Helge Skulstad
Position: PhD Senior scientist, MD, PhD
Phone: +47 23074144
Email:

Stipendiates: Espen Bøe, Christian Eek, Ole-Johannes Grymyr, Stefan Hyler

Main focus:

Assessment of regional and global myocardial function during ischemia and acute coronary syndrome

Main methods:

Echocardiography. Clinical and experimental studies.

Project:

Shunt effect on ischemia during coronary surgery on the beating heart

Collaborators:

The Interventional Centre at Rikshospitalet

Aim:

To study myocardial ischemia and a possible protection effect of transitional LAD-shunting during off-pump coronary surgery

 

Author network for Helge Skulstad by COREMINE medical


Publications 2017

Pischke SE, Gustavsen A, Orrem HL, Egge KH, Courivaud F, Fontenelle H, Despont A, Bongoni AK, Rieben R, Tønnessen TI, Nunn MA, Scott H, Skulstad H, Barratt-Due A, Mollnes TE (2017)
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
Basic Res Cardiol, 112 (3), 20
PubMed 28258298

Publications 2016

Bergan HA, Halvorsen PS, Skulstad H, Fosse E, Bugge JF (2016)
Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?
J Transl Med, 14 (1), 345
PubMed 27998282

Publications 2015

Bergan HA, Halvorsen PS, Skulstad H, Edvardsen T, Fosse E, Bugge JF (2015)
Successful ECMO-cardiopulmonary resuscitation with the associated post-arrest cardiac dysfunction as demonstrated by MRI
Intensive Care Med Exp, 3 (1), 61
PubMed 26335546

Boe E, Russell K, Eek C, Eriksen M, Remme EW, Smiseth OA, Skulstad H (2015)
Non-invasive myocardial work index identifies acute coronary occlusion in patients with non-ST-segment elevation-acute coronary syndrome
Eur Heart J Cardiovasc Imaging, 16 (11), 1247-55
PubMed 25851329

Grymyr OJ, Nguyen AT, Tjulkins F, Espinoza A, Remme EW, Skulstad H, Fosse E, Imenes K, Halvorsen PS (2015)
Continuous monitoring of cardiac function by 3-dimensional accelerometers in a closed-chest pig model
Interact Cardiovasc Thorac Surg, 21 (5), 573-82
PubMed 26254463

Hyler S, Pischke SE, Halvorsen PS, Espinoza A, Bergsland J, Tønnessen TI, Fosse E, Skulstad H (2015)
Continuous monitoring of regional function by a miniaturized ultrasound transducer allows early quantification of low-grade myocardial ischemia
J Am Soc Echocardiogr, 28 (4), 486-94
PubMed 25636368

Kerans V, Espinoza A, Skulstad H, Halvorsen PS, Edvardsen T, Bugge JF (2015)
Systolic left ventricular function is preserved during therapeutic hypothermia, also during increases in heart rate with impaired diastolic filling
Intensive Care Med Exp, 3 (1), 41
PubMed 26215808

Opdahl A, Helle-Valle T, Skulstad H, Smiseth OA (2015)
Strain, strain rate, torsion, and twist: echocardiographic evaluation
Curr Cardiol Rep, 17 (3), 568
PubMed 25676830

Smedsrud MK, Gravning J, Omland T, Eek C, Mørkrid L, Skulstad H, Aaberge L, Bendz B, Kjekshus J, Edvardsen T (2015)
Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain
Int J Cardiovasc Imaging, 31 (5), 967-73
PubMed 25788439

Publications 2014

Boe E, Russell K, Remme EW, Gjesdal O, Smiseth OA, Skulstad H (2014)
Cardiac responses to left ventricular pacing in hearts with normal electrical conduction: beneficial effect of improved filling is counteracted by dyssynchrony
Am J Physiol Heart Circ Physiol, 307 (3), H370-8
PubMed 24906920

Dahlslett T, Karlsen S, Grenne B, Eek C, Sjøli B, Skulstad H, Smiseth OA, Edvardsen T, Brunvand H (2014)
Early assessment of strain echocardiography can accurately exclude significant coronary artery stenosis in suspected non-ST-segment elevation acute coronary syndrome
J Am Soc Echocardiogr, 27 (5), 512-9
PubMed 24612899

