Main focus:
Coronary disease. Heart failure. Clinical trialss.
Main methods:
Hemodynamic studies. Laboratory testing.
Project:
Low-frequency helicopter noise as a cardiovascular risk factor
Aim:
Prospective investigation of noise and effects provoked by noise on endothelial function and signal markers for endothelial function and inflammation
Author network for John Kjekshus by COREMINE medical
Publications in press
Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology
Eur J Heart Fail (in press)
PubMed 22302661
The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*
J Intern Med (in press)
PubMed 22211640
Publications 2011
ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
Atherosclerosis, 217 (1), 3-46
PubMed 21882396
ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
Eur Heart J, 32 (14), 1769-818
PubMed 21712404
ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
Atherosclerosis, 217 Suppl 1, S1-44
PubMed 21723445
Osteoprotegerin predicts progression of chronic heart failure: results from CORONA
Circ Heart Fail, 4 (2), 145-52
PubMed 21216833
Publications 2010
Relation of coronary artery calcium score to premature coronary artery disease in survivors >15 years of Hodgkin's lymphoma
Am J Cardiol, 105 (2), 149-52
PubMed 20102909
Intermittent claudication as a predictor of outcome in patients with ischaemic systolic heart failure: analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure trial (CORONA)
Eur J Heart Fail, 12 (7), 698-705
PubMed 20501489
Effects of ACE2 inhibition in the post-myocardial infarction heart
J Card Fail, 16 (9), 777-85
PubMed 20797602
An economic evaluation of rosuvastatin treatment in systolic heart failure: evidence from the CORONA trial
Eur J Heart Fail, 12 (1), 66-74
PubMed 20023047
Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure)
J Am Coll Cardiol, 56 (15), 1196-204
PubMed 20883926
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
Lancet, 375 (9716), 735-42
PubMed 20167359
C-reactive protein; a potential marker of second cancer and cardiovascular disease in testicular cancer survivors?
Eur J Cancer, 46 (18), 3425-33
PubMed 20832295
Publications 2009
Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: data from the OPTIMAAL trial
Eur Heart J, 30 (11), 1331-9
PubMed 19383732
Plasma concentration of amino-terminal pro-brain natriuretic peptide in chronic heart failure: prediction of cardiovascular events and interaction with the effects of rosuvastatin: a report from CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure)
J Am Coll Cardiol, 54 (20), 1850-9
PubMed 19892235
The influence of renal function on clinical outcome and response to beta-blockade in systolic heart failure: insights from Metoprolol CR/XL Randomized Intervention Trial in Chronic HF (MERIT-HF)
J Card Fail, 15 (4), 310-8
PubMed 19398079
Effect of simvastatin on kidney function loss in patients with coronary heart disease: findings from the Scandinavian Simvastatin Survival Study (4S)
Atherosclerosis, 205 (1), 202-6
PubMed 19124121
Is there a heart rate paradox--demystification of the myths?
J Intern Med, 266 (3), 242-7
PubMed 19702792
A helicopter flight does not induce significant changes in systemic biomarker profiles
Scand J Clin Lab Invest, 69 (4), 462-74
PubMed 19333819
Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): a retrospective analysis
Circulation, 120 (22), 2188-96
PubMed 19917888
Predictors of fatal and non-fatal outcomes in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): incremental value of apolipoprotein A-1, high-sensitivity C-reactive peptide and N-terminal pro B-type natriuretic peptide
Eur J Heart Fail, 11 (3), 281-91
PubMed 19168876
Valvular dysfunction and left ventricular changes in Hodgkin's lymphoma survivors. A longitudinal study
Br J Cancer, 101 (4), 575-81
PubMed 19623176
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure
Eur Heart J, 30 (10), 1229-36
PubMed 19329498
Publications 2008
The perfect biomarker in acute coronary syndrome: a challenge for diagnosis, prognosis, and treatment
Eur Heart J, 29 (23), 2827-8
PubMed 18957473
Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris
Scand Cardiovasc J, 42 (3), 214-21
PubMed 18569954
Risk associated with statin treatment
J Am Coll Cardiol, 51 (1), 91; author reply 92
PubMed 18174047
What are the effects of patient age and blood pressure on the cholesterol-related risk of vascular mortality?
