Per Kristian Eide received his MD from Faculty of Medicine, University of Bergen in 1989, and the same year his PhD in Neurophysiology from the Department of Physiology, Faculty of Medicine, University of Bergen, Bergen, Norway. He is a professor of clinical neurosurgery, Faculty of Medicine, University of Oslo, and senior consultant neurosurgeon/section chief (hydrocephalus) at the Department of Neurosurgery, Oslo University Hospital – Rikshospitalet. Eide’s current research involves several areas: (1) Pathophysiology of hydrocephalus and other diseases with imbalance in brain water homeostasis (idiopathic intracranial hypertension, cysts, Chiari malformation etc.) (2) Physiological monitoring of patients with brain disease/injury regarding (intracranial pressure, arterial blood pressure, intracranial compliance, cerebral auto-regulation, and non-invasive ICP monitoring). (3) Monitoring and treatment of patients with subarachnoid hemorrhage. His current main clinical activities are shunt/endoscopic surgery for hydrocephalus and other cerebrospinal fluid (CSF ) circulation disorders (idiopathic intracranial hypertension, normal pressure hydrocephalus, Chiari malformation), cerebrovascular surgery (cerebral aneurysms, cerebal vascular malformations), microvascular decompressions (trigeminal neuralgia, hemifacial spasms, glossopharyngeal neuralgia, vertigo), and surgery for brain tumors (posterior skull base, ventricular).
Thesis: Function and plasticity of serotonergic systems in the regulation of nociception
Author network for Per Kristian Eide by COREMINE medical
Publications in press
Letter to the Editor, regarding >A Randomized and Blinded Single-center Trial Comparing the Effect of Intracranial Pressure (ICP) versus ICP Wave Amplitude Guided Intensive Care Management on Early Clinical State and 12 Months Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage>
Neurosurgery (in press)
PubMed 22562087
Morphological characterization of cardiac induced intracranial pressure (ICP) waves in patients with overdrainage of cerebrospinal fluid and negative ICP
Med Eng Phys (in press)
PubMed 22153319
Publications 2012
Pressure-derived versus pressure wave amplitude-derived indices of cerebrovascular pressure reactivity in relation to early clinical state and 12-month outcome following aneurysmal subarachnoid hemorrhage
J Neurosurg, 116 (5), 961-71
PubMed 22324419
Publications 2011
Cardiac output in idiopathic normal pressure hydrocephalus: association with arterial blood pressure and intracranial pressure wave amplitudes and outcome of shunt surgery
Fluids Barriers CNS, 8 (1), 11
PubMed 21349148
The baseline pressure of intracranial pressure (ICP) sensors can be altered by electrostatic discharges
Biomed Eng Online, 10, 75
PubMed 21859487
A randomized and blinded single-center trial comparing the effect of intracranial pressure and intracranial pressure wave amplitude-guided intensive care management on early clinical state and 12-month outcome in patients with aneurysmal subarachnoid hemorrhage
Neurosurgery, 69 (5), 1105-15
PubMed 21670714
Static and pulsatile intracranial pressure in idiopathic intracranial hypertension
Clin Neurol Neurosurg, 113 (2), 123-8
PubMed 21075509
The presigmoid approach for removal of tumours causing ventral compression of the brainstem. Surgical results and postoperative quality of life
Br J Neurosurg, 25 (1), 86-93
PubMed 20979440
The pulsating brain: A review of experimental and clinical studies of intracranial pulsatility
Fluids Barriers CNS, 8 (1), 5
PubMed 21349153
Publications 2010
Cerebrospinal fluid pulse pressure amplitude during lumbar infusion in idiopathic normal pressure hydrocephalus can predict response to shunting
Cerebrospinal Fluid Res, 7, 5
PubMed 20205911
Arterial blood pressure vs intracranial pressure in normal pressure hydrocephalus
Acta Neurol Scand, 122 (4), 262-9
PubMed 20070274
A dynamic nonlinear relationship between the static and pulsatile components of intracranial pressure in patients with subarachnoid hemorrhage
J Neurosurg, 112 (3), 616-25
PubMed 19731984
Is ventriculomegaly in idiopathic normal pressure hydrocephalus associated with a transmantle gradient in pulsatile intracranial pressure?