Erikssen G, Liestøl K, Seem E, Birkeland S, Saatvedt KJ, Hoel TN, Døhlen G, Skulstad H, Svennevig JL, Thaulow E, Lindberg HL (2014)
Achievements in congenital heart defect surgery: a prospective, 40-year study of 7038 patients
Circulation, 131 (4), 337-46; discussion 346
PubMed 25538230

Grymyr OJ, Remme EW, Espinoza A, Skulstad H, Elle OJ, Fosse E, Halvorsen PS (2014)
Assessment of 3D motion increases the applicability of accelerometers for monitoring left ventricular function
Interact Cardiovasc Thorac Surg, 20 (3), 329-37
PubMed 25472979

Hestenes SM, Halvorsen PS, Skulstad H, Remme EW, Espinoza A, Hyler S, Bugge JF, Fosse E, Nielsen EW, Edvardsen T (2014)
Advantages of strain echocardiography in assessment of myocardial function in severe sepsis: an experimental study
Crit Care Med, 42 (6), e432-40
PubMed 24633187

Hyler S, Espinoza A, Skulstad H, Fosse E, Halvorsen PS (2014)
Left ventricular function can be continuously monitored with an epicardially attached accelerometer sensor
Eur J Cardiothorac Surg, 46 (2), 313-20
PubMed 24482390

Pischke SE, Hyler S, Tronstad C, Bergsland J, Fosse E, Halvorsen PS, Skulstad H, Tønnessen TI (2014)
Myocardial tissue CO2 tension detects coronary blood flow reduction after coronary artery bypass in real-time†
Br J Anaesth, 114 (3), 414-22
PubMed 25392231

Zahid W, Eek CH, Remme EW, Skulstad H, Fosse E, Edvardsen T (2014)
Early systolic lengthening may identify minimal myocardial damage in patients with non-ST-elevation acute coronary syndrome
Eur Heart J Cardiovasc Imaging, 15 (10), 1152-60
PubMed 24866900

Publications 2013

Espinoza A, Kerans V, Opdahl A, Skulstad H, Halvorsen PS, Bugge JF, Fosse E, Edvardsen T (2013)
Effects of therapeutic hypothermia on left ventricular function assessed by ultrasound imaging
J Am Soc Echocardiogr, 26 (11), 1353-63
PubMed 23891124

Gravning J, Smedsrud MK, Omland T, Eek C, Skulstad H, Aaberge L, Bendz B, Kjekshus J, Mørkrid L, Edvardsen T (2013)
Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: prediction of significant coronary lesions and long-term prognosis
Am Heart J, 165 (5), 716-24
PubMed 23622908

Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Gjesdal O, Edvardsen T, Smiseth OA (2013)
Assessment of wasted myocardial work: a novel method to quantify energy loss due to uncoordinated left ventricular contractions
Am J Physiol Heart Circ Physiol, 305 (7), H996-1003
PubMed 23893165

Smiseth OA, Edvardsen T, Skulstad H (2013)
Cardioprotection during chemotherapy: need for faster transfer of knowledge from cardiology to oncology and role for a cardio-oncologist
J Am Coll Cardiol, 61 (23), 2363-4
PubMed 23583243

Zahid W, Johnson J, Westholm C, Eek CH, Haugaa KH, Smedsrud MK, Skulstad H, Fosse E, Winter R, Edvardsen T (2013)
Mitral annular displacement by Doppler tissue imaging may identify coronary occlusion and predict mortality in patients with non-ST-elevation myocardial infarction
J Am Soc Echocardiogr, 26 (8), 875-84
PubMed 23791116

Publications 2012

Broch K, Eek C, Wergeland R, Ueland T, Skårdal R, Aukrust P, Skulstad H, Gullestad L (2012)
NT-proBNP predicts myocardial recovery after non-ST-elevation acute coronary syndrome
Scand Cardiovasc J, 46 (2), 65-71
PubMed 22191851

Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Remme EW, Haugaa KH, Opdahl A, Fjeld JG, Gjesdal O, Edvardsen T, Smiseth OA (2012)
A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work
Eur Heart J, 33 (6), 724-33
PubMed 22315346

Skulstad H, Aakhus S (2012)
Stress echocardiography with semi-supine bicycle
Tidsskr Nor Laegeforen, 132 (19), 2175-8
PubMed 23076486

Publications 2011

Eek C, Grenne B, Brunvand H, Aakhus S, Endresen K, Smiseth OA, Edvardsen T, Skulstad H (2011)
Postsystolic shortening is a strong predictor of recovery of systolic function in patients with non-ST-elevation myocardial infarction
Eur J Echocardiogr, 12 (7), 483-9
PubMed 21609975

Gjesdal O, Remme EW, Opdahl A, Skulstad H, Russell K, Kongsgaard E, Edvardsen T, Smiseth OA (2011)
Mechanisms of abnormal systolic motion of the interventricular septum during left bundle-branch block
Circ Cardiovasc Imaging, 4 (3), 264-73
PubMed 21393502

Grenne B, Eek C, Sjøli B, Dahlslett T, Hol PK, Orn S, Skulstad H, Smiseth OA, Edvardsen T, Brunvand H (2011)
Mean strain throughout the heart cycle by longitudinal two-dimensional speckle-tracking echocardiography enables early prediction of infarct size
J Am Soc Echocardiogr, 24 (10), 1118-25
PubMed 21764553

Haugaa KH, Bergestuen DS, Sahakyan LG, Skulstad H, Aakhus S, Thiis-Evensen E, Edvardsen T (2011)
Evaluation of right ventricular dysfunction by myocardial strain echocardiography in patients with intestinal carcinoid disease
J Am Soc Echocardiogr, 24 (6), 644-50
PubMed 21440415

Russell K, Smiseth OA, Gjesdal O, Qvigstad E, Norseng PA, Sjaastad I, Opdahl A, Skulstad H, Edvardsen T, Remme EW (2011)
Mechanism of prolonged electromechanical delay in late activated myocardium during left bundle branch block
Am J Physiol Heart Circ Physiol, 301 (6), H2334-43
PubMed 21984549

Smiseth OA, Russell K, Skulstad H (2011)
The role of echocardiography in quantification of left ventricular dyssynchrony: state of the art and future directions
Eur Heart J Cardiovasc Imaging, 13 (1), 61-8
PubMed 22094237

Publications 2010

Eek C, Grenne B, Brunvand H, Aakhus S, Endresen K, Hol PK, Smith HJ, Smiseth OA, Edvardsen T, Skulstad H (2010)
Strain echocardiography and wall motion score index predicts final infarct size in patients with non-ST-segment-elevation myocardial infarction
Circ Cardiovasc Imaging, 3 (2), 187-94
PubMed 20075142

Eek C, Grenne B, Brunvand H, Aakhus S, Endresen K, Smiseth OA, Edvardsen T, Skulstad H (2010)
Strain echocardiography predicts acute coronary occlusion in patients with non-ST-segment elevation acute coronary syndrome
Eur J Echocardiogr, 11 (6), 501-8
PubMed 20185525

Espinoza A, Halvorsen PS, Skulstad H, Lundblad R, Bugge JF, Hoff L, Fosse E, Edvardsen T (2010)
Automated detection of myocardial ischaemia by epicardial miniature ultrasound transducers--a novel tool for patient monitoring during cardiac surgery
Eur J Cardiothorac Surg, 39 (1), 53-9
PubMed 20627751

Grenne B, Eek C, Sjøli B, Dahlslett T, Uchto M, Hol PK, Skulstad H, Smiseth OA, Edvardsen T, Brunvand H (2010)
Acute coronary occlusion in non-ST-elevation acute coronary syndrome: outcome and early identification by strain echocardiography
Heart, 96 (19), 1550-6
PubMed 20643662

