
| Lars Gullestad | |
| Position: | Professor |
| Phone: | +47 23070641 |
| Email: | |
Stipendiates: Odd Erik Johansen, Christen Peder Dahl, Satish Arora
Scientific projects
The role of inflammatory and immunological factors in cardiovascular disease
Main methods:
Clinical trials, analysis of inflammatory parameters in blood and tissue, PCR, gene array
Project I:
The importance of immunological and inflammatory factors in heart failure
Aim:
Investigate inflammatory variables in patients with heart failure of various etiologies
Project II:
Psychological and social factors in patients with heart failure and heart transplant patients
Collaborators:
Institute of Psychology, University of Bergen
Aim:
Examine psychological and social factors in patients with end-stage heart disease heart transplant patients in relation to later outcome
Project III:
Effect of Intravenous Immunglobulin on left ventricular remodelling after acute myocardial infarction
Collaborators:
Department of Cardiology, Rogaland University Hospital
Aim:
Investigate the effect of IVIg on left ventricular remodelling in patients with myocardial infarction and left ventricular dysfunction
Project IV:
Inflammatory and immunological factors in patients with coronary artery disease
Aim:
Examine immunological and inflammatory mechanism in patients with angina pectoris, unstable coronary syndromes, STEMI and hypercholesterolemia in relation to the clinical presentation and outcome
Project V:
Effect of Rosuvastatin in patients with dilated cardiomyopathy
Collaborators:
Buskerud Hospital
Aim:
Investigate the effect of Rosuvastatin on left ventricular remodelling in patients with dilated CMP
Author network for Lars Gullestad by COREMINE medical
Publications in press
NT-proBNP predicts myocardial recovery after non-ST-elevation acute coronary syndrome
Scand Cardiovasc J (in press)
PubMed 22191851
Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology
Eur J Heart Fail (in press)
PubMed 22302661
Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
Lipids Health Dis, 10 (1), 245 (in press)
PubMed 22206454
The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*
J Intern Med (in press)
PubMed 22211640
Activin A and cardiovascular disease in type 2 diabetes mellitus
Diab Vasc Dis Res (in press)
PubMed 22234949
Publications 2012
Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease
Scand Cardiovasc J, 46 (1), 23-31
PubMed 22017530
Baseline anemia is not a predictor of all-cause mortality in outpatients with advanced heart failure or severe renal dysfunction results from the norwegian heart failure registry
J Am Coll Cardiol, 59 (4), 371-8
PubMed 22261159
Publications 2011
Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial
Transplantation, 92 (2), 235-43
PubMed 21677600
Tumor necrosis factor superfamily molecules in acute coronary syndromes
Ann Med, 43 (2), 90-103
PubMed 21039303
QT response after a test dose and during maintenance therapy with AZD1305 in patients with atrial fibrillation: a double-blind, randomized, placebo-controlled trial
Am J Cardiovasc Drugs, 11 (3), 199-208
PubMed 21619383
Characteristics, implementation of evidence-based management and outcome in patients with chronic heart failure: results from the Norwegian heart failure registry
Eur J Cardiovasc Nurs, 10 (1), 44-9
PubMed 20452825
Chronotropic responses to exercise in heart transplant recipients: 1-yr follow-up
Am J Phys Med Rehabil, 90 (7), 579-88
PubMed 21765276
No impact of atrial fibrillation on mortality risk in optimally treated heart failure patients
Clin Cardiol, 34 (9), 537-42
PubMed 21796642
Galectin-3 in heart failure: high levels are associated with all-cause mortality
Int J Cardiol, 150 (3), 361-4
PubMed 21641051
Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis
J Intern Med, 270 (5), 452-60
PubMed 21623962
Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure
Clin Sci (Lond), 121 (3), 119-27
PubMed 21294711
Osteoprotegerin predicts progression of chronic heart failure: results from CORONA
Circ Heart Fail, 4 (2), 145-52
PubMed 21216833
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
PLoS One, 6 (4), e18668
PubMed 21533157
Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality
J Intern Med, 270 (3), 263-72
PubMed 21466599
Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy
Am Heart J, 161 (6), 1031-7
PubMed 21641347
Publications 2010
Systemic markers of inflammation are associated with cardiac allograft vasculopathy and an increased intimal inflammatory component
Am J Transplant, 10 (6), 1428-36
PubMed 20486911
Activated platelets and atherosclerosis
Expert Rev Cardiovasc Ther, 8 (9), 1297-307
PubMed 20828352
Warning on diuretic use
