Kjetil Taskén
Position: Professor
Phone: +47 228 40505
Email:
 

Author network for Kjetil Tasken by COREMINE medical


Publications 2017

Chellappa S, Hugenschmidt H, Hagness M, Subramani S, Melum E, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2017)
CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer
J Immunol, 198 (4), 1729-1739
PubMed 28053236

Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K (2017)
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
Cell Signal, 32, 1-11
PubMed 28077322

Publications 2016

Bains SJ, Mahic M, Myklebust TĹ, Smĺstuen MC, Yaqub S, Dřrum LM, Bjřrnbeth BA, Mřller B, Brudvik KW, Taskén K (2016)
Aspirin As Secondary Prevention in Patients With Colorectal Cancer: An Unselected Population-Based Study
J Clin Oncol, 34 (21), 2501-8
PubMed 27247217

Bjerregaard-Andersen K, Řstensen E, Scott JD, Taskén K, Morth JP (2016)
Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state
Acta Crystallogr F Struct Biol Commun, 72 (Pt 8), 591-7
PubMed 27487922

Dukic AR, McClymont DW, Taskén K (2016)
A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43-Ezrin Interaction Disruptors Using IncuCyte ZOOM
J Biomol Screen (in press)
PubMed 27628689

Landskron J, Taskén K (2016)
Phosphoprotein Detection by High-Throughput Flow Cytometry
Methods Mol Biol, 1355, 275-90
PubMed 26584933

Liu LL, Landskron J, Ask EH, Enqvist M, Sohlberg E, Traherne JA, Hammer Q, Goodridge JP, Larsson S, Jayaraman J, Oei VY, Schaffer M, Taskén K, Ljunggren HG, Romagnani C, Trowsdale J, Malmberg KJ, Béziat V (2016)
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Cell Rep, 15 (5), 1088-99
PubMed 27117418

Moltu K, Henjum K, Oberprieler NG, Bjřrnbeth BA, Taskén K (2016)
Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2
Hum Immunol, 78 (2), 129-137
PubMed 27769746

Stiksrud B, Lorvik KB, Kvale D, Mollnes TE, Ueland PM, Trřseid M, Taskén K, Dyrhol-Riise AM (2016)
Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
J Acquir Immune Defic Syndr, 73 (2), 138-48
PubMed 27632144

Tonby K, Wergeland I, Lieske NV, Kvale D, Tasken K, Dyrhol-Riise AM (2016)
The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection
BMC Infect Dis, 16 (1), 599
PubMed 27776487

Wehbi VL, Taskén K (2016)
Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units
Front Immunol, 7, 222
PubMed 27375620

Publications 2015

Calejo AI, Taskén K (2015)
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins
Front Pharmacol, 6, 192
PubMed 26441649

Chellappa S, Hugenschmidt H, Hagness M, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2015)
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer
Oncoimmunology, 5 (4), e1102828
PubMed 27141387

Chellappa S, Lieske NV, Hagness M, Line PD, Taskén K, Aandahl EM (2015)
Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells
J Leukoc Biol, 100 (1), 5-16
PubMed 26715685

Gerbaud P, Taskén K, Pidoux G (2015)
Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion
Front Pharmacol, 6, 202
PubMed 26441659

Lieske NV, Tonby K, Kvale D, Dyrhol-Riise AM, Tasken K (2015)
Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors
PLoS One, 10 (11), e0141903
PubMed 26544592

Parente-Ribes A, Skĺnland SS, Bürgler S, Os A, Wang D, Bogen B, Tjřnnfjord GE, Taskén K, Munthe LA (2015)
Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells
Haematologica, 101 (2), e59-62
PubMed 26589914

Pidoux G, Taskén K (2015)
Anchored PKA as a gatekeeper for gap junctions
Commun Integr Biol, 8 (4), e1057361
PubMed 26478781

Raslan Z, Magwenzi S, Aburima A, Taskén K, Naseem KM (2015)
Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3',5'-cyclic adenosine monophosphate-signaling pathway
J Thromb Haemost, 13 (9), 1721-34
PubMed 26176741

Santegoets SJ, Dijkgraaf EM, Battaglia A, Beckhove P, Britten CM, Gallimore A, Godkin A, Gouttefangeas C, de Gruijl TD, Koenen HJ, Scheffold A, Shevach EM, Staats J, Taskén K, Whiteside TL, Kroep JR, Welters MJ, van der Burg SH (2015)
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry
Cancer Immunol Immunother, 64 (10), 1271-86
PubMed 26122357

Publications 2014

Ellinger B, Silber J, Prashar A, Landskron J, Weber J, Rehermann S, Müller FJ, Smith S, Wrigley S, Taskén K, Gribbon P, Labes A, Imhoff JF (2014)
A phenotypic screening approach to identify anticancer compounds derived from marine fungi
Assay Drug Dev Technol, 12 (3), 162-75
PubMed 24735443

Halvorsen B, Smedbakken LM, Michelsen AE, Skjelland M, Bjerkeli V, Sagen EL, Taskén K, Bendz B, Gullestad L, Holm S, Biessen EA, Aukrust P (2014)
Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13
Atherosclerosis, 234 (2), 352-9
PubMed 24732574

Landskron J, Helland Ř, Torgersen KM, Aandahl EM, Gjertsen BT, Bjřrge L, Taskén K (2014)
Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients
Cancer Immunol Immunother, 64 (3), 337-47
PubMed 25416072

Pidoux G, Gerbaud P, Dompierre J, Lygren B, Solstad T, Evain-Brion D, Taskén K (2014)
A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion
J Cell Sci, 127 (Pt 19), 4172-85
PubMed 25052094

Rogne M, Taskén K (2014)
Compartmentalization of cAMP signaling in adipogenesis, lipogenesis, and lipolysis
Horm Metab Res, 46 (12), 833-40
PubMed 25247872

Skĺnland SS, Moltu K, Berge T, Aandahl EM, Taskén K (2014)
T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses
Biochem J, 460 (3), 399-410
PubMed 24665965

Spurgeon BE, Aburima A, Oberprieler NG, Taskén K, Naseem KM (2014)
Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets
J Thromb Haemost, 12 (10), 1733-43
PubMed 25056834

Publications 2013

Brudvik KW, Bains SJ, Seeberg LT, Labori KJ, Waage A, Taskén K, Aandahl EM, Bjřrnbeth BA (2013)
Aggressive treatment of patients with metastatic colorectal cancer increases survival: a scandinavian single-center experience
HPB Surg, 2013, 727095
PubMed 23840074

