
| Thor Edvardsen | |
| Position: | Professor |
| Phone: | +47 23071393 |
| Email: | |
Research fellows: Ola Gjesdal, Andreas Espinoza, Stein Ørn, Trond Vartdal, Marit Kristine Smedsrud, Kristina Hermann Haugaa, Siv Hestenes
Main focus:
Assessment of regional LV function for prognostic considerations in patient care
Main methods:
Echocardiography, MR, LV hemodynamics
Author network for Thor Edvardsen by COREMINE medical
Publications in press
The continued discovery of left atrial function
Eur Heart J Cardiovasc Imaging (in press)
PubMed 22277116
Publications 2012
Republished article: Imaging assessment of ventricular mechanics
Postgrad Med J, 88 (1036), 105-12
PubMed 22262782
Impaired diastolic function and disruption of the force-frequency relationship in the right ventricle of newborn pigs resuscitated with 100% oxygen
Neonatology, 101 (2), 147-53
PubMed 21952615
Publications 2011
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, 300 (4), H1291-302
PubMed 21186275
Left ventricular systolic and diastolic function improve after acute myocardial infarction treated with acute percutaneous coronary intervention, but are not influenced by intracoronary injection of autologous mononuclear bone marrow cells: a 3 year serial echocardiographic sub-study of the randomized-controlled ASTAMI study
Eur J Echocardiogr, 12 (2), 98-106
PubMed 20851818
Can modern echocardiographic techniques predict drug-induced cardiotoxicity?
J Am Coll Cardiol, 57 (22), 2271-2
PubMed 21616288
Imaging assessment of ventricular mechanics
Heart, 97 (16), 1349-56
PubMed 21775511
Postsystolic shortening is a strong predictor of recovery of systolic function in patients with non-ST-elevation myocardial infarction
Eur J Echocardiogr, 12 (7), 483-9
PubMed 21609975
Automated detection of myocardial ischaemia by epicardial miniature ultrasound transducers--a novel tool for patient monitoring during cardiac surgery
Eur J Cardiothorac Surg, 39 (1), 53-9
PubMed 20627751
Mechanisms of abnormal systolic motion of the interventricular septum during left bundle-branch block
Circ Cardiovasc Imaging, 4 (3), 264-73
PubMed 21393502
Detection of irregular patterns of myocardial contraction in patients with hypertensive heart disease: a two-dimensional ultrasound speckle tracking study
J Hypertens, 29 (11), 2255-64
PubMed 21946697
Mean strain throughout the heart cycle by longitudinal two-dimensional speckle-tracking echocardiography enables early prediction of infarct size
J Am Soc Echocardiogr, 24 (10), 1118-25
PubMed 21764553
Evaluation of right ventricular dysfunction by myocardial strain echocardiography in patients with intestinal carcinoid disease
J Am Soc Echocardiogr, 24 (6), 644-50
PubMed 21440415
Prediction of life-threatening arrhythmias--still an unresolved problem
Cardiology, 118 (2), 129-37
PubMed 21555886
Regional myocardial function after intracoronary bone marrow cell injection in reperfused anterior wall infarction - a cardiovascular magnetic resonance tagging study
J Cardiovasc Magn Reson, 13, 22
PubMed 21414223
Echocardiographic evaluation of hemodynamics in patients with decompensated systolic heart failure
Circ Cardiovasc Imaging, 4 (3), 220-7
PubMed 21398512
Longitudinal myocardial contribution to peak systolic flow and stroke volume in the neonatal heart
Pediatr Res, 70 (4), 345-51
PubMed 21691252
Mechanism of prolonged electromechanical delay in late activated myocardium during left bundle branch block
Am J Physiol Heart Circ Physiol, 301 (6), H2334-43
PubMed 21984549
Prognostic usefulness of circulating high-sensitivity troponin T in aortic stenosis and relation to echocardiographic indexes of cardiac function and anatomy
Am J Cardiol, 108 (1), 88-91
PubMed 21529731
Right ventricular mechanical dispersion is related to malignant arrhythmias: a study of patients with arrhythmogenic right ventricular cardiomyopathy and subclinical right ventricular dysfunction
