Odd Terje Brustugun
Position: Project group leader, assoc. prof., MD, Ph.D.
Phone: +47 22 78 14 87
Email:
 

Author network for Odd Terje Brustugun by COREMINE medical


Publications 2016

Brustugun OT, Sprauten M, Helland Å (2016)
Real-world data on nivolumab treatment of non-small cell lung cancer
Acta Oncol, 56 (3), 438-440
PubMed 27892773

Eide HA, Halvorsen AR, Bjaanæs MM, Piri H, Holm R, Solberg S, Jørgensen L, Brustugun OT, Kiserud CE, Helland Å (2016)
The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma--differences in histological subtypes
BMC Cancer, 16, 71
PubMed 26858029

Eide HA, Halvorsen AR, Sandhu V, Fåne A, Berg J, Haakensen VD, Kure EH, Brustugun OT, Kiserud CE, Kyte JA, Helland Å (2016)
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease
Clin Transl Immunology, 5 (11), e109
PubMed 27990285

Halvorsen AR, Bjaanæs M, LeBlanc M, Holm AM, Bolstad N, Rubio L, Peñalver JC, Cervera J, Mojarrieta JC, López-Guerrero JA, Brustugun OT, Helland Å (2016)
A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer
Oncotarget, 7 (24), 37250-37259
PubMed 27191990

Halvorsen AR, Silwal-Pandit L, Meza-Zepeda LA, Vodak D, Vu P, Sagerup C, Hovig E, Myklebost O, Børresen-Dale AL, Brustugun OT, Helland Å (2016)
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
Front Genet, 7, 85
PubMed 27242894

Halvorsen TO, Herje M, Levin N, Bremnes RM, Brustugun OT, Fløtten Ø, Kaasa S, Sundstrøm S, Grønberg BH (2016)
Tumour size reduction after the first chemotherapy-course and outcomes of chemoradiotherapy in limited disease small-cell lung cancer
Lung Cancer, 102, 9-14
PubMed 27987595

Halvorsen TO, Sundstrøm S, Fløtten Ø, Brustugun OT, Brunsvig P, Aasebø U, Bremnes RM, Kaasa S, Grønberg BH (2016)
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
Acta Oncol, 55 (11), 1349-1354
PubMed 27549509

Joly-Battaglini A, Hammarström C, Stankovic B, Aamodt H, Stjärne J, Brustugun OT, Helland Å, Øynebråten I, Corthay A (2016)
Rituximab efficiently depletes B cells in lung tumors and normal lung tissue
F1000Res, 5, 38
PubMed 27081474

Manegold C, Dingemans AC, Gray JE, Nakagawa K, Nicolson M, Peters S, Reck M, Wu YL, Brustugun OT, Crinò L, Felip E, Fennell D, Garrido P, Huber RM, Marabelle A, Moniuszko M, Mornex F, Novello S, Papotti M, Pérol M, Smit EF, Syrigos K, van Meerbeeck JP, van Zandwijk N, Chih-Hsin Yang J et al. (2016)
The Potential of Combined Immunotherapy and Antiangiogenesis for the Synergistic Treatment of Advanced NSCLC
J Thorac Oncol, 12 (2), 194-207
PubMed 27729297

McGowan M, Hoven AS, Lund-Iversen M, Solberg S, Helland Å, Hirsch FR, Brustugun OT (2016)
PIK3CA mutations as prognostic factor in squamous cell lung carcinoma
Lung Cancer, 103, 52-57
PubMed 28024696

Nyman J, Hallqvist A, Lund JÅ, Brustugun OT, Bergman B, Bergström P, Friesland S, Lewensohn R, Holmberg E, Lax I (2016)
SPACE - A randomized study of SBRT vs conventional fractionated radiotherapy in medically inoperable stage I NSCLC
Radiother Oncol, 121 (1), 1-8
PubMed 27600155

Rud AK, Boye K, Fodstad Ø, Juell S, Jørgensen LH, Solberg S, Helland Å, Brustugun OT, Mælandsmo GM (2016)
Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
Diagn Pathol, 11 (1), 50
PubMed 27316334

Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R et al. (2016)
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
Nat Genet, 49 (1), 65-74
PubMed 27869826

Publications 2015

Berg AS, Løndalen A, Brustugun OT (2015)
[Typical growth pattern in malignant pleural mesothelioma]
Tidsskr Nor Laegeforen, 135 (11), 1050
PubMed 26080781

Berg J, Fjellbirkeland L, Suhrke P, Jebsen P, Lund-Iversen M, Kleinberg L, Helgeland L, Brustugun OT, Helland Å (2015)
EGFR mutation testing of lung cancer patients - Experiences from Vestfold Hospital Trust
Acta Oncol, 55 (2), 149-55
PubMed 26313507

Bjaanæs MM, Fleischer T, Halvorsen AR, Daunay A, Busato F, Solberg S, Jørgensen L, Kure E, Edvardsen H, Børresen-Dale AL, Brustugun OT, Tost J, Kristensen V, Helland Å (2015)
Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
Mol Oncol, 10 (2), 330-43
PubMed 26601720

Brustugun OT (2015)
[Re: In momentous development?]
Tidsskr Nor Laegeforen, 135 (5), 413-4
PubMed 25761018

Donnem T, Hald SM, Paulsen EE, Richardsen E, Al-Saad S, Kilvaer TK, Brustugun OT, Helland A, Lund-Iversen M, Poehl M, Olsen KE, Ditzel HJ, Hansen O, Al-Shibli K, Kiselev Y, Sandanger TM, Andersen S, Pezzella F, Bremnes RM, Busund LT (2015)
Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non-Small Cell Lung Cancer
Clin Cancer Res, 21 (11), 2635-43
PubMed 25680376

Donnem T, Kilvaer TK, Andersen S, Richardsen E, Paulsen EE, Hald SM, Al-Saad S, Brustugun OT, Helland A, Lund-Iversen M, Solberg S, Gronberg BH, Wahl SG, Helgeland L, Fløtten O, Pohl M, Al-Shibli K, Sandanger TM, Pezzella F, Busund LT, Bremnes RM (2015)
Strategies for clinical implementation of TNM-Immunoscore in resected nonsmall-cell lung cancer
Ann Oncol, 27 (2), 225-32
PubMed 26578726

Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schöttle J, Ullrich RT, Altmüller J, Becker C, Nürnberg P, Seidel H, Böhm D, Göke F, Ansén S, Russell PA, Wright GM, Wainer Z et al. (2015)
Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
Genome Biol, 16, 7
PubMed 25650807

George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N et al. (2015)
Comprehensive genomic profiles of small cell lung cancer
Nature, 524 (7563), 47-53
PubMed 26168399

Grønberg BH, Halvorsen TO, Fløtten Ø, Brustugun OT, Brunsvig PF, Aasebø U, Bremnes RM, Tollåli T, Hornslien K, Aksnessæther BY, Liaaen ED, Sundstrøm S, Norwegian Lung Cancer Study Group (2015)
Randomized phase II trial comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy in limited disease small cell lung cancer
Acta Oncol, 55 (5), 591-7
PubMed 26494411

Lund-Iversen M, Grøholt KK, Helland Å, Borgen E, Brustugun OT (2015)
NUT expression in primary lung tumours
Diagn Pathol, 10, 156
PubMed 26341600

Nilssen Y, Strand TE, Fjellbirkeland L, Bartnes K, Brustugun OT, O'Connell DL, Yu XQ, Møller B (2015)
Lung cancer treatment is influenced by income, education, age and place of residence in a country with universal health coverage
Int J Cancer, 138 (6), 1350-60
PubMed 26421593

Publications 2014

Bjaanaes MM, Halvorsen AR, Solberg S, Jørgensen L, Dragani TA, Galvan A, Colombo F, Anderlini M, Pastorino U, Kure E, Børresen-Dale AL, Brustugun OT, Helland A (2014)
Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas
Int J Cancer, 135 (8), 1812-21
PubMed 24599520

Brustugun OT (2014)
Hypoxia as a cause of treatment failure in non-small cell carcinoma of the lung
Semin Radiat Oncol, 25 (2), 87-92
PubMed 25771412

