Article on classification of GISTs by array CGH published in "Cancer Research"
Histologically related connective tissue tumors, leiomyosarcomas (LMSs) and gastrointestinal stromal tumors (GISTs), were until recently diagnosed as one tumor type. Leonardo Meza-Zepeda et al has shown that that the patterns of genome copy-number aberrations reflect the underlying biology of the tumors. These important findings were recently published in the well reputed journal "Cancer Research" (impact factor 7,6). Meza-Zepeda is working as a post doc in Ola Myklebost's group at the Department of Tumor Biology.
By global array CGH analysis they could, without supervision, separate completely the two tumor types. Because GISTs are sensitive to specific tyrosinase inhibitors, this may indicate clinical utility for array CGH to assist in this clinically important distinction.