Nat Clin Pract Cardiovasc Med, 5 (6), 310-1
PubMed 18446135
Rosuvastatin in older patients with systolic heart failure - Reply
N. Engl. J. Med., 358 (12), 1301
Publications 2007
Simvastatin for secondary prevention of all-cause mortality and major coronary events in patients with mild chronic renal insufficiency
Am J Kidney Dis, 49 (3), 373-82
PubMed 17336698
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization
Arterioscler Thromb Vasc Biol, 27 (3), 614-20
PubMed 17170367
Impact of neurohormonal blockade on association between body mass index and mortality
Int J Cardiol, 119 (1), 33-40
PubMed 17052777
Prescription of beta-blockers in patients with advanced heart failure and preserved left ventricular ejection fraction. Clinical implications and survival
Eur J Heart Fail, 9 (9), 962; author reply 962-3
PubMed 17652021
Rosuvastatin in older patients with systolic heart failure
N Engl J Med, 357 (22), 2248-61
PubMed 17984166
Treatment-related differences in cardiovascular risk factors in long-term survivors of testicular cancer
J Cancer Surviv, 1 (1), 8-16
PubMed 18648940
Publications 2006
The impact of morbid events on survival following hospitalization for complicated myocardial infarction
Eur J Heart Fail, 8 (1), 74-80
PubMed 16081319
Prognostic value of plasma chromogranin A levels in patients with complicated myocardial infarction
Am Heart J, 152 (5), 927.e1-6
PubMed 17070161
[Unexpected sudden death after percutaneous coronary intervention]
Tidsskr Nor Laegeforen, 126 (16), 2111-3
PubMed 16960998
A protective anti-inflammatory phenotype in high-risk individuals who do not develop coronary artery disease
J Am Coll Cardiol, 47 (5), 1085-6
PubMed 16516099
Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction
J Card Fail, 12 (8), 659-63
PubMed 17045187
Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MERIT-HF Study
Eur J Heart Fail, 8 (5), 539-46
PubMed 16567126
Mechanisms behind the postprandial increase in cardiac output: a clue obtained from transplanted hearts
Eur J Appl Physiol, 97 (5), 516-20
PubMed 16718506
Publications 2005
Heart failure and statins--why do we need a clinical trial?
Z Kardiol, 94 (4), 223-30
PubMed 15803258
Efficacy, safety and tolerability of metoprolol CR/XL in patients with diabetes and chronic heart failure: experiences from MERIT-HF
Am Heart J, 149 (1), 159-67
PubMed 15660048
Agents targeting inflammation in heart failure
Expert Opin Investig Drugs, 14 (5), 557-66
PubMed 15926863
Effect of thalidomide on cardiac remodeling in chronic heart failure: results of a double-blind, placebo-controlled study
Circulation, 112 (22), 3408-14
PubMed 16301340
What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF)
J Am Coll Cardiol, 45 (2), 252-9
PubMed 15653024
Etanercept or intravenous immunoglobulin attenuates expression of genes involved in post-myocardial infarction remodeling
Cardiovasc Res, 67 (1), 106-15
PubMed 15949474
Serial measurements of peripheral vascular reactivity and exercise capacity in congestive heart failure and after heart transplantation
J Card Fail, 11 (6), 447-54
PubMed 16105636
A statin in the treatment of heart failure? Controlled rosuvastatin multinational study in heart failure (CORONA): study design and baseline characteristics
Eur J Heart Fail, 7 (6), 1059-69
PubMed 16227145
Recurrent infarction causes the most deaths following myocardial infarction with left ventricular dysfunction
Am J Med, 118 (7), 752-8
PubMed 15989909
Soluble CD40 ligand in acute and chronic heart failure
Eur Heart J, 26 (11), 1101-7
PubMed 15716285
Plasma levels of soluble tumor necrosis factor receptor type I during the acute phase following complicated myocardial infarction predicts survival in high-risk patients
J Am Coll Cardiol, 46 (11), 2018-21
PubMed 16325035
Publications 2004
The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)
Am J Cardiol, 93 (2), 136-41
PubMed 14715336
Predictors of exercise capacity and the impact of angiographic coronary artery disease in heart transplant recipients
Am Heart J, 147 (1), 49-54
PubMed 14691418
Effect of combined statin and beta-blocker treatment on one-year morbidity and mortality after acute myocardial infarction associated with heart failure
Am J Cardiol, 93 (5), 603-6
PubMed 14996587
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). 1994
Atheroscler Suppl, 5 (3), 81-7
PubMed 15531279
Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S). 1998
Atheroscler Suppl, 5 (3), 99-106
PubMed 15531282
Reduction of cardiovascular events by simvastatin in nondiabetic coronary heart disease patients with and without the metabolic syndrome: subgroup analyses of the Scandinavian Simvastatin Survival Study (4S)
Diabetes Care, 27 (7), 1735-40
PubMed 15220255
Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S)
Lancet, 364 (9436), 771-7
PubMed 15337403
Prognostic value of osteoprotegerin in heart failure after acute myocardial infarction