Cornez I, Joel M, Taskén K, Langmoen IA, Glover JC, Berge T (2013)
EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry
J Neurooncol, 112 (1), 49-57
PubMed 23299461

Landskron J, Taskén K (2013)
CD147 in regulatory T cells
Cell Immunol, 282 (1), 17-20
PubMed 23665204

Lone AM, Taskén K (2013)
Proinflammatory and immunoregulatory roles of eicosanoids in T cells
Front Immunol, 4, 130
PubMed 23760108

Rogne M, Taskén K (2013)
Cell signalling analyses in the functional genomics era
N Biotechnol, 30 (3), 333-8
PubMed 23369868

Singh M, Singh P, Vaira D, Torheim EA, Rahmouni S, Taskén K, Moutschen M (2013)
The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice
Eur J Clin Invest, 44 (2), 146-52
PubMed 24283208

Střrvold GL, Landskron J, Strozynski M, Arntzen MŘ, Koehler CJ, Kalland ME, Taskén K, Thiede B (2013)
Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis
J Proteomics, 91, 344-57
PubMed 23933134

Vang T, Landskron J, Viken MK, Oberprieler N, Torgersen KM, Mustelin T, Tasken K, Tautz L, Rickert RC, Lie BA (2013)
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses
Hum Immunol, 74 (5), 574-85
PubMed 23333624

Publications 2012

Brudvik KW, Taskén K (2012)
Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states
Br J Pharmacol, 166 (2), 411-9
PubMed 22141738

Hagness M, Henjum K, Landskron J, Brudvik KW, Bjřrnbeth BA, Foss A, Taskén K, Aandahl EM (2012)
Kinetics and activation requirements of contact-dependent immune suppression by human regulatory T cells
J Immunol, 188 (11), 5459-66
PubMed 22539784

Kalland ME, Solheim SA, Skĺnland SS, Taskén K, Berge T (2012)
Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG
Exp Cell Res, 318 (14), 1611-9
PubMed 22659621

Pollheimer J, Bodin J, Sundnes O, Edelmann RJ, Skĺnland SS, Sponheim J, Brox MJ, Sundlisaeter E, Loos T, Vatn M, Kasprzycka M, Wang J, Küchler AM, Taskén K, Haraldsen G, Hol J (2012)
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells
Arterioscler Thromb Vasc Biol, 33 (2), e47-55
PubMed 23162017

Scott JD, Dessauer CW, Taskén K (2012)
Creating order from chaos: cellular regulation by kinase anchoring
Annu Rev Pharmacol Toxicol, 53, 187-210
PubMed 23043438

Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Musumeci L, Francis D, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L (2012)
LYP inhibits T-cell activation when dissociated from CSK
Nat Chem Biol, 8 (5), 437-46
PubMed 22426112

Publications 2011

Andrei M, Bakkebř T, Klaveness J, Taskén K, Undheim K (2011)
Stereoselective synthesis of (RP)-8-substituted-N⁶-acylated and N⁶-alkylated adenosine-3',5'-cyclic phosphorothioic acids as cAMP antagonists
Eur J Med Chem, 46 (12), 5935-40
PubMed 22041460

Bjřrgo E, Moltu K, Taskén K (2011)
Phosphodiesterases as targets for modulating T-cell responses
Handb Exp Pharmacol (204), 345-63
PubMed 21695648

Brudvik KW, Henjum K, Aandahl EM, Bjřrnbeth BA, Taskén K (2011)
Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
Cancer Immunol Immunother, 61 (7), 1045-53
PubMed 22159472

Brudvik KW, Paulsen JE, Aandahl EM, Roald B, Taskén K (2011)
Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice
Mol Cancer, 10, 149
PubMed 22168384

Kalland ME, Oberprieler NG, Vang T, Taskén K, Torgersen KM (2011)
T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells
J Immunol, 187 (10), 5233-45
PubMed 22013130

Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD (2011)
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria
Proc Natl Acad Sci U S A, 108 (48), E1227-35
PubMed 22084075

Mosenden R, Moltu K, Ruppelt A, Berge T, Taskén K (2011)
Effects of type I protein kinase A modulation on the T cell distal pole complex
Scand J Immunol, 74 (6), 568-73
PubMed 21854406

Mosenden R, Singh P, Cornez I, Heglind M, Ruppelt A, Moutschen M, Enerbäck S, Rahmouni S, Taskén K (2011)
Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency
J Immunol, 186 (9), 5119-30
PubMed 21430226

Pettersen FO, Torheim EA, Dahm AE, Aaberge IS, Lind A, Holm M, Aandahl EM, Sandset PM, Taskén K, Kvale D (2011)
An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses
J Virol, 85 (13), 6557-66
PubMed 21490090

Pidoux G, Witczak O, Jarnćss E, Myrvold L, Urlaub H, Stokka AJ, Küntziger T, Taskén K (2011)
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis
EMBO J, 30 (21), 4371-86
PubMed 21983901

Solstad T, Bains SJ, Landskron J, Aandahl EM, Thiede B, Taskén K, Torgersen KM (2011)
CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells
Blood, 118 (19), 5141-51
PubMed 21937704

Weedon-Fekjćr MS, Taskén K (2011)
Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function
Placenta, 33 Suppl, S87-91
PubMed 22103973

Ĺnensen N, Hjelle SM, Van Belle W, Haaland I, Silden E, Bourdon JC, Hovland R, Taskén K, Knappskog S, Lřnning PE, Bruserud Ř, Gjertsen BT (2011)
Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia
Oncogene, 31 (12), 1533-45
PubMed 21860418

Publications 2010

Bjřrgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, Okkenhaug K, Houslay MD, Taskén K (2010)
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex
Mol Cell Biol, 30 (7), 1660-72
PubMed 20086095

Bjřrgo E, Taskén K (2010)
Novel mechanism of signaling by CD28
Immunol Lett, 129 (1), 1-6
PubMed 20123110

Cornez I, Taskén K (2010)
Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells
FEBS Lett, 584 (12), 2681-8
PubMed 20420835

Mosenden R, Taskén K (2010)
Cyclic AMP-mediated immune regulation--overview of mechanisms of action in T cells
Cell Signal, 23 (6), 1009-16
PubMed 21130867

Ndhlovu LC, Leal FE, Eccles-James IG, Jha AR, Lanteri M, Norris PJ, Barbour JD, Wachter DJ, Andersson J, Taskén K, Torheim EA, Aandahl EM, Kallas EG, Nixon DF (2010)
A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties
Eur J Immunol, 40 (1), 134-41
PubMed 19877008

