Key achievements
- Preclinical and clinical studies of the anticancer effects of the toxins abrin and ricin. (Fodstad et al: Br J Cancer 1976; Fodstad et al: Cancer Res 1977; Fodstad et al: Cancer Res 1984)
- Establishment of human tumor models in nude mice and rats and their use in preclinical drug evaluation (Fodstad et al Cancer Res 1977; Fodstad et al: Br. J. Cancer 1980; Fodstad et al : Cancer Res 1984; Fodstad et al : Cancer Res 1985; Breistoel et al : Cancer Res 1999 )
- Development of human tumor metastasis models in nude rodents. (Fodstad et al: Cancer Res 1988, Fodstad et al: Int J Cancer 1988; Kjoenniksen et al: Cancer Res 1989; Kjoenniksen et al: J Natl Cancer Inst 1990; Fodstad and Kjoenniksen: J Natl Cancer Inst 1990; Fodstad: J Natl Cancer Inst 1991; Kjoenniksen et al: J Natl Cancer Inst 1991)
- Studies of tissue-preferenced metastasis formation and the effects of tumor microenvironment on metastasis formation and on sensitivity to treatment. (Kjoenniksen et al: Cancer Res 1992; Fodstad and Kjoenniksen, J Cell Biochem 1994; Myklebust et al: J Neuro-Oncology 1994; Engebraaten and Fodstad: Int J Cancer 1999
- Development and clinical implementation of bone marrow and progenitor cell transplantation after purging of tumor cells (Kvalheim et al: Cancer Res 1987; Kvalheim et al: Bone Marrow Transplantation 1988; Kvalheim et al: J Hematotherapy 1994; Kvalheim et al: J Hematotherapy, 1996)
- Studies on mechanisms of action of immunotoxins and of their efficacy for ex vivo and in vivo use (Godal et al: J Natl Cancer Inst 1986; Godal et al: Cancer Res 1987; Hall and Fodstad: Neurosurgery 1992; Myklebust et al: Cancer Res 1993; Hall et al: Neurosurgery, 1994; Myklebust et al: Cancer Res 1994; Engebraaten et al: Int J Cancer 2000; Engebraten et al: Int J Cancer 2002; Hjortland et al: J Neurosurgery 2004
- Development of methods for detection, selection and characterization of micrometastatic cells by the use of immunomagnetic beads and fluorescent latex particles (Fodstad: In Rietmueller et al (eds.) 1996). The presence of micrometases correlates with overall survival for patients with cutaneous melanoma (Faye et al: Clin Cancer Res in press), with therapy response in osteosarcoma patients (Bruland et al: submitted) and with tumor stage at time of diagnosis in colorectal carcinomas (Flatmark et al: Clin Caner Res 2002).
- Development of an mRNA amplification protocol to generate sufficient material from cells selected by immunomagnetic beads for molecular profiling analysis (Nygaard et al: BMC Genomics, 2003).
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