J Am Coll Cardiol, 55 (23), 2609-10; author reply 2610
PubMed 20513605
Acute renal failure early after heart transplantation: risk factors and clinical consequences
Clin Transplant, 24 (6), E207-13
PubMed 20184627
Benefit of early conversion from CNI-based to everolimus-based immunosuppression in heart transplantation
J Heart Lung Transplant, 29 (6), 641-7
PubMed 20304681
Pulmonary hypertension in heart transplantation: discrepant prognostic impact of pre-operative compared with 1-year post-operative right heart hemodynamics
J Heart Lung Transplant, 29 (2), 216-23
PubMed 19837606
Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial
Transplantation, 89 (7), 864-72
PubMed 20061999
Two-year outcomes in thoracic transplant recipients after conversion to everolimus with reduced calcineurin inhibitor within a multicenter, open-label, randomized trial
Transplantation, 90 (12), 1581-9
PubMed 21030905
Determinants and prognostic implications of cardiac troponin T measured by a sensitive assay in type 2 diabetes mellitus
Cardiovasc Diabetol, 9, 52
PubMed 20843304
The peripheral blood mononuclear cell microRNA signature of coronary artery disease
Biochem Biophys Res Commun, 394 (3), 792-7
PubMed 20230787
Improved quality of life in Norwegian heart failure patients after follow-up in outpatient heart failure clinics: results from the Norwegian Heart Failure Registry
Eur J Heart Fail, 12 (11), 1247-52
PubMed 20847014
Osteoprotegerin concentrations and prognosis in acute ischaemic stroke
J Intern Med, 267 (4), 410-7
PubMed 19895657
EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot)
Eur J Heart Fail, 12 (10), 1076-84
PubMed 20805094
Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis
J Intern Med, 268 (5), 483-92
PubMed 20804515
Renal function in outpatients with chronic heart failure
J Card Fail, 16 (5), 374-80
PubMed 20447572
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Res Cardiol, 105 (1), 89-98
PubMed 19823891
Assessment of response criteria to cardiac resynchronization therapy (CRT) and prediction of response
Scand Cardiovasc J, 44 (6), 337-45
PubMed 21080864
Publications 2009
The prognostic importance of modifiable risk factors after heart transplantation
Am Heart J, 158 (3), 431-6
PubMed 19699867
Elevated serum uric acid levels following heart transplantation predict all-cause and cardiac mortality
Eur J Heart Fail, 11 (10), 1005-13
PubMed 19737803
Testosterone: a novel therapeutic approach in chronic heart failure?
J Am Coll Cardiol, 54 (10), 928-9
PubMed 19712803
Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling
Circ Heart Fail, 2 (6), 624-32
PubMed 19919988
Intra-aortic balloon counterpulsation as a bridge to heart transplantation does not impair long-term survival
Eur J Heart Fail, 11 (7), 709-14
PubMed 19515719
Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
Eur J Heart Fail, 11 (2), 119-29
PubMed 19168509
Diabetic foot ulcer burden may be modified by high-dose atorvastatin: A 6-month randomized controlled pilot trial
J Diabetes, 1 (3), 182-7
PubMed 20923537
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure
Eur J Heart Fail, 11 (8), 771-8
PubMed 19567409
Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): a retrospective analysis
Circulation, 120 (22), 2188-96
PubMed 19917888
Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis
Circ Res, 104 (1), 60-8
PubMed 19023130
The tumour necrosis factor superfamily ligand APRIL (TNFSF13) is released upon platelet activation and expressed in atherosclerosis
Thromb Haemost, 102 (4), 704-10
PubMed 19806256
Osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand and risk for coronary events: a nested case-control approach in the prospective EPIC-Norfolk population study 1993-2003
Arterioscler Thromb Vasc Biol, 29 (6), 975-80
PubMed 19325145
Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis
Arterioscler Thromb Vasc Biol, 29 (8), 1228-34
PubMed 19498175
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure
Eur Heart J, 30 (10), 1229-36
PubMed 19329498
Publications 2008
Pre-transplant Toxoplasma gondii seropositivlty among heart transplant recipients and mortality - Reply
J. Am. Coll. Cardiol., 51 (18), 1827-1828
Chemokines and cardiovascular risk
Arterioscler Thromb Vasc Biol, 28 (11), 1909-19
PubMed 18669888
The complex role of T-cell-based immunity in atherosclerosis
Curr Atheroscler Rep, 10 (3), 236-43
PubMed 18489852
A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins
Arterioscler Thromb Vasc Biol, 28 (5), 1005-11
PubMed 18276907
Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure
Eur J Heart Fail, 10 (4), 352-9
PubMed 18353719
Atherosclerotic plaque stability--what determines the fate of a plaque?