Brustugun OT, Helland Å, Julsrud L (2014)
[Time counts!]
Tidsskr Nor Laegeforen, 134 (9), 915
PubMed 24828708

Brustugun OT, Khattak AM, Trømborg AK, Beigi M, Beiske K, Lund-Iversen M, Helland Å (2014)
BRAF-mutations in non-small cell lung cancer
Lung Cancer, 84 (1), 36-8
PubMed 24552757

Brustugun OT, Møller B, Helland A (2014)
Years of life lost as a measure of cancer burden on a national level
Br J Cancer, 111 (5), 1014-20
PubMed 24983370

Fernandez-Cuesta L, Peifer M, Lu X, Sun R, Ozretić L, Seidel D, Zander T, Leenders F, George J, Müller C, Dahmen I, Pinther B, Bosco G, Konrad K, Altmüller J, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soltermann A, Brustugun OT, Helland Å, Solberg S, Lund-Iversen M et al. (2014)
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
Nat Commun, 5, 3518
PubMed 24670920

Mynarek G, Aaløkken TM, Martinsen AC, Brustugun OT (2014)
[Re: Limited malignancy screening of patients with idiopathic venous thromboembolism]
Tidsskr Nor Laegeforen, 134 (8), 814-5
PubMed 24780975

Sagerup CM, Nymoen DA, Halvorsen AR, Lund-Iversen M, Helland A, Brustugun OT (2014)
Human papilloma virus detection and typing in 334 lung cancer patients
Acta Oncol, 53 (7), 952-7
PubMed 24446743

Publications 2013

Brustugun OT, Helland Å (2013)
Rapid reduction in the incidence of cancer of unknown primary. A population-based study
Acta Oncol, 53 (1), 134-7
PubMed 23550957

Grønberg BH, Lund-Iversen M, Strøm EH, Brustugun OT, Scott H (2013)
Associations between TS, TTF-1, FR-α, FPGS, and overall survival in patients with advanced non-small-cell lung cancer receiving pemetrexed plus carboplatin or gemcitabine plus carboplatin as first-line chemotherapy
J Thorac Oncol, 8 (10), 1255-64
PubMed 24457236

Nordgård O, Singh G, Solberg S, Jørgensen L, Halvorsen AR, Smaaland R, Brustugun OT, Helland Å (2013)
Novel molecular tumor cell markers in regional lymph nodes and blood samples from patients undergoing surgery for non-small cell lung cancer
PLoS One, 8 (5), e62153
PubMed 23671585

Rud AK, Borgen E, Mælandsmo GM, Flatmark K, Le H, Josefsen D, Solvoll I, Schirmer CB, Helland Å, Jørgensen L, Brustugun OT, Fodstad Ø, Boye K (2013)
Clinical significance of disseminated tumour cells in non-small cell lung cancer
Br J Cancer, 109 (5), 1264-70
PubMed 23942067

Rud AK, Boye K, Oijordsbakken M, Lund-Iversen M, Halvorsen AR, Solberg SK, Berge G, Helland A, Brustugun OT, Mælandsmo GM (2013)
Osteopontin is a prognostic biomarker in non-small cell lung cancer
BMC Cancer, 13, 540
PubMed 24215488

Publications 2012

Brustugun OT, Helland Å, Fjellbirkeland L, Kleinberg L, Ariansen S, Jebsen P, Scott H, Dønnem T, Bremnes R, Berg T, Grønberg BH, Dai HY, Wahl SG, Mangseth K, Helgeland L (2012)
[Mutation testing for non-small-cell lung cancer]
Tidsskr Nor Laegeforen, 132 (8), 952-5
PubMed 22562326

Helland Å, Solberg S, Brustugun OT (2012)
Incidence and survival of malignant pleural mesothelioma in norway: a population-based study of 1686 cases
J Thorac Oncol, 7 (12), 1858-61
PubMed 23154557

Lund-Iversen M, Kleinberg L, Fjellbirkeland L, Helland Å, Brustugun OT (2012)
Clinicopathological characteristics of 11 NSCLC patients with EGFR-exon 20 mutations
J Thorac Oncol, 7 (9), 1471-3
PubMed 22895145