J Am Coll Cardiol, 44 (10), 1970-6
PubMed 15542278
Publications 2003
The statin wars
Lancet, 362 (9398), 1854; discussion 1856
PubMed 14654327
[Use of beta-blockaders in heart failure]
Tidsskr Nor Laegeforen, 123 (5), 651-2
PubMed 12683197
N-terminal proatrial natriuretic peptide in primary care: relation to echocardiographic indices of cardiac function in mild to moderate cardiac disease
Int J Cardiol, 89 (2-3), 197-205
PubMed 12767543
CXC-chemokines in coronary artery disease: possible pathogenic role of interactions between oxidized low-density lipoprotein, platelets and peripheral blood mononuclear cells
J Thromb Haemost, 1 (2), 257-62
PubMed 12871498
COMET: a proposed mechanism of action to explain the results and concerns about dose
Lancet, 362 (9389), 1076-7; author reply 1077-8
PubMed 14522542
How should subgroup analyses affect clinical practice? Insights from the Metoprolol Succinate Controlled-Release/Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF)
Card Electrophysiol Rev, 7 (3), 264-75
PubMed 14739726
Publications 2002
Low high-density lipoprotein cholesterol and response to simvastatin therapy in Scandinavian Simvastatin Survival Study (4S) - Response
Circulation, 106 (2), E8
Inflammatory predictors of mortality in the Scandinavian Simvastatin Survival Study
Clin Cardiol, 25 (10), 461-6
PubMed 12375804
The OPTIMAL trial: losartan or captopril after acute myocardial infarction - Reply
Lancet, 360 (9348), 1885
Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan
Lancet, 360 (9335), 752-60
PubMed 12241832
Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF)
Circulation, 105 (10), 1182-8
PubMed 11889011
Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension
Transplantation, 74 (10), 1395-400
PubMed 12451238
The effect of aortic valve replacement on N-terminal natriuretic propeptides in patients with aortic stenosis
Clin Cardiol, 25 (4), 174-80
PubMed 12000075
Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10
Eur J Clin Invest, 32 (11), 803-10
PubMed 12423320
Dose of metoprolol CR/XL and clinical outcomes in patients with heart failure: analysis of the experience in metoprolol CR/XL randomized intervention trial in chronic heart failure (MERIT-HF)
J Am Coll Cardiol, 40 (3), 491-8
PubMed 12142116
Publications 2001
[Inhalation of a prostacyclin analog (iloprost) in primary and secondary pulmonary hypertension]
Tidsskr Nor Laegeforen, 121 (10), 1220-3
PubMed 11402748
Increase in anti-inflammatory cytokine levels in chronic heart failure: A measure of treatment success or failure? Response
Circulation, 104 (18), E97-E98
Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S
Circulation, 104 (25), 3046-51
PubMed 11748098
Comparison of baseline data, initial course, and management: losartan versus captopril following acute myocardial infarction (The OPTIMAAL Trial). OPTIMAAL Trial Steering Committee and Investigators. Optimal Trial in Myocardial Infarction with the Angiotensin II Antagonist Losartan
Am J Cardiol, 87 (6), 766-71, A7
PubMed 11249900
Metoprolol controlled release/extended release in patients with severe heart failure: analysis of the experience in the MERIT-HF study
J Am Coll Cardiol, 38 (4), 932-8
PubMed 11583861
Effect of metoprolol CR/XL on exercise tolerance in chronic heart failure - a substudy to the MERIT-HF trial
Eur J Heart Fail, 3 (4), 463-8
PubMed 11511433
Effect of metoprolol on cytokine levels in chronic heart failure--a substudy in the Metoprolol Controlled-Release Randomised Intervention Trial in Heart Failure (MERIT-HF)
Am Heart J, 141 (3), 418-21
PubMed 11231439
[Immunomodulating treatment in advanced heart failure--effect of intravenous immunoglobulin]
Tidsskr Nor Laegeforen, 121 (16), 1902-7
PubMed 11488180
Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure
Circulation, 103 (2), 220-5
PubMed 11208680
Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients
Eur Heart J, 22 (5), 428-36
PubMed 11207085
Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients
Am J Cardiol, 87 (6), 815-8, A9
PubMed 11249916
Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients
Transplantation, 72 (4), 706-11
PubMed 11544435
Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects
Am J Med, 110 (7), 536-42
PubMed 11343667
Debate: Statins should be used in patients with heart failure
Curr Control Trials Cardiovasc Med, 2 (6), 268-270
PubMed 11806812
Stenting in small coronary arteries (SISCA) trial. A randomized comparison between balloon angioplasty and the heparin-coated beStent
J Am Coll Cardiol, 38 (6), 1598-603
PubMed 11704369
Natriuretic peptides in patients with aortic stenosis
Am Heart J, 142 (4), 725-32
PubMed 11579366
Challenges of subgroup analyses in multinational clinical trials: experiences from the MERIT-HF trial
Am Heart J, 142 (3), 502-11
PubMed 11526365
Publications 2000
Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group
JAMA, 283 (10), 1295-302
PubMed 10714728
Distribution of myocardial injury and its relation to epicardial ST-segment changes after coronary artery occlusion in the dog
Cardiovasc. Res., 45 (1), 109-110
Distribution of myocardial injury and its relation to epicardial ST-segment change after coronary occlusion in the dog
Cardiovasc Res, 45 (1), 107-10
PubMed 10728320
Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin: systematic overview of individual data from 96,712 randomized patients. Angiotensin-converting Enzyme Inhibitor Myocardial Infarction Collaborative Group
J Am Coll Cardiol, 35 (7), 1801-7
PubMed 10841227
Statin drugs and the risk of fracture. 4S Study Group
JAMA, 284 (15), 1921-2
PubMed 11035877
Follow-up study of patients randomized in the Scandinavian simvastatin survival study (4S) of cholesterol lowering
Am J Cardiol, 86 (3), 257-62
PubMed 10922429
Differential responses of plasma atrial and brain natriuretic peptides to acute alteration in atrial pressure in pigs
Scand J Clin Lab Invest, 60 (1), 55-63
PubMed 10757454
Publications 1999
Comparison of the effects of losartan and captopril on mortality in patients after acute myocardial infarction: the OPTIMAAL trial design. Optimal Therapy in Myocardial Infarction with the Angiotensin II Antagonist Losartan
Am J Cardiol, 83 (4), 477-81
PubMed 10073846
[Current use of beta-blockers in coronary artery disease]
Tidsskr Nor Laegeforen, 119 (1), 24-8
PubMed 10025200
Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study
Arch Intern Med, 159 (22), 2661-7
PubMed 10597756
Effect of simvastatin treatment on cardiovascular resource utilization in impaired fasting glucose and diabetes. Findings from the Scandinavian Simvastatin Survival Study
Diabetes Care, 22 (11), 1771-8
PubMed 10546006
Heart rate as a therapeutic target in heart failure
Eur. Heart J. Suppl., 1 (H), H64-H69
Long-term survival in severe heart failure in patients treated with enalapril. Ten year follow-up of CONSENSUS I
Eur Heart J, 20 (2), 136-9
PubMed 10099910
[Chronic heart failure--suggestion to a management program]
Tidsskr Nor Laegeforen, 119 (23), 3427-31
PubMed 10553340
Publications 1998
Exercise capacity in heart transplant recipients: relation to impaired endothelium-dependent vasodilation of the peripheral microcirculation
Am Heart J, 136 (2), 320-8
PubMed 9704697
Elevated circulating levels of C-C chemokines in patients with congestive heart failure
Circulation, 97 (12), 1136-43
PubMed 9537339
Influence of guidewire and catheter type on the frequency of cerebral microembolic signals during left heart catheterization
Am J Cardiol, 82 (5), 632-7
PubMed 9732893
Differences in the treatment of coronary heart disease between countries as revealed in the Scandinavian Simvastatin Survival Study (4S)
Eur Heart J, 19 (10), 1531-7
PubMed 9820992
Angiotensin II receptor subtype AT1 and AT2 expression after heart transplantation
Cardiovasc Res, 38 (2), 340-7
PubMed 9709394
Neuropeptide Y receptor 1 (NPY-Y1) expression in human heart failure and heart transplantation
J Auton Nerv Syst, 70 (1-2), 84-91
PubMed 9686908
An experimental study of cardiac natriuretic peptides as markers of development of congestive heart failure
Scand J Clin Lab Invest, 58 (8), 683-91
PubMed 10088206
Effect of simvastatin on ischemic signs and symptoms in the Scandinavian simvastatin survival study (4S)
Am J Cardiol, 81 (3), 333-5
PubMed 9468077
Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S)
Circulation, 97 (15), 1453-60
PubMed 9576425
Left ventricular volumes assessed by different new three-dimensional echocardiographic methods and ordinary biplane technique
Int J Card Imaging, 14 (1), 55-63
PubMed 9559379
Sustained benefit of stenting chronic coronary occlusion: long-term clinical follow-up of the Stenting in Chronic Coronary Occlusion (SICCO) study
J Am Coll Cardiol, 32 (2), 305-10
PubMed 9708454
Publications 1997
Lp(a) lipoprotein level predicts survival and major coronary events in the Scandinavian Simvastatin Survival Study
Clin Genet, 52 (5), 254-61
PubMed 9520115
[Cholesterol depression prevents heart disease]
Ugeskr Laeger, 159 (15), 2193
PubMed 9148540
Gas exchange and neurohumoral response to exercise: influence of the exercise protocol
Med Sci Sports Exerc, 29 (4), 496-502
PubMed 9107632
[Treatment of heart failure with beta-blockaders]
Tidsskr Nor Laegeforen, 117 (4), 526-8
PubMed 9148453
[Calcium channel blockers in heart failure]
Tidsskr Nor Laegeforen, 117 (16), 2329-32
PubMed 9265278
Cost effectiveness of simvastatin treatment to lower cholesterol levels in patients with coronary heart disease. Scandinavian Simvastatin Survival Study Group
N Engl J Med, 336 (5), 332-6
PubMed 9011785
[Lipid reduction--benefit without risk?]
Tidsskr Nor Laegeforen, 117 (22), 3184-5
PubMed 9411850
[Prevention--are we not good enough?]
