Espen Melum
Position: Group leader, Senior scientist, MD, PhD
Phone: +47 23 07 36 19
Email:

Education

MD University of Oslo, 2006

PhD University of Oslo, 2010

Positions

2012-present Post.doc., Norwegian PSC Research Center, OUS Rikshospitalet

2010-2012 Post.doc., Brigham and Women's Hospital / Harvard Medical School, Boston, USA

2008-2010 PhD Research fellow, Norwegian PSC Research Center, OUS Rikshospitalet

2007-2008 Internship in Medicine, Surgery and General Practice, Hamar/Elverum

2006-2007 Research fellow, Institute of Immunology, Rikshospitalet

Research interests

Natural Killer T-cells and immune mediated diseases, Primary sclerosing cholangitis, Experimental models of cholangitis, Complex genetics

 

Author network for Espen Melum by COREMINE medical


Publications 2016

Henriksen EK, Jørgensen KK, Kaveh F, Holm K, Hamm D, Olweus J, Melum E, Chung BK, Eide TJ, Lundin KE, Boberg KM, Karlsen TH, Hirschfield GM, Liaskou E (2016)
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J Hepatol (in press)
PubMed 27647428

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS (2016)
Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Nature, 536 (7616), 359 (in press)
PubMed 26982724

Maroni L, Agostinelli L, Saccomanno S, Pinto C, Giordano D, Rychlicki C, De Minicis S, Trozzi L, Banales JM, Melum E, Karlsen TH, Benedetti A, Baroni GS, Marzioni M (2016)
Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes
Am J Pathol (in press)
PubMed 27912077

Pihlstrøm HK, Mjøen G, Mucha S, Haraldsen G, Franke A, Jardine A, Fellström B, Holdaas H, Melum E (2016)
Single Nucleotide Polymorphisms and Long-Term Clinical Outcome in Renal Transplant Patients: A Validation Study
Am J Transplant (in press)
PubMed 27483393

Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Bäckhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E (2016)
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
J Hepatol (in press)
PubMed 27720803

Vesterhus M, Melum E (2016)
Prognostic biomarkers and surrogate end points in PSC
Liver Int, 36 (12), 1748-1751
PubMed 27864874

Publications 2015

Andersen IM, Fosby B, Boberg KM, Clausen OP, Jebsen P, Melum E, Line PD, Foss A, Schrumpf E, Karlsen TH (2015)
Indications and Outcomes in Liver Transplantation in Patients With Primary Sclerosing Cholangitis in Norway
Transplant Direct, 1 (9), e39
PubMed 27500239

Fosby B, Melum E, Bjøro K, Bennet W, Rasmussen A, Andersen IM, Castedal M, Olausson M, Wibeck C, Gotlieb M, Gjertsen H, Toivonen L, Foss S, Makisalo H, Nordin A, Sanengen T, Bergquist A, Larsson ME, Soderdahl G, Nowak G, Boberg KM, Isoniemi H, Keiding S, Foss A, Line PD et al. (2015)
Liver transplantation in the Nordic countries - An intention to treat and post-transplant analysis from The Nordic Liver Transplant Registry 1982-2013
Scand J Gastroenterol, 50 (6), 797-808
PubMed 25959101

Liaskou E, Klemsdal Henriksen EK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM (2015)
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-19
PubMed 26257205

Olin P, Hausken J, Foss A, Karlsen TH, Melum E, Haugaa H (2015)
Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation
Scand J Gastroenterol, 50 (9), 1127-34
PubMed 25865318

Sampaziotis F, Cardoso de Brito M, Madrigal P, Bertero A, Saeb-Parsy K, Soares FA, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WT, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NR, Vallier L (2015)
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
Nat Biotechnol, 33 (8), 845-52
PubMed 26167629

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E (2015)
The biliary epithelium presents antigens to and activates natural killer T cells
Hepatology, 62 (4), 1249-59
PubMed 25855031

Publications 2014

Eskesen AN, Bjøro K, Aandahl EM, Line PD, Melum E (2014)
Low use of surveillance and early diagnosis of hepatocellular carcinoma in Norway--a population-based cohort study
Cancer Epidemiol, 38 (6), 741-7
PubMed 25454262

Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M, International PSC Study Group (IPSCSG) (2014)
Characterization of animal models for primary sclerosing cholangitis (PSC)
J Hepatol, 60 (6), 1290-303
PubMed 24560657

Fosby B, Næss S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH (2014)
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
World J Gastroenterol, 20 (14), 3986-4000
PubMed 24744588

Henriksen EK, Melum E, Karlsen TH (2014)
Update on primary sclerosing cholangitis genetics
Curr Opin Gastroenterol, 30 (3), 310-9
PubMed 24565892

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS (2014)
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Nature, 517 (7534), 386-90
PubMed 25363763

Naess S, Björnsson E, Anmarkrud JA, Al Mamari S, Juran BD, Lazaridis KN, Chapman R, Bergquist A, Melum E, Marsh SG, Schrumpf E, Lie BA, Boberg KM, Karlsen TH, Hov JR (2014)
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease
Liver Int, 34 (10), 1488-95
PubMed 24517468

Næss S, Lie BA, Melum E, Olsson M, Hov JR, Croucher PJ, Hampe J, Thorsby E, Bergquist A, Traherne JA, Schrumpf E, Boberg KM, Schreiber S, Franke A, Karlsen TH (2014)
Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
PLoS One, 9 (12), e114486
PubMed 25521205

Zeissig S, Petersen BS, Tomczak M, Melum E, Huc-Claustre E, Dougan SK, Laerdahl JK, Stade B, Forster M, Schreiber S, Weir D, Leichtner AM, Franke A, Blumberg RS (2014)
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4
Gut, 64 (12), 1889-97
PubMed 25367873

Publications 2013

Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismüller TJ, Schramm C, Wittig M, Bergquist A, Björnsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK et al. (2013)
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-83
PubMed 22821403

Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S et al. (2013)
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nat Genet, 45 (6), 670-5
PubMed 23603763

Zeissig S, Olszak T, Melum E, Blumberg RS (2013)
Analyzing antigen recognition by Natural Killer T cells
Methods Mol Biol, 960, 557-72
PubMed 23329514

Publications 2012

Eskesen AN, Melum E, Moghaddam A, Bjøro K, Verbaan H, Ring-Larsen H, Dalgard O (2012)
Genetic variants at the ITPA locus protect against ribavirin-induced hemolytic anemia and dose reduction in an HCV G2/G3 cohort
Eur J Gastroenterol Hepatol, 24 (8), 890-6
PubMed 22584257

Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE et al. (2012)
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J Hepatol, 57 (2), 366-75
PubMed 22521342

Forster M, Forster P, Elsharawy A, Hemmrich G, Kreck B, Wittig M, Thomsen I, Stade B, Barann M, Ellinghaus D, Petersen BS, May S, Melum E, Schilhabel MB, Keller A, Schreiber S, Rosenstiel P, Franke A (2012)
From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software
Nucleic Acids Res, 41 (1), e16
PubMed 22965131

Fosby B, Karlsen TH, Melum E (2012)
Recurrence and rejection in liver transplantation for primary sclerosing cholangitis
World J Gastroenterol, 18 (1), 1-15
PubMed 22228965

Srivastava B, Mells GF, Cordell HJ, Muriithi A, Brown M, Ellinghaus E, Franke A, UK-PSC Consortium, Karlsen TH, Sandford RN, Alexander GJ, Chapman RW, Rushbrook SM, Melum E (2012)
Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis
Scand J Gastroenterol, 47 (7), 820-6
PubMed 22554193

Publications 2011

Folseraas T, Melum E, Franke A, Karlsen TH (2011)
Genetics in primary sclerosing cholangitis
Best Pract Res Clin Gastroenterol, 25 (6), 713-26
PubMed 22117637

Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismüller TJ, Wedemeyer J, Schramm C, Sterneck M, Günther R, Braun F et al. (2011)
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
Hepatology, 53 (6), 1977-85
PubMed 21425313

Moghaddam A, Melum E, Reinton N, Ring-Larsen H, Verbaan H, Bjøro K, Dalgard O (2011)
IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection
Hepatology, 53 (3), 746-54
PubMed 21374656

Publications 2010

Evang JA, Borota OC, Melum E, Holm R, Ramm-Pettersen J, Bollerslev J, Berg JP (2010)
HDAC2 expression and variable number of repeats in exon 1 of the HDAC2 gene in corticotroph adenomas
Clin Endocrinol (Oxf), 73 (2), 229-35
PubMed 20346000

Holm K, Melum E, Franke A, Karlsen TH (2010)
SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
BMC Bioinformatics, 11, 600
PubMed 21167019

Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH et al. (2010)
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
PLoS One, 5 (8), e12403
PubMed 20811628

Karlsen TH, Melum E, Franke A (2010)
The utility of genome-wide association studies in hepatology
Hepatology, 51 (5), 1833-42
PubMed 20232293

Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF (2010)
Association to the Glypican-5 gene in multiple sclerosis
J Neuroimmunol, 226 (1-2), 194-7
PubMed 20692050

Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M et al. (2010)
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nat Genet, 43 (1), 17-9
PubMed 21151127

Melum E, May S, Schilhabel MB, Thomsen I, Karlsen TH, Rosenstiel P, Schreiber S, Franke A (2010)
SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region
Hum Mutat, 31 (7), 875-85
PubMed 20506538

Publications 2009

Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P et al. (2009)
Genome-wide association analysis in primary sclerosing cholangitis
Gastroenterology, 138 (3), 1102-11
PubMed 19944697

Melum E, Franke A, Karlsen TH (2009)
Genome-wide association studies--a summary for the clinical gastroenterologist
World J Gastroenterol, 15 (43), 5377-96
PubMed 19916168

Publications 2008

Melum E, Buch S, Schafmayer C, Kalthoff H, Tepel J, Schreiber S, Karlsen TH, Hampe J (2008)
Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma
Int J Cancer, 123 (1), 241-2
PubMed 18398827

Melum E, Karlsen TH, Bergquist A, Schrumpf E, Boberg KM (2008)
An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis
Am J Gastroenterol, 103 (4), 1045; author reply 1045-6
PubMed 18397431

Melum E, Karlsen TH, Schrumpf E, Bergquist A, Thorsby E, Boberg KM, Lie BA (2008)
Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms
Hepatology, 47 (1), 90-6
PubMed 18023027

Publications 2007

Lindner E, Nordang GB, Melum E, Flatø B, Selvaag AM, Thorsby E, Kvien TK, Førre OT, Lie BA (2007)
Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis
BMC Med Genet, 8, 33
PubMed 17565662

Melum E, Friman S, Bjøro K, Rasmussen A, Isoniemi H, Gjertsen H, Bäckman L, Oksanen A, Olausson M, Duraj FF, Ericzon BG (2007)
Hepatitis C impairs survival following liver transplantation irrespective of concomitant hepatocellular carcinoma
J Hepatol, 47 (6), 777-83
PubMed 17714825

Publications 2006

Melum E, Karlsen TH, Broomé U, Thorsby E, Schrumpf E, Boberg KM, Lie BA (2006)
The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients
Tissue Antigens, 68 (1), 78-81
PubMed 16774544

Melum E, Schrumpf E, Bjøro K (2006)
Liver TX for hepatitis C cirrhosis in a low prevalence population: risk factors and status at evaluation
Scand J Gastroenterol, 41 (5), 592-6
PubMed 16638703