Eur Heart J, 32 (9), 1089-96
PubMed 21406439
The advantage of global strain compared to left ventricular ejection fraction to predict outcome after acute myocardial infarction
Echocardiography, 28 (5), 556-63
PubMed 21535118
Detection of left ventricular dysfunction by global longitudinal systolic strain in patients with chronic aortic regurgitation
J Am Soc Echocardiogr, 24 (11), 1253-9
PubMed 21908174
Left ventricular function assessed by two-dimensional speckle tracking echocardiography in long-term survivors of Hodgkin's lymphoma treated by mediastinal radiotherapy with or without anthracycline therapy
Am J Cardiol, 107 (3), 472-7
PubMed 21257017
Publications 2010
Relation of coronary artery calcium score to premature coronary artery disease in survivors >15 years of Hodgkin's lymphoma
Am J Cardiol, 105 (2), 149-52
PubMed 20102909
Activin A in carcinoid heart disease: a possible role in diagnosis and pathogenesis
Neuroendocrinology, 92 (3), 168-77
PubMed 20720391
Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors
BMC Cancer, 10, 6
PubMed 20053285
[Dramatic case report caused by a rare bacteria]
Tidsskr Nor Laegeforen, 130 (2), 149-51
PubMed 20125205
Strain echocardiography and wall motion score index predicts final infarct size in patients with non-ST-segment-elevation myocardial infarction
Circ Cardiovasc Imaging, 3 (2), 187-94
PubMed 20075142
Strain echocardiography predicts acute coronary occlusion in patients with non-ST-segment elevation acute coronary syndrome
Eur J Echocardiogr, 11 (6), 501-8
PubMed 20185525
Detecting myocardial ischaemia using miniature ultrasonic transducers--a feasibility study in a porcine model
Eur J Cardiothorac Surg, 37 (1), 119-26
PubMed 19581103
Acute coronary occlusion in non-ST-elevation acute coronary syndrome: outcome and early identification by strain echocardiography
Heart, 96 (19), 1550-6
PubMed 20643662
Changes of myocardial function in patients with non-ST-elevation acute coronary syndrome awaiting coronary angiography
Am J Cardiol, 105 (9), 1212-8
PubMed 20403468
Automatic real-time detection of myocardial ischemia by epicardial accelerometer
J Thorac Cardiovasc Surg, 139 (4), 1026-32
PubMed 19717169
Transmural differences in myocardial contraction in long-QT syndrome: mechanical consequences of ion channel dysfunction
Circulation, 122 (14), 1355-63
PubMed 20855658
High prevalence of exercise-induced arrhythmias in catecholaminergic polymorphic ventricular tachycardia mutation-positive family members diagnosed by cascade genetic screening
Europace, 12 (3), 417-23
PubMed 20106799
Mechanical dispersion assessed by myocardial strain in patients after myocardial infarction for risk prediction of ventricular arrhythmia
JACC Cardiovasc Imaging, 3 (3), 247-56
PubMed 20223421
[Catecholaminergic polymorphic ventricular tachycardia]
Tidsskr Nor Laegeforen, 130 (2), 139-42
PubMed 20125202
Atrioventricular valve annulus velocity and acceleration during global hypoxia in newborn pigs - assessment of myocardial function
Neonatology, 97 (2), 100-7
PubMed 19713716
Ejection time-corrected systolic velocity improves accuracy in the evaluation of myocardial dysfunction: a study in piglets
Pediatr Cardiol, 31 (7), 1070-8
PubMed 20721662
Evaluation of left ventricular dyssynchrony by onset of active myocardial force generation: a novel method that differentiates between electrical and mechanical etiologies
Circ Cardiovasc Imaging, 3 (4), 405-14
PubMed 20494943
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Res Cardiol, 105 (1), 89-98
PubMed 19823891
Publications 2009
Intra-aortic balloon counterpulsation as a bridge to heart transplantation does not impair long-term survival
Eur J Heart Fail, 11 (7), 709-14
PubMed 19515719
Left ventricle longitudinal deformation assessment by mitral annulus displacement or global longitudinal strain in chronic ischemic heart disease: are they interchangeable?
