Publications CRU
Publications in press
Role functioning before start of adjuvant treatment was an independent prognostic factor for survival and time to failure. A report from the Nordic adjuvant interferon trial for patients with high-risk melanoma
Acta Oncol (in press)
PubMed 23621752
Publications 2013
A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies
Eur J Cancer, 49 (7), 1521-9
PubMed 23433846
Liver transplantation for nonresectable liver metastases from colorectal cancer
Ann Surg, 257 (5), 800-6
PubMed 23360920
Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study
Ann Oncol, 24 (1), 152-60
PubMed 22967994
Publications 2012
Quality of life following liver transplantation in patients with liver metastases from colorectal carcinoma
Scand J Caring Sci, 26 (4), 713-9
PubMed 22452269
Health-related quality of life in patients with high-risk melanoma randomised in the Nordic phase 3 trial with adjuvant intermediate-dose interferon alfa-2b
Eur J Cancer, 48 (13), 2012-9
PubMed 22196968
Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours
Br J Cancer, 106 (11), 1728-34
PubMed 22531637
Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer
PLoS One, 7 (11), e50806
PubMed 23226389
Evaluation of complete cytoreductive surgery and two intraperitoneal chemotherapy techniques in Pseudomyxoma peritonei
Eur J Surg Oncol, 38 (10), 969-76
PubMed 22763244
Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study
J Clin Oncol, 30 (15), 1755-62
PubMed 22473155
Mechanisms involved in PGE2-induced transactivation of the epidermal growth factor receptor in MH1C1 hepatocarcinoma cells
J Exp Clin Cancer Res, 31, 72
PubMed 22967907
Publications 2011
Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy
Radiat Oncol, 6, 33
PubMed 21473790
Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial
Clin Cancer Res, 17 (21), 6847-57
PubMed 21918169
Defining the critical hurdles in cancer immunotherapy
J Transl Med, 9 (1), 214
PubMed 22168571
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
J Transl Med, 9, 204
PubMed 22123319
Two different durations of adjuvant therapy with intermediate-dose interferon alfa-2b in patients with high-risk melanoma (Nordic IFN trial): a randomised phase 3 trial
Lancet Oncol, 12 (2), 144-52
PubMed 21256809
Telomerase peptide vaccination combined with temozolomide: a clinical trial in stage IV melanoma patients
Clin Cancer Res, 17 (13), 4568-80
PubMed 21586625
Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells
BMC Cancer, 11, 421
PubMed 21961726
Potentially curative radiotherapy for non-small-cell lung cancer in Norway: a population-based study of survival
Int J Radiat Oncol Biol Phys, 80 (1), 133-41
PubMed 20452137
hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
Cancer Immunol Immunother, 60 (6), 809-18
PubMed 21365467
Salvage surgery for locally recurrent rectal cancer: total mesorectal excision during the primary operation does not influence the outcome
Colorectal Dis, 13 (5), 506-11
PubMed 20236148
The preclinical and clinical activity of aviscumine: a potential anticancer drug
Eur J Cancer, 47 (10), 1450-7
PubMed 21482461
Current approaches to adjuvant therapy of melanoma
Eur J Cancer, 47 Suppl 3, S336-7
PubMed 21944005
Publications 2010
SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance
Pharmacogenomics J, 10 (6), 513-23
PubMed 20157331
Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling
Int J Radiat Oncol Biol Phys, 78 (2), 555-62
PubMed 20675069
Liver transplantation for colorectal liver metastases: revisiting the concept
Transpl Int, 23 (7), 679-85
PubMed 20477993
IL-7 is expressed and secreted by human skeletal muscle cells
Am J Physiol Cell Physiol, 298 (4), C807-16
PubMed 20089933
Human malignant melanoma harbours a large fraction of highly clonogenic cells that do not express markers associated with cancer stem cells
Pigment Cell Melanoma Res, 23 (3), 449-51
PubMed 20236249
Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study
Lancet Oncol, 11 (5), 459-64
PubMed 20378407
Publications 2009
Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced non-small-cell lung cancer
J Clin Oncol, 27 (25), 4116-23
PubMed 19636016
Autoimmune antibodies and recurrence-free interval in melanoma patients treated with adjuvant interferon
