Institute seminar June 1st

Tom Grotmol

The upcoming Institute Seminar at the Institute for Cancer Research will take place on June 1st of May at 12:00 in the Auditorium in the Research Building at Montebello with the following speaker:

Prof. Tom Grotmol – Cancer Registry of Norway

Title of his talk:: “Testicular cancer – studies in genetic epidemiology

Summary

Testicular cancer is the most common malignancy in young males. The aetiology is largely unknown, although genetic components and conditions during pregnancy play a role. The incidence rate in Norway is one of the highest in the world, almost twice as high as in our neighbouring country, Sweden. A widely accepted model is that in utero events in primordial germ cells lead to the development of carcinoma in situ lesions, which may develop into cancer from puberty onwards. The incidence rate of testicular cancer in the Western world has increased several-fold over the past 50 years, and the increase is thought to be due to gene-environment interaction. Which environmental factors are responsible for this increase, and the mechanisms involved in the carcinogenesis, are currently largely unknown. This seminar is basically focusing on the genetic susceptibility to testicular cancer, and some recent results will be presented, based on a large Norwegian-Swedish genetic association study.