Oberprieler NG, Lemeer S, Kalland ME, Torgersen KM, Heck AJ, Taskén K (2010)
High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells
Blood, 116 (13), 2253-65
PubMed 20558615

Oberprieler NG, Taskén K (2010)
Analysing phosphorylation-based signalling networks by phospho flow cytometry
Cell Signal, 23 (1), 14-8
PubMed 20643206

Pettersen FO, Taskén K, Kvale D (2010)
Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4 T cell loss rates in human immunodeficiency virus-1 infection
Clin Exp Immunol, 161 (2), 315-23
PubMed 20491784

Pidoux G, Taskén K (2010)
Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins
J Mol Endocrinol, 44 (5), 271-84
PubMed 20150326

Solstad T, Bjřrgo E, Koehler CJ, Strozynski M, Torgersen KM, Taskén K, Thiede B (2010)
Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells
Proteomics, 10 (15), 2758-68
PubMed 20486122

Soond DR, Bjřrgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JS, Taskén K, Bunyard P, Okkenhaug K (2010)
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
Blood, 115 (11), 2203-13
PubMed 20081091

Publications 2009

Jarnaess E, Stokka AJ, Kvissel AK, Skĺlhegg BS, Torgersen KM, Scott JD, Carlson CR, Taskén K (2009)
Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments
J Biol Chem, 284 (50), 35154-64
PubMed 19840947

Ngai J, Inngjerdingen M, Berge T, Taskén K (2009)
Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation
BMC Immunol, 10, 27
PubMed 19426503

Stokka AJ, Mosenden R, Ruppelt A, Lygren B, Taskén K (2009)
The adaptor protein EBP50 is important for localization of the protein kinase A-Ezrin complex in T-cells and the immunomodulating effect of cAMP
Biochem J, 425 (2), 381-8
PubMed 19857202

Taskén K (2009)
Waking up regulatory T cells
Blood, 114 (6), 1136-7
PubMed 19661275

Torheim EA, Jarnaess E, Lygren B, Taskén K (2009)
Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling
Biochem J, 424 (1), 69-78
PubMed 19715558

Torheim EA, Ndhlovu LC, Pettersen FO, Larsen TL, Jha AR, Torgersen KM, Kvale D, Nixon DF, Taskén K, Aandahl EM (2009)
Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population
Eur J Immunol, 39 (5), 1280-7
PubMed 19384871

Publications 2008

Berg T, Degerman E, Tasken K (2008)
Increased cAMP signaling can ameliorate the hypertensive condition in spontaneously hypertensive rats
J Vasc Res, 46 (1), 25-35
PubMed 18515972

Bryn T, Mahic M, Aandahl EM, Frřland SS, Aukrust P, Taskén K (2008)
Inhibition of protein kinase A improves effector function of monocytes from HIV-infected patients
AIDS Res Hum Retroviruses, 24 (7), 1013-5
PubMed 18593346

Jarnaess E, Ruppelt A, Stokka AJ, Lygren B, Scott JD, Taskén K (2008)
Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I
J Biol Chem, 283 (48), 33708-18
PubMed 18824551

Larsen KO, Lygren B, Sjaastad I, Krobert KA, Arnkvaern K, Florholmen G, Larsen AK, Levy FO, Taskén K, Skjřnsberg OH, Christensen G (2008)
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A
Cardiovasc Res, 80 (1), 47-54
PubMed 18599478

Lygren B, Taskén K (2008)
The potential use of AKAP18delta as a drug target in heart failure patients
Expert Opin Biol Ther, 8 (8), 1099-108
PubMed 18613762

Mahic M, Henjum K, Yaqub S, Bjřrnbeth BA, Torgersen KM, Taskén K, Aandahl EM (2008)
Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulation
Eur J Immunol, 38 (3), 640-6
PubMed 18266270

Mahic M, Kalland ME, Aandahl EM, Torgersen KM, Taskén K (2008)
Human naturally occurring and adaptive regulatory T cells secrete high levels of leukaemia inhibitory factor upon activation
Scand J Immunol, 68 (4), 391-6
PubMed 18782268

Mahic M, Yaqub S, Bryn T, Henjum K, Eide DM, Torgersen KM, Aandahl EM, Taskén K (2008)
Differentiation of naive CD4+ T cells into CD4+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation
J Leukoc Biol, 83 (5), 1111-7
PubMed 18270250

Methi T, Berge T, Torgersen KM, Taskén K (2008)
Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels
Eur J Immunol, 38 (9), 2557-63
PubMed 18792408

Ngai J, Methi T, Andressen KW, Levy FO, Torgersen KM, Vang T, Wettschureck N, Taskén K (2008)
The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway
Eur J Immunol, 38 (11), 3208-18
PubMed 18991294

Rogne M, Stokka AJ, Taskén K, Collas P, Küntziger T (2008)
Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network
Hum Mol Genet, 18 (5), 978-87
PubMed 19074462

Solheim SA, Petsalaki E, Stokka AJ, Russell RB, Taskén K, Berge T (2008)
Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity
FEBS J, 275 (19), 4863-74
PubMed 18721137

Torgersen KM, Aandahl EM, Taskén K (2008)
Molecular architecture of signal complexes regulating immune cell function
Handb Exp Pharmacol (186), 327-63
PubMed 18491059

Yaqub S, Taskén K (2008)
Role for the cAMP-protein kinase A signaling pathway in suppression of antitumor immune responses by regulatory T cells
Crit Rev Oncog, 14 (1), 57-77
PubMed 19105570

Aandahl EM, Torgersen KM, Taskén K (2008)
CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?
Hum Immunol, 69 (11), 696-9
PubMed 18817824

Publications 2007

Andrei M, Bjřrnstad V, Langli G, Rřmming C, Klaveness J, Taskén K, Undheim K (2007)
Stereoselective preparation of (RP)-8-hetaryladenosine-3',5'-cyclic phosphorothioic acids
Org Biomol Chem, 5 (13), 2070-80
PubMed 17581650

Bryn T, Yaqub S, Mahic M, Henjum K, Aandahl EM, Taskén K (2007)
LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism
Int Immunol, 20 (2), 235-45
PubMed 18156149

Jarnaess E, Taskén K (2007)
Spatiotemporal control of cAMP signalling processes by anchored signalling complexes
Biochem Soc Trans, 35 (Pt 5), 931-7
PubMed 17956249

