Lars Gullestad
Position: Professor
Phone: +47 23070641
Email:

Stipendiates: Odd Erik Johansen, Christen Peder Dahl, Satish Arora

PubMed publications

 

Scientific projects

Main focus:

The role of inflammatory and immunological factors in cardiovascular disease

Main methods:

Clinical trials, analysis of inflammatory parameters in blood and tissue, PCR, gene array


Project I:
The importance of immunological and inflammatory factors in heart failure

Aim:

Investigate inflammatory variables in patients with heart failure of various etiologies

Project II:
Psychological and social factors in patients with heart failure and heart transplant patients

Collaborators:

Institute of Psychology, University of Bergen

Aim:

Examine psychological and social factors in patients with end-stage heart disease heart transplant patients in relation to later outcome

Project III:
Effect of Intravenous Immunglobulin on left ventricular remodelling after acute myocardial infarction

Collaborators:

Department of Cardiology, Rogaland University Hospital

Aim:

Investigate the effect of IVIg on left ventricular remodelling in patients with myocardial infarction and left ventricular dysfunction

Project IV:
Inflammatory and immunological factors in patients with coronary artery disease

Aim:

Examine immunological and inflammatory mechanism in patients with angina pectoris, unstable coronary syndromes, STEMI and hypercholesterolemia in relation to the clinical presentation and outcome

Project V:
Effect of Rosuvastatin in patients with dilated cardiomyopathy

Collaborators:

Buskerud Hospital

Aim:

Investigate the effect of Rosuvastatin on left ventricular remodelling in patients with dilated CMP

 

Author network for Lars Gullestad by COREMINE medical


Publications in press

Broch K, Eek C, Wergeland R, Ueland T, Skårdal R, Aukrust P, Skulstad H, Gullestad L
NT-proBNP predicts myocardial recovery after non-ST-elevation acute coronary syndrome
Scand Cardiovasc J (in press)
PubMed 22191851

Broch K, Ueland T, Nymo SH, Kjekshus J, Hulthe J, Muntendam P, McMurray JJ, Wikstrand J, Cleland JG, Aukrust P, Gullestad L
Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology
Eur J Heart Fail (in press)
PubMed 22302661

Fosshaug LE, Berge RK, Beitnes JO, Berge K, Vik H, Aukrust P, Gullestad L, Vinge LE, Oie E
Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
Lipids Health Dis, 10 (1), 245 (in press)
PubMed 22206454

Nymo SH, Ueland T, Askevold ET, Flo TH, Kjekshus J, Hulthe J, Wikstrand J, McMurray J, Van Veldhuisen DJ, Gullestad L, Aukrust P, Yndestad A
The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*
J Intern Med (in press)
PubMed 22211640

Ueland T, Aukrust P, Aakhus S, Smith C, Endresen K, Birkeland KI, Gullestad L, Johansen OE
Activin A and cardiovascular disease in type 2 diabetes mellitus
Diab Vasc Dis Res (in press)
PubMed 22234949

Publications 2012

Gullestad L, Pernow J, Bjurö T, Aaberge L, Skårdal R, Kjekshus E, Høglund L, Mellgård AJ, Wahlquist I, Ablad B (2012)
Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease
Scand Cardiovasc J, 46 (1), 23-31
PubMed 22017530

Waldum B, Westheim AS, Sandvik L, Flønæs B, Grundtvig M, Gullestad L, Hole T, Os I (2012)
Baseline anemia is not a predictor of all-cause mortality in outpatients with advanced heart failure or severe renal dysfunction results from the norwegian heart failure registry
J Am Coll Cardiol, 59 (4), 371-8
PubMed 22261159

Publications 2011

Arora S, Ueland T, Wennerblom B, Sigurdadottir V, Eiskjær H, Bøtker HE, Ekmehag B, Jansson K, Mortensen SA, Saunamaki K, Simonsen S, Gude E, Bendz B, Solbu D, Aukrust P, Gullestad L (2011)
Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial
Transplantation, 92 (2), 235-43
PubMed 21677600

Aukrust P, Sandberg WJ, Otterdal K, Vinge LE, Gullestad L, Yndestad A, Halvorsen B, Ueland T (2011)
Tumor necrosis factor superfamily molecules in acute coronary syndromes
Ann Med, 43 (2), 90-103
PubMed 21039303

Egstrup K, Bergfeldt L, Duris T, Gullestad L, Kochmanski M, Ku?nierz B, Nielsen T, Sawicki S, Aunes-Jansson M, Edvardsson N, Frison L, Johansson S, Berggren A (2011)
QT response after a test dose and during maintenance therapy with AZD1305 in patients with atrial fibrillation: a double-blind, randomized, placebo-controlled trial
Am J Cardiovasc Drugs, 11 (3), 199-208
PubMed 21619383

Grundtvig M, Gullestad L, Hole T, Flønæs B, Westheim A (2011)
Characteristics, implementation of evidence-based management and outcome in patients with chronic heart failure: results from the Norwegian heart failure registry
Eur J Cardiovasc Nurs, 10 (1), 44-9
PubMed 20452825

Nytrøen K, Myers J, Chan KN, Geiran OR, Gullestad L (2011)
Chronotropic responses to exercise in heart transplant recipients: 1-yr follow-up
Am J Phys Med Rehabil, 90 (7), 579-88
PubMed 21765276

Tveit A, Flonaes B, Aaser E, Korneliussen K, Froland G, Gullestad L, Grundtvig M (2011)
No impact of atrial fibrillation on mortality risk in optimally treated heart failure patients
Clin Cardiol, 34 (9), 537-42
PubMed 21796642

Ueland T, Aukrust P, Broch K, Aakhus S, Skårdal R, Muntendam P, Gullestad L (2011)
Galectin-3 in heart failure: high levels are associated with all-cause mortality
Int J Cardiol, 150 (3), 361-4
PubMed 21641051

Ueland T, Aukrust P, Dahl CP, Husebye T, Solberg OG, Tønnessen T, Aakhus S, Gullestad L (2011)
Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis
J Intern Med, 270 (5), 452-60
PubMed 21623962

Ueland T, Dahl CP, Gullestad L, Aakhus S, Broch K, Skårdal R, Vermeer C, Aukrust P, Schurgers LJ (2011)
Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure
Clin Sci (Lond), 121 (3), 119-27
PubMed 21294711

Ueland T, Dahl CP, Kjekshus J, Hulthe J, Böhm M, Mach F, Goudev A, Lindberg M, Wikstrand J, Aukrust P, Gullestad L (2011)
Osteoprotegerin predicts progression of chronic heart failure: results from CORONA
Circ Heart Fail, 4 (2), 145-52
PubMed 21216833

Waehre A, Halvorsen B, Yndestad A, Husberg C, Sjaastad I, Nygård S, Dahl CP, Ahmed MS, Finsen AV, Reims H, Louch WE, Hilfiker-Kleiner D, Vinge LE, Roald B, Attramadal H, Lipp M, Gullestad L, Aukrust P, Christensen G (2011)
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
PLoS One, 6 (4), e18668
PubMed 21533157

Øie E, Ueland T, Dahl CP, Bohov P, Berge C, Yndestad A, Gullestad L, Aukrust P, Berge RK (2011)
Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality
J Intern Med, 270 (3), 263-72
PubMed 21466599

Aarones M, Gullestad L, Aakhus S, Ueland T, Skaardal R, Aass H, Wergeland R, Smith HJ, Aukrust P, Kongsgaard E (2011)
Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy
Am Heart J, 161 (6), 1031-7
PubMed 21641347

Publications 2010

Arora S, Gunther A, Wennerblom B, Ueland T, Andreassen AK, Gude E, Endresen K, Geiran O, Wilhelmsen N, Andersen R, Aukrust P, Gullestad L (2010)
Systemic markers of inflammation are associated with cardiac allograft vasculopathy and an increased intimal inflammatory component
Am J Transplant, 10 (6), 1428-36
PubMed 20486911

Aukrust P, Halvorsen B, Ueland T, Michelsen AE, Skjelland M, Gullestad L, Yndestad A, Otterdal K (2010)
Activated platelets and atherosclerosis
Expert Rev Cardiovasc Ther, 8 (9), 1297-307
PubMed 20828352

Grundtvig M, Westheim A, Hole T, Flønaes B, Gullestad L, Norwegian Heart Failure Registry (2010)
Warning on diuretic use
J Am Coll Cardiol, 55 (23), 2609-10; author reply 2610
PubMed 20513605

Gude E, Andreassen AK, Arora S, Gullestad L, Grov I, Hartmann A, Leivestad T, Fiane AE, Geiran OR, Vardal M, Simonsen S (2010)
Acute renal failure early after heart transplantation: risk factors and clinical consequences
Clin Transplant, 24 (6), E207-13
PubMed 20184627