Acta Neurochir (Wien), 152 (6), 989-95
PubMed 20130957
Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients
Neurosurgery, 66 (1), 80-91
PubMed 20023540
Simultaneous measurements of intracranial pressure parameters in the epidural space and in brain parenchyma in patients with hydrocephalus
J Neurosurg, 113 (6), 1317-25
PubMed 20799859
Cerebral microdialysis and intracranial pressure monitoring in patients with idiopathic normal-pressure hydrocephalus: association with clinical response to extended lumbar drainage and shunt surgery
J Neurosurg, 112 (2), 414-24
PubMed 19538048
The effect of microvascular decompression in patients with multiple sclerosis and trigeminal neuralgia
Neurosurgery, 67 (3), 749-53; discussion 753-4
PubMed 20651626
Publications 2009
Lumbar infusion testing in the selection of patients with normal pressure hydrocephalus for surgery
Eur. J. Neurol., 16 (2), E8
Five-year incidence of surgery for idiopathic normal pressure hydrocephalus in Norway
Acta Neurol Scand, 120 (5), 314-6
PubMed 19832773
Impact of sampling rate for time domain analysis of continuous intracranial pressure (ICP) signals
Med Eng Phys, 31 (5), 601-6
PubMed 19185527
Publications 2008
Differential effects of osmotherapy on static and pulsatile intracranial pressure
Crit Care Med, 36 (8), 2414-9
PubMed 18596629
Prevalence of probable idiopathic normal pressure hydrocephalus in a Norwegian population
Acta Neurol Scand, 118 (1), 48-53
PubMed 18205881
Assessment of idiopathic normal pressure patients in neurological practice: the role of lumbar infusion testing for referral of patients to neurosurgery
Eur J Neurol, 15 (6), 605-12
PubMed 18410369
Stroke with subarachnoid hemorrhage: assessment of cerebrovascular pressure regulation and simulated cerebrovascular resistance
Acta Neurochir Suppl, 102, 321-5
PubMed 19388338
Comparison of simultaneous continuous intracranial pressure (ICP) signals from ICP sensors placed within the brain parenchyma and the epidural space
Med Eng Phys, 30 (1), 34-40
PubMed 17336574
Demonstration of uneven distribution of intracranial pulsatility in hydrocephalus patients
J Neurosurg, 109 (5), 912-7
PubMed 18976084
Changes in intracranial pulse pressure amplitudes after shunt implantation and adjustment of shunt valve opening pressure in normal pressure hydrocephalus
Acta Neurochir (Wien), 150 (11), 1141-7; discussion 1147
PubMed 18936877
The frequency domain versus time domain methods for processing of intracranial pressure (ICP) signals
Med Eng Phys, 30 (2), 164-70
PubMed 17468029
Effect of microvascular decompression in trigeminal neuralgia patients with or without constant pain
Neurosurgery, 63 (1), 93-9; discussion 99-100
PubMed 18728573
Rapid and severe rise in static and pulsatile intracranial pressures during a generalized epileptic seizure
Seizure, 17 (8), 740-3
PubMed 18554932
Surgical treatment of aneurysmal subarachnoid haemorrhage in the presence of 24-h endovascular availability: management and results
Br J Neurosurg, 22 (1), 53-62
PubMed 17852110
Publications 2007
Association between intracranial pulse pressure levels and brain energy metabolism in a patient with an aneurysmal subarachnoid haemorrhage
Acta Anaesthesiol Scand, 51 (9), 1273-6
PubMed 17714572
Association between intracranial, arterial pulse pressure amplitudes and cerebral autoregulation in head injury patients
Neurol Res, 29 (6), 578-82
PubMed 17535570
Is intracranial pressure waveform analysis useful in the management of pediatric neurosurgical patients?
