Guttorm Haraldsen
Position: Research Director, MD, PhD
Phone: 23071492
Email:
 

Author network for Guttorm Haraldsen by COREMINE medical


Publications 2017

Pihlstrøm HK, Gatti F, Hammarström C, Eide IA, Kasprzycka M, Wang J, Haraldsen G, Svensson MHS, Midtvedt K, Mjøen G, Dahle DO, Hartmann A, Holdaas H (2017)
Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study
Transpl Int (in press)
PubMed 28436117

Stav-Noraas TE, Edelmann RJ, Poulsen LC, Sundnes O, Phung D, Küchler AM, Müller F, Kamen AA, Haraldsen G, Kaarbø M, Hol J (2017)
Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery
J Immunol, 198 (8), 3318-3325
PubMed 28258201

Publications 2016

Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, Chaturvedi P, Hol J, Thienpont B, Teuwen LA, Schoors S, Boeckx B, Vriens J, Kuchnio A, Veys K, Cruys B, Finotto L, Treps L, Stav-Noraas TE, Bifari F, Stapor P, Decimo I, Kampen K, De Bock K, Haraldsen G et al. (2016)
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
Cancer Cell, 30 (6), 968-985
PubMed 27866851

Gundersen MD, Goll R, Hol J, Olsen T, Rismo R, Sørbye SW, Sundnes O, Haraldsen G, Florholmen J (2016)
Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis
Sci Rep, 6, 35403
PubMed 27748438

Jahnsen FL, Johansen FE, Haraldsen G (2016)
Obituary - In Memoriam Per Brandtzaeg
Scand J Immunol, 84 (6), 370-372
PubMed 28025869

Lorvik KB, Hammarström C, Fauskanger M, Haabeth OA, Zangani M, Haraldsen G, Bogen B, Corthay A (2016)
Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response
Cancer Res, 76 (23), 6864-6876
PubMed 27634753

Pihlstrøm HK, Mjøen G, Mucha S, Haraldsen G, Franke A, Jardine A, Fellström B, Holdaas H, Melum E (2016)
Single Nucleotide Polymorphisms and Long-Term Clinical Outcome in Renal Transplant Patients: A Validation Study
Am J Transplant, 17 (2), 528-533
PubMed 27483393

Publications 2015

Kasprzycka M, Hammarström C, Haraldsen G (2015)
Tenascins in fibrotic disorders-from bench to bedside
Cell Adh Migr, 9 (1-2), 83-9
PubMed 25793575

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E (2015)
The biliary epithelium presents antigens to and activates natural killer T cells
Hepatology, 62 (4), 1249-59
PubMed 25855031

Sundnes O, Pietka W, Loos T, Sponheim J, Rankin AL, Pflanz S, Bertelsen V, Sitek JC, Hol J, Haraldsen G, Khnykin D (2015)
Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences
J Invest Dermatol, 135 (7), 1771-80
PubMed 25739051

Øynebråten I, Barois N, Bergeland T, Küchler AM, Bakke O, Haraldsen G (2015)
Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells
Sci Rep, 5, 9261
PubMed 25791723

Publications 2014

Pandya AD, Leergaard TB, Dissen E, Haraldsen G, Spurkland A (2014)
Expression of the T cell-specific adapter protein in human tissues
Scand J Immunol, 80 (3), 169-79
PubMed 24910151

Skårn M, Noordhuis P, Wang MY, Veuger M, Kresse SH, Egeland EV, Micci F, Namløs HM, Håkelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA, Myklebost O (2014)
Generation and characterization of an immortalized human mesenchymal stromal cell line
Stem Cells Dev, 23 (19), 2377-89
PubMed 24857590

Tveita AA, Schjesvold FH, Sundnes O, Haabeth OA, Haraldsen G, Bogen B (2014)
Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatially restricted and fails to prevent escape of antigen-negative cells
Eur J Immunol, 44 (9), 2625-37
PubMed 24846412