J Natl Cancer Inst, 101 (12), 869-77
PubMed 19509353
Cancer therapy targeted at cellular signal transduction mechanisms: strategies, clinical results, and unresolved issues
Eur J Pharmacol, 625 (1-3), 6-22
PubMed 19836383
Intravenous administration of CP-4055 (ELACYT) in patients with solid tumours. A Phase I study
Acta Oncol, 48 (1), 137-45
PubMed 18607882
Phase III study by the Norwegian lung cancer study group: pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer
J Clin Oncol, 27 (19), 3217-24
PubMed 19433683
A prospective phase II study: high-dose pemetrexed as second-line chemotherapy in small-cell lung cancer
Lung Cancer, 63 (1), 88-93
PubMed 18538889
Assessing quality of life in a randomized clinical trial: correcting for missing data
BMC Med Res Methodol, 9, 28
PubMed 19405936
Extended total mesorectal excision in locally advanced rectal cancer (T4a) and the clinical role of MRI-evaluated neo-adjuvant downstaging
Colorectal Dis, 11 (7), 759-67
PubMed 18662240
Publications 2008
Radiotherapy for rectal cancer is associated with reduced serum testosterone and increased FSH and LH
Int J Radiat Oncol Biol Phys, 70 (3), 722-7
PubMed 18262088
Bone marrow micrometastases in advanced stage non-small cell lung carcinoma patients
Lung Cancer, 61 (2), 170-6
PubMed 18261824
Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes
J Cell Physiol, 214 (2), 371-80
PubMed 17654493
S100B in bone marrow aspirates in healthy individuals and malignant melanoma patients
Melanoma Res, 18 (2), 134-40
PubMed 18337650
Treatment outcome in performance status 2 advanced NSCLC patients administered platinum-based combination chemotherapy
Lung Cancer, 62 (2), 253-60
PubMed 18417246
Population-based prevalence of CDKN2A and CDK4 mutations in patients with multiple primary melanomas
Genes Chromosomes Cancer, 47 (2), 175-84
PubMed 18023021
Prognostic factors after preoperative irradiation and surgery for locally advanced rectal cancer
Eur J Surg Oncol, 34 (4), 410-7
PubMed 17614249
A threefold dose intensity treatment with ifosfamide, carboplatin, and etoposide for patients with small cell lung cancer: a randomized trial
J Natl Cancer Inst, 100 (8), 533-41
PubMed 18398095
[Molecular targeted therapy in colorectal cancer]
Tidsskr Nor Laegeforen, 128 (2), 190-3
PubMed 18202731
Preoperative irradiation and surgery for local recurrence of rectal and rectosigmoid cancer. Prognostic factors with regard to survival and further local recurrence
Colorectal Dis, 10 (1), 48-57
PubMed 18028472
Publications 2007
Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy
BMC Cancer, 7, 197
PubMed 17956601
Vinorelbine/carboplatin vs gemcitabine/carboplatin in advanced NSCLC shows similar efficacy, but different impact of toxicity
Br J Cancer, 97 (3), 283-9
PubMed 17595658
The prognostic role of blood lymphocyte subset distribution in patients with resected high-risk primary or regionally metastatic melanoma
J Immunother, 30 (7), 773-9
PubMed 17893569
T cell responses in melanoma patients after vaccination with tumor-mRNA transfected dendritic cells
Cancer Immunol Immunother, 56 (5), 659-75
PubMed 16947019
Prostaglandins enhance epidermal growth factor-induced DNA synthesis in hepatocytes by stimulation of E prostanoid 3 and F prostanoid receptors
J Pharmacol Exp Ther, 322 (3), 1044-50
PubMed 17567965
[Treatment of locally recurrent rectal cancer]
Tidsskr Nor Laegeforen, 127 (23), 3097-101
PubMed 18049503
Publications 2006
High sensitivity assays for docetaxel and paclitaxel in plasma using solid-phase extraction and high-performance liquid chromatography with UV detection
BMC Clin Pharmacol, 6, 2
PubMed 16412237
Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer
Cancer Immunol Immunother, 55 (12), 1553-64
PubMed 16491401
Dietary intake and nutritional indicators are transiently compromised during radiotherapy for rectal cancer
Eur J Clin Nutr, 60 (1), 113-9
PubMed 16205744
[Malignant melanoma--diagnosis and treatment]
Tidsskr Nor Laegeforen, 126 (23), 3094-7
PubMed 17160112
Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA
Cancer Gene Ther, 13 (10), 905-18
PubMed 16710345
Palliative thoracic radiotherapy in locally advanced non-small cell lung cancer: can quality-of-life assessments help in selection of patients for short- or long-course radiotherapy?