Nordlund MS, Stieber P, Brustugun OT, Warren DJ, Paus E (2012)
Characteristics and clinical validity of two immunoassays for ProGRP
Tumour Biol, 33 (4), 1105-13
PubMed 22399443

Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I et al. (2012)
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Nat Genet, 44 (10), 1104-10
PubMed 22941188

Rud AK, Lund-Iversen M, Berge G, Brustugun OT, Solberg SK, Mælandsmo GM, Boye K (2012)
Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer
BMC Cancer, 12, 333
PubMed 22853000

Sagerup CM, Småstuen M, Johannesen TB, Helland A, Brustugun OT (2012)
Increasing age and carcinoma not otherwise specified: a 20-year population study of 40,118 lung cancer patients
J Thorac Oncol, 7 (1), 57-63
PubMed 21900838

Waldeland E, Brustugun OT, Ramberg C, Helland Å (2012)
[Stereotactic irradiation in spinal metastases]
Tidsskr Nor Laegeforen, 132 (22), 2478-9
PubMed 23338027

Waldeland E, Ramberg C, Arnesen MR, Helland A, Brustugun OT, Malinen E (2012)
Dosimetric impact of a frame-based strategy in stereotactic radiotherapy of lung tumors
Acta Oncol, 51 (5), 603-9
PubMed 22304490

Publications 2011

Berg A, Brustugun OT, Lund-Iversen M, Helland Å (2011)
Palmar bullous blistering induced by erlotinib
J Thorac Oncol, 6 (5), 954
PubMed 21623268

Hammerman PS, Sos ML, Ramos AH, Xu C, Dutt A, Zhou W, Brace LE, Woods BA, Lin W, Zhang J, Deng X, Lim SM, Heynck S, Peifer M, Simard JR, Lawrence MS, Onofrio RC, Salvesen HB, Seidel D, Zander T, Heuckmann JM, Soltermann A, Moch H, Koker M, Leenders F et al. (2011)
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
Cancer Discov, 1 (1), 78-89
PubMed 22328973

Helland Å, Skaug HM, Kleinberg L, Iversen ML, Rud AK, Fleischer T, Sagerup C, Solberg S, Jørgensen L, Ariansen S, Brustugun OT (2011)
EGFR gene alterations in a Norwegian cohort of lung cancer patients selected for surgery
J Thorac Oncol, 6 (5), 947-50
PubMed 21623266

Knudtsen IS, Rødal J, Brustugun OT, Helland Å, Skretting A, Malinen E (2011)
Dynamic respiratory gated (18)FDG-PET of lung tumors - a feasibility study
Acta Oncol, 50 (6), 889-96
PubMed 21767189

Sagerup CM, Småstuen M, Johannesen TB, Helland Å, Brustugun OT (2011)
Sex-specific trends in lung cancer incidence and survival: a population study of 40,118 cases
Thorax, 66 (4), 301-7
PubMed 21199818

Turzer M, Brustugun OT, Waldeland E, Helland A (2011)
Stereotactic body radiation therapy is effective and safe in patients with early-stage non-small cell lung cancer with low performance status and severe comorbidity
Case Rep Oncol, 4 (1), 25-34
PubMed 21526003

Publications 2010

Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT (2010)
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways
PLoS One, 5 (3), e9633
PubMed 20224789

Turzer M, Brustugun OT, Helland A (2010)
Excessive Soft Tissue Reaction after Stereotactic Body Radiation Therapy in a Woman with Four Different Cancer Diagnoses
Case Rep Oncol, 3 (2), 195-201
PubMed 20740196

Weiss J, Sos ML, Seidel D, Peifer M, Zander T, Heuckmann JM, Ullrich RT, Menon R, Maier S, Soltermann A, Moch H, Wagener P, Fischer F, Heynck S, Koker M, Schöttle J, Leenders F, Gabler F, Dabow I, Querings S, Heukamp LC, Balke-Want H, Ansén S, Rauh D, Baessmann I et al. (2010)
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
Sci Transl Med, 2 (62), 62ra93
PubMed 21160078