Prog Cardiovasc Dis, 51 (3), 183-94
PubMed 19026853
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure
J Mol Cell Cardiol, 45 (2), 261-9
PubMed 18585734
Heart rate adjustments and analysis of recovery patterns of ST-segment depression in type 2 diabetes
Int J Cardiol, 127 (1), 129-32
PubMed 17532067
Raised LIGHT levels in pulmonary arterial hypertension: potential role in thrombus formation
Am J Respir Crit Care Med, 177 (2), 202-7
PubMed 17962639
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc Res, 79 (1), 195-203
PubMed 18339644
Publications 2007
Prognostic importance of renal function 1 year after heart transplantation for all-cause and cardiac mortality and development of allograft vasculopathy
Transplantation, 84 (2), 149-54
PubMed 17667805
Probrain natriuretic peptide and C-reactive protein as markers of acute rejection, allograft vasculopathy, and mortality in heart transplantation
Transplantation, 83 (10), 1308-15
PubMed 17519779
Pre-transplant Toxoplasma gondii seropositivity among heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality
J Am Coll Cardiol, 50 (20), 1967-72
PubMed 17996562
Potential mechanisms of benefit with thalidomide in chronic heart failure
Am J Cardiovasc Drugs, 7 (2), 127-34
PubMed 17503883
T cells in coronary artery disease: different effects of different T-cell subsets
J Am Coll Cardiol, 50 (15), 1459-61
PubMed 17919565
Chemokines in cardiovascular risk prediction
Thromb Haemost, 97 (5), 748-54
PubMed 17479185
Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization
Circulation, 115 (8), 972-80
PubMed 17283255
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization
Arterioscler Thromb Vasc Biol, 27 (3), 614-20
PubMed 17170367
[Diuretics not the first-choice-drug in chronic heart failure]
Tidsskr Nor Laegeforen, 127 (5), 621; author reply 621
PubMed 17332822
The role of statins in heart failure
Fundam Clin Pharmacol, 21 Suppl 2, 35-40
PubMed 18001320
Depressive symptoms and all-cause mortality after heart transplantation
Transplantation, 84 (1), 97-103
PubMed 17627244
Inflammation and coronary angiography in asymptomatic type 2 diabetic subjects
Scand J Clin Lab Invest, 67 (3), 306-16
PubMed 17454845
Effects of structured hospital-based care compared with standard care for Type 2 diabetes-The Asker and Baerum Cardiovascular Diabetes Study, a randomized trial
Diabet Med, 24 (9), 1019-27
PubMed 17509068
Rosuvastatin in older patients with systolic heart failure
N Engl J Med, 357 (22), 2248-61
PubMed 17984166
[Survival after heart transplantation in Norway]
Tidsskr Nor Laegeforen, 127 (7), 865-8
PubMed 17435806
[Self-assessed health and psychological symptoms after heart transplantation]
Tidsskr Nor Laegeforen, 127 (24), 3198-201
PubMed 18084359
Role of inflammation in the progression of heart failure
Curr Cardiol Rep, 9 (3), 236-41
PubMed 17470337
Publications 2006
The role of intravenous immunoglobulin in the treatment of chronic heart failure
Int J Cardiol, 112 (1), 40-5
PubMed 16893578
Anti-inflammatory trials in chronic heart failure
Heart Fail Monit, 5 (1), 2-9
PubMed 16547529
A protective anti-inflammatory phenotype in high-risk individuals who do not develop coronary artery disease
J Am Coll Cardiol, 47 (5), 1085-6
PubMed 16516099
Undiagnosed dysglycaemia and inflammation in cardiovascular disease
Eur J Clin Invest, 36 (8), 544-51
PubMed 16893376
Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization
Arterioscler Thromb Vasc Biol, 26 (4), 857-63
PubMed 16424351
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation
J Am Coll Cardiol, 48 (8), 1591-9
PubMed 17045893
The tumor necrosis factor superfamily in heart failure
Future Cardiol, 2 (1), 101-11
PubMed 19804137
Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction
J Card Fail, 12 (8), 659-63
PubMed 17045187
Decreased endomyocardial RANKL expression in transplant coronary artery disease
Transplantation, 81 (10), 1467-70
PubMed 16732187
Increased inflammatory markers in children with familial hypercholesterolaemia
Eur J Clin Invest, 36 (3), 147-52
PubMed 16506958
Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MERIT-HF Study
Eur J Heart Fail, 8 (5), 539-46
PubMed 16567126
