Study by Ane Hansen Kjenseth et al. featured on the cover of Journal of Biological Chemistry
A study by PhD student Ane Hansen Kjenseth and colleagues at Department of Cancer Prevention, Institute for Cancer Research and Centre for Cancer Biomedicine, has identified a novel mechanism for regulation of intercellular communication. The article was published in the May 4 issue of Journal of Biological Chemistry, and was featured on the cover of the journal.
The cover image is a three-dimensional reconstruction of a confocal Z-stack, illustrating how connexin43 and SUMO localize in the cell, and was acquired in collaboration with Dr. Ellen Skarpen at the Confocal Microscopy Core Facility at the Norwegian Radium Hospital, Oslo University Hospital.
The gap junction channel protein connexin43 is covalently modified and regulated by SUMOylation. Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Kolberg M, Yohannes Z, Omori Y, Rivedal E, Leithe E. J Biol Chem. 2012 Mar 12. [Epub ahead of print] Link to PubMed