Gude E, Gullestad L, Arora S, Simonsen S, Hoel I, Hartmann A, Holdaas H, Fiane AE, Geiran OR, Andreassen AK (2010)
Benefit of early conversion from CNI-based to everolimus-based immunosuppression in heart transplantation
J Heart Lung Transplant, 29 (6), 641-7
PubMed 20304681

Gude E, Simonsen S, Geiran OR, Fiane AE, Gullestad L, Arora S, Relbo A, Andreassen AK (2010)
Pulmonary hypertension in heart transplantation: discrepant prognostic impact of pre-operative compared with 1-year post-operative right heart hemodynamics
J Heart Lung Transplant, 29 (2), 216-23
PubMed 19837606

Gullestad L, Iversen M, Mortensen SA, Eiskjaer H, Riise GC, Mared L, Bjørtuft O, Ekmehag B, Jansson K, Simonsen S, Gude E, Rundqvist B, Fagertun HE, Solbu D, Bergh CH (2010)
Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial
Transplantation, 89 (7), 864-72
PubMed 20061999

Gullestad L, Mortensen SA, Eiskjær H, Riise GC, Mared L, Bjørtuft O, Ekmehag B, Jansson K, Simonsen S, Gude E, Rundqvist B, Fagertun HE, Solbu D, Iversen M (2010)
Two-year outcomes in thoracic transplant recipients after conversion to everolimus with reduced calcineurin inhibitor within a multicenter, open-label, randomized trial
Transplantation, 90 (12), 1581-9
PubMed 21030905

Hallén J, Johansen OE, Birkeland KI, Gullestad L, Aakhus S, Endresen K, Tjora S, Jaffe AS, Atar D (2010)
Determinants and prognostic implications of cardiac troponin T measured by a sensitive assay in type 2 diabetes mellitus
Cardiovasc Diabetol, 9, 52
PubMed 20843304

Hoekstra M, van der Lans CA, Halvorsen B, Gullestad L, Kuiper J, Aukrust P, van Berkel TJ, Biessen EA (2010)
The peripheral blood mononuclear cell microRNA signature of coronary artery disease
Biochem Biophys Res Commun, 394 (3), 792-7
PubMed 20230787

Hole T, Grundtvig M, Gullestad L, Flønæs B, Westheim A (2010)
Improved quality of life in Norwegian heart failure patients after follow-up in outpatient heart failure clinics: results from the Norwegian Heart Failure Registry
Eur J Heart Fail, 12 (11), 1247-52
PubMed 20847014

Jensen JK, Ueland T, Atar D, Gullestad L, Mickley H, Aukrust P, Januzzi JL (2010)
Osteoprotegerin concentrations and prognosis in acute ischaemic stroke
J Intern Med, 267 (4), 410-7
PubMed 19895657

Maggioni AP, Dahlström U, Filippatos G, Chioncel O, Leiro MC, Drozdz J, Fruhwald F, Gullestad L, Logeart D, Metra M, Parissis J, Persson H, Ponikowski P, Rauchhaus M, Voors A, Nielsen OW, Zannad F, Tavazzi L, Heart Failure Association of ESC (HFA) (2010)
EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot)
Eur J Heart Fail, 12 (10), 1076-84
PubMed 20805094

Ueland T, Gullestad L, Dahl CP, Aukrust P, Aakhus S, Solberg OG, Vermeer C, Schurgers LJ (2010)
Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis
J Intern Med, 268 (5), 483-92
PubMed 20804515

Waldum B, Westheim AS, Sandvik L, Flønaes B, Grundtvig M, Gullestad L, Hole T, Os I (2010)
Renal function in outpatients with chronic heart failure
J Card Fail, 16 (5), 374-80
PubMed 20447572

Øie E, Ahmed MS, Ueland T, Sikkeland LI, Dahl CP, Hagelin EM, von Lueder T, Edvardsen T, Andreassen AK, Gullestad L, Aukrust P, Yndestad A, Vinge LE, Attramadal H (2010)
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Res Cardiol, 105 (1), 89-98
PubMed 19823891

Aarønæs M, Aakhus S, Aass H, Moum T, Wergeland R, Gullestad L, Kongsgård E (2010)
Assessment of response criteria to cardiac resynchronization therapy (CRT) and prediction of response
Scand Cardiovasc J, 44 (6), 337-45
PubMed 21080864

Publications 2009

Arora S, Aukrust P, Andreassen A, Simonsen S, Gude E, Grov I, Geiran O, Fiane A, Gullestad L (2009)
The prognostic importance of modifiable risk factors after heart transplantation
Am Heart J, 158 (3), 431-6
PubMed 19699867

Arora S, Aukrust P, Ueland T, Broch K, Simonsen S, Gude E, Fiane AE, Geiran O, Wergeland R, Andreassen AK, Gullestad L (2009)
Elevated serum uric acid levels following heart transplantation predict all-cause and cardiac mortality
Eur J Heart Fail, 11 (10), 1005-13
PubMed 19737803

Aukrust P, Ueland T, Gullestad L, Yndestad A (2009)
Testosterone: a novel therapeutic approach in chronic heart failure?
J Am Coll Cardiol, 54 (10), 928-9
PubMed 19712803

Dahl CP, Husberg C, Gullestad L, Waehre A, Damås JK, Vinge LE, Finsen AV, Ueland T, Florholmen G, Aakhus S, Halvorsen B, Aukrust P, Oie E, Yndestad A, Christensen G (2009)
Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling
Circ Heart Fail, 2 (6), 624-32
PubMed 19919988

Gjesdal O, Gude E, Arora S, Leivestad T, Andreassen AK, Gullestad L, Aaberge L, Brunvand H, Edvardsen T, Geiran OR, Simonsen S (2009)
Intra-aortic balloon counterpulsation as a bridge to heart transplantation does not impair long-term survival
Eur J Heart Fail, 11 (7), 709-14
PubMed 19515719

Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschöpe C, Van Bilsen M, Zannad F, McMurray J, Shah AM (2009)
Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
Eur J Heart Fail, 11 (2), 119-29
PubMed 19168509

Johansen OE, Birkeland KI, Jørgensen AP, Orvik E, Sørgård B, Torjussen BR, Ueland T, Aukrust P, Gullestad L (2009)
Diabetic foot ulcer burden may be modified by high-dose atorvastatin: A 6-month randomized controlled pilot trial
J Diabetes, 1 (3), 182-7
PubMed 20923537

Kjekshus JK, Torp-Pedersen C, Gullestad L, Køber L, Edvardsen T, Olsen IC, Sjaastad I, Qvigstad E, Skomedal T, Osnes JB, Levy FO (2009)
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure
Eur J Heart Fail, 11 (8), 771-8
PubMed 19567409

McMurray JJ, Kjekshus J, Gullestad L, Dunselman P, Hjalmarson A, Wedel H, Lindberg M, Waagstein F, Grande P, Hradec J, Kamenský G, Korewicki J, Kuusi T, Mach F, Ranjith N, Wikstrand J, CORONA Study Group (2009)
Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): a retrospective analysis
Circulation, 120 (22), 2188-96
PubMed 19917888

Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR, Frøland SS, Olofsson PS, Damås JK, Gullestad L, Hansson GK, Oie E, Aukrust P (2009)
Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis
Circ Res, 104 (1), 60-8
PubMed 19023130

Sandberg WJ, Otterdal K, Gullestad L, Halvorsen B, Ragnarsson A, Frøland SS, Damås JK, Oie E, Aukrust P, Hansson GK, Yndestad A (2009)
The tumour necrosis factor superfamily ligand APRIL (TNFSF13) is released upon platelet activation and expressed in atherosclerosis
Thromb Haemost, 102 (4), 704-10
PubMed 19806256

Semb AG, Ueland T, Aukrust P, Wareham NJ, Luben R, Gullestad L, Kastelein JJ, Khaw KT, Boekholdt SM (2009)
Osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand and risk for coronary events: a nested case-control approach in the prospective EPIC-Norfolk population study 1993-2003
Arterioscler Thromb Vasc Biol, 29 (6), 975-80
PubMed 19325145

Ueland T, Otterdal K, Lekva T, Halvorsen B, Gabrielsen A, Sandberg WJ, Paulsson-Berne G, Pedersen TM, Folkersen L, Gullestad L, Oie E, Hansson GK, Aukrust P (2009)
Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis
Arterioscler Thromb Vasc Biol, 29 (8), 1228-34
PubMed 19498175