Grenne B, Eek C, Sjøli B, Skulstad H, Aakhus S, Smiseth OA, Edvardsen T, Brunvand H (2010)
Changes of myocardial function in patients with non-ST-elevation acute coronary syndrome awaiting coronary angiography
Am J Cardiol, 105 (9), 1212-8
PubMed 20403468

Russell K, Opdahl A, Remme EW, Gjesdal O, Skulstad H, Kongsgaard E, Edvardsen T, Smiseth OA (2010)
Evaluation of left ventricular dyssynchrony by onset of active myocardial force generation: a novel method that differentiates between electrical and mechanical etiologies
Circ Cardiovasc Imaging, 3 (4), 405-14
PubMed 20494943

Publications 2009

Bergsland J, Lingaas PS, Skulstad H, Hol PK, Halvorsen PS, Andersen R, Småstuen M, Lundblad R, Svennevig J, Andersen K, Fosse E (2009)
Intracoronary shunt prevents ischemia in off-pump coronary artery bypass surgery
Ann Thorac Surg, 87 (1), 54-60
PubMed 19101268

Espinoza A, Halvorsen PS, Hoff L, Skulstad H, Fosse E, Ihlen H, Edvardsen T (2009)
Detecting myocardial ischaemia using miniature ultrasonic transducers--a feasibility study in a porcine model
Eur J Cardiothorac Surg, 37 (1), 119-26
PubMed 19581103

Halvorsen PS, Remme EW, Espinoza A, Skulstad H, Lundblad R, Bergsland J, Hoff L, Imenes K, Edvardsen T, Elle OJ, Fosse E (2009)
Automatic real-time detection of myocardial ischemia by epicardial accelerometer
J Thorac Cardiovasc Surg, 139 (4), 1026-32
PubMed 19717169

Remme EW, Hoff L, Halvorsen PS, Naerum E, Skulstad H, Fleischer LA, Elle OJ, Fosse E (2009)
Validation of cardiac accelerometer sensor measurements
Physiol Meas, 30 (12), 1429-44
PubMed 19907074

Publications 2008

Halvorsen PS, Espinoza A, Fleischer LA, Elle OJ, Hoff L, Lundblad R, Skulstad H, Edvardsen T, Ihlen H, Fosse E (2008)
Feasibility of a three-axis epicardial accelerometer in detecting myocardial ischemia in cardiac surgical patients
J Thorac Cardiovasc Surg, 136 (6), 1496-502
PubMed 19114197

Halvorsen PS, Fleischer LA, Espinoza A, Elle OJ, Hoff L, Skulstad H, Edvardsen T, Fosse E (2008)
Detection of myocardial ischaemia by epicardial accelerometers in the pig
Br J Anaesth, 102 (1), 29-37
PubMed 19022793

Publications 2007

Frich L, Halvorsen PS, Skulstad H, Damås JK, Gladhaug IP (2007)
Microbubbles in the pulmonary artery generated during experimental hepatic radiofrequency ablation is correlated with increased pulmonary arterial pressure
J Vasc Interv Radiol, 18 (3), 437-42
PubMed 17377191

Hol PK, Andersen K, Skulstad H, Halvorsen PS, Lingaas PS, Andersen R, Bergsland J, Fosse E (2007)
Epicardial ultrasonography: a potential method for intraoperative quality assessment of coronary bypass anastomoses?
Ann Thorac Surg, 84 (3), 801-7
PubMed 17720379

Vartdal T, Brunvand H, Pettersen E, Smith HJ, Lyseggen E, Helle-Valle T, Skulstad H, Ihlen H, Edvardsen T (2007)
Early prediction of infarct size by strain Doppler echocardiography after coronary reperfusion
J Am Coll Cardiol, 49 (16), 1715-21
PubMed 17448374

Publications 2006

Skulstad H, Urheim S, Edvardsen T, Andersen K, Lyseggen E, Vartdal T, Ihlen H, Smiseth OA (2006)
Grading of myocardial dysfunction by tissue Doppler echocardiography: a comparison between velocity, displacement, and strain imaging in acute ischemia
J Am Coll Cardiol, 47 (8), 1672-82
PubMed 16631008