Kesti T, Ruppelt A, Wang JH, Liss M, Wagner R, Taskén K, Saksela K (2007)
Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon
J Immunol, 179 (2), 878-85
PubMed 17617578

Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenberg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolo M, Taskén K, Klussmann E (2007)
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum
EMBO Rep, 8 (11), 1061-7
PubMed 17901878

Methi T, Ngai J, Vang T, Torgersen KM, Taskén K (2007)
Hypophosphorylated TCR/CD3zeta signals through a Grb2-SOS1-Ras pathway in Lck knockdown cells
Eur J Immunol, 37 (9), 2539-48
PubMed 17683112

Ruppelt A, Mosenden R, Grönholm M, Aandahl EM, Tobin D, Carlson CR, Abrahamsen H, Herberg FW, Carpén O, Taskén K (2007)
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin
J Immunol, 179 (8), 5159-68
PubMed 17911601

Solheim SA, Torgersen KM, Taskén K, Berge T (2007)
Regulation of FynT function by dual domain docking on PAG/Cbp
J Biol Chem, 283 (5), 2773-83
PubMed 18056706

Yaqub S, Henjum K, Mahic M, Jahnsen FL, Aandahl EM, Bjřrnbeth BA, Taskén K (2007)
Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner
Cancer Immunol Immunother, 57 (6), 813-21
PubMed 17962941

Publications 2006

Bjřrgo E, Taskén K (2006)
Role of cAMP phosphodiesterase 4 in regulation of T-cell function
Crit Rev Immunol, 26 (5), 443-51
PubMed 17341187

Bryn T, Mahic M, Enserink JM, Schwede F, Aandahl EM, Taskén K (2006)
The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages
J Immunol, 176 (12), 7361-70
PubMed 16751380

Carlson CR, Lygren B, Berge T, Hoshi N, Wong W, Taskén K, Scott JD (2006)
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor
J Biol Chem, 281 (30), 21535-45
PubMed 16728392

Damĺs JK, Smith C, Řie E, Fevang B, Halvorsen B, Waehre T, Boullier A, Breland U, Yndestad A, Ovchinnikova O, Robertson AK, Sandberg WJ, Kjekshus J, Taskén K, Frřland SS, Gullestad L, Hansson GK, Quehenberger O, Aukrust P (2006)
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization
Arterioscler Thromb Vasc Biol, 27 (3), 614-20
PubMed 17170367

Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Taskén K, Carlson CR, Scott JD, Barford D (2006)
Molecular basis of AKAP specificity for PKA regulatory subunits
Mol Cell, 24 (3), 383-95
PubMed 17081989

Grřnning LM, Baillie GS, Cederberg A, Lynch MJ, Houslay MD, Enerbäck S, Taskén K (2006)
Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice
FEBS Lett, 580 (17), 4126-30
PubMed 16828089

Kvale D, Ormaasen V, Kran AM, Johansson CC, Aukrust P, Aandahl EM, Frřland SS, Taskén K (2006)
Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment
AIDS, 20 (6), 813-20
PubMed 16549964

Lygren B, Taskén K (2006)
Compartmentalized cAMP signalling is important in the regulation of Ca(2+) cycling in the heart
Biochem Soc Trans, 34 (Pt 4), 489-91
PubMed 16856840

Mahic M, Yaqub S, Johansson CC, Taskén K, Aandahl EM (2006)
FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism
J Immunol, 177 (1), 246-54
PubMed 16785520

Stokka AJ, Gesellchen F, Carlson CR, Scott JD, Herberg FW, Taskén K (2006)
Characterization of A-kinase-anchoring disruptors using a solution-based assay
Biochem J, 400 (3), 493-9
PubMed 16948636

Tasken K, Ruppelt A (2006)
Negative regulation of T-cell receptor activation by the cAMP-PKA-Csk signalling pathway in T-cell lipid rafts
Front Biosci, 11, 2929-39
PubMed 16720365

Taskén K, Stokka AJ (2006)
The molecular machinery for cAMP-dependent immunomodulation in T-cells
Biochem Soc Trans, 34 (Pt 4), 476-9
PubMed 16856837

Publications 2005

Lygren B, Taskén K, Carlson CR (2005)
A fast and sensitive method for isolation of detergent-resistant membranes from T cells
J Immunol Methods, 305 (2), 199-205
PubMed 16176818

McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD (2005)
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region
Cell Signal, 17 (9), 1158-73
PubMed 15905070

Methi T, Ngai J, Mahic M, Amarzguioui M, Vang T, Tasken K (2005)
Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses
J Immunol, 175 (11), 7398-406
PubMed 16301647

Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N (2005)
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
Nat Genet, 37 (12), 1317-9
PubMed 16273109

Wong L, Lieser SA, Miyashita O, Miller M, Tasken K, Onuchic JN, Adams JA, Woods VL, Jennings PA (2005)
Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation
J Mol Biol, 351 (1), 131-43
PubMed 16002086

Zeddou M, Greimers R, de Valensart N, Nayjib B, Tasken K, Boniver J, Moutschen M, Rahmouni S (2005)
Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway
Biochem Pharmacol, 70 (5), 714-24
PubMed 15978547

Publications 2004

Abrahamsen H, Baillie G, Ngai J, Vang T, Nika K, Ruppelt A, Mustelin T, Zaccolo M, Houslay M, Taskén K (2004)
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling
J Immunol, 173 (8), 4847-58
PubMed 15470025

Enserink JM, Price LS, Methi T, Mahic M, Sonnenberg A, Bos JL, Taskén K (2004)
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
J Biol Chem, 279 (43), 44889-96
PubMed 15302884

Johansson CC, Bryn T, Yndestad A, Eiken HG, Bjerkeli V, Frřland SS, Aukrust P, Taskén K (2004)
Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP
AIDS, 18 (2), 171-9
PubMed 15075533

Johansson CC, Bryn T, Aandahl EM, Areklett MA, Aukrust P, Taskén K, Frřland SS (2004)
Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy
AIDS, 18 (6), 951-2
PubMed 15060445

Johansson CC, Yndestad A, Enserink JM, Ree AH, Aukrust P, Taskén K (2004)
The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types
Endocrinology, 145 (11), 5177-84
PubMed 15284208

Nika K, Hyunh H, Williams S, Paul S, Bottini N, Taskén K, Lombroso PJ, Mustelin T (2004)
Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location
Biochem J, 378 (Pt 2), 335-42
PubMed 14613483