Yndestad A, Landrø L, Ueland T, Dahl CP, Flo TH, Vinge LE, Espevik T, Frøland SS, Husberg C, Christensen G, Dickstein K, Kjekshus J, Øie E, Gullestad L, Aukrust P (2009)
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure
Eur Heart J, 30 (10), 1229-36
PubMed 19329498

Publications 2008

Arora S, Jenum PA, Aukrust P, Rollag H, Andreassen AK, Simonsen S, Guide E, Fiane AE, Geiran O, Gullestad L (2008)
Pre-transplant Toxoplasma gondii seropositivlty among heart transplant recipients and mortality - Reply
J. Am. Coll. Cardiol., 51 (18), 1827-1828

Aukrust P, Halvorsen B, Yndestad A, Ueland T, Øie E, Otterdal K, Gullestad L, Damås JK (2008)
Chemokines and cardiovascular risk
Arterioscler Thromb Vasc Biol, 28 (11), 1909-19
PubMed 18669888

Aukrust P, Otterdal K, Yndestad A, Sandberg WJ, Smith C, Ueland T, Øie E, Damås JK, Gullestad L, Halvorsen B (2008)
The complex role of T-cell-based immunity in atherosclerosis
Curr Atheroscler Rep, 10 (3), 236-43
PubMed 18489852

Breland UM, Halvorsen B, Hol J, Øie E, Paulsson-Berne G, Yndestad A, Smith C, Otterdal K, Hedin U, Waehre T, Sandberg WJ, Frøland SS, Haraldsen G, Gullestad L, Damås JK, Hansson GK, Aukrust P (2008)
A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins
Arterioscler Thromb Vasc Biol, 28 (5), 1005-11
PubMed 18276907

Dahl CP, Gullestad L, Fevang B, Holm AM, Landrø L, Vinge LE, Fiane AE, Sandberg WJ, Otterdal K, Frøland SS, Damås JK, Halvorsen B, Aukrust P, Øie E, Yndestad A (2008)
Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure
Eur J Heart Fail, 10 (4), 352-9
PubMed 18353719

Halvorsen B, Otterdal K, Dahl TB, Skjelland M, Gullestad L, Øie E, Aukrust P (2008)
Atherosclerotic plaque stability--what determines the fate of a plaque?
Prog Cardiovasc Dis, 51 (3), 183-94
PubMed 19026853

Husberg C, Nygård S, Finsen AV, Damås JK, Frigessi A, Oie E, Waehre A, Gullestad L, Aukrust P, Yndestad A, Christensen G (2008)
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure
J Mol Cell Cardiol, 45 (2), 261-9
PubMed 18585734

Johansen OE, Bjurö T, Endresen K, Blaasaas KG, Birkeland K, Aakhus S, Gullestad L (2008)
Heart rate adjustments and analysis of recovery patterns of ST-segment depression in type 2 diabetes
Int J Cardiol, 127 (1), 129-32
PubMed 17532067

Otterdal K, Andreassen AK, Yndestad A, Oie E, Sandberg WJ, Dahl CP, Pedersen TM, Ueland T, Gullestad L, Brosstad FR, Aukrust P, Damås JK (2008)
Raised LIGHT levels in pulmonary arterial hypertension: potential role in thrombus formation
Am J Respir Crit Care Med, 177 (2), 202-7
PubMed 17962639

Smith C, Halvorsen B, Otterdal K, Waehre T, Yndestad A, Fevang B, Sandberg WJ, Breland UM, Frøland SS, Oie E, Gullestad L, Damås JK, Aukrust P (2008)
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc Res, 79 (1), 195-203
PubMed 18339644

Publications 2007

Arora S, Andreassen A, Simonsen S, Gude E, Dahl C, Skaardal R, Hoel I, Geiran O, Gullestad L (2007)
Prognostic importance of renal function 1 year after heart transplantation for all-cause and cardiac mortality and development of allograft vasculopathy
Transplantation, 84 (2), 149-54
PubMed 17667805

Arora S, Gullestad L, Wergeland R, Simonsen S, Holm T, Hognestad A, Ueland T, Geiran O, Andreassen A (2007)
Probrain natriuretic peptide and C-reactive protein as markers of acute rejection, allograft vasculopathy, and mortality in heart transplantation
Transplantation, 83 (10), 1308-15
PubMed 17519779

Arora S, Jenum PA, Aukrust P, Rollag H, Andreassen AK, Simonsen S, Gude E, Fiane AE, Geiran O, Gullestad L (2007)
Pre-transplant Toxoplasma gondii seropositivity among heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality
J Am Coll Cardiol, 50 (20), 1967-72
PubMed 17996562

Aukrust P, Yndestad A, Damås JK, Ueland T, Øie E, Gullestad L (2007)
Potential mechanisms of benefit with thalidomide in chronic heart failure
Am J Cardiovasc Drugs, 7 (2), 127-34
PubMed 17503883

Aukrust P, Yndestad A, Sandberg WJ, Gullestad L, Damås JK (2007)
T cells in coronary artery disease: different effects of different T-cell subsets
J Am Coll Cardiol, 50 (15), 1459-61
PubMed 17919565

Aukrust P, Yndestad A, Smith C, Ueland T, Gullestad L, Damås JK (2007)
Chemokines in cardiovascular risk prediction
Thromb Haemost, 97 (5), 748-54
PubMed 17479185

Dahl TB, Yndestad A, Skjelland M, Øie E, Dahl A, Michelsen A, Damås JK, Tunheim SH, Ueland T, Smith C, Bendz B, Tonstad S, Gullestad L, Frøland SS, Krohg-Sørensen K, Russell D, Aukrust P, Halvorsen B (2007)
Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization
Circulation, 115 (8), 972-80
PubMed 17283255

Damås JK, Smith C, Øie E, Fevang B, Halvorsen B, Waehre T, Boullier A, Breland U, Yndestad A, Ovchinnikova O, Robertson AK, Sandberg WJ, Kjekshus J, Taskén K, Frøland SS, Gullestad L, Hansson GK, Quehenberger O, Aukrust P (2007)
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization
Arterioscler Thromb Vasc Biol, 27 (3), 614-20
PubMed 17170367

Gullestad L, Madsen S (2007)
[Diuretics not the first-choice-drug in chronic heart failure]
Tidsskr Nor Laegeforen, 127 (5), 621; author reply 621
PubMed 17332822

Gullestad L, Oie E, Ueland T, Yndestad A, Aukrust P (2007)
The role of statins in heart failure
Fundam Clin Pharmacol, 21 Suppl 2, 35-40
PubMed 18001320

Havik OE, Sivertsen B, Relbo A, Hellesvik M, Grov I, Geiran O, Andreassen AK, Simonsen S, Gullestad L (2007)
Depressive symptoms and all-cause mortality after heart transplantation
Transplantation, 84 (1), 97-103
PubMed 17627244

Johansen OE, Birkeland KI, Orvik E, Flesland Ø, Wergeland R, Ueland T, Smith C, Endresen K, Aukrust P, Gullestad L (2007)
Inflammation and coronary angiography in asymptomatic type 2 diabetic subjects
Scand J Clin Lab Invest, 67 (3), 306-16
PubMed 17454845

Johansen OE, Gullestad L, Blaasaas KG, Orvik E, Birkeland KI (2007)
Effects of structured hospital-based care compared with standard care for Type 2 diabetes-The Asker and Baerum Cardiovascular Diabetes Study, a randomized trial
Diabet Med, 24 (9), 1019-27
PubMed 17509068

Kjekshus J, Apetrei E, Barrios V, Böhm M, Cleland JG, Cornel JH, Dunselman P, Fonseca C, Goudev A, Grande P, Gullestad L, Hjalmarson A, Hradec J, Jánosi A, Kamenský G, Komajda M, Korewicki J, Kuusi T, Mach F, Mareev V, McMurray JJ, Ranjith N, Schaufelberger M, Vanhaecke J, van Veldhuisen DJ et al. (2007)
Rosuvastatin in older patients with systolic heart failure
N Engl J Med, 357 (22), 2248-61
PubMed 17984166

Simonsen S, Andreassen AK, Gullestad L, Leivestad T, Fiane AE, Geiran OR (2007)
[Survival after heart transplantation in Norway]
Tidsskr Nor Laegeforen, 127 (7), 865-8
PubMed 17435806

Sivertsen B, Relbo A, Gullestad L, Hellesvik M, Grov I, Andreassen A, Simonsen S, Geiran O, Havik OE (2007)
[Self-assessed health and psychological symptoms after heart transplantation]
Tidsskr Nor Laegeforen, 127 (24), 3198-201
PubMed 18084359

Yndestad A, Damås JK, Øie E, Ueland T, Gullestad L, Aukrust P (2007)
Role of inflammation in the progression of heart failure
Curr Cardiol Rep, 9 (3), 236-41
PubMed 17470337