J Thorac Oncol, 1 (8), 816-24
PubMed 17409965
[Retraction of: Diagnostics and treatment of early stages of oral cancer]
Tidsskr Nor Laegeforen, 126 (17), 2287
PubMed 16967079
Publications 2005
Weekly docetaxel with concurrent radiotherapy in locally advanced non-small cell lung cancer: a phase I/II study with 5 years' follow-up
Lung Cancer, 50 (1), 97-105
PubMed 16005105
[Antineoplastic agents targeting tyrosine kinases]
Tidsskr Nor Laegeforen, 125 (22), 3115-9
PubMed 16299568
Preclinical full-scale evaluation of dendritic cells transfected with autologous tumor-mRNA for melanoma vaccination
Cancer Gene Ther, 12 (6), 579-91
PubMed 15818380
Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma
Invest New Drugs, 23 (3), 253-6
PubMed 15868382
Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients
Br J Cancer, 93 (7), 749-56
PubMed 16136047
Sustained diacylglycerol accumulation resulting from prolonged G protein-coupled receptor agonist-induced phosphoinositide breakdown in hepatocytes
J Cell Biochem, 94 (2), 389-402
PubMed 15526278
Demonstration of EGFR gene copy loss in colorectal carcinomas by fluorescence in situ hybridization (FISH): a surrogate marker for sensitivity to specific anti-EGFR therapy?
Histopathology, 47 (6), 560-4
PubMed 16324192
Phase II study of E7070 in patients with metastatic melanoma
Ann Oncol, 16 (1), 158-61
PubMed 15598954
Immediate or delayed radiotherapy in advanced non-small cell lung cancer (NSCLC)? Data from a prospective randomised study
Radiother Oncol, 75 (2), 141-8
PubMed 16094739
Second-line chemotherapy in recurrent small cell lung cancer. Results from a crossover schedule after primary treatment with cisplatin and etoposide (EP-regimen) or cyclophosphamide, epirubicin, and vincristin (CEV-regimen)
Lung Cancer, 48 (2), 251-61
PubMed 15829326
Clinical outcome in patients with complete pathologic response (pT0) to preoperative irradiation/chemo-irradiation operated for locally advanced or locally recurrent rectal cancer
J Surg Oncol, 92 (1), 70-5
PubMed 16180215
Publications 2004
Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study
J Clin Oncol, 22 (6), 1118-25
PubMed 15020614
Development of an optimal sampling strategy for clinical pharmacokinetic studies of the novel anthracycline disaccharide analogue MEN-10755
Cancer Chemother Pharmacol, 54 (1), 64-70
PubMed 15069581
Individualized patient dosing in phase I clinical trials: the role of escalation with overdose control in PNU-214936
J Clin Oncol, 22 (4), 602-9
PubMed 14966084
Immunomagnetic detection and clinical significance of micrometastatic tumor cells in malignant melanoma patients
Clin Cancer Res, 10 (12 Pt 1), 4134-9
PubMed 15217950
Biochemical signs of impaired cobalamin status during and after radiotherapy for rectal cancer
Int J Radiat Oncol Biol Phys, 60 (3), 807-13
PubMed 15465197
Hypofractionated palliative radiotherapy (17 Gy per two fractions) in advanced non-small-cell lung carcinoma is comparable to standard fractionation for symptom control and survival: a national phase III trial
J Clin Oncol, 22 (5), 801-10
PubMed 14990635
Publications 2003
The value of prognostic factors in small cell lung cancer: results from a randomised multicenter study with minimum 5 year follow-up
Lung Cancer, 39 (3), 303-13
PubMed 12609569
Radiation therapy induced changes in male sex hormone levels in rectal cancer patients
Radiother Oncol, 68 (3), 249-53
PubMed 13129632
Epidermal growth factor receptor inhibition induces trichomegaly