Tidsskr Nor Laegeforen, 117 (16), 2293
PubMed 9265266
Use of statins. Cost effectiveness was studied in 4S study
BMJ, 315 (7122), 1619-20
PubMed 9437297
The effects of simvastatin on the incidence of heart failure in patients with coronary heart disease
J Card Fail, 3 (4), 249-54
PubMed 9547437
Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S)
Circulation, 96 (12), 4211-8
PubMed 9416884
Interaction between enalapril and aspirin on mortality after acute myocardial infarction: subgroup analysis of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II)
Am J Cardiol, 79 (2), 115-9
PubMed 9193008
Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease - A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)
Diabetes Care, 20 (4), 614-620
Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)
Diabetes Care, 20 (4), 614-20
PubMed 9096989
Left ventricular mass assessed by three-dimensional echocardiography using rotational acquisition
Clin Cardiol, 20 (11), 957-62
PubMed 9383590
Putting low-density lipoproteins at center stage in atherogenesis
Am J Cardiol, 79 (1), 64-7
PubMed 9024738
Effect of bolus injection versus continuous infusion of furosemide on diuresis and neurohormonal activation in patients with severe congestive heart failure
Scand J Clin Lab Invest, 57 (4), 361-7
PubMed 9249883
Publications 1996
Exercise capacity of heart transplant recipients: the importance of chronotropic incompetence
J Heart Lung Transplant, 15 (11), 1075-83
PubMed 8956116
Influence of the exercise protocol on hemodynamic, gas exchange, and neurohumoral responses to exercise in heart transplant recipients
J Heart Lung Transplant, 15 (3), 304-13
PubMed 8777215
[ProANF and heart failure in general practice]
Tidsskr Nor Laegeforen, 116 (25), 3048
PubMed 8975436
Cost-effectiveness of cholesterol lowering. Results from the Scandinavian Simvastatin Survival Study (4S)
Eur Heart J, 17 (7), 1001-7
PubMed 8809516
Treating the diabetic patient with coronary disease
Eur Heart J, 17 (9), 1298-301
PubMed 8880010
[Cardio-reparation--or cardioversion]
Tidsskr Nor Laegeforen, 116 (15), 1774-5
PubMed 8693457
[Reduction of cholesterol prevents disease]
Tidsskr Nor Laegeforen, 116 (28), 3319-20
PubMed 9011985
Lipid-lowering therapy for patients with or at risk of coronary artery disease
Curr Opin Cardiol, 11 (4), 418-27
PubMed 8879953
Treatment of heart failure
J Intern Med, 239 (4), 335-43
PubMed 8774388
Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the Scandinavian Simvastatin Survival Study
Arch Intern Med, 156 (18), 2085-92
PubMed 8862101
Cholesterol lowering and the use of healthcare resources. Results of the Scandinavian Simvastatin Survival Study
Circulation, 93 (10), 1796-802
PubMed 8635258
Stenting in Chronic Coronary Occlusion (SICCO): a randomized, controlled trial of adding stent implantation after successful angioplasty
J Am Coll Cardiol, 28 (6), 1444-51
PubMed 8917256
Publications 1995
[Intermittent claudication and beta-blockaders. An unfortunate combination?]
Tidsskr Nor Laegeforen, 115 (6), 725-8
PubMed 7900137
ISIS-4 - A RANDOMIZED FACTORIAL TRIAL ASSESSING EARLY ORAL CAPTOPRIL, ORAL MONONITRATE, AND INTRAVENOUS MAGNESIUM-SULFATE IN 58,050 PATIENTS WITH SUSPECTED ACUTE MYOCARDIAL-INFARCTION
Lancet, 345 (8951), 669-685
Comparison of the effects of losartan and enalapril on clinical status and exercise performance in patients with moderate or severe chronic heart failure
J Am Coll Cardiol, 26 (2), 438-45
PubMed 7608448
Atrial natriuretic peptide ANP(1-98) and ANP(99-126) in patients with severe chronic congestive heart failure: relation to echocardiographic measurements. A subgroup analysis from the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
J Card Fail, 1 (2), 109-16
PubMed 9420640
[Reduced physical tolerance in patients with heart failure. Mechanisms and therapeutic effects]
Tidsskr Nor Laegeforen, 115 (1), 38-42
PubMed 7846658
Beta-blockers and sudden cardiac death
Ann Intern Med, 123 (5), 358-67
PubMed 7625625
REDUCING THE RISK OF CORONARY EVENTS - EVIDENCE FROM THE SCANDINAVIAN SIMVASTATIN SURVIVAL STUDY (4S)
Am. J. Cardiol., 76 (9), C64-C68
Reducing the risk of coronary events: evidence from the Scandinavian Simvastatin Survival Study (4S)
Am J Cardiol, 76 (9), 64C-68C
PubMed 7572690
[Chronic left heart ventricle failure and inotropic stimulation]
Tidsskr Nor Laegeforen, 115 (3), 360-4
PubMed 7855836