Rahmouni S, Aandahl EM, Nayjib B, Zeddou M, Giannini S, Verlaet M, Greimers R, Boniver J, Tasken K, Moutschen M (2004)
Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
Biochem J, 384 (Pt 3), 469-76
PubMed 15344910

Taskén K, Aandahl EM (2004)
Localized effects of cAMP mediated by distinct routes of protein kinase A
Physiol Rev, 84 (1), 137-67
PubMed 14715913

Vang T, Abrahamsen H, Myklebust S, Enserink J, Prydz H, Mustelin T, Amarzguioui M, Tasken K (2004)
Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells
Eur J Immunol, 34 (8), 2191-9
PubMed 15259016

Waehre T, Damĺs JK, Yndestad A, Taskén K, Pedersen TM, Smith C, Halvorsen B, Frřland SS, Solum NO, Aukrust P (2004)
Effect of activated platelets on expression of cytokines in peripheral blood mononuclear cells - potential role of prostaglandin E2
Thromb Haemost, 92 (6), 1358-67
PubMed 15583745

Publications 2003

Abrahamsen H, Vang T, Taskén K (2003)
Protein kinase A intersects SRC signaling in membrane microdomains
J Biol Chem, 278 (19), 17170-7
PubMed 12606547

Carlson CR, Ruppelt A, Taskén K (2003)
A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system
J Mol Biol, 327 (3), 609-18
PubMed 12634056

Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (2003)
Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication
J Biol Chem, 278 (29), 26750-6
PubMed 12740381

Grönholm M, Vossebein L, Carlson CR, Kuja-Panula J, Teesalu T, Alfthan K, Vaheri A, Rauvala H, Herberg FW, Taskén K, Carpén O (2003)
Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A
J Biol Chem, 278 (42), 41167-72
PubMed 12896975

Holm AM, Aukrust P, Aandahl EM, Müller F, Taskén K, Frřland SS (2003)
Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I
J Immunol, 170 (11), 5772-7
PubMed 12759461

Johansson CC, Dahle MK, Blomqvist SR, Grřnning LM, Aandahl EM, Enerbäck S, Taskén K (2003)
A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha
J Biol Chem, 278 (19), 17573-9
PubMed 12621056

Keryer G, Witczak O, Delouvée A, Kemmner WA, Rouillard D, Tasken K, Bornens M (2003)
Dissociating the centrosomal matrix protein AKAP450 from centrioles impairs centriole duplication and cell cycle progression
Mol Biol Cell, 14 (6), 2436-46
PubMed 12808041

Mustelin T, Taskén K (2003)
Positive and negative regulation of T-cell activation through kinases and phosphatases
Biochem J, 371 (Pt 1), 15-27
PubMed 12485116

Vang T, Abrahamsen H, Myklebust S, Horejsí V, Taskén K (2003)
Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling
J Biol Chem, 278 (20), 17597-600
PubMed 12665526

Yaqub S, Abrahamsen H, Zimmerman B, Kholod N, Torgersen KM, Mustelin T, Herberg FW, Taskén K, Vang T (2003)
Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain
Biochem J, 372 (Pt 1), 271-8
PubMed 12600271

Yaqub S, Solhaug V, Vang T, Solberg R, Aasen A, Taskén K, Wang JE (2003)
A human whole blood model of LPS-mediated suppression of T cell activation
Med Sci Monit, 9 (3), BR120-6
PubMed 12640334

Aandahl EM, Sandberg JK, Beckerman KP, Taskén K, Moretto WJ, Nixon DF (2003)
CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets
J Immunol, 170 (5), 2349-55
PubMed 12594257

Publications 2002

Birkeli KA, Llorente A, Torgersen ML, Keryer G, Taskén K, Sandvig K (2002)
Endosome-to-Golgi transport is regulated by protein kinase A type II alpha
J Biol Chem, 278 (3), 1991-7
PubMed 12419802

Dahle MK, Grřnning LM, Cederberg A, Blomhoff HK, Miura N, Enerbäck S, Taskén KA, Taskén K (2002)
Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP
J Biol Chem, 277 (25), 22902-8
PubMed 11943768

Dahle MK, Taskén K, Taskén KA (2002)
USF2 inhibits C/EBP-mediated transcriptional regulation of the RIIbeta subunit of cAMP-dependent protein kinase
BMC Mol Biol, 3, 10
PubMed 12086590

Eide T, Carlson C, Taskén KA, Hirano T, Taskén K, Collas P (2002)
Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting
EMBO Rep, 3 (5), 426-32
PubMed 11964380

Grřnning LM, Cederberg A, Miura N, Enerbäck S, Taskén K (2002)
Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways
Mol Endocrinol, 16 (4), 873-83
PubMed 11923482

Hoover F, Kalhovde JM, Dahle MK, Skĺlhegg B, Taskén K, Lřmo T (2002)
Electrical muscle activity pattern and transcriptional and posttranscriptional mechanisms regulate PKA subunit expression in rat skeletal muscle
Mol Cell Neurosci, 19 (2), 125-37
PubMed 11860267

Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Taskén K (2002)
Molecular mechanisms for protein kinase A-mediated modulation of immune function
Cell Signal, 14 (1), 1-9
PubMed 11747983

Aandahl EM, Moretto WJ, Haslett PA, Vang T, Bryn T, Tasken K, Nixon DF (2002)
Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I
J Immunol, 169 (2), 802-8
PubMed 12097383

Publications 2001

Carlson CR, Witczak O, Vossebein L, Labbé JC, Skĺlhegg BS, Keryer G, Herberg FW, Collas P, Taskén K (2001)
CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis
J Cell Sci, 114 (Pt 18), 3243-54
PubMed 11591813

Cederberg A, Grřnning LM, Ahrén B, Taskén K, Carlsson P, Enerbäck S (2001)
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
Cell, 106 (5), 563-73
PubMed 11551504

Dahle MK, Knutsen HK, Taskén KA, Pilz R, Taskén K (2001)
Cyclic AMP regulates expression of the RI alpha subunit of cAMP-dependent protein kinase through an alternatively spliced 5' UTR
Eur J Biochem, 268 (22), 5920-9
PubMed 11722580

Dahle MK, Reinton N, Orstavik S, Taskén KA, Taskén K (2001)
Novel alternatively spliced mRNA (1c) of the protein kinase A RIα subunit is implicated in haploid germ cell specific expression
Mol Reprod Dev, 59 (1), 11-6
PubMed 11335941