Acta Oncol, 42 (4), 345-6
PubMed 12899508
Quality of life during radiotherapy for rectal cancer
Eur J Cancer, 39 (5), 587-94
PubMed 12628837
EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes
J Cell Physiol, 196 (1), 113-23
PubMed 12767047
Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report
Eur J Cancer, 39 (1), 70-7
PubMed 12504661
Role of ERK, p38 and PI3-kinase in EGF receptor-mediated mitogenic signalling in cultured rat hepatocytes: requirement for sustained ERK activation
Cell Physiol Biochem, 13 (4), 229-38
PubMed 12876381
Publications 2002
Ca2+-mediated activation of ERK in hepatocytes by norepinephrine and prostaglandin F2 alpha: role of calmodulin and Src kinases
BMC Cell Biol, 3, 5
PubMed 11914123
Cisplatin and etoposide regimen is superior to cyclophosphamide, epirubicin, and vincristine regimen in small-cell lung cancer: results from a randomized phase III trial with 5 years' follow-up
J Clin Oncol, 20 (24), 4665-72
PubMed 12488411
Publications 2001
Pharmacokinetics of MEN-10755, a novel anthracycline disaccharide analogue, in two phase I studies in adults with advanced solid tumours
Cancer Chemother Pharmacol, 48 (5), 361-9
PubMed 11761453
Cutaneous relapse of testicular embryonic carcinoma
J Urol, 165 (3), 909
PubMed 11176507
Immunobead-based detection and characterization of circulating tumor cells in melanoma patients
Recent Results Cancer Res, 158, 40-50
PubMed 11092032
Quality of life in patients with urinary diversion after operation for locally advanced rectal cancer
Eur J Surg Oncol, 27 (7), 645-51
PubMed 11669593
[Gene therapy in cancer]
Tidsskr Nor Laegeforen, 121 (4), 482-8
PubMed 11255868
[Diagnosis and treatment of oral precancerous lesions]
Tidsskr Nor Laegeforen, 121 (26), 3066-71 (Retracted)
PubMed 11757442
Publications 2000
Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma
J Clin Oncol, 18 (1), 158-66
PubMed 10623706
Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a study of the EORTC early clinical studies group (ECSG)
Cancer Chemother Pharmacol, 46 (2), 167-71
PubMed 10972487
Impaired nuclear accumulation and shortened phosphorylation of ERK after growth factor stimulation in cultured hepatocytes from rats exposed to 2-acetylaminofluorene
Mol Carcinog, 28 (2), 84-96
PubMed 10900465
In nonhepatic cells, cholesterol 7alpha-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis
J Lipid Res, 41 (8), 1347-55
PubMed 10946023
Phase I trial with weekly EO9, a novel bioreductive alkylating indoloquinone, by the EORTC Early Clinical Study Group (ECSG)
Cancer Chemother Pharmacol, 45 (1), 85-8
PubMed 10647507
Publications 1999
Role of diacylglycerol (DAG) in hormonal induction of S phase in hepatocytes: the DAG-dependent protein kinase C pathway is not activated by epidermal growth factor (EGF), but is involved in mediating the enhancement of responsiveness to EGF by vasopressin, angiotensin II, and norepinephrine
J Cell Physiol, 180 (2), 203-14
PubMed 10395290
EGF-induced activation of Stat1, Stat3, and Stat5b is unrelated to the stimulation of DNA synthesis in cultured hepatocytes
Biochem Biophys Res Commun, 258 (3), 565-71
PubMed 10329425
The relationship between activation of phosphoinositide-specific phospholipase C and growth stimulation by Ca2+-mobilizing hormones in hepatocytes
Pharmacol Toxicol, 84 (5), 234-40
PubMed 10361980
Publications 1998
Treatment and outcome of patients with extragonadal germ cell tumours--the Norwegian Radium Hospital's experience 1979-94