Publications 2006

Aukrust P, Yndestad A, Ueland T, Damås JK, Frøland SS, Gullestad L (2006)
The role of intravenous immunoglobulin in the treatment of chronic heart failure
Int J Cardiol, 112 (1), 40-5
PubMed 16893578

Aukrust P, Yndestad A, Ueland T, Damås JK, Gullestad L (2006)
Anti-inflammatory trials in chronic heart failure
Heart Fail Monit, 5 (1), 2-9
PubMed 16547529

Holm T, Ueland T, Halvorsen B, Hognestad A, Holm AG, Wergeland R, Gullestad L, Aukrust P, Kjekshus J (2006)
A protective anti-inflammatory phenotype in high-risk individuals who do not develop coronary artery disease
J Am Coll Cardiol, 47 (5), 1085-6
PubMed 16516099

Johansen OE, Birkeland KI, Brustad E, Aaser E, Lindahl AK, Midha R, Ueland T, Aukrust P, Gullestad L (2006)
Undiagnosed dysglycaemia and inflammation in cardiovascular disease
Eur J Clin Invest, 36 (8), 544-51
PubMed 16893376

Sandberg WJ, Yndestad A, Øie E, Smith C, Ueland T, Ovchinnikova O, Robertson AK, Müller F, Semb AG, Scholz H, Andreassen AK, Gullestad L, Damås JK, Frøland SS, Hansson GK, Halvorsen B, Aukrust P (2006)
Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization
Arterioscler Thromb Vasc Biol, 26 (4), 857-63
PubMed 16424351

Smith C, Damås JK, Otterdal K, Øie E, Sandberg WJ, Yndestad A, Waehre T, Scholz H, Endresen K, Olofsson PS, Halvorsen B, Gullestad L, Frøland SS, Hansson GK, Aukrust P (2006)
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation
J Am Coll Cardiol, 48 (8), 1591-9
PubMed 17045893

Ueland T, Aukrust P, Damas JK, Gullestad L, Yndestad A (2006)
The tumor necrosis factor superfamily in heart failure
Future Cardiol, 2 (1), 101-11
PubMed 19804137

Ueland T, Espevik T, Kjekshus J, Gullestad L, Omland T, Squire IB, Frøland SS, Mollnes TE, Dickstein K, Aukrust P (2006)
Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction
J Card Fail, 12 (8), 659-63
PubMed 17045187

Ueland T, Gullestad L, Simonsen S, Endresen K, Scott H, Frøland SS, Geiran O, Fiane AE, Aukrust P (2006)
Decreased endomyocardial RANKL expression in transplant coronary artery disease
Transplantation, 81 (10), 1467-70
PubMed 16732187

Ueland T, Vissers MN, Wiegman A, Rodenburg J, Hutten B, Gullestad L, Ose L, Rifai N, Ridker PM, Kastelein JJ, Aukrust P, Semb AG (2006)
Increased inflammatory markers in children with familial hypercholesterolaemia
Eur J Clin Invest, 36 (3), 147-52
PubMed 16506958

van Veldhuisen DJ, Aass H, El Allaf D, Dunselman PH, Gullestad L, Halinen M, Kjekshus J, Ohlsson L, Wedel H, Wikstrand J, MERIT-HF Study Group (2006)
Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MERIT-HF Study
Eur J Heart Fail, 8 (5), 539-46
PubMed 16567126

Waehre T, Damås JK, Pedersen TM, Gullestad L, Yndestad A, Andreassen AK, Frøland SS, Semb AG, Hansteen V, Gjertsen E, Ueland T, Brosstad F, Solum NO, Aukrust P (2006)
Clopidogrel increases expression of chemokines in peripheral blood mononuclear cells in patients with coronary artery disease: results of a double-blind placebo-controlled study
J Thromb Haemost, 4 (10), 2140-7
PubMed 16856976

Yndestad A, Damås JK, Oie E, Ueland T, Gullestad L, Aukrust P (2006)
Systemic inflammation in heart failure--the whys and wherefores
Heart Fail Rev, 11 (1), 83-92
PubMed 16819581

Publications 2005

Aukrust P, Gullestad L, Ueland T, Damås JK, Yndestad A (2005)
Inflammatory and anti-inflammatory cytokines in chronic heart failure: potential therapeutic implications
Ann Med, 37 (2), 74-85
PubMed 16026115

Aukrust P, Yndestad A, Smith C, Sandberg WJ, Ueland T, Waehre T, Halvorsen B, Gullestad L, Damås JK (2005)
Potential role for immunomodulatory therapy in atherosclerotic plaque stabilisation
Expert Opin Pharmacother, 6 (13), 2169-80
PubMed 16218879

Aukrust P, Yndestad A, Waehre T, Gullestad L, Halvorsen B, Damås JK (2005)
Inflammation in coronary artery disease: potential role for immunomodulatory therapy
Expert Rev Cardiovasc Ther, 3 (6), 1111-24
PubMed 16293001

Fiane AE, Ueland T, Simonsen S, Scott H, Endresen K, Gullestad L, Geiran OR, Haraldsen G, Heggelund L, Andreassen AK, Wergeland R, Frøland S, Aukrust P, Mollnes TE (2005)
Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation
Eur Heart J, 26 (16), 1660-5
PubMed 15821010

Gullestad L, Aukrust P (2005)
Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches
Am J Cardiol, 95 (11A), 17C-23C; discussion 38C-40C
PubMed 15925560

Gullestad L, Kjekshus J, Damås JK, Ueland T, Yndestad A, Aukrust P (2005)
Agents targeting inflammation in heart failure
Expert Opin Investig Drugs, 14 (5), 557-66
PubMed 15926863

Gullestad L, Ueland T, Fjeld JG, Holt E, Gundersen T, Breivik K, Følling M, Hodt A, Skårdal R, Kjekshus J, Andreassen A, Kjekshus E, Wergeland R, Yndestad A, Frøland SS, Semb AG, Aukrust P (2005)
Effect of thalidomide on cardiac remodeling in chronic heart failure: results of a double-blind, placebo-controlled study
Circulation, 112 (22), 3408-14
PubMed 16301340

Gullestad L, Wikstrand J, Deedwania P, Hjalmarson A, Egstrup K, Elkayam U, Gottlieb S, Rashkow A, Wedel H, Bermann G, Kjekshus J, MERIT-HF Study Group (2005)
What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF)
J Am Coll Cardiol, 45 (2), 252-9
PubMed 15653024

Scholz H, Sandberg W, Damås JK, Smith C, Andreassen AK, Gullestad L, Frøland SS, Yndestad A, Aukrust P, Halvorsen B (2005)
Enhanced plasma levels of LIGHT in unstable angina: possible pathogenic role in foam cell formation and thrombosis
Circulation, 112 (14), 2121-9
PubMed 16186421

Ueland T, Aukrust P, Yndestad A, Otterdal K, Frøland SS, Dickstein K, Kjekshus J, Gullestad L, Damås JK (2005)
Soluble CD40 ligand in acute and chronic heart failure
Eur Heart J, 26 (11), 1101-7
PubMed 15716285

Ueland T, Kjekshus J, Frøland SS, Omland T, Squire IB, Gullestad L, Dickstein K, Aukrust P (2005)
Plasma levels of soluble tumor necrosis factor receptor type I during the acute phase following complicated myocardial infarction predicts survival in high-risk patients
J Am Coll Cardiol, 46 (11), 2018-21
PubMed 16325035

Ueland T, Yndestad A, Øie E, Florholmen G, Halvorsen B, Frøland SS, Simonsen S, Christensen G, Gullestad L, Aukrust P (2005)
Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure
Circulation, 111 (19), 2461-8
PubMed 15883214

Publications 2004

Aukrust P, Yndestad A, Damås JK, Gullestad L (2004)
Therapeutic potential of anticytokine therapy in congestive heart failure
Am J Cardiovasc Drugs, 4 (3), 169-77
PubMed 15134469

Aukrust P, Yndestad A, Damås JK, Gullestad L (2004)
Inflammation and chronic heart failure-potential therapeutic role of intravenous immunoglobulin
Autoimmun Rev, 3 (3), 221-7
PubMed 15110235

Bjurö T, Gullestad L, Endresen K, Nordlander M, Malm A, Höglund L, Wahlqvist I, Pernow J (2004)
Evaluation of ST-segment changes during and after maximal exercise tests in one-, two- and three-vessel coronary artery disease
Scand Cardiovasc J, 38 (5), 270-7
PubMed 15513309

