Torgeir Wethal
Position: Ph.D. student
Phone: (230) 70826
Email:

Project I:
Induction of coronary risk factors, including endothelial dysfunction and inflammation in patients treated for cancer and in healthy subjects. Significance for morbidity and mortality.

Supervisor: John Kjekshus

Collaborators: Pål Aukrust, Sophie Fosså, Rune Andersen

Aim:

To study the development of coronary risk factors and cardiovascular morbidity and mortality in long-term survivors of testicular cancer treated with chemotherapy and/or radiotherapy
To study the long-term consequences of treatment for patients who have had Hodgkin’s disease with respect to the development of cardiovascular disease (and with emphasis on cardiac valve regurgitations)
To study the induction of lipid streaks in connection with induced inflammation after vaccination for typhoid fever in young healthy individuals.
To measure endothelial function in young healthy males with different methods before and after work load and correlate these results with indices of inflammation and endothelial dysfunction measured in blood samples.


Project II:
Endogenous and exogenous causes for endothelial dysfunction

Supervisors: John Kjekshus, Sopie D. Fosså

Collaborators: Department of Clinical Cancer Research, Research Institute for Internal Medicine, Department of Radiology, Department of Respiratory Medicine

Aim:

To analyze the long-term consequences of modern cancer therapy on cardiovascular morbidity, mortality and endothelial function. To investigate the relation between different methods measuring endothelial dysfunction in healthy individuals and measure if the endothelial function is altered by vaccination against typhoid fever.

 

Author network for Torgeir Wethal by COREMINE medical


Publications 2016

Murbraech K, Wethal T, Smeland KB, Holte H, Loge JH, Holte E, Rösner A, Dalen H, Kiserud CE, Aakhus S (2016)
Valvular Dysfunction in Lymphoma Survivors Treated With Autologous Stem Cell Transplantation: A National Cross-Sectional Study
JACC Cardiovasc Imaging, 9 (3), 230-9
PubMed 26897666

Stenehjem JS, Smeland KB, Murbraech K, Holte H, Kvaløy S, Wethal T, Kiserud CE, Lund MB (2016)
Diffusing capacity impairment is prevalent in long-term lymphoma survivors after high-dose therapy with autologous stem cell transplantation
Bone Marrow Transplant (in press)
PubMed 27991891

Publications 2015

Murbraech K, Smeland KB, Holte H, Loge JH, Lund MB, Wethal T, Holte E, Rösner A, Dalen H, Kvaløy S, Falk RS, Aakhus S, Kiserud CE (2015)
Heart Failure and Asymptomatic Left Ventricular Systolic Dysfunction in Lymphoma Survivors Treated With Autologous Stem-Cell Transplantation: A National Cross-Sectional Study
J Clin Oncol, 33 (24), 2683-91
PubMed 26169610

Varmdal T, Bakken IJ, Janszky I, Wethal T, Ellekjær H, Rohweder G, Fjærtoft H, Ebbing M, Bønaa KH (2015)
Comparison of the validity of stroke diagnoses in a medical quality register and an administrative health register
Scand J Public Health, 44 (2), 143-9
PubMed 26660300

Wethal T, Røysland R, Torbjørn O, Kjekshus J (2015)
Exercise-induced vasodilation in healthy males: A marker of reduced endothelial function
Scand Cardiovasc J, 49 (3), 123-9
PubMed 25752356

Publications 2013

Wethal T, Nedregaard B, Andersen R, Fosså A, Lund MB, Günther A, Kvaløy S, Fosså SD, Kjekshus J (2013)
Atherosclerotic lesions in lymphoma survivors treated with radiotherapy
Radiother Oncol, 110 (3), 448-54
PubMed 24231235

Publications 2011

Tsai HR, Gjesdal O, Wethal T, Haugaa KH, Fosså A, Fosså SD, Edvardsen T (2011)
Left ventricular function assessed by two-dimensional speckle tracking echocardiography in long-term survivors of Hodgkin's lymphoma treated by mediastinal radiotherapy with or without anthracycline therapy
Am J Cardiol, 107 (3), 472-7
PubMed 21257017

Publications 2010

Haugnes HS, Wethal T, Aass N, Dahl O, Klepp O, Langberg CW, Wilsgaard T, Bremnes RM, Fosså SD (2010)
Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study
J Clin Oncol, 28 (30), 4649-57
PubMed 20855830

Wethal T, Haugnes HS, Kjekshus J, Småstuen MC, Ueland T, Aukrust P, Fosså SD (2010)
C-reactive protein; a potential marker of second cancer and cardiovascular disease in testicular cancer survivors?
Eur J Cancer, 46 (18), 3425-33
PubMed 20832295

Publications 2009

Andersen R, Wethal T, Günther A, Fosså A, Edvardsen T, Fosså SD, Kjekshus J (2009)
Relation of coronary artery calcium score to premature coronary artery disease in survivors >15 years of Hodgkin's lymphoma
Am J Cardiol, 105 (2), 149-52
PubMed 20102909

Wethal T, Lund MB, Edvardsen T, Fosså SD, Pripp AH, Holte H, Kjekshus J, Fosså A (2009)
Valvular dysfunction and left ventricular changes in Hodgkin's lymphoma survivors. A longitudinal study
Br J Cancer, 101 (4), 575-81
PubMed 19623176

Publications 2007

Wethal T, Kjekshus J, Røislien J, Ueland T, Andreassen AK, Wergeland R, Aukrust P, Fosså SD (2007)
Treatment-related differences in cardiovascular risk factors in long-term survivors of testicular cancer
J Cancer Surviv, 1 (1), 8-16
PubMed 18648940