Br J Cancer, 77 (2), 329-35
PubMed 9461006
Dacarbazine-vindesine versus dacarbazine-vindesine-cisplatin in disseminated malignant melanoma. A randomised phase III trial
Eur J Cancer, 34 (9), 1368-74
PubMed 9849419
Clinical experience of fotemustine, cisplatin and high dose tamoxifen in patients with metastatic malignant melanoma
Melanoma Res, 8 (6), 565-72
PubMed 9918419
Zilascorb(H-2), a low-toxicity protein synthesis inhibitor that exhibits signs of anticancer activity in malignant melanoma
Anti-Cancer Drugs, 9 (9), 797-802
Zilascorb(2H), a low-toxicity protein synthesis inhibitor that exhibits signs of anticancer activity in malignant melanoma
Anticancer Drugs, 9 (9), 797-802
PubMed 9840726
Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment
J Clin Oncol, 16 (10), 3426-32
PubMed 9779722
Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1
Exp Cell Res, 243 (1), 161-72
PubMed 9716460
Response to transforming growth factor alpha (TGFalpha) and epidermal growth factor (EGF) in hepatocytes: lower EGF receptor affinity of TGFalpha is associated with more sustained activation of p42/p44 mitogen-activated protein kinase and greater efficacy in stimulation of DNA synthesis
J Cell Physiol, 175 (1), 10-8
PubMed 9491776
Publications 1997
[The project Better Cancer Care in Buskerud]
Tidsskr Nor Laegeforen, 117 (15), 2170-3
PubMed 9235704
Cholesterol 7alpha-hydroxylase influences the expression of hepatic apoA-I in two inbred mouse strains displaying different susceptibilities to atherosclerosis and in hepatoma cells
J Lipid Res, 38 (7), 1445-53
PubMed 9254069
Zilascorb(H-2), a new reversible protein synthesis inhibitor: Clinical study of an oral preparation
Anti-Cancer Drugs, 8 (3), 296-303
Zilascorb(2H), a new reversible protein synthesis inhibitor: clinical study of an oral preparation
Anticancer Drugs, 8 (3), 296-303
PubMed 9095337
Zeniplatin in advanced malignant melanoma and renal cancer: phase II studies with unexpected nephrotoxicity
Cancer Chemother Pharmacol, 40 (5), 439-43
PubMed 9272122
Publications 1996
Growth-promoting effects of Ca(2+)-mobilizing agents in hepatocytes: lack of correlation between the acute activation of phosphoinositide-specific phospholipase C and the stimulation of DNA synthesis by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2 alpha
J Cell Physiol, 168 (3), 608-17
PubMed 8816915
Epidermal growth factor behaves as a partial agonist in hepatocytes: effects on DNA synthesis in primary culture and competition with transforming growth factor alpha
Growth Factors, 13 (3-4), 171-9
PubMed 8919025
Phase II clinical trials with rhizoxin in breast cancer and melanoma. The EORTC Early Clinical Trials Group
Br J Cancer, 73 (3), 397-9
PubMed 8562349
Correlation of DNA ploidy and S-phase fraction with chemotherapeutic response and survival in a randomized study of disseminated malignant melanoma
Int J Cancer, 65 (1), 1-5
PubMed 8543385
Phase I pharmacokinetics and limited sampling strategies for the bioreductive alkylating drug EO9. EORTC Early Clinical Trials Group
Eur J Cancer, 32A (9), 1518-22
PubMed 8911111
Multicentre phase II pharmacological evaluation of rhizoxin. Eortc early clinical studies (ECSG)/pharmacology and molecular mechanisms (PAMM) groups
Br J Cancer, 74 (12), 1944-8
PubMed 8980394
Transcapillary forces of the subcutaneous tissue in patients treated with interleukin-2 and alpha-interferon: no capillary protein leak syndrome?