Clopidogrel increases expression of chemokines in peripheral blood mononuclear cells in patients with coronary artery disease: results of a double-blind placebo-controlled study
J Thromb Haemost, 4 (10), 2140-7
PubMed 16856976
Systemic inflammation in heart failure--the whys and wherefores
Heart Fail Rev, 11 (1), 83-92
PubMed 16819581
Publications 2005
Inflammatory and anti-inflammatory cytokines in chronic heart failure: potential therapeutic implications
Ann Med, 37 (2), 74-85
PubMed 16026115
Potential role for immunomodulatory therapy in atherosclerotic plaque stabilisation
Expert Opin Pharmacother, 6 (13), 2169-80
PubMed 16218879
Inflammation in coronary artery disease: potential role for immunomodulatory therapy
Expert Rev Cardiovasc Ther, 3 (6), 1111-24
PubMed 16293001
Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation
Eur Heart J, 26 (16), 1660-5
PubMed 15821010
Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches
Am J Cardiol, 95 (11A), 17C-23C; discussion 38C-40C
PubMed 15925560
Agents targeting inflammation in heart failure
Expert Opin Investig Drugs, 14 (5), 557-66
PubMed 15926863
Effect of thalidomide on cardiac remodeling in chronic heart failure: results of a double-blind, placebo-controlled study
Circulation, 112 (22), 3408-14
PubMed 16301340
What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF)
J Am Coll Cardiol, 45 (2), 252-9
PubMed 15653024
Enhanced plasma levels of LIGHT in unstable angina: possible pathogenic role in foam cell formation and thrombosis
Circulation, 112 (14), 2121-9
PubMed 16186421
Soluble CD40 ligand in acute and chronic heart failure
Eur Heart J, 26 (11), 1101-7
PubMed 15716285
Plasma levels of soluble tumor necrosis factor receptor type I during the acute phase following complicated myocardial infarction predicts survival in high-risk patients
J Am Coll Cardiol, 46 (11), 2018-21
PubMed 16325035
Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure
Circulation, 111 (19), 2461-8
PubMed 15883214
Publications 2004
Therapeutic potential of anticytokine therapy in congestive heart failure
Am J Cardiovasc Drugs, 4 (3), 169-77
PubMed 15134469
Inflammation and chronic heart failure-potential therapeutic role of intravenous immunoglobulin
Autoimmun Rev, 3 (3), 221-7
PubMed 15110235
Evaluation of ST-segment changes during and after maximal exercise tests in one-, two- and three-vessel coronary artery disease
Scand Cardiovasc J, 38 (5), 270-7
PubMed 15513309
[Modern diagnosis and treatment of heart failure]
Tidsskr Nor Laegeforen, 124 (8), 1107-10
PubMed 15114390
Predictors of exercise capacity and the impact of angiographic coronary artery disease in heart transplant recipients
Am Heart J, 147 (1), 49-54
PubMed 14691418
Effects of conventional and aggressive statin treatment on markers of endothelial function and inflammation
Clin Cardiol, 27 (4), 199-203
PubMed 15119693
Metoprolol CR/XL improves systolic and diastolic left ventricular function in patients with chronic heart failure
Echocardiography, 21 (3), 215-23
PubMed 15053783
Beneficial effect on cardiac function by intravenous immunoglobulin treatment in patients with dilated cardiomyopathy is not due to neutralization of anti-receptor autoantibody
Autoimmunity, 37 (6-7), 489-93
PubMed 15621576
Potential anti-inflammatory role of activin A in acute coronary syndromes
J Am Coll Cardiol, 44 (2), 369-75
PubMed 15261933
Analysis of pravastatin to prevent recurrence of atrial fibrillation after electrical cardioversion
Am J Cardiol, 93 (6), 780-2
PubMed 15019894
Prognostic value of osteoprotegerin in heart failure after acute myocardial infarction
J Am Coll Cardiol, 44 (10), 1970-6
PubMed 15542278
Increased expression of interleukin-1 in coronary artery disease with downregulatory effects of HMG-CoA reductase inhibitors
Circulation, 109 (16), 1966-72
PubMed 15051633
Elevated levels of activin A in heart failure: potential role in myocardial remodeling
Circulation, 109 (11), 1379-85
PubMed 14993131
Publications 2003
Immunomodulating therapy: new treatment modality in congestive heart failure
Congest Heart Fail, 9 (2), 64-9
PubMed 12671336
Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets
Circulation, 107 (21), 2670-6
PubMed 12742982
The effect of a neuropeptide Y Y1 receptor antagonist in patients with angina pectoris