Fax P, Carlson CR, Collas P, Taskén K, Esche H, Brockmann D (2001)
Binding of PKA-RIIalpha to the Adenovirus E1A12S oncoprotein correlates with its nuclear translocation and an increase in PKA-dependent promoter activity
Virology, 285 (1), 30-41
PubMed 11414803

Hoover F, Mathiesen I, Skĺlhegg BS, Lřmo T, Taskén K (2001)
Differential expression and regulation of the PKA signalling pathway in fast and slow skeletal muscle
Anat Embryol (Berl), 203 (3), 193-201
PubMed 11303905

Landsverk HB, Carlson CR, Steen RL, Vossebein L, Herberg FW, Taskén K, Collas P (2001)
Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis
J Cell Sci, 114 (Pt 18), 3255-64
PubMed 11591814

Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V (2001)
Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein
Mol Endocrinol, 15 (12), 2211-28
PubMed 11731621

Rahmouni S, Aandahl EM, Trebak M, Boniver J, Taskén K, Moutschen M (2001)
Increased cAMP levels and protein kinase (PKA) type I activation in CD4+ T cells and B cells contribute to retrovirus-induced immunodeficiency of mice (MAIDS): a useful in vivo model for drug testing
FASEB J, 15 (8), 1466-8
PubMed 11387259

Taskén KA, Collas P, Kemmner WA, Witczak O, Conti M, Taskén K (2001)
Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area
J Biol Chem, 276 (25), 21999-2002
PubMed 11285255

Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Horejsí V, Schraven B, Rolstad B, Mustelin T, Taskén K (2001)
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts
J Biol Chem, 276 (31), 29313-8
PubMed 11390365

Torgersen KM, Vaage JT, Rolstad B, Taskén K (2001)
A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains
Cell Signal, 13 (3), 213-20
PubMed 11282460

Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skĺlhegg BS, Hansson V, Mustelin T, Taskén K (2001)
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
J Exp Med, 193 (4), 497-507
PubMed 11181701

Publications 2000

Grřnning LM, Wang JE, Ree AH, Haugen TB, Taskén K, Taskén KA (2000)
Regulation of tissue inhibitor of metalloproteinases-1 in rat Sertoli cells: induction by germ cell residual bodies, interleukin-1alpha, and second messengers
Biol Reprod, 62 (4), 1040-6
PubMed 10727275

Hansson V, Skalhegg BS, Tasken K (2000)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
J Steroid Biochem Mol Biol, 73 (1-2), 81-92
PubMed 10822028

Hansson V, Skĺlhegg BS, Taskén K (2000)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
J Steroid Biochem Mol Biol, 73 (1-2), 81-92
PubMed 10905822

Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (2000)
Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding
J Mol Biol, 298 (2), 329-39
PubMed 10764601

Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skĺlhegg BS (2000)
Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95
Biol Cell, 92 (1), 27-37
PubMed 10761695

Pursiheimo JP, Jalkanen M, Taskén K, Jaakkola P (2000)
Involvement of protein kinase A in fibroblast growth factor-2-activated transcription
Proc Natl Acad Sci U S A, 97 (1), 168-73
PubMed 10618389

Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000)
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis
Dev Biol, 223 (1), 194-204
PubMed 10864471

Reinton N, Orstavik S, Haugen TB, Jahnsen T, Taskén K, Skĺlhegg BS (2000)
A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece
Biol Reprod, 63 (2), 607-11
PubMed 10906071

Skalhegg BS, Tasken K (2000)
Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA
Front Biosci, 5, D678-93
PubMed 10922298

Steen RL, Martins SB, Taskén K, Collas P (2000)
Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly
J Cell Biol, 150 (6), 1251-62
PubMed 10995432

Taskén K, Hansson V, Aukrust P, Frřland S, Skĺlhegg BS, Müller F, Tobin D, Vang T, Torgersen KM, Aandahl EM (2000)
PKAI as a potential target for therapeutic intervention
Drug News Perspect, 13 (1), 12-8
PubMed 12937648

Publications 1999

Aukrust P, Aandahl EM, Skĺlhegg BS, Nordřy I, Hansson V, Taskén K, Frřland SS, Müller F (1999)
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency
J Immunol, 162 (2), 1178-85
PubMed 9916750

Collas P, Le Guellec K, Taskén K (1999)
The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis
J Cell Biol, 147 (6), 1167-80
PubMed 10601332

Gronning LM, Knutsen HK, Eskild W, Hansson V, Taskén K, Taskén KA (1999)
Method of transfection affects the cAMP-mediated induction of the RIIbeta subunit of protein kinase A in Sertoli cells: inhibition of response by increase in intracellullar calcium
Eur J Endocrinol, 141 (1), 75-82
PubMed 10407227

Grřnning LM, Dahle MK, Taskén KA, Enerbäck S, Hedin L, Taskén K, Knutsen HK (1999)
Isoform-specific regulation of the CCAAT/enhancer-binding protein family of transcription factors by 3',5'-cyclic adenosine monophosphate in Sertoli cells
Endocrinology, 140 (2), 835-43
PubMed 9927313

Hansson V, Skĺlhegg BS, Taskén K (1999)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
J Steroid Biochem Mol Biol, 69 (1-6), 367-78
PubMed 10419014

Keryer G, Skĺlhegg BS, Landmark BF, Hansson V, Jahnsen T, Taskén K (1999)
Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area
Exp Cell Res, 249 (1), 131-46
PubMed 10328961

Krall J, Taskén K, Staheli J, Jahnsen T, Movsesian MA (1999)
Identification and quantitation of cAMP-dependent protein kinase R subunit isoforms in subcellular fractions of failing human myocardium
J Mol Cell Cardiol, 31 (5), 971-80
PubMed 10336837

Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM (1999)
Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes
J Immunol, 162 (9), 5639-48
PubMed 10228048

Maronde E, Wicht H, Taskén K, Genieser HG, Dehghani F, Olcese J, Korf HW (1999)
CREB phosphorylation and melatonin biosynthesis in the rat pineal gland: involvement of cyclic AMP dependent protein kinase type II
J Pineal Res, 27 (3), 170-82
PubMed 10535767

Saxena M, Williams S, Taskén K, Mustelin T (1999)
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
Nat Cell Biol, 1 (5), 305-11
PubMed 10559944

Witczak O, Skĺlhegg BS, Keryer G, Bornens M, Taskén K, Jahnsen T, Orstavik S (1999)
Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450
EMBO J, 18 (7), 1858-68
PubMed 10202149