Gullestad L, Madsen S (2004)
[Modern diagnosis and treatment of heart failure]
Tidsskr Nor Laegeforen, 124 (8), 1107-10
PubMed 15114390

Gullestad L, Myers J, Edvardsen T, Kjekshus J, Geiran O, Simonsen S (2004)
Predictors of exercise capacity and the impact of angiographic coronary artery disease in heart transplant recipients
Am Heart J, 147 (1), 49-54
PubMed 14691418

Hognestad A, Aukrust P, Wergeland R, Stokke O, Gullestad L, Semb AG, Holm T, Andreassen AK, Kjekshus JK (2004)
Effects of conventional and aggressive statin treatment on markers of endothelial function and inflammation
Clin Cardiol, 27 (4), 199-203
PubMed 15119693

Hole T, Frøland G, Gullestad L, Offstad J, Skjaerpe T (2004)
Metoprolol CR/XL improves systolic and diastolic left ventricular function in patients with chronic heart failure
Echocardiography, 21 (3), 215-23
PubMed 15053783

Larsson L, Mobini R, Aukrust P, Gullestad L, Wallukat G, Waagstein F, Fu M (2004)
Beneficial effect on cardiac function by intravenous immunoglobulin treatment in patients with dilated cardiomyopathy is not due to neutralization of anti-receptor autoantibody
Autoimmunity, 37 (6-7), 489-93
PubMed 15621576

Smith C, Yndestad A, Halvorsen B, Ueland T, Waehre T, Otterdal K, Scholz H, Endresen K, Gullestad L, Frøland SS, Damås JK, Aukrust P (2004)
Potential anti-inflammatory role of activin A in acute coronary syndromes
J Am Coll Cardiol, 44 (2), 369-75
PubMed 15261933

Tveit A, Grundtvig M, Gundersen T, Vanberg P, Semb AG, Holt E, Gullestad L (2004)
Analysis of pravastatin to prevent recurrence of atrial fibrillation after electrical cardioversion
Am J Cardiol, 93 (6), 780-2
PubMed 15019894

Ueland T, Jemtland R, Godang K, Kjekshus J, Hognestad A, Omland T, Squire IB, Gullestad L, Bollerslev J, Dickstein K, Aukrust P (2004)
Prognostic value of osteoprotegerin in heart failure after acute myocardial infarction
J Am Coll Cardiol, 44 (10), 1970-6
PubMed 15542278

Waehre T, Yndestad A, Smith C, Haug T, Tunheim SH, Gullestad L, Frøland SS, Semb AG, Aukrust P, Damås JK (2004)
Increased expression of interleukin-1 in coronary artery disease with downregulatory effects of HMG-CoA reductase inhibitors
Circulation, 109 (16), 1966-72
PubMed 15051633

Yndestad A, Ueland T, Øie E, Florholmen G, Halvorsen B, Attramadal H, Simonsen S, Frøland SS, Gullestad L, Christensen G, Damås JK, Aukrust P (2004)
Elevated levels of activin A in heart failure: potential role in myocardial remodeling
Circulation, 109 (11), 1379-85
PubMed 14993131

Publications 2003

Aukrust P, Damås JK, Gullestad L (2003)
Immunomodulating therapy: new treatment modality in congestive heart failure
Congest Heart Fail, 9 (2), 64-9
PubMed 12671336

Damås JK, Waehre T, Yndestad A, Otterdal K, Hognestad A, Solum NO, Gullestad L, Frøland SS, Aukrust P (2003)
Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets
Circulation, 107 (21), 2670-6
PubMed 12742982

Gullestad L, Bjurø T, Aaberge L, Apelland T, Skårdal R, Kjekshus E, Nordlander M, Ablad B, Pernow J (2003)
The effect of a neuropeptide Y Y1 receptor antagonist in patients with angina pectoris
Eur Heart J, 24 (12), 1120-7
PubMed 12804926

Gullestad L, Kjekshus J (2003)
[Use of beta-blockaders in heart failure]
Tidsskr Nor Laegeforen, 123 (5), 651-2
PubMed 12683197

Holm T, Damås JK, Holven K, Nordøy I, Brosstad FR, Ueland T, Währe T, Kjekshus J, Frøland SS, Eiken HG, Solum NO, Gullestad L, Nenseter M, Aukrust P (2003)
CXC-chemokines in coronary artery disease: possible pathogenic role of interactions between oxidized low-density lipoprotein, platelets and peripheral blood mononuclear cells
J Thromb Haemost, 1 (2), 257-62
PubMed 12871498

Myers J, Geiran O, Simonsen S, Ghuyoumi A, Gullestad L (2003)
Clinical and exercise test determinants of survival after cardiac transplantation
Chest, 124 (5), 2000-5
PubMed 14605079

Myers J, Gullestad L, Bellin D, Ross H, Vagelos R, Fowler M (2003)
Physical activity patterns and exercise performance in cardiac transplant recipients
J Cardiopulm Rehabil, 23 (2), 100-6
PubMed 12668931

Ronnevig M, Bjorsvik E, Gullestad L, Forfang K (2003)
A descriptive study of early nonspecific chest pain after PTCA: important area for the acute health care personnel
Heart Lung, 32 (4), 241-9
PubMed 12891164

Semb AG, van Wissen S, Ueland T, Smilde T, Waehre T, Tripp MD, Frøland SS, Kastelein JJ, Gullestad L, Pedersen TR, Aukrust P, Stalenhoef AF (2003)
Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy
J Am Coll Cardiol, 41 (2), 275-9
PubMed 12535822

Ueland T, Sikkeland LI, Yndestad A, Eiken HG, Holm T, Guevara C, Haug T, Endresen K, Frøland SS, Gullestad L, Andreassen AK, Geiran O, Simonsen S, Aukrust P (2003)
Myocardial gene expression of inflammatory cytokines after heart transplantation in relation to the development of transplant coronary artery disease
Am J Cardiol, 92 (6), 715-7
PubMed 12972116

Waehre T, Damås JK, Gullestad L, Holm AM, Pedersen TR, Arnesen KE, Torsvik H, Frøland SS, Semb AG, Aukrust P (2003)
Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease
J Am Coll Cardiol, 41 (9), 1460-7
PubMed 12742282

Yndestad A, Holm AM, Müller F, Simonsen S, Frøland SS, Gullestad L, Aukrust P (2003)
Enhanced expression of inflammatory cytokines and activation markers in T-cells from patients with chronic heart failure
Cardiovasc Res, 60 (1), 141-6
PubMed 14522416

Publications 2002

Damås JK, Waehre T, Yndestad A, Ueland T, Müller F, Eiken HG, Holm AM, Halvorsen B, Frøland SS, Gullestad L, Aukrust P (2002)
Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects
Circulation, 106 (1), 36-42
PubMed 12093767

Gottlieb SS, Fisher ML, Kjekshus J, Deedwania P, Gullestad L, Vitovec J, Wikstrand J, MERIT-HF Investigators (2002)
Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF)
Circulation, 105 (10), 1182-8
PubMed 11889011

Gullestad L, Semb AG, Holt E, Skårdal R, Ueland T, Yndestad A, Frøland SS, Aukrust P (2002)
Effect of thalidomide in patients with chronic heart failure
Am Heart J, 144 (5), 847-50
PubMed 12422154

Holm T, Aukrust P, Aagaard E, Ueland T, Haugstad TS, Kjekshus J, Simonsen S, Frøland SS, Gullestad L, Andreassen AK (2002)
Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension
Transplantation, 74 (10), 1395-400
PubMed 12451238

Lund TM, Torsvik H, Falch D, Christophersen B, Skårdal R, Gullestad L (2002)
Effect of morning versus evening intake of simvastatin on the serum cholesterol level in patients with coronary artery disease
Am J Cardiol, 90 (7), 784-6
PubMed 12356401

Waehre T, Halvorsen B, Damås JK, Yndestad A, Brosstad F, Gullestad L, Kjekshus J, Frøland SS, Aukrust P (2002)
Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10
Eur J Clin Invest, 32 (11), 803-10
PubMed 12423320

Yndestad A, Damås JK, Geir Eiken H, Holm T, Haug T, Simonsen S, Frøland SS, Gullestad L, Aukrust P (2002)
Increased gene expression of tumor necrosis factor superfamily ligands in peripheral blood mononuclear cells during chronic heart failure
Cardiovasc Res, 54 (1), 175-82
PubMed 12062373

Publications 2001

Aukrust P, Berge RK, Ueland T, Aaser E, Damås JK, Wikeby L, Brunsvig A, Müller F, Forfang K, Frøland SS, Gullestad L (2001)
Interaction between chemokines and oxidative stress: possible pathogenic role in acute coronary syndromes
J Am Coll Cardiol, 37 (2), 485-91
PubMed 11216967