Publications 2005

Lyseggen E, Rabben SI, Skulstad H, Urheim S, Risoe C, Smiseth OA (2005)
Myocardial acceleration during isovolumic contraction: relationship to contractility
Circulation, 111 (11), 1362-9
PubMed 15753217

Lyseggen E, Skulstad H, Helle-Valle T, Vartdal T, Urheim S, Rabben SI, Opdahl A, Ihlen H, Smiseth OA (2005)
Myocardial strain analysis in acute coronary occlusion: a tool to assess myocardial viability and reperfusion
Circulation, 112 (25), 3901-10
PubMed 16365210

Urheim S, Rabben SI, Skulstad H, Lyseggen E, Ihlen H, Smiseth OA (2005)
Regional myocardial work by strain Doppler echocardiography and LV pressure: a new method for quantifying myocardial function
Am J Physiol Heart Circ Physiol, 288 (5), H2375-80
PubMed 15637114

Publications 2004

Remme EW, Hunter PJ, Smiseth O, Stevens C, Rabben SI, Skulstad H, Angelsen B (2004)
Development of an in vivo method for determining material properties of passive myocardium
Model. Identif. Control, 25 (4), 237-252

Remme EW, Hunter PJ, Smiseth O, Stevens C, Rabben SI, Skulstad H, Angelsen BB (2004)
Development of an in vivo method for determining material properties of passive myocardium
J Biomech, 37 (5), 669-78
PubMed 15046996

Skulstad H, Andersen K, Edvardsen T, Rein KA, Tønnessen TI, Hol PK, Fosse E, Ihlen H (2004)
Detection of ischemia and new insight into left ventricular physiology by strain Doppler and tissue velocity imaging: assessment during coronary bypass operation of the beating heart
J Am Soc Echocardiogr, 17 (12), 1225-33
PubMed 15562259

Publications 2003

Urheim S, Edvardsen T, Steine K, Skulstad H, Lyseggen E, Rodevand O, Smiseth OA (2003)
Postsystolic shortening of ischemic myocardium: a mechanism of abnormal intraventricular filling
Am J Physiol Heart Circ Physiol, 284 (6), H2343-50
PubMed 12574003

Publications 2002

Edvardsen T, Urheim S, Skulstad H, Steine K, Ihlen H, Smiseth OA (2002)
Quantification of left ventricular systolic function by tissue Doppler echocardiography: added value of measuring pre- and postejection velocities in ischemic myocardium
Circulation, 105 (17), 2071-7
PubMed 11980687

Skulstad H, Edvardsen T, Urheim S, Rabben SI, Stugaard M, Lyseggen E, Ihlen H, Smiseth OA (2002)
Postsystolic shortening in ischemic myocardium: active contraction or passive recoil?
Circulation, 106 (6), 718-24
PubMed 12163433

Publications 2001

Edvardsen T, Skulstad H, Aakhus S, Urheim S, Ihlen H (2001)
Regional myocardial systolic function during acute myocardial ischemia assessed by strain Doppler echocardiography
J Am Coll Cardiol, 37 (3), 726-30
PubMed 11693743

Publications 2000

Ghanima W, Skulstad H, Falk K, Ringstad J (2000)
[Time delay in the thrombolytic treatment of myocardial infarction]
Tidsskr Nor Laegeforen, 120 (16), 1851-3
PubMed 10925610

Størdal K, Bentsen B, Skulstad H, Moum B (2000)
[Reflux disease and 24-hour esophageal pH monitoring in children]
Tidsskr Nor Laegeforen, 120 (2), 183-6
PubMed 10851912

Publications 1999

Skulstad H, Backström J (1999)
[Fatal coronary heart disease in a young woman 20 years after radiotherapy for Hodgkin disease]
Tidsskr Nor Laegeforen, 119 (10), 1431-2
PubMed 10354750

Publications 1997

Skulstad H, Jacobsen MB, Moum B, Odegaard A (1997)
[Gastrointestinal amyloidosis. Differential diagnosis or a complication of inflammatory bowel disease?]
Tidsskr Nor Laegeforen, 117 (24), 3489-91
PubMed 9411905