Publications 2012

Hol J, Otterdal K, Breland UM, Stang E, Pedersen TM, Hagelsteen K, Ranheim T, Kasprzycka M, Halvorsen B, Haraldsen G, Aukrust P (2012)
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies
PLoS One, 7 (7), e40673
PubMed 22815786

Pollheimer J, Bodin J, Sundnes O, Edelmann RJ, Skånland SS, Sponheim J, Brox MJ, Sundlisaeter E, Loos T, Vatn M, Kasprzycka M, Wang J, Küchler AM, Taskén K, Haraldsen G, Hol J (2012)
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells
Arterioscler Thromb Vasc Biol, 33 (2), e47-55
PubMed 23162017

Sundlisaeter E, Edelmann RJ, Hol J, Sponheim J, Küchler AM, Weiss M, Udalova IA, Midwood KS, Kasprzycka M, Haraldsen G (2012)
The alarmin IL-33 is a notch target in quiescent endothelial cells
Am J Pathol, 181 (3), 1099-111
PubMed 22809957

Publications 2011

Haabeth OA, Lorvik KB, Hammarström C, Donaldson IM, Haraldsen G, Bogen B, Corthay A (2011)
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer
Nat Commun, 2, 240
PubMed 21407206

Pollheimer J, Haslinger P, Fock V, Prast J, Saleh L, Biadasiewicz K, Jetne-Edelmann R, Haraldsen G, Haider S, Hirtenlehner-Ferber K, Knöfler M (2011)
Endostatin suppresses IGF-II-mediated signaling and invasion of human extravillous trophoblasts
Endocrinology, 152 (11), 4431-42
PubMed 21933871

Publications 2010

Mikalsen B, Fosby B, Wang J, Hammarström C, Bjaerke H, Lundström M, Kasprzycka M, Scott H, Line PD, Haraldsen G (2010)
Genome-wide transcription profile of endothelial cells after cardiac transplantation in the rat
Am J Transplant, 10 (7), 1534-44
PubMed 20642680

Sponheim J, Pollheimer J, Olsen T, Balogh J, Hammarström C, Loos T, Kasprzycka M, Sørensen DR, Nilsen HR, Küchler AM, Vatn MH, Haraldsen G (2010)
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts
Am J Pathol, 177 (6), 2804-15
PubMed 21037074

Publications 2009

Etokebe GE, Küchler AM, Haraldsen G, Landin M, Osmundsen H, Dembic Z (2009)
Family-with-sequence-similarity-46, member A (Fam46a) gene is expressed in developing tooth buds
Arch Oral Biol, 54 (11), 1002-7
PubMed 19740458

Haraldsen G, Balogh J, Pollheimer J, Sponheim J, Küchler AM (2009)
Interleukin-33 - cytokine of dual function or novel alarmin?
Trends Immunol, 30 (5), 227-33
PubMed 19359217

Hol J, Küchler AM, Johansen FE, Dalhus B, Haraldsen G, Oynebråten I (2009)
Molecular requirements for sorting of the chemokine interleukin-8/CXCL8 to endothelial Weibel-Palade bodies
J Biol Chem, 284 (35), 23532-9
PubMed 19578117

Hol J, Wilhelmsen L, Haraldsen G (2009)
The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies
J Leukoc Biol, 87 (3), 501-8
PubMed 20007247

Norrmén C, Vandevelde W, Ny A, Saharinen P, Gentile M, Haraldsen G, Puolakkainen P, Lukanidin E, Dewerchin M, Alitalo K, Petrova TV (2009)
Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
Blood, 115 (4), 906-9
PubMed 19965622

Publications 2008

Breland UM, Halvorsen B, Hol J, Øie E, Paulsson-Berne G, Yndestad A, Smith C, Otterdal K, Hedin U, Waehre T, Sandberg WJ, Frøland SS, Haraldsen G, Gullestad L, Damås JK, Hansson GK, Aukrust P (2008)
A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins
Arterioscler Thromb Vasc Biol, 28 (5), 1005-11
PubMed 18276907