Publications 2009

Helland A, Brustugun OT (2009)
[Lung cancer in smokers and never-smokers]
Tidsskr Nor Laegeforen, 129 (18), 1859-62
PubMed 19844277

Sagerup CM, Brustugun OT, Jørgensen L (2009)
[A 67-year old man with right arm paresthesias]
Tidsskr Nor Laegeforen, 129 (24), 2613-5
PubMed 20029558

Publications 2008

Fredriksson S, Horecka J, Brustugun OT, Schlingemann J, Koong AC, Tibshirani R, Davis RW (2008)
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer
Clin Chem, 54 (3), 582-9
PubMed 18171715

Lyng H, Lando M, Brøvig RS, Svendsrud DH, Johansen M, Galteland E, Brustugun OT, Meza-Zepeda LA, Myklebost O, Kristensen GB, Hovig E, Stokke T (2008)
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
Genome Biol, 9 (5), R86
PubMed 18500990

Publications 2005

Brustugun OT, Reed W, Poulsen JP, Bruland OS (2005)
Primary osteosarcoma of the breast
Acta Oncol, 44 (7), 767-70
PubMed 16227171

Publications 2004

Lyng H, Beigi M, Svendsrud DH, Brustugun OT, Stokke T, Kristensen GB, Sundfør K, Skjønsberg A, De Angelis PM (2004)
Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix
Int J Cancer, 111 (3), 358-66
PubMed 15221962

Publications 2003

Brustugun OT, Nome O, Bruland S ØS, Ottestad L, Lilleby W (2003)
[Breast cancer patients' assessment of waiting time before radiotherapy]
Tidsskr Nor Laegeforen, 123 (12), 1685-6
PubMed 12821991

Tronstad KJ, Gjertsen BT, Krakstad C, Berge K, Brustugun OT, Døskeland SO, Berge RK (2003)
Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells
Chem Biol, 10 (7), 609-18
PubMed 12890534

Publications 2001

Fladmark KE, Brustugun OT, Mellgren G, Krakstad C, Boe R, Vintermyr OK, Schulman H, Doskeland SO (2001)
Ca2+/calmodulin-dependent protein kinase II is required for microcystin-induced apoptosis
J Biol Chem, 277 (4), 2804-11
PubMed 11713251

Publications 2000

Schwede F, Brustugun OT, Zorn-Kruppa M, Døskeland SO, Jastorff B (2000)
Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells
Bioorg Med Chem Lett, 10 (6), 571-3
PubMed 10741556

Publications 1999

Fladmark KE, Brustugun OT, Hovland R, Boe R, Gjertsen BT, Zhivotovsky B, Døskeland SO (1999)
Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors
Cell Death Differ, 6 (11), 1099-108
PubMed 10578179

Publications 1998

Brustugun OT, Fladmark KE, Doskeland SO, Orrenius S, Zhivotovsky B (1998)
Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2
Cell Death Differ, 5 (8), 660-8
PubMed 10200521

Zhivotovsky B, Orrenius S, Brustugun OT, Døskeland SO (1998)
Injected cytochrome c induces apoptosis
Nature, 391 (6666), 449-50
PubMed 9461210

Publications 1995

Bruserud O, Tore Gjertsen B, Brustugun OT, Bassøe CF, Nesthus I, Espen Akselsen P, Bühring HJ, Pawelec G (1995)
Effects of interleukin 10 on blast cells derived from patients with acute myelogenous leukemia
Leukemia, 9 (11), 1910-20
PubMed 7475283

Brustugun OT, Mellgren G, Gjertsen BT, Bjerkvig R, Døskeland SO (1995)
Sensitive and rapid detection of beta-galactosidase expression in intact cells by microinjection of fluorescent substrate
Exp Cell Res, 219 (2), 372-8
PubMed 7641787

Vintermyr OK, Bøe R, Brustugun OT, Maronde E, Aakvaag A, Døskeland SO (1995)
Cyclic adenosine monophosphate (cAMP) analogs 8-Cl- and 8-NH2-cAMP induce cell death independently of cAMP kinase-mediated inhibition of the G1/S transition in mammary carcinoma cells (MCF-7)
Endocrinology, 136 (6), 2513-20
PubMed 7750473