Aandahl EM, Aukrust P, Müller F, Hansson V, Taskén K, Frřland SS (1999)
Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART
AIDS, 13 (17), F109-14
PubMed 10597771

Publications 1998

Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skâlhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Taskén K (1998)
Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95
Exp Cell Res, 238 (2), 305-16
PubMed 9473338

Keryer G, Alsat E, Tasken K, Evain-Brion D (1998)
Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro
J Cell Sci, 111 ( Pt 7), 995-1004
PubMed 9490643

Keryer G, Yassenko M, Labbé JC, Castro A, Lohmann SM, Evain-Brion D, Taskén K (1998)
Mitosis-specific phosphorylation and subcellular redistribution of the RIIalpha regulatory subunit of cAMP-dependent protein kinase
J Biol Chem, 273 (51), 34594-602
PubMed 9852131

Reinton N, Haugen TB, Orstavik S, Skĺlhegg BS, Hansson V, Jahnsen T, Taskén K (1998)
The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon
Genomics, 49 (2), 290-7
PubMed 9598317

Singh AK, Taskén K, Walker W, Frizzell RA, Watkins SC, Bridges RJ, Bradbury NA (1998)
Characterization of PKA isoforms and kinase-dependent activation of chloride secretion in T84 cells
Am J Physiol, 275 (2 Pt 1), C562-70
PubMed 9688611

Skarpen E, Thoresen GH, Taskén K, Samuelsen JT, Jahnsen T, Schwarze PE, Huitfeldt HS (1998)
Localization of cAMP-dependent signal transducers in early rat liver carcinogenesis
Histochem Cell Biol, 109 (3), 203-9
PubMed 9541468

Skĺlhegg BS, Johansen AK, Levy FO, Andersson KB, Aandahl EM, Blomhoff HK, Hansson V, Taskén K (1998)
Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines
J Cell Physiol, 177 (1), 85-93
PubMed 9731748

Strömstedt M, Waterman MR, Haugen TB, Taskén K, Parvinen M, Rozman D (1998)
Elevated expression of lanosterol 14alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats
Endocrinology, 139 (5), 2314-21
PubMed 9564839

Taskén K, Naylor SL, Solberg R, Jahnsen T (1998)
Mapping of the gene encoding the regulatory subunit RII alpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2
Genomics, 50 (3), 378-81
PubMed 9676433

Taskén K, Schulz T, Elgjo K, Skullerud K, Relman D, Brubakk O (1998)
Diagnostic utility of the polymerase chain reaction in 2 cases of suspected Whipple disease
Arch Intern Med, 158 (7), 801-3
PubMed 9554687

Vang T, Taskén K, Skĺlhegg BS, Hansson V, Levy FO (1998)
Kinetic properties of the C-terminal Src kinase, p50csk
Biochim Biophys Acta, 1384 (2), 285-93
PubMed 9659389

Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT (1998)
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells
J Exp Med, 187 (7), 1157-61
PubMed 9529333

Aandahl EM, Aukrust P, Skĺlhegg BS, Müller F, Frřland SS, Hansson V, Taskén K (1998)
Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients
FASEB J, 12 (10), 855-62
PubMed 9657525

Publications 1997

Foss KB, Solberg R, Simard J, Myklebust F, Hansson V, Jahnsen T, Taskén K (1997)
Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase
Biochim Biophys Acta, 1350 (1), 98-108
PubMed 9003463

Knutsen HK, Taskén K, Eskild W, Richards JS, Kurten RC, Torjesen PA, Jahnsen T, Hansson V, Guérin S, Taskén KA (1997)
Characterization of the 5'-flanking region of the gene for the cAMP-inducible protein kinase A subunit, RIIbeta, in Sertoli cells
Mol Cell Endocrinol, 129 (1), 101-14
PubMed 9175634

Maronde E, Middendorff R, Telgmann R, Müller D, Hemmings B, Taskén K, Olcese J (1997)
Melatonin synthesis in the bovine pineal gland is regulated by type II cyclic AMP-dependent protein kinase
J Neurochem, 68 (2), 770-7
PubMed 9003068

Orstavik S, Natarajan V, Taskén K, Jahnsen T, Sandberg M (1997)
Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1)
Genomics, 42 (2), 311-8
PubMed 9192852

Skĺlhegg BS, Taskén K (1997)
Specificity in the cAMP/PKA signaling pathway. differential expression, regulation, and subcellular localization of subunits of PKA
Front Biosci, 2, d331-42
PubMed 9236186

Solberg R, Sandberg M, Natarajan V, Torjesen PA, Hansson V, Jahnsen T, Taskén K (1997)
The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids
Endocrinology, 138 (1), 169-81
PubMed 8977401

Taskén K, Skĺlhegg BS, Taskén KA, Solberg R, Knutsen HK, Levy FO, Sandberg M, Orstavik S, Larsen T, Johansen AK, Vang T, Schrader HP, Reinton NT, Torgersen KM, Hansson V, Jahnsen T (1997)
Structure, function, and regulation of human cAMP-dependent protein kinases
Adv Second Messenger Phosphoprotein Res, 31, 191-204
PubMed 9344252

Telgmann R, Maronde E, Taskén K, Gellersen B (1997)
Activated protein kinase A is required for differentiation-dependent transcription of the decidual prolactin gene in human endometrial stromal cells
Endocrinology, 138 (3), 929-37
PubMed 9048592

Torgersen KM, Vaage JT, Levy FO, Hansson V, Rolstad B, Taskén K (1997)
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity
J Biol Chem, 272 (9), 5495-500
PubMed 9038153

Publications 1996

Hansson V, Skĺlhegg BS, Taskén K (1996)
Is basic endocrinology disappearing?
Eur J Endocrinol, 134 (1), 7-8
PubMed 8590959

Levy FO, Rasmussen AM, Taskén K, Skĺlhegg BS, Huitfeldt HS, Funderud S, Smeland EB, Hansson V (1996)
Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation
Eur J Immunol, 26 (6), 1290-6
PubMed 8647207

Levy FO, Taskén K, Hansson V (1996)
Report on the 9th European Workshop on the Molecular and Cellular Endocrinology of the Testis
Mol Cell Endocrinol, 122 (1), 1-13
PubMed 8898343

Orstavik S, Solberg R, Taskén K, Nordahl M, Altherr MR, Hansson V, Jahnsen T, Sandberg M (1996)
Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase
Biochem Biophys Res Commun, 220 (3), 759-65
PubMed 8607838

