Welcome to Bjørn Dalhus' research group:

Structural Biology – DNA repair

 
Bjørn Dalhus<br>Group leader
Bjørn Dalhus
Group leader

The group works with the structural biology of DNA repair with the aim to understand the damage recognition mechanisms and enzymatic catalysis at the atomic level. The major focus is on base excision repair and DNA glycosylases, which are involved in detection and elimination of chemically modified nucleotides with a mutagenic potential. The human DNA glycosylases are also potential drug targets in cancer therapy, and we also use structure-based methods to identify possible inhibitors that may work as adjuvants in cancer therapy. The group is also responsible for the daily operation of the Helse Sør-Øst regional core facility for structural biology. The core facility has been involved in projects related to a diverse range of topics such as immunology, DNA repair and replication, metabolic diseases (tyrosinemima, cholesterol, MSUD, vitamin B12-metabolism), cancer and protein kinases.

Projects

  • Structural biology of DNA base repair
  • Inhibitors of human DNA glycosylases
  • Endonuclease V and RNA metabolism/editing
  • Core-facility projects

Selected publications

  1. Vik ES, Nawaz MS, Strøm-Andersen P, Fladeby C, Bjøras M, Dalhus B, Alseth I (2013)
    Endonuclease V cleaves at inosines in RNA. Nature Commun, 4:2271
    PubMed 23912683
  2. Krokeide SZ, Laerdahl JK, Salah M, Luna L, Cederkvist FH, Flemming AM, Burrows CJ, Dalhus B*, Bjøras M* (2013)
    Human Neil3 is mainly a monofunctional DNA glycosylase removing spiroiminodihydantoin and guanodihydantoin DNA Repair (Amst), 12 (12), 1159-64
    PubMed 23755964
  3. Rosnes I, Rowe AD, Vik ES, Forstrøm RJ, Alseth I, Bjørås M, Dalhus B (2013)
    Structural basis of DNA loop recognition by endonuclease V, Structure, 21 (2), 257-265
    PubMed 23313664
  4. Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrøm RJ, McMurray CT, Alseth I, Tainer JA, Bjørås M (2013)
    Sculpting of DNA atabasic sites by DNA glycosylase homolog mag2, Structure, 21 (1), 154-166
    PubMed 23245849

Contact information:
Group leader Bjørn Dalhus, research scientist, Dr. scient. Department of Microbiology & Department of Medical Biochemsitry Oslo University Hospital Rikshospitalet PO Box 4950 Nydalen NO-0424 Oslo, Norway Tel: +47 23070809 Fax: +47 23074061 E-mail: bjorn-dalhus@medisin.uio.no