine administered during zinc supplementation
Infect Immun, 71 (7), 3909-13
PubMed 12819076

Laerum H, Karlsen TH, Faxvaag A (2003)
Effects of scanning and eliminating paper-based medical records on hospital physicians' clinical work practice
J Am Med Inform Assoc, 10 (6), 588-95
PubMed 12925550

Publications 2000

Grewal HM, Karlsen TH, Vetvik H, Ahrén C, Gjessing HK, Sommerfelt H, Haneberg B (2000)
Measurement of specific IgA in faecal extracts and intestinal lavage fluid for monitoring of mucosal immune responses
J Immunol Methods, 239 (1-2), 53-62
PubMed 10821947