The research group of Anne-Lise Børresen-Dale

Systematic investigation of genetic variation, both inherited and somatically altered, gene expression patterns and genome wide copy number alterations in human breast and ovarian tumors and their correlation to specific features of phenotypic variations will provide the basis for an improved molecular taxonomy. When hundreds of tumors have been systematically characterized, a better tumor classification is likely to appear, and statistically significant relationships with different clinical parameters may be uncovered. Recognizing the expression “motifs” that represent important clinical phenotypes, like resistance or sensitivity to specific therapies, invasiveness, or metastatic potential, is an important challenge in our ongoing studies.

The following subprojects are ongoing: