Tor Inge Tønnessen
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Publications in press

Pischke SE, Tronstad C, Holhjem L, Halvorsen PS, Tønnessen TI
Perioperative detection of myocardial ischaemia/reperfusion with a novel tissue CO2 monitoring technology
Eur J Cardiothorac Surg (in press)
PubMed 22290904

Publications 2012

Waelgaard L, Dahl BM, Kvarstein G, Tønnessen TI (2012)
Tissue gas tensions and tissue metabolites for detection of organ hypoperfusion and ischemia
Acta Anaesthesiol Scand, 56 (2), 200-9
PubMed 22103593

Publications 2011

Barratt-Due A, Johansen HT, Sokolov A, Thorgersen EB, Hellerud BC, Reubsaet JL, Seip KF, Tønnessen TI, Lindstad JK, Pharo A, Castellheim A, Mollnes TE, Nielsen EW (2011)
The role of bradykinin and the effect of the bradykinin receptor antagonist icatibant in porcine sepsis
Shock, 36 (5), 517-23
PubMed 21921836

Krushinitskaya O, Tonnessen TI, Jakobsen H, Johannessen EA (2011)
Characterization of nanoporous membranes for implementation in an osmotic glucose sensor based on the concanavalin A-dextran affinity assay
J. Membr. Sci., 376 (1-2), 153-161

Krushinitskaya O, Tønnessen TI, Jakobsen H, Johannessen E (2011)
The assessment of potentially interfering metabolites and dietary components in blood using an osmotic glucose sensor based on the concanavalin A-dextran affinity assay
Biosens Bioelectron, 28 (1), 195-203
PubMed 21816599

Publications 2010

Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tønnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P (2010)
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis
Crit Care Med, 38 (6), 1467-74
PubMed 20400898

Johannessen E, Krushinitskaya O, Sokolov A, Philipp H, Hoogerwerf A, Hinderling C, Kautio K, Lenkkeri J, Strömmer E, Kondratyev V, Tønnessen TI, Mollnes TE, Jakobsen H, Zimmer E, Akselsen B (2010)
Toward an injectable continuous osmotic glucose sensor
J Diabetes Sci Technol, 4 (4), 882-92
PubMed 20663452

Kvarstein G, Måwe L, Indahl A, Hol PK, Tennøe B, Digernes R, Tønnessen TI, Beivik H, Stubhaug A (2010)
Placebo control--still the most ethical study design
Pain, 148 (1), 174-5
PubMed 19962241

Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tønnessen TI, Johansen HT, Castellheim A, Mollnes TE (2010)
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs
FASEB J, 24 (3), 712-22
PubMed 19841036

Tronstad C, Pischke SE, Holhjem L, Tønnessen TI, Martinsen OG, Grimnes S (2010)
Early detection of cardiac ischemia using a conductometric pCO(2) sensor: real-time drift correction and parameterization
Physiol Meas, 31 (9), 1241-55
PubMed 20702916

Publications 2009

Kvarstein G, Måwe L, Indahl A, Hol PK, Tennøe B, Digernes R, Stubhaug A, Tønnessen TI, Beivik H (2009)
A randomized double-blind controlled trial of intra-annular radiofrequency thermal disc therapy--a 12-month follow-up
Pain, 145 (3), 279-86
PubMed 19647940

Nielsen EW, Hellerud BC, Thorgersen EB, Castellheim A, Pharo A, Lindstad J, Tønnessen TI, Brandtzaeg P, Mollnes TE (2009)
A new dynamic porcine model of meningococcal shock
Shock, 32 (3), 302-9
PubMed 19174740

Publications 2008

Castellheim A, Thorgersen EB, Hellerud BC, Pharo A, Johansen HT, Brosstad F, Gaustad P, Brun H, Fosse E, Tønnessen TI, Nielsen EW, Mollnes TE (2008)
New biomarkers in an acute model of live Escherichia coli-induced sepsis in pigs
Scand J Immunol, 68 (1), 75-84
PubMed 18466195

Waelgaard L, Thorgersen EB, Line PD, Foss A, Mollnes TE, Tønnessen TI (2008)
Microdialysis monitoring of liver grafts by metabolic parameters, cytokine production, and complement activation
Transplantation, 86 (8), 1096-103
PubMed 18946348

Publications 2007

Andersen MH, Mathisen L, Veenstra M, Oyen O, Edwin B, Digernes R, Kvarstein G, Tønnessen TI, Wahl AK, Hanestad BR, Fosse E (2007)
Quality of life after randomization to laparoscopic versus open living donor nephrectomy: long-term follow-up
Transplantation, 84 (1), 64-9
PubMed 17627239

Halvorsen PS, Sokolov A, Cvancarova M, Hol PK, Lundblad R, Tønnessen TI (2007)
Continuous cardiac output during off-pump coronary artery bypass surgery: pulse-contour analyses vs pulmonary artery thermodilution
Br J Anaesth, 99 (4), 484-92
PubMed 17650518

Publications 2006

Andersen MH, Mathisen L, Oyen O, Edwin B, Digernes R, Kvarstein G, Tønnessen TI, Wahl AK, Hanestad BR, Fosse E (2006)
Postoperative pain and convalescence in living kidney donors-laparoscopic versus open donor nephrectomy: a randomized study
Am J Transplant, 6 (6), 1438-43
PubMed 16686768

Halvorsen PS, Espinoza A, Lundblad R, Cvancarova M, Hol PK, Fosse E, Tønnessen TI (2006)
Agreement between PiCCO pulse-contour analysis, pulmonal artery thermodilution and transthoracic thermodilution during off-pump coronary artery by-pass surgery
Acta Anaesthesiol Scand, 50 (9), 1050-7
PubMed 16987335

Waelgaard L, Pharo A, Tønnessen TI, Mollnes TE (2006)
Microdialysis for monitoring inflammation: efficient recovery of cytokines and anaphylotoxins provided optimal catheter pore size and fluid velocity conditions
Scand J Immunol, 64 (3), 345-52
PubMed 16918704

Publications 2005

Mathisen L, Andersen MH, Hol PK, Lingaas PS, Lundblad R, Rein KA, Tønnessen TI, Mørk BE, Svennevig JL, Wahl AK, Hanestad BR, Fosse E (2005)
Patient-reported outcome after randomization to on-pump versus off-pump coronary artery surgery
Ann Thorac Surg, 79 (5), 1584-9
PubMed 15854937

Publications 2004

Kvarstein G, Mirtaheri P, Tønnessen TI (2004)
Detection of ischemia by PCO2 before adenosine triphosphate declines in skeletal muscle
Crit Care Med, 32 (1), 232-7
PubMed 14707584

Mirtaheri P, Grimnes S, Martinsen OG, Tønnessen TI (2004)
A new biomedical sensor for measuring PCO2
Physiol Meas, 25 (2), 421-36
PubMed 15132308

Mirtaheri P, Omtveit T, Klotzbuecher T, Grimnes S, Martinsen OG, Tønnessen TI (2004)
Miniaturization of a biomedical gas sensor
Physiol Meas, 25 (6), 1511-22
PubMed 15712728

Skulstad H, Andersen K, Edvardsen T, Rein KA, Tønnessen TI, Hol PK, Fosse E, Ihlen H (2004)
Detection of ischemia and new insight into left ventricular physiology by strain Doppler and tissue velocity imaging: assessment during coronary bypass operation of the beating heart
J Am Soc Echocardiogr, 17 (12), 1225-33
PubMed 15562259

Publications 2003

Bjørnstad PG, Smevik B, Holmstrøm H, Thaulow E, Hagemo PS, Ihlen H, Bjørnerheim R, Lindberg HL, Seem E, Tønnessen TI, Hustveit O, Fosse E (2003)
[Transcatheter closure of atrial septal defects in the oval fossa]
Tidsskr Nor Laegeforen, 123 (15), 2052-4
PubMed 12934130

Kvarstein G, Barstad M, Mirtaheri P, Tønnessen TI (2003)
Tissue carbon dioxide tension: a putative specific indicator of ischemia in porcine latissimus dorsi flaps
Plast Reconstr Surg, 112 (7), 1825-31
PubMed 14663226

Kvarstein G, Mirtaheri P, Tønnessen TI (2003)
Detection of organ ischemia during hemorrhagic shock
Acta Anaesthesiol Scand, 47 (6), 675-86
PubMed 12803584

Tønnessen TI (2003)
Detection of hypoperfusion: read your patient's hand
Crit Care Med, 31 (9), 2407-8
PubMed 14501978

Publications 2002

Bjørnstad PG, Holmstrøm H, Smevik B, Tønnessen TI, Fosse E (2002)
Transcatheter closure of atrial septal defects in the oval fossa: is the method applicable in small children?
Cardiol Young, 12 (4), 352-6
PubMed 12206558

Rasmussen H, Mirtaheri P, Dirven H, Johnsen H, Kvarstein G, Tønnessen TI, Midtvedt T (2002)
PCO(2) in the large intestine of mice, rats, guinea pigs, and dogs and effects of the dietary substrate
J Appl Physiol, 92 (1), 219-24
PubMed 11744663

Publications 2001

Edwin B, Kazaryan AM, Mala T, Pfeffer PF, Tønnessen TI, Fosse E (2001)
Laparoscopic and open surgery for pheochromocytoma
BMC Surg, 1, 2
PubMed 11580870

Hol PK, Fosse E, Mork BE, Lundblad R, Rein KA, Lingaas PS, Geiran O, Svennevig JL, Tonnessen TI, Nitter-Hauge S, Due-Tonnessen P, Vatne K, Smith HJ (2001)
Graft control by transit time flow measurement and intraoperative angiography in coronary artery bypass surgery
Heart Surg Forum, 4 (3), 254-7; discussion 257-8
PubMed 11673148

Kvarstein G, Tønnessen TI (2001)
[Pain--difficult for both laymen and professionals]
Tidsskr Nor Laegeforen, 121 (22), 2577
PubMed 11668750

Lund C, Lundblad R, Fosse E, Tønnessen TI, Sundet K, Brucher R, Russell D (2001)
Ventricular fibrillation during off-pump coronary artery bypass grafting: transcranial Doppler and clinical findings
Cerebrovasc Dis, 12 (2), 139-41
PubMed 11490108

Publications 2000

Fosse E, Elle OJ, Samset E, Johansen M, Røtnes JS, Tønnessen TI, Edwin B (2000)
[Image guided and robotic treatment--the advance of cybernetics in clinical medicine]
Tidsskr Nor Laegeforen, 120 (1), 65-9
PubMed 10815485

Hol PK, Kvarstein G, Viken O, Smedby O, Tønnessen TI (2000)
MRI-guided celiac plexus block
J Magn Reson Imaging, 12 (4), 562-4
PubMed 11042637

Publications 1999

Rasmussen H, Kvarstein G, Johnsen H, Dirven H, Midtvedt T, Mirtaheri P, Tønnessen TI (1999)
Gas supersaturation in the cecal wall of mice due to bacterial CO2 production
J Appl Physiol, 86 (4), 1311-8
PubMed 10194217

Publications 1998

Barstad RM, Fosse E, Geiran OR, Simonsen S, Vatne K, Andersen K, Tønnessen TI (1998)
Minimally invasive direct coronary artery bypass grafting without cardiopulmonary bypass in combination with intraoperative percutaneous transluminal coronary angioplasty for palliative coronary revascularization in a heart transplant recipient
J Heart Lung Transplant, 17 (6), 629-34
PubMed 9662100

Dishart MK, Schlichtig R, Tonnessen TI, Rozenfeld RA, Simplaceanu E, Williams D, Gayowski TJ (1998)
Mitochondrial redox state as a potential detector of liver dysoxia in vivo
J Appl Physiol, 84 (3), 791-7
PubMed 9480934

Publications 1997

Barstad RM, Fosse E, Vatne K, Andersen K, Tønnessen TI, Svennevig JL, Geiran OR (1997)
Intraoperative angiography in minimally invasive direct coronary artery bypass grafting
Ann Thorac Surg, 64 (6), 1835-9
PubMed 9436590

Bjørnstad PG, Thaulow E, Smevik B, Michelsen SS, Tønnessen TI, Fosse E (1997)
[Catheter treatment of congenital heart defects. Arterial septal defects and open ductus arteriosus]
Tidsskr Nor Laegeforen, 117 (20), 2961-4
PubMed 9340856

Fosse E, Lilleås F, Røtnes JS, Edwin B, Tønnessen TI, Hafsahl G, Laerum F (1997)
[The intervention center at the Rikshospital. Experiences from the first year of activity]
Tidsskr Nor Laegeforen, 117 (19), 2779-83
PubMed 9312869

Kvarstein G, Tønnessen TI (1997)
[CO2 pressure used in the diagnosis of ischemia]
Tidsskr Nor Laegeforen, 117 (29), 4251-5
PubMed 9441471

Tønnessen TI (1997)
Biological basis for PCO2 as a detector of ischemia
Acta Anaesthesiol Scand, 41 (6), 659-69
PubMed 9241323

Publications 1996

Rozenfeld RA, Dishart MK, Tønnessen TI, Schlichtig R (1996)
Methods for detecting local intestinal ischemic anaerobic metabolic acidosis by PCO2
J Appl Physiol, 81 (4), 1834-42
PubMed 8904606

Tønnessen TI, Kvarstein G (1996)
PCO2 electrodes at the surface of the kidney detect ischaemia
Acta Anaesthesiol Scand, 40 (5), 510-9
PubMed 8792878

Publications 1995

Aas AT, Tønnessen TI, Brun A, Salford LG (1995)
Growth inhibition of rat glioma cells in vitro and in vivo by aspirin
J Neurooncol, 24 (2), 171-80
PubMed 7562004

Publications 1991

Ludt J, Tønnessen TI, Sandvig K, Olsnes S (1991)
Evidence for involvement of protein kinase C in regulation of intracellular pH by Cl-/HCO-3 antiport
J Membr Biol, 119 (2), 179-86
PubMed 2046087

Tønnessen TI, Tveter KJ (1991)
Drug treatment of pain in patients with urological cancers
Scand J Urol Nephrol Suppl, 138, 253-64
PubMed 1785017

Publications 1990

Tønnessen TI, Sandvig K, Olsnes S (1990)
Role of Na(+)-H+ and Cl(-)-HCO3- antiports in the regulation of cytosolic pH near neutrality
Am J Physiol, 258 (6 Pt 1), C1117-26
PubMed 2163200

Tønnessen TI, Aas AT, Ludt J, Blomhoff HK, Olsnes S (1990)
Regulation of Na+/H+ and Cl-/HCO3- antiports in Vero cells
J Cell Physiol, 143 (1), 178-87
PubMed 2156872

Publications 1989

Tønnessen TI, Aas AT, Sandvig K, Olsnes S (1989)
Effect of anti-inflammatory analgesic drugs on the regulation of cytosolic pH by anion antiport
J Pharmacol Exp Ther, 248 (3), 1197-206
PubMed 2703970

Tønnessen TI, Aas AT, Sandvig K, Olsnes S (1989)
Inhibition of chloride/bicarbonate antiports in monkey kidney cells (Vero) by non-steroidal anti-inflammatory drugs
Biochem Pharmacol, 38 (20), 3583-91
PubMed 2818647

Publications 1988

Reinertsen KV, Tønnessen TI, Jacobsen J, Sandvig K, Olsnes S (1988)
Role of chloride/bicarbonate antiport in the control of cytosolic pH. Cell-line differences in activity and regulation of antiport
J Biol Chem, 263 (23), 11117-25
PubMed 3403517

Publications 1987

Madshus IH, Tønnessen TI, Olsnes S, Sandvig K (1987)
Effect of potassium depletion of Hep 2 cells on intracellular pH and on chloride uptake by anion antiport
J Cell Physiol, 131 (1), 6-13
PubMed 3571337

Olsnes S, Ludt J, Tønnessen TI, Sandvig K (1987)
Bicarbonate/chloride antiport in Vero cells: II. Mechanisms for bicarbonate-dependent regulation of intracellular pH
J Cell Physiol, 132 (2), 192-202
PubMed 3624315

Olsnes S, Tønnessen TI, Ludt J, Sandvig K (1987)
Effect of intracellular pH on the rate of chloride uptake and efflux in different mammalian cell lines
Biochemistry, 26 (10), 2778-85
PubMed 3606992

Tønnessen TI, Ludt J, Sandvig K, Olsnes S (1987)
Bicarbonate/chloride antiport in Vero cells: I. Evidence for both sodium-linked and sodium-independent exchange
J Cell Physiol, 132 (2), 183-91
PubMed 3624314

Publications 1986

Olsnes S, Tønnessen TI, Sandvig K (1986)
pH-regulated anion antiport in nucleated mammalian cells
J Cell Biol, 102 (3), 967-71
PubMed 3949885

Sandvig K, Tønnessen TI, Olsnes S (1986)
Ability of inhibitors of glycosylation and protein synthesis to sensitize cells to abrin, ricin, Shigella toxin, and Pseudomonas toxin
Cancer Res, 46 (12 Pt 1), 6418-22
PubMed 3096563

Sandvig K, Tønnessen TI, Sand O, Olsnes S (1986)
Requirement of a transmembrane pH gradient for the entry of diphtheria toxin into cells at low pH
J Biol Chem, 261 (25), 11639-44
PubMed 3745160

van Deurs B, Tønnessen TI, Petersen OW, Sandvig K, Olsnes S (1986)
Routing of internalized ricin and ricin conjugates to the Golgi complex
J Cell Biol, 102 (1), 37-47
PubMed 3001103

Publications 1982

Tönnessen TI, Nyland H, Aarli JA (1982)
Complement factors and acute phase reactants in the Guillain-Barré syndrome
Eur Neurol, 21 (2), 124-8
PubMed 6920298