J Am Soc Echocardiogr, 22 (7), 823-30
PubMed 19505792
Detection of myocardial ischaemia by epicardial accelerometers in the pig
Br J Anaesth, 102 (1), 29-37
PubMed 19022793
Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome
Eur Heart J, 30 (3), 330-7
PubMed 18940888
Abnormal left ventricular relaxation in patients with long QT syndrome: reply
Eur. Heart J., 30 (22), 2814-2815
Clinical assessment of left ventricular rotation and strain: a novel approach for quantification of function in infarcted myocardium and its border zones
Am J Physiol Heart Circ Physiol, 297 (1), H257-67
PubMed 19395547
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure
Eur J Heart Fail, 11 (8), 771-8
PubMed 19567409
A novel echocardiographic marker of end systole in the ischemic left ventricle: "tug of war" sign
Am J Physiol Heart Circ Physiol, 296 (3), H645-54
PubMed 19122168
Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load
Circulation, 119 (19), 2578-86
PubMed 19414640
Response to Letter Regarding Article, "Mechanisms of Preejection and Postejection Velocity Spikes in Left Ventricular Myocardium: Interaction Between Wall Deformation and Valve Events"
Circulation, 119 (6), E205
Diagnostic capability and reproducibility of strain by Doppler and by speckle tracking in patients with acute myocardial infarction
JACC Cardiovasc Imaging, 2 (1), 24-33
PubMed 19356529
Comparison of left ventricular ejection fraction and left ventricular global strain as determinants of infarct size in patients with acute myocardial infarction
J Am Soc Echocardiogr, 22 (11), 1232-8
PubMed 19815383
Valvular dysfunction and left ventricular changes in Hodgkin's lymphoma survivors. A longitudinal study
Br J Cancer, 101 (4), 575-81
PubMed 19623176
Microvascular obstruction is a major determinant of infarct healing and subsequent left ventricular remodelling following primary percutaneous coronary intervention
Eur Heart J, 30 (16), 1978-85
PubMed 19502624
C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction
Eur Heart J, 30 (10), 1180-6
PubMed 19299430
Publications 2008
Noninvasive separation of large, medium, and small myocardial infarcts in survivors of reperfused ST-elevation myocardial infarction: a comprehensive tissue Doppler and speckle-tracking echocardiography study
Circ Cardiovasc Imaging, 1 (3), 189-96, 2 p following 196
PubMed 19808542
Feasibility of a three-axis epicardial accelerometer in detecting myocardial ischemia in cardiac surgical patients
J Thorac Cardiovasc Surg, 136 (6), 1496-502
PubMed 19114197
Apical rotation by speckle tracking echocardiography: a simplified bedside index of left ventricular twist
J Am Soc Echocardiogr, 21 (10), 1121-8
PubMed 18760568
Left ventricular function in patients with transposition of the great arteries operated with atrial switch
Pediatr Cardiol, 29 (3), 597-603
PubMed 18040733
Mechanisms of preejection and postejection velocity spikes in left ventricular myocardium: interaction between wall deformation and valve events
Circulation, 118 (4), 373-80
PubMed 18606917
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
J Biol Chem, 283 (16), 10601-10
PubMed 18165681
Publications 2007
The influence of left ventricular size and global function on regional myocardial contraction and relaxation in an adult population free of cardiovascular disease: a tagged CMR study of the MESA cohort
J Cardiovasc Magn Reson, 9 (6), 921-30
PubMed 18066753
Global longitudinal strain by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease: authors' reply
Clin. Sci., 113 (9-10), 394-395
Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease
Clin Sci (Lond), 113 (6), 287-96
PubMed 17501720
Effects of preload alterations on peak early diastolic mitral annulus velocities evaluated by tissue Doppler echocardiography
Eur J Anaesthesiol, 24 (2), 159-65
PubMed 17202014
Regional left ventricular function in individuals with mild to moderate renal insufficiency: the Multi-Ethnic Study of Atherosclerosis
Am Heart J, 153 (4), 545-51
PubMed 17383292
Effect of left ventricular scar size, location, and transmurality on left ventricular remodeling with healed myocardial infarction
Am J Cardiol, 99 (8), 1109-14
PubMed 17437737
Contraction pattern of the systemic right ventricle shift from longitudinal to circumferential shortening and absent global ventricular torsion
J Am Coll Cardiol, 49 (25), 2450-6
PubMed 17599609
Relationship between C-reactive protein levels and regional left ventricular function in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis
J Am Coll Cardiol, 49 (5), 594-600
PubMed 17276184
Early prediction of infarct size by strain Doppler echocardiography after coronary reperfusion
J Am Coll Cardiol, 49 (16), 1715-21
PubMed 17448374
Publications 2006
Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging
J Am Coll Cardiol, 47 (4), 789-93
PubMed 16487846
[Treatment of cardiac failure with an intra-aortic balloon pump]
Tidsskr Nor Laegeforen, 126 (16), 2104-6
PubMed 16932779
Reduced left ventricular function in hypoxemic newborn pigs: a strain Doppler echocardiographic study
Pediatr Res, 59 (5), 630-5
PubMed 16627872
Coronary artery atherosclerosis is related to reduced regional left ventricular function in individuals without history of clinical cardiovascular disease: the Multiethnic Study of Atherosclerosis
Arterioscler Thromb Vasc Biol, 26 (1), 206-11
PubMed 16269666
Systolic dysfunction in heart failure with normal ejection fraction: speckle-tracking echocardiography
Prog Cardiovasc Dis, 49 (3), 207-14
PubMed 17084180
Regional diastolic dysfunction in individuals with left ventricular hypertrophy measured by tagged magnetic resonance imaging--the Multi-Ethnic Study of Atherosclerosis (MESA)
Am Heart J, 151 (1), 109-14
PubMed 16368301
The benefit of upgrading chronically right ventricle-paced heart failure patients to resynchronization therapy demonstrated by strain rate imaging
Heart Rhythm, 3 (4), 435-42
PubMed 16567291
Subclinical atherosclerosis and incipient regional myocardial dysfunction in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis (MESA)
J Am Coll Cardiol, 47 (12), 2420-8
PubMed 16781369
Lower myocardial perfusion reserve is associated with decreased regional left ventricular function in asymptomatic participants of the multi-ethnic study of atherosclerosis
Circulation, 114 (4), 289-97
PubMed 16847154
Hypertension and smoking are associated with reduced regional left ventricular function in asymptomatic: individuals the Multi-Ethnic Study of Atherosclerosis
J Am Coll Cardiol, 47 (6), 1150-8
PubMed 16545644
Grading of myocardial dysfunction by tissue Doppler echocardiography: a comparison between velocity, displacement, and strain imaging in acute ischemia
J Am Coll Cardiol, 47 (8), 1672-82
PubMed 16631008
Publications 2005
The effect of intra-aortic balloon counterpulsation on left ventricular functional recovery early after acute myocardial infarction: a randomized experimental magnetic resonance imaging study
Eur Heart J, 26 (12), 1235-41
PubMed 15716282
Interaction between left ventricular wall motion and intraventricular flow propagation in acute and chronic ischemia
Am J Physiol Heart Circ Physiol, 289 (2), H732-7
PubMed 15849233
Why do we need magnetic resonance imaging in cardiology?