J Exp Ther Oncol, 1 (3), 155-61
PubMed 9414399
Rat hepatoma L35 cells, a liver-differentiated cell line, display resistance to bile acid repression of cholesterol 7 alpha-hydroxylase
J Lipid Res, 37 (3), 588-98
PubMed 8728321
Publications 1995
Serum levels of cytokines and soluble cytokine receptors in patients with metastatic renal cell carcinoma or malignant melanoma receiving IL-2/interferon-alpha combination therapy
Acta Oncol, 34 (5), 599-603
PubMed 7546824
On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: the relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C
J Cell Physiol, 164 (3), 465-73
PubMed 7650056
Dexamethasone inversely regulates DNA synthesis and phosphoenolpyruvate carboxykinase mRNA levels in cultured rat hepatocytes: interactions with insulin, glucagon, and transforming growth factor beta 1
Pharmacol Toxicol, 76 (3), 163-70
PubMed 7617540
Phase II studies of docetaxel in the treatment of various solid tumours. EORTC Early Clinical Trials Group and the EORTC Soft Tissue and Bone Sarcoma Group
Eur J Cancer, 31A Suppl 4, S21-4
PubMed 7577101
Publications 1994
Elevated glucose concentrations inhibit DNA synthesis and expression of c-myc in cultured hepatocytes
Biochem Biophys Res Commun, 202 (3), 1476-82
PubMed 8060330
Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2 alpha: additivity with the effect of norepinephrine, and synergism with epidermal growth factor
J Cell Physiol, 159 (1), 35-40
PubMed 8138589
Gemcitabine in patients with advanced malignant melanoma or gastric cancer: phase II studies of the EORTC Early Clinical Trials Group
Ann Oncol, 5 (5), 471-2
PubMed 8075055
Clinical studies with EO9, a new indoloquinone bioreductive alkylating cytotoxic agent. EORTC Early Clinical Trials Group
Oncol Res, 6 (10-11), 519-23
PubMed 7620220
Docetaxel (Taxotere) in advanced malignant melanoma: a phase II study of the EORTC Early Clinical Trials Group
Eur J Cancer, 30A (8), 1061-4
PubMed 7654429
Publications 1993
Effect of dietary cholesterol and taurocholate on cholesterol 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice
J Lipid Res, 34 (6), 923-31
PubMed 8354958
Activity and unexpected lung toxicity of the sequential administration of two alkylating agents--dacarbazine and fotemustine--in patients with melanoma
Eur J Cancer, 29A (5), 711-9
PubMed 8471329
A double blind study to evaluate the tolerability of gadodiamide injection and its effect on renal function in patients undergoing cerebral magnetic resonance imaging
Br J Radiol, 66 (790), 871-6
PubMed 8220968
Publications 1992
Detection of bone marrow metastases in small cell lung cancer patients. Comparison of immunologic and morphologic methods
Am J Pathol, 141 (3), 531-8
PubMed 1381558
Expression of 7 alpha-hydroxylase in non-hepatic cells results in liver phenotypic resistance of the low density lipoprotein receptor to cholesterol repression
J Biol Chem, 267 (32), 22695-8
PubMed 1429619
Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression
Cancer Res, 52 (21), 6088-91
PubMed 1356624
Stimulatory and inhibitory effects of catecholamines on DNA synthesis in primary rat hepatocyte cultures: role of alpha 1- and beta-adrenergic mechanisms
J Cell Physiol, 151 (1), 164-71
PubMed 1313818
Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line
Proc Natl Acad Sci U S A, 89 (19), 9161-5
PubMed 1409618
Neuron-specific enolase as a prognostic factor in metastatic malignant melanoma
Eur J Cancer, 28A (10), 1692-5
PubMed 1389487
Can ondansetron hydrochloride (Zofran) enhance the nephrotoxic potential of other drugs?