BASE-LINE SERUM-CHOLESTEROL AND TREATMENT EFFECT IN THE SCANDINAVIAN SIMVASTATIN SURVIVAL STUDY (4S)
Lancet, 345 (8960), 1274-1275
Publications 1994
Neuroendocrine activation in relation to left ventricular function in chronic severe congestive heart failure: a subgroup analysis from the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
Clin Cardiol, 17 (11), 603-6
PubMed 7834934
Patient characteristics in cases of chronic severe heart failure with different degrees of left ventricular systolic dysfunction
Cardiology, 85 (3-4), 137-44
PubMed 7987868
The magnesium loading test: reference values in healthy subjects
Scand J Clin Lab Invest, 54 (1), 23-31
PubMed 8171268
Magnesium status in healthy free-living elderly Norwegians
J Am Coll Nutr, 13 (1), 45-50
PubMed 8157853
The plasma concentration of N-terminal proatrial natriuretic factor ANF(1-98) is related to prognosis in severe heart failure
Clin Cardiol, 17 (4), 191-5
PubMed 8187369
[Treatment of heart failure--life and doctrine]
Tidsskr Nor Laegeforen, 114 (21), 2471-2
PubMed 7940445
SCANDINAVIAN SIMVASTATIN STUDY (4S) - REPLY
Lancet, 344 (8939-4), 1767-1768
[Chronic heart failure. A management program. Proposal for diagnosis and treatment]
Tidsskr Nor Laegeforen, 114 (12), 1424-7
PubMed 8079230
Publications 1993
The effect of magnesium versus verapamil on supraventricular arrhythmias
Clin Cardiol, 16 (5), 429-34
PubMed 8504578
DESIGN AND BASE-LINE RESULTS OF THE SCANDINAVIAN SIMVASTATIN SURVIVAL STUDY OF PATIENTS WITH STABLE ANGINA AND OR PREVIOUS MYOCARDIAL-INFARCTION
Am. J. Cardiol., 71 (5), 393-400
ACE INHIBITORS AFTER MYOCARDIAL-INFARCTION
N. Engl. J. Med., 328 (13), 968-969
ACE inhibitors after myocardial infarction
BMJ, 306 (6882), 926-7
PubMed 8490427
Publications 1992
Cholesterol and total mortality: need for larger trials
BMJ, 304 (6843), 1689
PubMed 1633527
Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics
Alcohol Clin Exp Res, 16 (5), 986-90
PubMed 1443440
Magnesium deficiency diagnosed by an intravenous loading test
Scand J Clin Lab Invest, 52 (4), 245-53
PubMed 1439510
[Sudden cardiac death. Significance of beta blockaders]
Tidsskr Nor Laegeforen, 112 (22), 2843-7
PubMed 1357774
[Myocardial disease in diabetes mellitus]
Tidsskr Nor Laegeforen, 112 (8), 1016-9
PubMed 1553723
[Treatment of chronic heart failure]
Tidsskr Nor Laegeforen, 112 (17), 2177-8
PubMed 1523647
Effects of enalapril on long-term mortality in severe congestive heart failure. CONSENSUS Trial Group
Am J Cardiol, 69 (1), 103-7
PubMed 1729857
Renal function in severe congestive heart failure during treatment with enalapril (the Cooperative North Scandinavian Enalapril Survival Study [CONSENSUS] Trial)
Am J Cardiol, 70 (4), 479-87
PubMed 1642186
Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II)
N Engl J Med, 327 (10), 678-84
PubMed 1495520
Publications 1991
Effects of selective beta 2-adrenoceptor blockade on serum potassium and exercise performance in normal men
Br J Clin Pharmacol, 32 (2), 201-7
PubMed 1681847
Oral versus intravenous magnesium supplementation in patients with magnesium deficiency
Magnes Trace Elem, 10 (1), 11-6
PubMed 1814318
Publications 1990
M-mode echocardiography in patients with severe congestive heart failure. A subgroup analysis in the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
Drugs, 39 Suppl 4, 43-8; discussion 53-4
PubMed 2191854
Predicting 1-year outcome following acute myocardial infarction: physicians versus computers
Comput Biomed Res, 23 (1), 46-63
PubMed 2306934
Influence of heart rate on mortality after acute myocardial infarction
Am J Cardiol, 65 (9), 547-53
PubMed 1968702
Arrhythmias and mortality in congestive heart failure
Am J Cardiol, 65 (19), 42I-48I
PubMed 2159694
Diabetic patients and beta-blockers after acute myocardial infarction
Eur Heart J, 11 (1), 43-50
PubMed 1968386
Effects of enalapril and neuroendocrine activation on prognosis in severe congestive heart failure (follow-up of the CONSENSUS trial). CONSENSUS Trial Study Group
Am J Cardiol, 66 (11), 40D-44D; discussion 44D-45D
PubMed 2220604
Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group
Circulation, 82 (5), 1730-6
PubMed 2225374
Effect of enalapril on mortality in congestive heart failure. Follow-up survival data from the CONSENSUS trial
Drugs, 39 Suppl 4, 49-52; discussion 53-4
PubMed 2191855
Publications 1989
Effect of beta-adrenergic blockade on hormonal responses during continuous and intermittent exercise
Cardiovasc Drugs Ther, 3 (1), 63-71