Aukrust P, Damås JK, Gullestad L, Frøland SS (2001)
Chemokines in myocardial failure -- pathogenic importance and potential therapeutic targets
Clin Exp Immunol, 124 (3), 343-5
PubMed 11472392

Aukrust P, Gullestad L, Lappegård KT, Ueland T, Aass H, Wikeby L, Simonsen S, Frøland SS, Mollnes TE (2001)
Complement activation in patients with congestive heart failure: effect of high-dose intravenous immunoglobulin treatment
Circulation, 104 (13), 1494-500
PubMed 11571242

Aukrust P, Gullestad L, Aass H, Fjeld JG, Wikeby L, Andreassen AK, Ihlen H, Simonsen S, Kjekshus J, Nitter-Hauge S, Ueland T, Froland SS (2001)
Increase in anti-inflammatory cytokine levels in chronic heart failure: A measure of treatment success or failure? Response
Circulation, 104 (18), E97-E98

Aukrust P, Waehre T, Damås JK, Gullestad L, Solum NO (2001)
Inflammatory role of platelets in acute coronary syndromes
Heart, 86 (6), 605-6
PubMed 11711447

Dahle MG, Gullestad L, Simonsen S (2001)
Plasma N-terminal proatrial natriuretic factor can predict normal pulmonary capillary wedge pressure in cardiac transplant recipients
Scand Cardiovasc J, 35 (6), 367-71
PubMed 11837515

Damås JK, Aukrust P, Ueland T, Odegaard A, Eiken HG, Gullestad L, Sejersted OM, Christensen G (2001)
Monocyte chemoattractant protein-1 enhances and interleukin-10 suppresses the production of inflammatory cytokines in adult rat cardiomyocytes
Basic Res Cardiol, 96 (4), 345-52
PubMed 11518190

Damås JK, Gullestad L, Aukrust P (2001)
Cytokines as new treatment targets in chronic heart failure
Curr Control Trials Cardiovasc Med, 2 (6), 271-277
PubMed 11806813

Damås JK, Gullestad L, Aass H, Simonsen S, Fjeld JG, Wikeby L, Ueland T, Eiken HG, Frøland SS, Aukrust P (2001)
Enhanced gene expression of chemokines and their corresponding receptors in mononuclear blood cells in chronic heart failure--modulatory effect of intravenous immunoglobulin
J Am Coll Cardiol, 38 (1), 187-93
PubMed 11451272

Eiken HG, Øie E, Damås JK, Yndestad A, Bjerkeli V, Aass H, Simonsen S, Geiran OR, Tønnessen T, Christensen G, Frøland SS, Gullestad L, Attramadal H, Aukrust P (2001)
Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure
Eur J Clin Invest, 31 (5), 389-97
PubMed 11380590

Gullestad L, Aukrust P (2001)
The cytokine network in heart failure: pathogenetic importance and potential therapeutic targets
Heart Fail Monit, 2 (1), 8-13
PubMed 12634893

Gullestad L, Manhenke C, Aarsland T, Skårdal R, Fagertun H, Wikstrand J, Kjekshus J (2001)
Effect of metoprolol CR/XL on exercise tolerance in chronic heart failure - a substudy to the MERIT-HF trial
Eur J Heart Fail, 3 (4), 463-8
PubMed 11511433

Gullestad L, Ueland T, Brunsvig A, Kjekshus J, Simonsen S, Frøland SS, Aukrust P (2001)
Effect of metoprolol on cytokine levels in chronic heart failure--a substudy in the Metoprolol Controlled-Release Randomised Intervention Trial in Heart Failure (MERIT-HF)
Am Heart J, 141 (3), 418-21
PubMed 11231439

Gullestad L, Aass H, Andreassen AK, Ihlen H, Simonsen S, Kjekshus J, Wikeby L, Nitter-Hauge S, Fjeld JG, Lien E, Ueland T, Frøland SS, Aukrust P (2001)
[Immunomodulating treatment in advanced heart failure--effect of intravenous immunoglobulin]
Tidsskr Nor Laegeforen, 121 (16), 1902-7
PubMed 11488180

Gullestad L, Aass H, Fjeld JG, Wikeby L, Andreassen AK, Ihlen H, Simonsen S, Kjekshus J, Nitter-Hauge S, Ueland T, Lien E, Frøland SS, Aukrust P (2001)
Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure
Circulation, 103 (2), 220-5
PubMed 11208680

Holm T, Andreassen AK, Aukrust P, Andersen K, Geiran OR, Kjekshus J, Simonsen S, Gullestad L (2001)
Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients
Eur Heart J, 22 (5), 428-36
PubMed 11207085

Holm T, Andreassen AK, Ueland T, Kjekshus J, Frøland SS, Kjekshus E, Simonsen S, Aukrust P, Gullestad L (2001)
Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients
Am J Cardiol, 87 (6), 815-8, A9
PubMed 11249916

Holm T, Berge RK, Andreassen AK, Ueland T, Kjekshus J, Simonsen S, Frøland S, Gullestad L, Aukrust P (2001)
Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients
Transplantation, 72 (4), 706-11
PubMed 11544435

Holven KB, Holm T, Aukrust P, Christensen B, Kjekshus J, Andreassen AK, Gullestad L, Hagve TA, Svilaas A, Ose L, Nenseter MS (2001)
Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects
Am J Med, 110 (7), 536-42
PubMed 11343667

Publications 2000

Damås JK, Eiken HG, Oie E, Bjerkeli V, Yndestad A, Ueland T, Tonnessen T, Geiran OR, Aass H, Simonsen S, Christensen G, Froland SS, Attramadal H, Gullestad L, Aukrust P (2000)
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
Cardiovasc Res, 47 (4), 778-87
PubMed 10974226

Damås JK, Gullestad L, Ueland T, Solum NO, Simonsen S, Frøland SS, Aukrust P (2000)
CXC-chemokines, a new group of cytokines in congestive heart failure--possible role of platelets and monocytes
Cardiovasc Res, 45 (2), 428-36
PubMed 10728363

Gullestad L, Jorgensen B, Bjuro T, Pernow J, Lundberg JM, Dota CD, Hall C, Simonsen S, Ablad B (2000)
Postexercise ischemia is associated with increased neuropeptide Y in patients with coronary artery disease
Circulation, 102 (9), 987-93
PubMed 10961962

Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J, Wikstrand J, El Allaf D, Vítovec J, Aldershvile J, Halinen M, Dietz R, Neuhaus KL, Jánosi A, Thorgeirsson G, Dunselman PH, Gullestad L, Kuch J, Herlitz J, Rickenbacher P, Ball S, Gottlieb S, Deedwania P (2000)
Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group
JAMA, 283 (10), 1295-302
PubMed 10714728

Holm T, Aukrust P, Andreassen AK, Ueland T, Brosstad F, Frøland SS, Simonsen S, Gullestad L (2000)
Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines
Clin Transplant, 14 (3), 218-25
PubMed 10831080

Myers J, Gullestad L, Vagelos R, Do D, Bellin D, Ross H, Fowler MB (2000)
Cardiopulmonary exercise testing and prognosis in severe heart failure: 14 mL/kg/min revisited
Am Heart J, 139 (1 Pt 1), 78-84
PubMed 10618566

Publications 1999

Aukrust P, Gullestad L, Frøland SS (1999)
Is apoptosis an important pathogenic factor in cardiovascular disease?
Eur J Clin Invest, 29 (5), 369-71
PubMed 10354192

Aukrust P, Müller F, Ueland T, Berget T, Aaser E, Brunsvig A, Solum NO, Forfang K, Frøland SS, Gullestad L (1999)
Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes
Circulation, 100 (6), 614-20
PubMed 10441098

Aukrust P, Ueland T, Lien E, Bendtzen K, Müller F, Andreassen AK, Nordøy I, Aass H, Espevik T, Simonsen S, Frøland SS, Gullestad L (1999)
Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
Am J Cardiol, 83 (3), 376-82
PubMed 10072227

Gullestad L, Aukrust P, Ueland T, Espevik T, Yee G, Vagelos R, Frøland SS, Fowler M (1999)
Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure
J Am Coll Cardiol, 34 (7), 2061-7
PubMed 10588224

Gullestad L, Bjørnerheim R, Offstad J, Endresen K, Forfang K, Kjekshus J, Hansteen V (1999)
[Current use of beta-blockers in coronary artery disease]
Tidsskr Nor Laegeforen, 119 (1), 24-8
PubMed 10025200

Gullestad L, Nordal KP, Berg KJ, Cheng H, Schwartz MS, Simonsen S (1999)
Interaction between lovastatin and cyclosporine A after heart and kidney transplantation
Transplant Proc, 31 (5), 2163-5
PubMed 10456002