Pediatr Neurosurg, 43 (6), 472-81
PubMed 17992035
Association among intracranial compliance, intracranial pulse pressure amplitude and intracranial pressure in patients with intracranial bleeds
Neurol Res, 29 (8), 798-802
PubMed 17601366
From intracranial pressure to intracranial pressure wave-guided intensive care management of a patient with an aneurysmal subarachnoid haemorrhage
Acta Anaesthesiol Scand, 51 (4), 501-4
PubMed 17378790
Intracranial pressure parameters in idiopathic normal pressure hydrocephalus patients with or without improvement of cognitive function after shunt treatment
Dement Geriatr Cogn Disord, 23 (1), 47-54
PubMed 17077633
Microvascular decompression for hemifacial spasm: postoperative neurologic follow-up and evaluation of life quality
Eur J Neurol, 14 (3), 335-40
PubMed 17355557
Audits can improve neurosurgical practice--illustrated by endoscopic third ventriculostomy
Pediatr Neurosurg, 43 (6), 482-7
PubMed 17992036
Publications 2006
Comparison of intracranial pressure measured simultaneously within the brain parenchyma and cerebral ventricles
J Clin Monit Comput, 20 (6), 411-4
PubMed 17016744
Assessment of quality of continuous intracranial pressure recordings in children
Pediatr Neurosurg, 42 (1), 28-34
PubMed 16357498
Comparison of simultaneous continuous intracranial pressure (ICP) signals from a Codman and a Camino ICP sensor
Med Eng Phys, 28 (6), 542-9
PubMed 16253539
A new method for processing of continuous intracranial pressure signals
Med Eng Phys, 28 (6), 579-87
PubMed 16275153
Intracranial pressure parameters in idiopathic normal pressure hydrocephalus patients treated with ventriculo-peritoneal shunts
Acta Neurochir (Wien), 148 (1), 21-9; discussion 29
PubMed 16284706
Lumbar cerebrospinal fluid pressure waves versus intracranial pressure waves in idiopathic normal pressure hydrocephalus
Br J Neurosurg, 20 (6), 407-14
PubMed 17439094
Intracranial pulse pressure amplitude levels determined during preoperative assessment of subjects with possible idiopathic normal pressure hydrocephalus
Acta Neurochir (Wien), 148 (11), 1151-6; discussion 1156
PubMed 17039303
Intracranial pressure levels and single wave amplitudes, Glasgow Coma Score and Glasgow Outcome Score after subarachnoid haemorrhage
Acta Neurochir (Wien), 148 (12), 1267-75; discussion 1275-6
PubMed 17123038
Publications 2005
Assessment of childhood intracranial pressure recordings using a new method of processing intracranial pressure signals
Pediatr Neurosurg, 41 (3), 122-30
PubMed 15995328
Preoperative spinal hydrodynamics versus clinical change 1 year after shunt treatment in idiopathic normal pressure hydrocephalus patients
Br J Neurosurg, 19 (6), 475-83
PubMed 16574559
Publications 2004
A prospective study on the clinical effect of surgical treatment of normal pressure hydrocephalus: the value of hydrodynamic evaluation
Br J Neurosurg, 18 (2), 149-57
PubMed 15176556
Publications 2003
[Glossopharyngeal neuralgia]
Tidsskr Nor Laegeforen, 123 (23), 3381-3
PubMed 14713973
Quantitative analysis of continuous intracranial pressure recordings in symptomatic patients with extracranial shunts
J Neurol Neurosurg Psychiatry, 74 (2), 231-7
PubMed 12531957
The relationship between intracranial pressure and size of cerebral ventricles assessed by computed tomography
Acta Neurochir (Wien), 145 (3), 171-9; discussion 179
PubMed 12632112
A computer-based method for comparisons of continuous intracranial pressure recordings within individual cases
Acta Neurochir (Wien), 145 (5), 351-7; discussion 357-8
PubMed 12820041
Lack of relationship between resistance to cerebrospinal fluid outflow and intracranial pressure in normal pressure hydrocephalus
Acta Neurol Scand, 108 (6), 381-8
PubMed 14616289
Publications 2002
Differences in quantitative characteristics of intracranial pressure in hydrocephalic children treated surgically or conservatively