PubMed 2577280
The importance of potassium and lactate for maximal exercise performance during beta blockade
Scand J Clin Lab Invest, 49 (6), 521-8
PubMed 2574496
[Beta blockaders and physical performance. Limiting factors]
Tidsskr Nor Laegeforen, 109 (25), 2544-7
PubMed 2573167
Interaction of naloxone and timolol on maximal exercise capacity and the subjective perception of fatigue
Int J Sports Med, 10 (4), 259-63
PubMed 2606592
Enalapril for congestive heart failure
Am J Cardiol, 63 (8), 26D-32D
PubMed 2537563
Publications 1988
[Treatment of hypercholesterolemia in adults. An action plan]
Tidsskr Nor Laegeforen, 108 (27), 2285-8
PubMed 3206437
Difference between beta-1-selective and non-selective beta-blockade during continuous and intermittent exercise
Clin Physiol, 8 (5), 487-99
PubMed 3191663
Redistribution of peripheral blood flow during acute left ventricular failure in the dog
Scand J Clin Lab Invest, 48 (8), 785-94
PubMed 3238323
Tolerability of enalapril in congestive heart failure
Am J Cardiol, 62 (2), 67A-72A
PubMed 2839020
Cerebrospinal fluid creatine kinase isoenzyme BB levels do not predict the clinical outcome in patients unconscious following cardiac resuscitation
Clin Cardiol, 11 (5), 286, 364
PubMed 3383465
Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
Am J Cardiol, 62 (2), 60A-66A
PubMed 2839019
Publications 1987
The effects of naloxone and timolol on plasma catecholamine levels during short-term dynamic exercise
Scand J Clin Lab Invest, 47 (8), 847-51
PubMed 2893446
[Angiotensin-converting enzyme inhibitors in heart failure]
Tidsskr Nor Laegeforen, 107 (25), 2112-6
PubMed 2823410
[Magnesium deficiency. Diagnosis and occurrence of different disease conditions]
Tidsskr Nor Laegeforen, 107 (22), 1751-4
PubMed 3660356
Effect of ACE-inhibition on tissue blood flow during acute left ventricular failure in the dog
Res Exp Med (Berl), 187 (1), 59-70
PubMed 3033782
Heart rate reduction--a mechanism of benefit?
Eur Heart J, 8 Suppl L, 115-22
PubMed 2897914
Nitrates in acute myocardial infarction
Drugs, 33 Suppl 4, 140-6
PubMed 3304958
Temporal pattern of enzyme changes in cerebrospinal fluid in patients with neurologic complications after open heart surgery
Crit Care Med, 15 (8), 726-31
PubMed 3608528
Haemodynamics during repeated exercise tests with special reference to the 'warm-up' phenomenon in patients with angina pectoris
Clin Physiol, 7 (2), 83-94
PubMed 3568584
HEMODYNAMICS DURING REPEATED EXERCISE TESTS WITH SPECIAL REFERENCE TO THE WARM-UP PHENOMENON IN PATIENTS WITH ANGINA-PECTORIS
Clin. Physiol., 7 (2), 83-94
Publications 1986
[Magnesium and cardiovascular diseases]
Tidsskr Nor Laegeforen, 106 (7), 554-7
PubMed 3961781
Publications 1985
[Automatic implantable defibrillator. A method for the treatment of life-threatening arrhythmias]
Tidsskr Nor Laegeforen, 105 (19-21), 1310-1
PubMed 4012743
The importance of pre- and postinfarction angina on timolol-related reduction in mortality and reinfarction
Clin Cardiol, 8 (2), 87-92
PubMed 3882290
Timolol-related reduction in mortality and reinfarction in diabetic patients surviving acute myocardial infarction
Horm Metab Res Suppl, 15, 58-60
PubMed 3908282
Timolol maleate and HDL cholesterol after myocardial infarction
Eur Heart J, 6 (10), 840-4
PubMed 3908104
Effect of timolol on changes in serum potassium concentration during acute myocardial infarction
Br Heart J, 53 (4), 388-93
PubMed 3885979
Course of chest pain and its relation to CK release and ST/QRS vector changes in patients with acute myocardial infarction randomized to treatment with intravenous timolol or placebo
Am Heart J, 110 (3), 521-8
PubMed 3898795
Publications 1984
Cardiovascular responses to face immersion and apnea during steady state muscle exercise. A heart catheterization study on humans
Acta Physiol Scand, 120 (4), 605-12
PubMed 6485832
Acute and chronic hemodynamic effects of enalapril (MK-421) in congestive heart failure
Int J Cardiol, 6 (4), 445-58
PubMed 6092286
[Prazosin in exercise-induced angina pectoris. An open study of work capacity after a single dose of prazosin, isosorbide dinitrate, atenolol and nifedipine]
Tidsskr Nor Laegeforen, 104 (9), 657-60
PubMed 6729795
Effect of ACE-Inhibition on regional blood flow during acute left ventricular failure in the dog. Preliminary report
Scand J Urol Nephrol Suppl, 79, 121-4
PubMed 6089310
ACE Inhibitors in heart failure
Scand J Urol Nephrol Suppl, 79, 115-20