Eur Heart J, 24 (12), 1120-7
PubMed 12804926
[Use of beta-blockaders in heart failure]
Tidsskr Nor Laegeforen, 123 (5), 651-2
PubMed 12683197
CXC-chemokines in coronary artery disease: possible pathogenic role of interactions between oxidized low-density lipoprotein, platelets and peripheral blood mononuclear cells
J Thromb Haemost, 1 (2), 257-62
PubMed 12871498
Clinical and exercise test determinants of survival after cardiac transplantation
Chest, 124 (5), 2000-5
PubMed 14605079
Physical activity patterns and exercise performance in cardiac transplant recipients
J Cardiopulm Rehabil, 23 (2), 100-6
PubMed 12668931
A descriptive study of early nonspecific chest pain after PTCA: important area for the acute health care personnel
Heart Lung, 32 (4), 241-9
PubMed 12891164
Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy
J Am Coll Cardiol, 41 (2), 275-9
PubMed 12535822
Myocardial gene expression of inflammatory cytokines after heart transplantation in relation to the development of transplant coronary artery disease
Am J Cardiol, 92 (6), 715-7
PubMed 12972116
Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease
J Am Coll Cardiol, 41 (9), 1460-7
PubMed 12742282
Enhanced expression of inflammatory cytokines and activation markers in T-cells from patients with chronic heart failure
Cardiovasc Res, 60 (1), 141-6
PubMed 14522416
Publications 2002
Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects
Circulation, 106 (1), 36-42
PubMed 12093767
Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF)
Circulation, 105 (10), 1182-8
PubMed 11889011
Effect of thalidomide in patients with chronic heart failure
Am Heart J, 144 (5), 847-50
PubMed 12422154
Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension
Transplantation, 74 (10), 1395-400
PubMed 12451238
Effect of morning versus evening intake of simvastatin on the serum cholesterol level in patients with coronary artery disease
Am J Cardiol, 90 (7), 784-6
PubMed 12356401
Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10
Eur J Clin Invest, 32 (11), 803-10
PubMed 12423320
Increased gene expression of tumor necrosis factor superfamily ligands in peripheral blood mononuclear cells during chronic heart failure
Cardiovasc Res, 54 (1), 175-82
PubMed 12062373
Publications 2001
Interaction between chemokines and oxidative stress: possible pathogenic role in acute coronary syndromes
J Am Coll Cardiol, 37 (2), 485-91
PubMed 11216967
Chemokines in myocardial failure -- pathogenic importance and potential therapeutic targets
Clin Exp Immunol, 124 (3), 343-5
PubMed 11472392
Complement activation in patients with congestive heart failure: effect of high-dose intravenous immunoglobulin treatment
Circulation, 104 (13), 1494-500
PubMed 11571242
Increase in anti-inflammatory cytokine levels in chronic heart failure: A measure of treatment success or failure? Response
Circulation, 104 (18), E97-E98
Inflammatory role of platelets in acute coronary syndromes
Heart, 86 (6), 605-6
PubMed 11711447
Plasma N-terminal proatrial natriuretic factor can predict normal pulmonary capillary wedge pressure in cardiac transplant recipients
Scand Cardiovasc J, 35 (6), 367-71
PubMed 11837515
Monocyte chemoattractant protein-1 enhances and interleukin-10 suppresses the production of inflammatory cytokines in adult rat cardiomyocytes
Basic Res Cardiol, 96 (4), 345-52
PubMed 11518190
Cytokines as new treatment targets in chronic heart failure
Curr Control Trials Cardiovasc Med, 2 (6), 271-277
PubMed 11806813
Enhanced gene expression of chemokines and their corresponding receptors in mononuclear blood cells in chronic heart failure--modulatory effect of intravenous immunoglobulin
J Am Coll Cardiol, 38 (1), 187-93
PubMed 11451272
Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure
Eur J Clin Invest, 31 (5), 389-97
PubMed 11380590
The cytokine network in heart failure: pathogenetic importance and potential therapeutic targets
Heart Fail Monit, 2 (1), 8-13
PubMed 12634893
Effect of metoprolol CR/XL on exercise tolerance in chronic heart failure - a substudy to the MERIT-HF trial
Eur J Heart Fail, 3 (4), 463-8
PubMed 11511433
Effect of metoprolol on cytokine levels in chronic heart failure--a substudy in the Metoprolol Controlled-Release Randomised Intervention Trial in Heart Failure (MERIT-HF)