Pediatr Neurosurg, 36 (6), 304-13
PubMed 12077475
Assessment of continuous intracranial pressure recordings in childhood craniosynostosis
Pediatr Neurosurg, 37 (6), 310-20
PubMed 12422046
[Treatment of hydrocephalus with endoscopic third ventriculocisternostomy]
Tidsskr Nor Laegeforen, 122 (10), 994-8
PubMed 12082709
Publications 2001
Assessment of intracranial pressure volume relationships in childhood: the lumbar infusion test versus intracranial pressure monitoring
Childs Nerv Syst, 17 (7), 382-90
PubMed 11465790
A new method and software for quantitative analysis of continuous intracranial pressure recordings
Acta Neurochir (Wien), 143 (12), 1237-47
PubMed 11810388
Changes in intracranial pressure after calvarial expansion surgery in children with slit ventricle syndrome
Pediatr Neurosurg, 35 (4), 195-204
PubMed 11694797
Publications 2000
Wind-up and the NMDA receptor complex from a clinical perspective
Eur J Pain, 4 (1), 5-15
PubMed 10833550
Publications 1998
Pathophysiological mechanisms of central neuropathic pain after spinal cord injury
Spinal Cord, 36 (9), 601-12
PubMed 9773443
Trigeminal neuropathic pain: pathophysiological mechanisms examined by quantitative assessment of abnormal pain and sensory perception
Neurosurgery, 43 (5), 1103-10
PubMed 9802854
The effect of peripheral glycerol on trigeminal neuropathic pain examined by quantitative assessment of abnormal pain and sensory perception
Acta Neurochir (Wien), 140 (12), 1271-7
PubMed 9932128
[Vascular compression and cranial nerve diseases]
Tidsskr Nor Laegeforen, 118 (26), 4079-84
PubMed 9844512
Relief of trigeminal neuralgia after percutaneous retrogasserian glycerol rhizolysis is dependent on normalization of abnormal temporal summation of pain, without general impairment of sensory perception
Neurosurgery, 43 (3), 462-72; discussion 472-4
PubMed 9733301
Publications 1997
Sensory perception in patients with trigeminal neuralgia: effects of percutaneous retrogasserian glycerol rhizotomy
Stereotact Funct Neurosurg, 68 (1-4 Pt 1), 207-11
PubMed 9711718
Relief of glossopharyngeal neuralgia by ketamine-induced N-methyl-aspartate receptor blockade
Neurosurgery, 41 (2), 505-8
PubMed 9257324
Reply to S.T. Meller: Ketamine: relief from chronic pain through actions at the NMDA receptor
Pain, 72 (1-2), 289-91
PubMed 9272819
A prospective study of microvascular decompression for trigeminal neuralgia
Acta Neurochir (Wien), 139 (5), 421-5
PubMed 9204111
Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery
Acta Anaesthesiol Scand, 41 (9), 1124-32
PubMed 9366932
Publications 1996
Somatosensory findings in patients with spinal cord injury and central dysaesthesia pain
J Neurol Neurosurg Psychiatry, 60 (4), 411-5
PubMed 8774406
Publications 1995
Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation
Neurosurgery, 37 (6), 1080-7
PubMed 8584148
Publications 1994
Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo
Pain, 58 (3), 347-54
PubMed 7838584
[Teratoma of the medullary cone as a cause of peripheral polyneuropathy]
Tidsskr Nor Laegeforen, 114 (10), 1185-6
PubMed 8209315
Publications 1993
[New views on pathogenesis and treatment of pain caused by nerve injury]
Tidsskr Nor Laegeforen, 113 (23), 2917-20
PubMed 8236196
The role of 5-hydroxytryptamine (5-HT) receptor subtypes and plasticity in the 5-HT systems in the regulation of nociceptive sensitivity
Cephalalgia, 13 (2), 75-85
PubMed 7684323
[The significance of radiologically diagnosed brain concussion for the outcome after head injury]
Tidsskr Nor Laegeforen, 113 (10), 1227-9
PubMed 8493653
Publications 1992
Stimulation of 5-HT1 receptors in the spinal cord changes substance P-induced behaviour
Neuropharmacology, 31 (6), 541-5
PubMed 1383863
Supersensitivity to the antinociceptive effect of a 5-HT1 receptor agonist after lesion of raphe-spinal serotonergic neurones