PubMed 6089309
A DOUBLE-BLIND, CROSSOVER COMPARISON OF FLECAINIDE ACETATE AND DISOPYRAMIDE PHOSPHATE IN THE TREATMENT OF VENTRICULAR PREMATURE COMPLEXES
Am. J. Cardiol., 53 (5), B72-B78
A double-blind, crossover comparison of flecainide acetate and disopyramide phosphate in the treatment of ventricular premature complexes
Am J Cardiol, 53 (5), 72B-78B
PubMed 6421140
Publications 1983
Biochemical indices of cerebral ischemic injury
Scand J Clin Lab Invest, 43 (3), 261-5
PubMed 6622972
Timolol treatment after myocardial infarction in diabetic patients
Diabetes Care, 6 (3), 285-90
PubMed 6347581
Quantitative assessment of myocardial ischemia and necrosis by continuous vectorcardiography and measurement of creatine kinase release in patients
Circulation, 68 (5), 1006-12
PubMed 6616784
Publications 1982
Timolol-related reduction in mortality and reinfarction in patients ages 65-75 years surviving acute myocardial infarction. Prepared for the Norwegian Multicentre Study Group
Circulation, 66 (6), 1179-84
PubMed 6128084
Pacing induced angina and platelet reactivity
Scand J Clin Lab Invest, 42 (8), 607-11
PubMed 7167726
EFFECTS OF BED REST AND PRAZOSIN IN CONGESTIVE HEART-FAILURE
ACTA MED SCAND, 212 (3), 131-136
Effects of red rest and prazosin in congestive heart failure
Acta Med Scand, 212 (3), 131-6
PubMed 7148503
Publications 1981
LOSS OF PRAZOSIN EFFECT IN SEVERE CHRONIC CHF
ACTA MED SCAND (652), 149-154
Loss of prazosin effect in severe chronic CHF
Acta Med Scand Suppl, 652, 149-54
PubMed 6949461
Effect of timolol on platelet aggregation in coronary heart disease
Acta Med Scand Suppl, 651, 101-9
PubMed 7034470
EFFECT OF TIMOLOL ON PLATELET-AGGREGATION IN CORONARY HEART-DISEASE
ACTA MED SCAND (651), 101-109
Effect of timolol on late ventricular arrhythmias after acute myocardial infarction
Acta Med Scand Suppl, 651, 253-63
PubMed 6948502
Publications 1980
The relationship between cerebrospinal fluid creatine kinase and morphologic changes in the brain after transient cardiac arrest
Circulation, 61 (6), 1194-9
PubMed 7371132
Publications 1979
Escape rhythm in complete A-V block. The recovery phase after overdrive suppression from artificial ventricular suppression from artificial ventricular pacing
Pacing Clin Electrophysiol, 2 (4), 455-61
PubMed 95314
Publications 1978
Overdrive suppression of implanted pacemakers in patients with AV block
Br Heart J, 40 (2), 106-13
PubMed 637960
Effect of penbutolol (Hoe 893 d) and practolol on exercise-induced angina pectoris 2 and 24 hours after a signle oral dose
Eur J Clin Pharmacol, 13 (3), 157-62
PubMed 27370
Publications 1972
Effect of increased afterload on the inotropic state and uptake of free fatty acids in the intact dog heart
Acta Physiol Scand, 84 (3), 415-27
PubMed 5019038
Publications 1971
[Determining the blood flow through the myocardium in patients]
Nord Med, 86 (34), 1014
PubMed 5099376
Increased local metabolic rate by free fatty acids in the intact dog heart
Scand J Clin Lab Invest, 28 (4), 389-93
PubMed 5157041
Publications 1970
Left ventricular pressure and maximum rate of pressure rise as determinants of myocardial oxygen consumption during hemorrhagic hypotension in dogs
Acta Physiol Scand, 78 (2), 174-83
PubMed 4318564
Publications 1969
Renal autoregulation during infusion of noradrenaline, angiotensin and acetylcholine
Acta Physiol Scand, 76 (1), 10-23
PubMed 4309891
Role of autoregulation in maintaining glomerular filtration rate at large urine flow
Acta Physiol Scand, 76 (1), 24-39
PubMed 5823389
Oxygen cost of sodium reabsorption in proximal and distal parts of the nephron
Scand J Clin Lab Invest, 23 (4), 307-16
PubMed 4315557
Mechanisms in the maintenance of glomerular filttion rate during high urine flow
Acta Physiol Scand, 76 (1), 19A-20A
PubMed 5823377
Publications 1968
Effects of prolonged hypotension on myocardial function in dogs
Scand J Clin Lab Invest, 21 (2), 145-56
PubMed 5706638
Publications 1967
Relationship between ventricular pressures and right and left myocardial blood flow
Acta Physiol Scand, 70 (1), 116-26
PubMed 6035840
Local myocardial blood flow measured by hydrogen polarography; distribution and effect of hypoxia
Acta Physiol Scand, 70 (1), 99-111
PubMed 6035846
Publications 1966
Tubular salt and water transport in hydrated dogs studied with push-flow technique
Am J Physiol, 210 (5), 971-9
PubMed 5947274





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