Gullestad L, Simonsen S, Ueland T, Holm T, Aass H, Andreassen AK, Madsen S, Geiran O, Frøland SS, Aukrust P (1999)
Possible role of proinflammatory cytokines in heart allograft coronary artery disease
Am J Cardiol, 84 (9), 999-1003
PubMed 10569653

Kjekshus J, Gullestad L (1999)
Heart rate as a therapeutic target in heart failure
Eur. Heart J. Suppl., 1 (H), H64-H69

Simonsen S, Andreassen AK, Gullestad L, Lindberg H, Seem E, Geiran OR (1999)
[Heart transplantation in Norway]
Tidsskr Nor Laegeforen, 119 (23), 3447-50
PubMed 10553344

Publications 1998

Andreassen AK, Gullestad L, Endresen K (1998)
[Thrombolytic treatment in acute myocardial infarction. Choice of preparations in Norwegian hospitals]
Tidsskr Nor Laegeforen, 118 (17), 2630-1
PubMed 9673511

Andreassen AK, Gullestad L, Holm T, Simonsen S, Kvernebo K (1998)
Endothelium-dependent vasodilation of the skin microcirculation in heart transplant recipients
Clin Transplant, 12 (4), 324-32
PubMed 9686327

Andreassen AK, Kirkebøen KA, Gullestad L, Simonsen S, Kvernebo K (1998)
Effect of heart transplantation on impaired peripheral microvascular perfusion and reactivity in congestive heart failure
Int J Cardiol, 65 (1), 33-40
PubMed 9699928

Andreassen AK, Kvernebo K, Jørgensen B, Simonsen S, Kjekshus J, Gullestad L (1998)
Exercise capacity in heart transplant recipients: relation to impaired endothelium-dependent vasodilation of the peripheral microcirculation
Am Heart J, 136 (2), 320-8
PubMed 9704697

Andreassen AK, Nordøy I, Simonsen S, Ueland T, Müller F, Frøland SS, Gullestad L, Aukrust P (1998)
Levels of circulating adhesion molecules in congestive heart failure and after heart transplantation
Am J Cardiol, 81 (5), 604-8
PubMed 9514458

Aukrust P, Ueland T, Müller F, Andreassen AK, Nordøy I, Aas H, Kjekshus J, Simonsen S, Frøland SS, Gullestad L (1998)
Elevated circulating levels of C-C chemokines in patients with congestive heart failure
Circulation, 97 (12), 1136-43
PubMed 9537339

Gullestad L, Birkeland K, Bjønerheim R, Djøseland O, Trygstad O, Simonsen S (1998)
Exercise capacity and hormonal response in adults with childhood onset growth hormone deficiency during long-term somatropin treatment
Growth Horm IGF Res, 8 (5), 377-84
PubMed 10984298

Gullestad L, Haywood G, Aass H, Ross H, Yee G, Ueland T, Geiran O, Kjekshus J, Simonsen S, Bishopric N, Fowler M (1998)
Angiotensin II receptor subtype AT1 and AT2 expression after heart transplantation
Cardiovasc Res, 38 (2), 340-7
PubMed 9709394

Gullestad L, Myers J, Ross H, Rickenbacher P, Slauson S, Bellin D, Do D, Vagelos R, Fowler M (1998)
Serial exercise testing and prognosis in selected patients considered for cardiac transplantation
Am Heart J, 135 (2 Pt 1), 221-9
PubMed 9489968

Gullestad L, Aass H, Ross H, Ueland T, Geiran O, Kjekshus J, Simonsen S, Fowler M, Kobilka B (1998)
Neuropeptide Y receptor 1 (NPY-Y1) expression in human heart failure and heart transplantation
J Auton Nerv Syst, 70 (1-2), 84-91
PubMed 9686908

Myers J, Gullestad L (1998)
The role of exercise testing and gas-exchange measurement in the prognostic assessment of patients with heart failure
Curr Opin Cardiol, 13 (3), 145-55
PubMed 9649936

Myers J, Gullestad L, Vagelos R, Do D, Bellin D, Ross H, Fowler MB (1998)
Clinical, hemodynamic, and cardiopulmonary exercise test determinants of survival in patients referred for evaluation of heart failure
Ann Intern Med, 129 (4), 286-93
PubMed 9729181

Risum O, Arafa O, Svennevig JL, Levorstad K, Abdelnoor M, Gullestad L, Bjørnerheim R, Simonsen S, Nitter-Hauge S (1998)
[Mortality and morbidity after coronary bypass surgery in high-risk patients]
Tidsskr Nor Laegeforen, 118 (29), 4504-8
PubMed 9889633

Publications 1997

Gullestad L, Myers J, Bjornerheim R, Berg KJ, Djoseland O, Hall C, Lund K, Kjekshus J, Simonsen S (1997)
Gas exchange and neurohumoral response to exercise: influence of the exercise protocol
Med Sci Sports Exerc, 29 (4), 496-502
PubMed 9107632

Gullestad L, Nordal KP, Forfang K, Ihlen H, Høstmark A, Berg KJ, Cheng H, Schwartz MS, Geiran O, Simonsen S (1997)
Post-transplant hyperlipidaemia: low-dose lovastatin lowers atherogenic lipids without plasma accumulation of lovastatin
J Intern Med, 242 (6), 483-90
PubMed 9437409

Gullestad L, Ross H, Myers J, Hoang K, Hunt S, Stinson EB, Valantine HA (1997)
Importance of decreased heart rate in predicting transplant coronary artery disease
Clin Transplant, 11 (6), 628-32
PubMed 9408698

Haywood GA, Gullestad L, Katsuya T, Hutchinson HG, Pratt RE, Horiuchi M, Fowler MB (1997)
AT1 and AT2 angiotensin receptor gene expression in human heart failure
Circulation, 95 (5), 1201-6
PubMed 9054850

Kløw NE, Smith HJ, Gullestad L, Seem E, Endresen K (1997)
Outcome of bypass surgery in patients with chronic ischemic left ventricular dysfunction. Predictive value of MR imaging
Acta Radiol, 38 (1), 76-82
PubMed 9059406

Ross HJ, Gullestad L, Pak J, Slauson S, Valantine HA, Hunt SA (1997)
Methotrexate or total lymphoid radiation for treatment of persistent or recurrent allograft cellular rejection: a comparative study
J Heart Lung Transplant, 16 (2), 179-89
PubMed 9059929

Aaser E, Gullestad L, Tølløfsrud S, Lundberg J, Hall C, Djøseland O, Kjekshus J, Forfang K (1997)
Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure
Scand J Clin Lab Invest, 57 (4), 361-7
PubMed 9249883

Publications 1996

Gullestad L, Hallen J, Medbø JI, Grønnerød O, Holme I, Sejersted OM (1996)
The effect of acute vs chronic treatment with beta-adrenoceptor blockade on exercise performance, haemodynamic and metabolic parameters in healthy men and women
Br J Clin Pharmacol, 41 (1), 57-67
PubMed 8824694

Gullestad L, Haywood G, Ross H, Bjornerheim R, Geiran O, Kjekshus J, Simonsen S, Fowler M (1996)
Exercise capacity of heart transplant recipients: the importance of chronotropic incompetence
J Heart Lung Transplant, 15 (11), 1075-83
PubMed 8956116

Gullestad L, Myers J, Noddeland H, Bjørnerheim R, Djøseland O, Hall C, Gieran O, Kjekshus J, Simonsen S (1996)
Influence of the exercise protocol on hemodynamic, gas exchange, and neurohumoral responses to exercise in heart transplant recipients
J Heart Lung Transplant, 15 (3), 304-13
PubMed 8777215

Haywood GA, Rickenbacher PR, Trindade PT, Gullestad L, Jiang JP, Schroeder JS, Vagelos R, Oyer P, Fowler MB (1996)
Analysis of deaths in patients awaiting heart transplantation: impact on patient selection criteria
Heart, 75 (5), 455-62
PubMed 8665337

Risum O, Abdelnoor M, Svennevig JL, Levorstad K, Gullestad L, Bjørnerheim R, Simonsen S, Nitter-Hauge S (1996)
Diabetes mellitus and morbidity and mortality risks after coronary artery bypass surgery
Scand J Thorac Cardiovasc Surg, 30 (2), 71-5
PubMed 8857678

Ross HJ, Gullestad L, Hunt SA, Tovey DA, Puryear JB, McMillan A, Stinson EB, Valantine HA (1996)
Early Doppler echocardiographic dysfunction is associated with an increased mortality after orthotopic cardiac transplantation
Circulation, 94 (9 Suppl), II289-93
PubMed 8901762