Küchler AM, Pollheimer J, Balogh J, Sponheim J, Manley L, Sorensen DR, De Angelis PM, Scott H, Haraldsen G (2008)
Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation
Am J Pathol, 173 (4), 1229-42
PubMed 18787100

Saethre M, Schneider MK, Lambris JD, Magotti P, Haraldsen G, Seebach JD, Mollnes TE (2008)
Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model
J Immunol, 180 (9), 6346-53
PubMed 18424758

Publications 2007

Skovseth DK, Küchler AM, Haraldsen G (2007)
The HUVEC/Matrigel assay: an in vivo assay of human angiogenesis suitable for drug validation
Methods Mol Biol, 360, 253-68
PubMed 17172733

Publications 2006

Haraldsen G, Rot A (2006)
Coy decoy with a new ploy: interceptor controls the levels of homeostatic chemokines
Eur J Immunol, 36 (7), 1659-61
PubMed 16791884

Saethre M, Lea T, Borgen MS, Fiane AE, Michaelsen TE, Thorsby E, Haraldsen G, Mollnes TE (2006)
Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation
Xenotransplantation, 13 (3), 215-23
PubMed 16756564

Publications 2005

Baekkevold ES, Wurbel MA, Kivisäkk P, Wain CM, Power CA, Haraldsen G, Campbell JJ (2005)
A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
J Exp Med, 201 (7), 1045-51
PubMed 15795234

Carlsen HS, Haraldsen G, Brandtzaeg P, Baekkevold ES (2005)
Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules
Blood, 106 (2), 444-6
PubMed 15863780

Corthay A, Skovseth DK, Lundin KU, Røsjø E, Omholt H, Hofgaard PO, Haraldsen G, Bogen B (2005)
Primary antitumor immune response mediated by CD4+ T cells
Immunity, 22 (3), 371-83
PubMed 15780993

Fiane AE, Ueland T, Simonsen S, Scott H, Endresen K, Gullestad L, Geiran OR, Haraldsen G, Heggelund L, Andreassen AK, Wergeland R, Frøland S, Aukrust P, Mollnes TE (2005)
Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation
Eur Heart J, 26 (16), 1660-5
PubMed 15821010

Qiao SW, Piper J, Haraldsen G, Oynebråten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM (2005)
Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease
J Immunol, 174 (3), 1657-63
PubMed 15661929

Øynebråten I, Barois N, Hagelsteen K, Johansen FE, Bakke O, Haraldsen G (2005)
Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol
J Immunol, 175 (8), 5358-69
PubMed 16210642

Publications 2004

Carlsen HS, Baekkevold ES, Morton HC, Haraldsen G, Brandtzaeg P (2004)
Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis
Blood, 104 (10), 3021-7
PubMed 15284119

Lacorre DA, Baekkevold ES, Garrido I, Brandtzaeg P, Haraldsen G, Amalric F, Girard JP (2004)
Plasticity of endothelial cells: rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment
Blood, 103 (11), 4164-72
PubMed 14976058

Skovseth DK, Veuger MJ, Sorensen DR, De Angelis PM, Haraldsen G (2004)
Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo
Blood, 105 (3), 1044-51
PubMed 15466935

Øynebråten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G (2004)
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments
Blood, 104 (2), 314-20
PubMed 15044249

Publications 2003

Baekkevold ES, Roussigné M, Yamanaka T, Johansen FE, Jahnsen FL, Amalric F, Brandtzaeg P, Erard M, Haraldsen G, Girard JP (2003)
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules
Am J Pathol, 163 (1), 69-79
PubMed 12819012

Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn M, Botstein D, Brown PO (2003)
Endothelial cell diversity revealed by global expression profiling
Proc Natl Acad Sci U S A, 100 (19), 10623-8
PubMed 12963823

Publications 2002

Carlsen HS, Baekkevold ES, Johansen FE, Haraldsen G, Brandtzaeg P (2002)
B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue
Gut, 51 (3), 364-71
PubMed 12171958

Farstad IN, Malavasi F, Haraldsen G, Huitfeldt HS, Brandtzaeg P (2002)
CD38 is a marker of human lacteals
Virchows Arch, 441 (6), 605-13
PubMed 12461619