Am Heart J, 141 (3), 418-21
PubMed 11231439
[Immunomodulating treatment in advanced heart failure--effect of intravenous immunoglobulin]
Tidsskr Nor Laegeforen, 121 (16), 1902-7
PubMed 11488180
Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure
Circulation, 103 (2), 220-5
PubMed 11208680
Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients
Eur Heart J, 22 (5), 428-36
PubMed 11207085
Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients
Am J Cardiol, 87 (6), 815-8, A9
PubMed 11249916
Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients
Transplantation, 72 (4), 706-11
PubMed 11544435
Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects
Am J Med, 110 (7), 536-42
PubMed 11343667
Publications 2000
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
Cardiovasc Res, 47 (4), 778-87
PubMed 10974226
CXC-chemokines, a new group of cytokines in congestive heart failure--possible role of platelets and monocytes
Cardiovasc Res, 45 (2), 428-36
PubMed 10728363
Postexercise ischemia is associated with increased neuropeptide Y in patients with coronary artery disease
Circulation, 102 (9), 987-93
PubMed 10961962
Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group
JAMA, 283 (10), 1295-302
PubMed 10714728
Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines
Clin Transplant, 14 (3), 218-25
PubMed 10831080
Cardiopulmonary exercise testing and prognosis in severe heart failure: 14 mL/kg/min revisited
Am Heart J, 139 (1 Pt 1), 78-84
PubMed 10618566
Publications 1999
Is apoptosis an important pathogenic factor in cardiovascular disease?
Eur J Clin Invest, 29 (5), 369-71
PubMed 10354192
Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes
Circulation, 100 (6), 614-20
PubMed 10441098
Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
Am J Cardiol, 83 (3), 376-82
PubMed 10072227
Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure
J Am Coll Cardiol, 34 (7), 2061-7
PubMed 10588224
[Current use of beta-blockers in coronary artery disease]
Tidsskr Nor Laegeforen, 119 (1), 24-8
PubMed 10025200
Interaction between lovastatin and cyclosporine A after heart and kidney transplantation
Transplant Proc, 31 (5), 2163-5
PubMed 10456002
Possible role of proinflammatory cytokines in heart allograft coronary artery disease
Am J Cardiol, 84 (9), 999-1003
PubMed 10569653
Heart rate as a therapeutic target in heart failure
Eur. Heart J. Suppl., 1 (H), H64-H69
[Heart transplantation in Norway]
Tidsskr Nor Laegeforen, 119 (23), 3447-50
PubMed 10553344
Publications 1998
[Thrombolytic treatment in acute myocardial infarction. Choice of preparations in Norwegian hospitals]
Tidsskr Nor Laegeforen, 118 (17), 2630-1
PubMed 9673511
Endothelium-dependent vasodilation of the skin microcirculation in heart transplant recipients
Clin Transplant, 12 (4), 324-32
PubMed 9686327
Effect of heart transplantation on impaired peripheral microvascular perfusion and reactivity in congestive heart failure
Int J Cardiol, 65 (1), 33-40
PubMed 9699928
Exercise capacity in heart transplant recipients: relation to impaired endothelium-dependent vasodilation of the peripheral microcirculation
Am Heart J, 136 (2), 320-8
PubMed 9704697
Levels of circulating adhesion molecules in congestive heart failure and after heart transplantation
Am J Cardiol, 81 (5), 604-8
PubMed 9514458
Elevated circulating levels of C-C chemokines in patients with congestive heart failure
Circulation, 97 (12), 1136-43
PubMed 9537339
Exercise capacity and hormonal response in adults with childhood onset growth hormone deficiency during long-term somatropin treatment
Growth Horm IGF Res, 8 (5), 377-84
PubMed 10984298
Angiotensin II receptor subtype AT1 and AT2 expression after heart transplantation
Cardiovasc Res, 38 (2), 340-7
PubMed 9709394
Serial exercise testing and prognosis in selected patients considered for cardiac transplantation
Am Heart J, 135 (2 Pt 1), 221-9
PubMed 9489968
Neuropeptide Y receptor 1 (NPY-Y1) expression in human heart failure and heart transplantation
J Auton Nerv Syst, 70 (1-2), 84-91
PubMed 9686908
The role of exercise testing and gas-exchange measurement in the prognostic assessment of patients with heart failure
Curr Opin Cardiol, 13 (3), 145-55