Taskén K, Solberg R, Zhao Y, Hansson V, Jahnsen T, Siciliano MJ (1996)
The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1
Genomics, 36 (3), 535-8
PubMed 8884279

Publications 1994

Andersson KB, Taskén K, Blomhoff HK (1994)
Cyclic AMP downregulates c-myc expression by inhibition of transcript initiation in human B-precursor Reh cells
FEBS Lett, 337 (1), 71-6
PubMed 8276117

Berg JP, Ree AH, Sandvik JA, Taskén K, Landmark BF, Torjesen PA, Haug E (1994)
1,25-dihydroxyvitamin D3 alters the effect of cAMP in thyroid cells by increasing the regulatory subunit type II beta of the cAMP-dependent protein kinase
J Biol Chem, 269 (51), 32233-8
PubMed 7798223

Christoffersen J, Smeland EB, Stokke T, Taskén K, Andersson KB, Blomhoff HK (1994)
Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells
Cancer Res, 54 (8), 2245-50
PubMed 8174134

Foss KB, Landmark B, Skĺlhegg BS, Taskén K, Jellum E, Hansson V, Jahnsen T (1994)
Characterization of in-vitro-translated human regulatory and catalytic subunits of cAMP-dependent protein kinases
Eur J Biochem, 220 (1), 217-23
PubMed 8119290

Kristoffersen AK, Taskčn K, Rollag H (1994)
Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection
Arch Virol, 138 (1-2), 85-93
PubMed 7980013

Levy FO, Holtgreve-Grez H, Taskén K, Solberg R, Ried T, Gudermann T (1994)
Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15
Genomics, 22 (3), 637-40
PubMed 8001977

Ree AH, Taskén K, Hansson V (1994)
Regulation of glucocorticoid receptor (GR) mRNA and protein levels by phorbol ester in MCF-7 cells. Mechanism of GR mRNA induction and decay
J Steroid Biochem Mol Biol, 48 (1), 23-9
PubMed 8136303

Skĺlhegg BS, Rasmussen AM, Taskén K, Hansson V, Jahnsen T, Lea T (1994)
Cyclic AMP sensitive signalling by the CD28 marker requires concomitant stimulation by the T-cell antigen receptor (TCR/CD3) complex
Scand J Immunol, 40 (2), 201-8
PubMed 8047842

Skĺlhegg BS, Taskén K, Hansson V, Huitfeldt HS, Jahnsen T, Lea T (1994)
Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex
Science, 263 (5143), 84-7
PubMed 8272870

Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS (1994)
Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells
Exp Cell Res, 214 (2), 595-605
PubMed 7925653

Taskén K, Andersson KB, Erikstein BK, Hansson V, Jahnsen T, Blomhoff HK (1994)
Regulation of growth in a neoplastic B cell line by transfected subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinase
Endocrinology, 135 (5), 2109-19
PubMed 7956934

Publications 1993

Krajci P, Taskén K, Kvale D, Brandtzaeg P (1993)
Interferon-gamma stimulation of messenger RNA for human secretory component (poly-Ig receptor) depends on continuous intermediate protein synthesis
Scand J Immunol, 37 (2), 251-6
PubMed 8434236

Taskén K, Andersson KB, Skĺlhegg BS, Taskén KA, Hansson V, Jahnsen T, Blomhoff HK (1993)
Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RI alpha and C alpha) by cAMP in a neoplastic B cell line (Reh)
J Biol Chem, 268 (31), 23483-9
PubMed 8226875

Taskén K, Skĺlhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (1993)
Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes
J Biol Chem, 268 (28), 21276-83
PubMed 8407966

Publications 1992

Krajci P, Kvale D, Taskén K, Brandtzaeg P (1992)
Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)
Eur J Immunol, 22 (9), 2309-15
PubMed 1355431

Taskén KA, Knutsen HK, Eikvar L, Taskén K, Eskild W, Jahnsen T, Hansson V (1992)
Protein kinase C activation by 12-O-tetradecanoylphorbol 13-acetate modulates messenger ribonucleic acid levels for two of the regulatory subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinases (RII beta and RI alpha) via multiple and distinct mechanisms
Endocrinology, 130 (3), 1271-80
PubMed 1311233

Publications 1991

Solberg R, Taskén K, Keiserud A, Jahnsen T (1991)
Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases
Biochem Biophys Res Commun, 176 (1), 166-72
PubMed 1708242

Taskén KA, Knutsen HK, Attramadal H, Taskén K, Jahnsen T, Hansson V, Eskild W (1991)
Different mechanisms are involved in cAMP-mediated induction of mRNAs for subunits of cAMP-dependent protein kinases
Mol Endocrinol, 5 (1), 21-8
PubMed 1850108

Publications 1990

Dissen E, Vaage JT, Taskén K, Jahnsen T, Rolstad B, Fossum S (1990)
Alloreactive lymphokine-activated killer cells from athymic nude rats do not express CD3-associated alpha/beta or gamma/delta T cell receptors
Int Immunol, 2 (5), 453-60
PubMed 2150758

Taskén K, Kvale D, Hansson V, Jahnsen T (1990)
Protein kinase C activation selectively increases mRNA levels for one of the regulatory subunits (RI alpha) of cAMP-dependent protein kinases in HT-29 cells
Biochem Biophys Res Commun, 172 (2), 409-14
PubMed 2241943

Publications 1988

Levy FO, Oyen O, Sandberg M, Taskén K, Eskild W, Hansson V, Jahnsen T (1988)
Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis
Mol Endocrinol, 2 (12), 1364-73
PubMed 2851102

OYEN O, SANDBERG M, LEVY FO, TASKEN K, BEEBE S, HANSSON V, JAHNSEN T (1988)
MOLECULAR-CLONING AND CELL-SPECIFIC EXPRESSION OF NEWLY DISCOVERED SUBUNITS OF CAMP-DEPENDENT PROTEIN-KINASES - IMPLICATIONS FOR DIFFERENT CELLULAR-RESPONSES TO CAMP
APMIS, 96 2, 238-250

Oyen O, Sandberg M, Levy FO, Taskén K, Beebe S, Hansson V, Jahnsen T (1988)
Molecular cloning and cell-specific expression of newly discovered subunits of cAMP-dependent protein kinases. Implications for different cellular responses to cAMP
APMIS Suppl, 2, 238-50
PubMed 2846017

Publications 1987

Sandberg M, Taskén K, Oyen O, Hansson V, Jahnsen T (1987)
Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis
Biochem Biophys Res Commun, 149 (3), 939-45
PubMed 3426618