Saethre M, Sølvik UØ, Haraldsen G, Fiane AE, Boretti E, Thorsby E, Platt JL, Mollnes TE (2002)
Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies
Xenotransplantation, 9 (5), 350-8
PubMed 12199866

Skovseth DK, Yamanaka T, Brandtzaeg P, Butcher EC, Haraldsen G (2002)
Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice
Am J Pathol, 160 (5), 1629-37
PubMed 12000715

Publications 2001

Baekkevold ES, Yamanaka T, Palframan RT, Carlsen HS, Reinholt FP, von Andrian UH, Brandtzaeg P, Haraldsen G (2001)
The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment
J Exp Med, 193 (9), 1105-12
PubMed 11342595

Sølvik UO, Haraldsen G, Fiane AE, Boretti E, Thorsby E, Mollnes TE (2001)
C1-inhibitor attenuates human serum induced E-selectin expression of pig aortic endothelial cells
Transplant Proc, 33 (1-2), 789-90
PubMed 11267073

Sølvik UØ, Haraldsen G, Fiane AE, Boretti E, Lambris JD, Fung M, Thorsby E, Mollnes TE (2001)
Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated
Transplantation, 72 (12), 1967-73
PubMed 11773897

Publications 2000

Kunkel EJ, Campbell JJ, Haraldsen G, Pan J, Boisvert J, Roberts AI, Ebert EC, Vierra MA, Goodman SB, Genovese MC, Wardlaw AJ, Greenberg HB, Parker CM, Butcher EC, Andrew DP, Agace WW (2000)
Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity
J Exp Med, 192 (5), 761-8
PubMed 10974041

Sindre H, Haraldsen G, Beck S, Hestdal K, Kvale D, Brandtzaeg P, Degré M, Rollag H (2000)
Human intestinal endothelium shows high susceptibility to cytomegalovirus and altered expression of adhesion molecules after infection
Scand J Immunol, 51 (4), 354-60
PubMed 10736107

Publications 1999

Baekkevold ES, Jahnsen FL, Johansen FE, Bakke O, Gaudernack G, Brandtzaeg P, Haraldsen G (1999)
Culture characterization of differentiated high endothelial venule cells from human tonsils
Lab Invest, 79 (3), 327-36
PubMed 10092069

Brandtzaeg P, Farstad IN, Haraldsen G (1999)
Regional specialization in the mucosal immune system: primed cells do not always home along the same track
Immunol Today, 20 (6), 267-77
PubMed 10354552

Brandtzaeg P, Haraldsen G, Baekkevold ES, Jahnsen FL, Nilsen EM (1999)
Microvascular endothelial cells and leukocyte emigration
FALK SYMP, 110, 383-400

Brandtzaeg P, Haraldsen G, Helgeland L, Nilsen EM, Rugtveit J (1999)
New insights into the immunopathology of human inflammatory bowel disease
Drugs Today, 35 A, 33-70

Campbell JJ, Haraldsen G, Pan J, Rottman J, Qin S, Ponath P, Andrew DP, Warnke R, Ruffing N, Kassam N, Wu L, Butcher EC (1999)
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
Nature, 400 (6746), 776-80
PubMed 10466728

Girard JP, Baekkevold ES, Yamanaka T, Haraldsen G, Brandtzaeg P, Amalric F (1999)
Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization
Am J Pathol, 155 (6), 2043-55
PubMed 10595934

Publications 1998

Brandtzaeg F, Farstad IN, Haraldsen G, Jahnsen FL (1998)
Cellular and molecular mechanisms for induction of mucosal immunity
Dev. Biols, 92, 93-108

Brandtzaeg P, Farstad IN, Haraldsen G, Jahnsen FL (1998)
Cellular and molecular mechanisms for induction of mucosal immunity
Dev Biol Stand, 92, 93-108
PubMed 9554262