Publications 1995

Andreassen AK, Gullestad L, Bjørnerheim R, Forfang K, Kjekshus J (1995)
[Intermittent claudication and beta-blockaders. An unfortunate combination?]
Tidsskr Nor Laegeforen, 115 (6), 725-8
PubMed 7900137

Forfang K, Gullestad L (1995)
[Drug therapy of angina pectoris. Are the possibilities exploited well enough?]
Tidsskr Nor Laegeforen, 115 (18), 2264-7
PubMed 7652725

Gullestad L, Hallén J, Sejersted OM (1995)
K+ balance of the quadriceps muscle during dynamic exercise with and without beta-adrenoceptor blockade
J Appl Physiol, 78 (2), 513-23
PubMed 7759420

Gullestad L, Osnes JB (1995)
[Beta 3-receptors: incidence and properties, possible clinical significance]
Tidsskr Nor Laegeforen, 115 (1), 45-9
PubMed 7846660

Gullestad L, Simonsen S, Kjekshus J (1995)
[Reduced physical tolerance in patients with heart failure. Mechanisms and therapeutic effects]
Tidsskr Nor Laegeforen, 115 (1), 38-42
PubMed 7846658

Simonsen S, Forfang K, Gullestad L, Geiran O (1995)
[Treatment of terminal heart failure]
Tidsskr Nor Laegeforen, 115 (4), 467-70
PubMed 7871502

Simonsen S, Gullestad L, Forfang K, Ihlen H, Nordal KP, Geiran O, Høstmark AT (1995)
[Hypercholesterolemia--a clinical problem in heart transplantation. A therapeutic trial with low-dose lovastatin]
Tidsskr Nor Laegeforen, 115 (3), 357-9
PubMed 7855835

Publications 1994

Børsheim E, Bahr R, Hansson P, Gullestad L, Hallén J, Sejersted OM (1994)
Effect of beta-adrenoceptor blockade on post-exercise oxygen consumption
Metabolism, 43 (5), 565-71
PubMed 7909912

Gullestad L, Jacobsen T, Dolva LO (1994)
Effect of magnesium treatment on glycemic control and metabolic parameters in NIDDM patients
Diabetes Care, 17 (5), 460-1
PubMed 8062622

Gullestad L, Midtvedt K, Dolva LO, Norseth J, Kjekshus J (1994)
The magnesium loading test: reference values in healthy subjects
Scand J Clin Lab Invest, 54 (1), 23-31
PubMed 8171268

Gullestad L, Nes M, Rønneberg R, Midtvedt K, Falch D, Kjekshus J (1994)
Magnesium status in healthy free-living elderly Norwegians
J Am Coll Nutr, 13 (1), 45-50
PubMed 8157853

Hallén J, Gullestad L, Sejersted OM (1994)
K+ shifts of skeletal muscle during stepwise bicycle exercise with and without beta-adrenoceptor blockade
J Physiol, 477 ( Pt 1), 149-59
PubMed 8071881

SEJERSTED OM, HALLEN J, GULLESTAD L (1994)
BETA-ADRENERGIC CONTROL OF POTASSIUM SHIFTS DURING EXERCISE
EUROPEAN SECTION MEETING - INTERNATIONAL SOCIETY FOR HEART RESEARCH, 151-158

Publications 1993

Andreassen AK, Gullestad L (1993)
[Alpha blockers--first choice or second choice antihypertensive preparations?]
Tidsskr Nor Laegeforen, 113 (10), 1256-7
PubMed 8098555

Gullestad L, Birkeland K, Mølstad P, Høyer MM, Vanberg P, Kjekshus J (1993)
The effect of magnesium versus verapamil on supraventricular arrhythmias
Clin Cardiol, 16 (5), 429-34
PubMed 8504578

Gullestad L, Hallén J, Sejersted OM (1993)
Variable effects of beta-adrenoceptor blockade on muscle blood flow during exercise
Acta Physiol Scand, 149 (3), 257-71
PubMed 7906074

Publications 1992

Gullestad L, Dolva LO, Søyland E, Manger AT, Falch D, Kjekshus J (1992)
Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics
Alcohol Clin Exp Res, 16 (5), 986-90
PubMed 1443440

Gullestad L, Dolva LO, Waage A, Falch D, Fagerthun H, Kjekshus J (1992)
Magnesium deficiency diagnosed by an intravenous loading test
Scand J Clin Lab Invest, 52 (4), 245-53
PubMed 1439510

Gullestad L, Forfang K, Simonsen S (1992)
Differential effect of selective beta 1 and nonselective beta-adrenoceptor blockade on epinephrine and atropine response in normal humans
J Cardiovasc Pharmacol, 20 (6), 976-81
PubMed 1282602

Gullestad L, Kjekshus J (1992)
[Sudden cardiac death. Significance of beta blockaders]
Tidsskr Nor Laegeforen, 112 (22), 2843-7
PubMed 1357774

Gullestad L, Kjekshus J (1992)
[Myocardial disease in diabetes mellitus]
Tidsskr Nor Laegeforen, 112 (8), 1016-9
PubMed 1553723

Publications 1991

Birkeland KI, Gullestad L, Torsvik H (1991)
[Cholesterol-lowering effect of oat]
Tidsskr Nor Laegeforen, 111 (17), 2081-5
PubMed 1871737

Gullestad L, Birkeland K, Nordby G, Larsen S, Kjekshus J (1991)
Effects of selective beta 2-adrenoceptor blockade on serum potassium and exercise performance in normal men
Br J Clin Pharmacol, 32 (2), 201-7
PubMed 1681847

Gullestad L, Fløgstad T, Nordstrand K, Smith G, Smith H, Frøysaker T, Simonsen S (1991)
Intrapericardial left atrial aneurysm diagnosed by transoesophageal echocardiography and nuclear magnetic resonance imaging
Eur Heart J, 12 (2), 277-9
PubMed 2044565

Gullestad L, Oystein Dolva L, Birkeland K, Falch D, Fagertun H, Kjekshus J (1991)
Oral versus intravenous magnesium supplementation in patients with magnesium deficiency
Magnes Trace Elem, 10 (1), 11-6
PubMed 1814318

Publications 1989

Gullestad L, Dolva LO, Kjeldsen SE, Eide I, Kjekshus J (1989)
Effect of beta-adrenergic blockade on hormonal responses during continuous and intermittent exercise
Cardiovasc Drugs Ther, 3 (1), 63-71
PubMed 2577280

Gullestad L, Dolva LO, Nordby G, Skaaraas K, Larsen S, Kjekshus J (1989)
The importance of potassium and lactate for maximal exercise performance during beta blockade
Scand J Clin Lab Invest, 49 (6), 521-8
PubMed 2574496

Gullestad L, Dolva LO, Søyland E, Kjekshus J (1989)
[Beta blockaders and physical performance. Limiting factors]
Tidsskr Nor Laegeforen, 109 (25), 2544-7
PubMed 2573167

Gullestad L, Dolva LO, Aase O, Kjekshus J (1989)
Interaction of naloxone and timolol on maximal exercise capacity and the subjective perception of fatigue
Int J Sports Med, 10 (4), 259-63
PubMed 2606592

Publications 1988

Gullestad L, Dolva LO, Søyland E, Kjekshus J (1988)
Difference between beta-1-selective and non-selective beta-blockade during continuous and intermittent exercise
Clin Physiol, 8 (5), 487-99
PubMed 3191663

Publications 1987

Gullestad L, Dolva LO, Kjeldsen SE, Eide I, Kjekshus J (1987)
The effects of naloxone and timolol on plasma catecholamine levels during short-term dynamic exercise
Scand J Clin Lab Invest, 47 (8), 847-51
PubMed 2893446

Gullestad L, Søyland E, Dolva LO, Kjekshus J (1987)
[Angiotensin-converting enzyme inhibitors in heart failure]
Tidsskr Nor Laegeforen, 107 (25), 2112-6
PubMed 2823410

Gullestad L, Søyland E, Kjekshus J, Aase O, Bjørnstad P (1987)
[Magnesium deficiency. Diagnosis and occurrence of different disease conditions]
Tidsskr Nor Laegeforen, 107 (22), 1751-4
PubMed 3660356

Publications 1986

Gullestad L, Søyland E, Kjekshus J (1986)
[Magnesium and cardiovascular diseases]
Tidsskr Nor Laegeforen, 106 (7), 554-7
PubMed 3961781

Publications 1979

Gullestad L, Krüger MB, Krüger O, Bakketeig LS (1979)
[Smoking habits among pregnant women in Trøndelag]
Tidsskr Nor Laegeforen, 99 (12), 575-9
PubMed 442031