Scand Cardiovasc J, 39 (5), 260-3
PubMed 16269394
New noninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography
Circulation, 112 (20), 3149-56
PubMed 16286606
Left ventricular concentric remodeling is associated with decreased global and regional systolic function: the Multi-Ethnic Study of Atherosclerosis
Circulation, 112 (7), 984-91
PubMed 16103253
Publications 2004
Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging
Eur Heart J, 25 (16), 1419-27
PubMed 15321700
Predictors of exercise capacity and the impact of angiographic coronary artery disease in heart transplant recipients
Am Heart J, 147 (1), 49-54
PubMed 14691418
Late systolic onset of regional LV relaxation demonstrated in three-dimensional space by MRI tissue tagging
Am J Physiol Heart Circ Physiol, 287 (4), H1740-6
PubMed 15205167
Detection of ischemia and new insight into left ventricular physiology by strain Doppler and tissue velocity imaging: assessment during coronary bypass operation of the beating heart
J Am Soc Echocardiogr, 17 (12), 1225-33
PubMed 15562259
Mechanisms of elevated plasma endothelin-1 in CHF: congestion increases pulmonary synthesis and secretion of endothelin-1
Cardiovasc Res, 63 (1), 41-50
PubMed 15194460
Publications 2003
Doppler strain rate echocardiography versus magnetic resonance imaging - Response
Circulation, 107 (3), E23
Quantitative assessment of intrinsic regional myocardial deformation by Doppler strain rate echocardiography in humans - Response
Circulation, 107 (7), E49
Postsystolic shortening of ischemic myocardium: a mechanism of abnormal intraventricular filling
Am J Physiol Heart Circ Physiol, 284 (6), H2343-50
PubMed 12574003
Publications 2002
Quantitative assessment of intrinsic regional myocardial deformation by Doppler strain rate echocardiography in humans: validation against three-dimensional tagged magnetic resonance imaging
Circulation, 106 (1), 50-6
PubMed 12093769
Quantification of left ventricular systolic function by tissue Doppler echocardiography: added value of measuring pre- and postejection velocities in ischemic myocardium
Circulation, 105 (17), 2071-7
PubMed 11980687
Postsystolic shortening in ischemic myocardium: active contraction or passive recoil?
Circulation, 106 (6), 718-24
PubMed 12163433
Publications 2001
Myocardial function in ischemic heart disease - Reply
J. Am. Soc. Echocardiogr., 14 (5), 414
Regional myocardial systolic function during acute myocardial ischemia assessed by strain Doppler echocardiography
J Am Coll Cardiol, 37 (3), 726-30
PubMed 11693743
Publications 2000
Acute regional myocardial ischemia identified by 2-dimensional multiregion tissue Doppler imaging technique
J Am Soc Echocardiogr, 13 (11), 986-94
PubMed 11093100
Myocardial strain by Doppler echocardiography. Validation of a new method to quantify regional myocardial function
Circulation, 102 (10), 1158-64
PubMed 10973846
Publications 1999
Reversal of intraventricular flow propagation during isovolumic relaxation: A marker of anterior wall dysfunction
J Am Soc Echocardiogr, 12 (10), 801-10
PubMed 10511648
Diastolic flow pattern in the normal left ventricle
J Am Soc Echocardiogr, 12 (6), 500-7
PubMed 10359922




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