Pharmacol Toxicol, 71 (1), 62-4
PubMed 1523196
Early and late outcome in head injury patients with radiological evidence of brain damage
Acta Neurol Scand, 86 (2), 194-8
PubMed 1414231
The role of 5-HT1A and 5-HT1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour
Neuroreport, 3 (12), 1061-4
PubMed 1337283
Publications 1991
Different role of 5-HT1A and 5-HT2 receptors in spinal cord in the control of nociceptive responsiveness
Neuropharmacology, 30 (7), 727-31
PubMed 1717872
Interactions between serotonin and substance P in the spinal regulation of nociception
Brain Res, 550 (2), 225-30
PubMed 1715803
The behavioural response to intrathecal serotonin is changed by acute but not by repeated treatment with zimelidine or metergoline
Pharmacol Toxicol, 69 (5), 361-4
PubMed 1839446
Publications 1990
[Pain surgery seen from the physiologic point of view]
Tidsskr Nor Laegeforen, 110 (14), 1812-4
PubMed 2363142
Effects of intrathecal substance P and a substance P antagonist on a reflex to noxious heat are independent of changes in tail skin temperature
Acta Physiol Scand, 140 (4), 539-43
PubMed 1707212
The role of spinal cord 5-HT1A and 5-HT1B receptors in the modulation of a spinal nociceptive reflex
Brain Res, 536 (1-2), 195-200
PubMed 2150769
The tail-flick test needs to be improved
Pain, 43 (3), 391-3
PubMed 2293148
Publications 1989
Subsensitivity of serotonin and substance P receptors involved in nociception after repeated administration of a serotonin receptor agonist
J Neural Transm, 77 (1), 1-10
PubMed 2545812
The role of tail skin temperature in the facilitation of the tail-flick reflex after spinal transection or interference with descending serotonergic neurotransmission
Acta Physiol Scand, 135 (4), 427-33
PubMed 2544077
The apparent hyperalgesic effect of a serotonin antagonist in the tail flick test is mainly due to increased tail skin temperature
Pharmacol Biochem Behav, 32 (3), 601-5
PubMed 2740416
Publications 1988
Apparent hyperalgesia in the mouse tail-flick test due to increased tail skin temperature after lesioning of serotonergic pathways
Acta Physiol Scand, 134 (3), 413-20
PubMed 2976242
Intrathecal substance P modulates the depressant effect of 5-methoxy-N,N-dimethyltryptamine on a reflex response to radiant heat in mice
Neurosci Lett, 90 (1-2), 203-7
PubMed 2457854
Increased behavioural response to intrathecal serotonin after lesion of serotonergic pathways with 5,7-dihydroxytryptamine seems not to be due to depletion of serotonin
Acta Physiol Scand, 134 (2), 291-4
PubMed 2976239
Acute and chronic treatment with selective serotonin uptake inhibitors in mice: effects on nociceptive sensitivity and response to 5-methoxy-N,N-dimethyltryptamine
Pain, 32 (3), 333-40
PubMed 2966334
Mechanisms by which the putative serotonin receptor antagonist metitepin alters nociception in mice
J Neural Transm, 73 (1), 31-41
PubMed 2969948
5-HT depletion with 5,7-DHT, PCA and PCPA in mice: differential effects on the sensitivity to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests
Brain Res, 440 (1), 42-52
PubMed 2965956
Increased behavioural response to intrathecal substance P after intracerebroventricular 5,7-dihydroxytryptamine but not after p-chlorophenylalanine administration
Acta Physiol Scand, 132 (3), 419-23
PubMed 2465667
Effects of serotonin receptor antagonists and agonists on the tail-flick response in mice involve altered tail-skin temperature
Neuropharmacology, 27 (9), 889-93
PubMed 2972938
Apparent hyperalgesia after lesions of the descending serotonergic pathways is due to increased tail skin temperature
Pain, 33 (2), 225-31
PubMed 3380562
Publications 1987
Test-dependent changes in nociception after administration of the putative serotonin antagonist metitepin in mice
Neuropharmacology, 26 (8), 1121-6
PubMed 3658119





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