PubMed 9649936
Clinical, hemodynamic, and cardiopulmonary exercise test determinants of survival in patients referred for evaluation of heart failure
Ann Intern Med, 129 (4), 286-93
PubMed 9729181
[Mortality and morbidity after coronary bypass surgery in high-risk patients]
Tidsskr Nor Laegeforen, 118 (29), 4504-8
PubMed 9889633
Publications 1997
Gas exchange and neurohumoral response to exercise: influence of the exercise protocol
Med Sci Sports Exerc, 29 (4), 496-502
PubMed 9107632
Post-transplant hyperlipidaemia: low-dose lovastatin lowers atherogenic lipids without plasma accumulation of lovastatin
J Intern Med, 242 (6), 483-90
PubMed 9437409
Importance of decreased heart rate in predicting transplant coronary artery disease
Clin Transplant, 11 (6), 628-32
PubMed 9408698
AT1 and AT2 angiotensin receptor gene expression in human heart failure
Circulation, 95 (5), 1201-6
PubMed 9054850
Outcome of bypass surgery in patients with chronic ischemic left ventricular dysfunction. Predictive value of MR imaging
Acta Radiol, 38 (1), 76-82
PubMed 9059406
Methotrexate or total lymphoid radiation for treatment of persistent or recurrent allograft cellular rejection: a comparative study
J Heart Lung Transplant, 16 (2), 179-89
PubMed 9059929
Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure
Scand J Clin Lab Invest, 57 (4), 361-7
PubMed 9249883
Publications 1996
The effect of acute vs chronic treatment with beta-adrenoceptor blockade on exercise performance, haemodynamic and metabolic parameters in healthy men and women
Br J Clin Pharmacol, 41 (1), 57-67
PubMed 8824694
Exercise capacity of heart transplant recipients: the importance of chronotropic incompetence
J Heart Lung Transplant, 15 (11), 1075-83
PubMed 8956116
Influence of the exercise protocol on hemodynamic, gas exchange, and neurohumoral responses to exercise in heart transplant recipients
J Heart Lung Transplant, 15 (3), 304-13
PubMed 8777215
Analysis of deaths in patients awaiting heart transplantation: impact on patient selection criteria
Heart, 75 (5), 455-62
PubMed 8665337
Diabetes mellitus and morbidity and mortality risks after coronary artery bypass surgery
Scand J Thorac Cardiovasc Surg, 30 (2), 71-5
PubMed 8857678
Early Doppler echocardiographic dysfunction is associated with an increased mortality after orthotopic cardiac transplantation
Circulation, 94 (9 Suppl), II289-93
PubMed 8901762
Publications 1995
[Intermittent claudication and beta-blockaders. An unfortunate combination?]
Tidsskr Nor Laegeforen, 115 (6), 725-8
PubMed 7900137
[Drug therapy of angina pectoris. Are the possibilities exploited well enough?]
Tidsskr Nor Laegeforen, 115 (18), 2264-7
PubMed 7652725
K+ balance of the quadriceps muscle during dynamic exercise with and without beta-adrenoceptor blockade
J Appl Physiol, 78 (2), 513-23
PubMed 7759420
[Beta 3-receptors: incidence and properties, possible clinical significance]
Tidsskr Nor Laegeforen, 115 (1), 45-9
PubMed 7846660
[Reduced physical tolerance in patients with heart failure. Mechanisms and therapeutic effects]
Tidsskr Nor Laegeforen, 115 (1), 38-42
PubMed 7846658
[Treatment of terminal heart failure]
Tidsskr Nor Laegeforen, 115 (4), 467-70
PubMed 7871502
[Hypercholesterolemia--a clinical problem in heart transplantation. A therapeutic trial with low-dose lovastatin]
Tidsskr Nor Laegeforen, 115 (3), 357-9
PubMed 7855835
Publications 1994
Effect of beta-adrenoceptor blockade on post-exercise oxygen consumption
Metabolism, 43 (5), 565-71
PubMed 7909912
Effect of magnesium treatment on glycemic control and metabolic parameters in NIDDM patients
Diabetes Care, 17 (5), 460-1
PubMed 8062622
The magnesium loading test: reference values in healthy subjects
Scand J Clin Lab Invest, 54 (1), 23-31
PubMed 8171268
Magnesium status in healthy free-living elderly Norwegians
J Am Coll Nutr, 13 (1), 45-50
PubMed 8157853
K+ shifts of skeletal muscle during stepwise bicycle exercise with and without beta-adrenoceptor blockade
J Physiol, 477 ( Pt 1), 149-59
PubMed 8071881
BETA-ADRENERGIC CONTROL OF POTASSIUM SHIFTS DURING EXERCISE
EUROPEAN SECTION MEETING - INTERNATIONAL SOCIETY FOR HEART RESEARCH, 151-158
Publications 1993
[Alpha blockers--first choice or second choice antihypertensive preparations?]