Haraldsen G, Sollid LM, Bakke O, Farstad IN, Kvale D, Molberg, Norstein J, Stang E, Brandtzaeg P (1998)
Major histocompatibility complex class II-dependent antigen presentation by human intestinal endothelial cells
Gastroenterology, 114 (4), 649-56
PubMed 9516385

Nilsen EM, Johansen FE, Jahnsen FL, Lundin KE, Scholz T, Brandtzaeg P, Haraldsen G (1998)
Cytokine profiles of cultured microvascular endothelial cells from the human intestine
Gut, 42 (5), 635-42
PubMed 9659156

Utgaard JO, Jahnsen FL, Bakka A, Brandtzaeg P, Haraldsen G (1998)
Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells
J Exp Med, 188 (9), 1751-6
PubMed 9802986

Publications 1997

Brandtzaeg P, Berstad AE, Farstad IN, Haraldsen G, Helgeland L, Jahnsen FL, Johansen FE, Natvig IB, Nilsen EM, Rugtveit J (1997)
Mucosal immunity--a major adaptive defence mechanism
Behring Inst Mitt (98), 1-23
PubMed 9382729

Brandtzaeg P, Haraldsen G, Rugtveit J (1997)
Immunopathology of human inflammatory bowel disease (vol 18, pg 555, 1997)
Springer Semin. Immunopathol., 19 (2), 269

Brandtzaeg P, Haraldsen G, Rugtveit J (1997)
Immunopathology of human inflammatory bowel disease
Springer Semin Immunopathol, 18 (4), 555-89
PubMed 9144870

Brandtzaeg P, Haraldsen G, Rugtveit J (1997)
Immunopathological mechanisms in inflammatory bowel disease
FALK SYMP, 91, 15-51

Brandtzaeg P, Jahnsen FL, Farstad IN, Haraldsen G (1997)
Mucosal immunology of the upper airways: an overview
Ann N Y Acad Sci, 830, 1-18
PubMed 9616663

Jahnsen FL, Brandtzaeg P, Haye R, Haraldsen G (1997)
Expression of functional VCAM-1 by cultured nasal polyp-derived microvascular endothelium
Am J Pathol, 150 (6), 2113-23
PubMed 9176402

Natvig IB, Johansen FE, Nordeng TW, Haraldsen G, Brandtzaeg P (1997)
Mechanism for enhanced external transfer of dimeric IgA over pentameric IgM: studies of diffusion, binding to the human polymeric Ig receptor, and epithelial transcytosis
J Immunol, 159 (9), 4330-40
PubMed 9379029

Publications 1996

Haraldsen G, Kvale D, Lien B, Farstad IN, Brandtzaeg P (1996)
Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells
J Immunol, 156 (7), 2558-65
PubMed 8786319

Publications 1995

Haraldsen G, Rugtveit J, Kvale D, Scholz T, Muller WA, Hovig T, Brandtzaeg P (1995)
Isolation and longterm culture of human intestinal microvascular endothelial cells
Gut, 37 (2), 225-34
PubMed 7557573

Jahnsen FL, Haraldsen G, Aanesen JP, Haye R, Brandtzaeg P (1995)
Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps
Am J Respir Cell Mol Biol, 12 (6), 624-32
PubMed 7539273

Rugtveit J, Haraldsen G, Høgåsen AK, Bakka A, Brandtzaeg P, Scott H (1995)
Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14+L1+ monocyte derived cells
Gut, 37 (3), 367-73
PubMed 7590432

Publications 1994

Jahnsen FL, Haraldsen G, Rugtveit J, Halstensen TS, Brandtzaeg P (1994)
Differential interference contrast microscopy combined with immunofluorescence: a new method to phenotype eosinophils in situ
J Immunol Methods, 173 (1), 77-91
PubMed 8034989

Publications 1988

Schubert W, Kontozis L, Sticker G, Schwan H, Haraldsen G, Jerusalem F (1988)
Immunofluorescent evidence for presence of interleukin-1 in normal and diseased human skeletal muscle
Muscle Nerve, 11 (8), 890-2
PubMed 3050511