Ann Oncol, 3 (9), 774
PubMed 1450070
Sequential administration of dacarbazine and fotemustine in patients with disseminated malignant melanoma--an effective combination with unexpected toxicity
Eur J Cancer, 28 (2-3), 447-50
PubMed 1591062
Publications 1991
Increased plasma hypoxanthine values in humans during exposure to simulated altitude of 7,620 meters (25,000 feet)
Aviat Space Environ Med, 62 (11), 1044-9
PubMed 1741717
Uptake and degradation of filamentous actin and vitamin D-binding protein in the rat
Biochem J, 274 ( Pt 1), 237-41
PubMed 2001239
Regulation of cholesterol and bile acid homoeostasis in bile-obstructed rats
Biochem J, 280 ( Pt 2), 373-7
PubMed 1747109
Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol
Mol Cell Biol, 11 (4), 2049-56
PubMed 2005896
Selection of anti-SCLC antibodies for diagnosis of bone marrow metastasis
Br J Cancer Suppl, 14, 49-53
PubMed 1645572
Sequential administration of recombinant human interleukin-2 and dacarbazine in metastatic melanoma: a multicenter phase II study
J Clin Oncol, 9 (9), 1687-91
PubMed 1875225
Publications 1990
[Hyponatremia. A retrospective study of occurrence, etiology and mortality]
Tidsskr Nor Laegeforen, 110 (18), 2367-9
PubMed 2218994
Uptake and degradation of vitamin D binding protein and vitamin D binding protein-actin complex in vivo in the rat
Biochem J, 267 (3), 721-5
PubMed 2339982
Substrate stimulation of 7 alpha-hydroxylase, an enzyme located in the cholesterol-poor endoplasmic reticulum
J Biol Chem, 265 (13), 7145-9
PubMed 2332427
Studies of the L-myc DNA polymorphism and relation to metastasis in Norwegian lung cancer patients
Br J Cancer, 61 (6), 809-12
PubMed 1973618
Dual effects of glucagon and cyclic AMP on DNA synthesis in cultured rat hepatocytes: stimulatory regulation in early G1 and inhibition shortly before the S phase entry
J Cell Physiol, 144 (3), 523-30
PubMed 2167904
Neuron specific enolase (NSE) in serum of patients with malignant melanoma
Cancer Lett, 52 (1), 29-31
PubMed 2354416
Publications 1989
Sequential administration of recombinant human interleukin-2 and dacarbazine in metastatic melanoma. A multicentre phase II study
Eur J Cancer Clin Oncol, 25 Suppl 3, S41-3
PubMed 2697578
Publications 1988
Extrapulmonary, tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells
Cancer Res, 48 (15), 4382-8
PubMed 3390834
A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX
Int J Cancer, 41 (3), 442-9
PubMed 3346110
Sodium thiosulfate fails to increase the therapeutic index of intravenously administered cis-diamminedichloroplatinum (II) in mice bearing murine and human tumors
Cancer Chemother Pharmacol, 21 (2), 129-33
PubMed 3349560
Publications 1987
[Protracted digitalis poisoning]
Tidsskr Nor Laegeforen, 107 (9), 843-4
PubMed 3590123
Mitozolomide (NSC 353451), a new active drug in the treatment of malignant melanoma. Phase II trial in patients with advanced disease
Br J Cancer, 55 (4), 433-5
PubMed 3580266
Some procedures to reduce cis-platinum toxicity reduce antitumour activity