Tidsskr Nor Laegeforen, 113 (10), 1256-7
PubMed 8098555
The effect of magnesium versus verapamil on supraventricular arrhythmias
Clin Cardiol, 16 (5), 429-34
PubMed 8504578
Variable effects of beta-adrenoceptor blockade on muscle blood flow during exercise
Acta Physiol Scand, 149 (3), 257-71
PubMed 7906074
Publications 1992
Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics
Alcohol Clin Exp Res, 16 (5), 986-90
PubMed 1443440
Magnesium deficiency diagnosed by an intravenous loading test
Scand J Clin Lab Invest, 52 (4), 245-53
PubMed 1439510
Differential effect of selective beta 1 and nonselective beta-adrenoceptor blockade on epinephrine and atropine response in normal humans
J Cardiovasc Pharmacol, 20 (6), 976-81
PubMed 1282602
[Sudden cardiac death. Significance of beta blockaders]
Tidsskr Nor Laegeforen, 112 (22), 2843-7
PubMed 1357774
[Myocardial disease in diabetes mellitus]
Tidsskr Nor Laegeforen, 112 (8), 1016-9
PubMed 1553723
Publications 1991
[Cholesterol-lowering effect of oat]
Tidsskr Nor Laegeforen, 111 (17), 2081-5
PubMed 1871737
Effects of selective beta 2-adrenoceptor blockade on serum potassium and exercise performance in normal men
Br J Clin Pharmacol, 32 (2), 201-7
PubMed 1681847
Intrapericardial left atrial aneurysm diagnosed by transoesophageal echocardiography and nuclear magnetic resonance imaging
Eur Heart J, 12 (2), 277-9
PubMed 2044565
Oral versus intravenous magnesium supplementation in patients with magnesium deficiency
Magnes Trace Elem, 10 (1), 11-6
PubMed 1814318
Publications 1989
Effect of beta-adrenergic blockade on hormonal responses during continuous and intermittent exercise
Cardiovasc Drugs Ther, 3 (1), 63-71
PubMed 2577280
The importance of potassium and lactate for maximal exercise performance during beta blockade
Scand J Clin Lab Invest, 49 (6), 521-8
PubMed 2574496
[Beta blockaders and physical performance. Limiting factors]
Tidsskr Nor Laegeforen, 109 (25), 2544-7
PubMed 2573167
Interaction of naloxone and timolol on maximal exercise capacity and the subjective perception of fatigue
Int J Sports Med, 10 (4), 259-63
PubMed 2606592
Publications 1988
Difference between beta-1-selective and non-selective beta-blockade during continuous and intermittent exercise
Clin Physiol, 8 (5), 487-99
PubMed 3191663
Publications 1987
The effects of naloxone and timolol on plasma catecholamine levels during short-term dynamic exercise
Scand J Clin Lab Invest, 47 (8), 847-51
PubMed 2893446
[Angiotensin-converting enzyme inhibitors in heart failure]
Tidsskr Nor Laegeforen, 107 (25), 2112-6
PubMed 2823410
[Magnesium deficiency. Diagnosis and occurrence of different disease conditions]
Tidsskr Nor Laegeforen, 107 (22), 1751-4
PubMed 3660356
Publications 1986
[Magnesium and cardiovascular diseases]
Tidsskr Nor Laegeforen, 106 (7), 554-7
PubMed 3961781
Publications 1979
[Smoking habits among pregnant women in Trøndelag]
Tidsskr Nor Laegeforen, 99 (12), 575-9
PubMed 442031




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