Cancer Treat Rev, 14 (3-4), 389-95
PubMed 3326670
Publications 1986
Chemosensitivity profiles of human cancers assessed by the 6-day SRC assay on serially xenografted tumors
Int J Cancer, 37 (4), 579-87
PubMed 3957463
Publications 1985
Very high concentration in intestinal lymph after oral, but not after intravenous, cyclosporine in the rat
Transplantation, 40 (2), 220-2
PubMed 4024244
Binding protein for vitamin D and its metabolites in rat mesenteric lymph
Am J Physiol, 249 (1 Pt 1), E1-5
PubMed 2990230
Activity of mitozolomide (NSC 353451), a new imidazotetrazine, against xenografts from human melanomas, sarcomas, and lung and colon carcinomas
Cancer Res, 45 (4), 1778-86
PubMed 3978640
Characteristics of human tumour xenografts transplanted under the renal capsule of immunocompetent mice
Br J Cancer, 51 (3), 347-56
PubMed 3970811
The six-day subrenal capsule assay (SRCA) for testing the response of human tumours to anticancer agents. Validity and usefulness in cancer research and treatment
Ann Chir Gynaecol Suppl, 199, 51-9
PubMed 3864392
Methodological aspects of the 6-day subrenal capsule assay for measuring the response of human tumors to anticancer agents
Anticancer Res, 5 (4), 329-37
PubMed 4037730
Publications 1984
Lymphatic absorption and transport of retinol and vitamin D-3 from rat intestine. Evidence for different pathways
Biochim Biophys Acta, 772 (2), 109-16
PubMed 6326820
Phase I study of the plant protein ricin
Cancer Res, 44 (2), 862-5
PubMed 6692385
Estrogen receptors and long-term prognosis in breast cancer
Cancer, 53 (11), 2525-9
PubMed 6713348
Reduced antineoplastic activity in mice of cisplatin administered with high salt concentration in the vehicle
J Natl Cancer Inst, 73 (3), 743-52
PubMed 6590919
Human tumor xenografts transplanted under the renal capsule of conventional mice. Growth rates and host immune response
Int J Cancer, 34 (5), 725-30
PubMed 6500747
Publications 1983
Plasma clearance, transfer, and distribution of vitamin D3 from intestinal lymph
Am J Physiol, 245 (4), E326-31
PubMed 6312805
Absorption, distribution, and transport of vitamin D3 and 25-hydroxyvitamin D3 in the rat
Am J Physiol, 245 (5 Pt 1), E463-7
PubMed 6314821
Publications 1982
Evidence that reverse cholesterol transport occurs in vivo and requires lecithin-cholesterol acyltransferase
Biochim Biophys Acta, 689 (2), 410-4
PubMed 7115718
26-hydroxylation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol by isolated nonparenchymal cells and hepatocytes from rat liver
J Lipid Res, 23 (9), 1321-7
PubMed 7161561
Transport of vitamin D3 from rat intestine. Evidence for transfer of vitamin D3 from chylomicrons to alpha-globulins
J Biol Chem, 257 (1), 146-50
PubMed 6171567
Metabolism of ochratoxin A by primary cultures of rat hepatocytes
Appl Environ Microbiol, 43 (6), 1267-71
PubMed 7103484
Publications 1981
Uptake and 25-hydroxylation of vitamin D3 by isolated rat liver cells
J Biol Chem, 256 (20), 10430-4
PubMed 6270111




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