Øyvind S. Bruland appointed "Innovator of the Month" by Helse Sør-Øst

 
Øyvind S. Bruland
Øyvind S. Bruland

Professor Øyvind Sverre Bruland, senior consultant oncologist at the Department of Oncology at the Division of Cancer Medicine, has been interviewed in connection with being appointed "Innovator of the Month" by South-Eastern Norway Regional Health Authority (Helse Sør-Øst). His clinical experience and research are mainly devoted to primary bone and soft tissue cancers (sarcomas) and skeletal metastases from prostate cancer and breast cancer. In particular, targeted radionuclide therapy, e.g. Alpharadin (Algeta), based on Radium-223, is currently at center stage.

 
 

Lars Tjelta Westlye appointed "Scientist of the Month" by "Helse Sør-Øst" for the May 2017

 
Lars T. Westlye
Lars T. Westlye

The South-Eastern Norway Regional Health Authority (Helse Sør-Øst) aims to profile ongoing excellent research in the region by calling special attention to a "Scientist of the Month".

For the month of May 2017, this honour went to Lars Tjelta Westlye, senior scientist at the The Norwegian Centre for Mental Disorders Research (NORMENT). The centre is based on a collaboration between the University of Oslo (host institution), the University of Bergen and Oslo University Hospital, where Westlye has a position at the psychosis research section at the Division of Mental Health and Addiction.

 
 

Call for applications 2018

Annuncement of research funding from South-East Norway regional health authority for 2018

 

The South-Eastern Norway Regional Health Authority hereby announces a call for applications for research projects and research activities starting in 2018.

The total funding available for this call is approximately 100 million Norwegian kroner.

Application deadline is Tuesday, September 5th 2017 kl. 16:00.

 
 

Oslo University Hospital has awarded 6 excellent articles for the second half-year of 2016

 
Award winners during the ceremony (photo Marethe Falch)
Award winners during the ceremony (photo Marethe Falch)

Six research groups were awarded for their excellent papers published during the second half-year of 2016 during a ceremony June 16th. Each group received NOK 50.000 for use in further research. The prize winners gave short presentations of the main findings in their respective articles.

The six selected articles are of especially high quality, and they present important finding on both-short and long-term scales. The works reflect the good quality and the interdisciplinarity that characterises several research environments at Oslo University Hospital. The research is a fundamental condition for the institution to maintain and strenghten the quality in the patient treatment.

 
 

Clinically important genetic heterogeneity in colorectal cancers with microsatellite instability

 
First authors Anita Sveen, Torstein Tengs and Bjarne Johannessen (contributed equally)
First authors Anita Sveen, Torstein Tengs and Bjarne Johannessen (contributed equally)

Microsatellite instability (MSI) defines a small subgroup of approximately 15% of colorectal cancers (CRC) which currently receives much attention due to its overall good response to immune-checkpoint inhibition. In the latest issue of Genome Medicine, scientist Anita Sveen and colleagues publish the largest multilevel genetic analysis of this tumor type reported to date, describing substantial inter- and intra-tumor heterogeneity. The clinical importance of these results, in particular with respect to the optimized use of immunotherapeutics for treatment of human cancers, was emphasized in a Research Highlight in the same issue of the journal.

 
 

Per O. Seglen awarded King Olav V's cancer research prize for 2017

 
Per Ottar Seglen received the award from H.M. King Harald V and was congratulated by Anne Lise Ryel and Gunn-Elin Aa. Bjørneboe
Per Ottar Seglen received the award from H.M. King Harald V and was congratulated by Anne Lise Ryel and Gunn-Elin Aa. Bjørneboe

King Olav V's cancer research prize for 2017 was on June 6th given to professor Per O. Seglen, formerly head of the Proteomics & Mammalian Cell Biology Section at the Institute for Cancer Research, OUH, currently a guest researcher at NCMM.

The prestigious prize is distributed annually by the Norwegian Cancer Society, and the winner receives NOK 1.000.000.

 
 

New mechanism for rare skin disorder discovered

 
Jan C. Sitek
Jan C. Sitek

Norwegian scientists have found the genetic cause of the skin disease KWE (keratolytic winter erythema) - a rare autosomal-dominant skin disorder characterized by recurrent episodes of palmoplantar erythema and epidermal peeling, usually triggered by cold weather, moisture, or stress.
In an article recently published in the American Journal of Human Genetics (journal impact factor 10.8) it is concluded that KWE is caused by tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB, a gene encoding cathepsin B, resulting in upregulation of the protein in affected individuals.
The article was selected as "Editors choice" in AJHG for the month of May.
Head physician  and 2nd author of the paper Jan Cezary Sitek (photo) from the Dermatology Research Group at Oslo University Hospital initiated the research project six years ago, and treats several patients with KWE.

 
 

Less expensive medicine results in treatment for more patients

Norwegian research with international impact

 
Lancet article Norwegian co-authors
Lancet article Norwegian co-authors

A Norwegian randomized clinical trial shows that it is safe to change from expensive originator medicine to a less expensive biosimilar product. The effect is the same but the costs are reduced more than 50% in Norway. This means that more patients can receive this important treatment. The results of the study are now published in one of the world’s most recognised medical journals, The Lancet (journal impact factor 44.0). The findings have been covered by the Norwegian Broadcasting Corporation (NRK).
Scientists participating in the study affiliated to Oslo University Hospital were Merete Lorentzen (shared first authorship), Knut Lundin and Nils Bolstad.

 
 

The 2017 Excellent Research Awards to Kirsten Sandvig, Johannes Espolin Roksund Hov and Tor Paaske Utheim

 
From left: Johannes Espolin Roksund Hov, Kirsten Sandvig and Tor Paaske Utheim.
From left: Johannes Espolin Roksund Hov, Kirsten Sandvig and Tor Paaske Utheim.

Three scientists received awards for their outstanding research at a ceremony taking place at Oslo University Hospital May 5th.

The major prize - the "Excellent Researcher Award" - went to professor Kirsten Sandvig.
Johannes Espolin Roksund Hov and Tor Paaske Utheim both received the "Early Career Award".

The prize money - 300.000 and 150.000 NOK respectively - is earmarked for research activities. This prize is distributed anually in order to honour excellent scientific work.

 
 

OUH research seminar, Monday, May 8th 14:30 - 16:00

Organ donation for abdominal and thoracic organs

 

Welcome to the next Oslo University Hospital research seminar entitled "Organ donation for abdominal and thoracic organs".

Time: Monday, May 8th, 2017, at 14:30 – 16:00.
Place: Red Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

Speakers: Pål Dag Line, Arnt Fiane, Stein Foss and Jan E. Brinchmann

 
 

Program Info - workshops held May 8-9th:

Placing my research in an H2020 project

 

The objective of the workshop is to familiarize the participants with the prospective calls in the future EU thematic 2018-2020 health programme: Societal Challenge 1: Health, Demographic Change and Well-being.

After a presentation of the work programme content, resource personnel will be available for discussions to identify the calls that fit the participants' long-term scientific interests.

The workshop will last 2 hours.

It will be arranged
Rikshospitalet: Seminarrom 3 B1.1017, Monday 8th May at 9:00 – 11:00
Radiumhospitalet: Seminarrom 1 FOBY, Monday 8th May at 13:00 – 15:00
Ullevål: Rom 390 at Søsterhjemmet, Tuesday 9th May at 13:00 – 15:00

 
 

New insight into late effects after cancer treatment presented by the Norwegian Cancer Society

 
Cecilie Kiserud
Cecilie Kiserud

The Norwegian Cancer Society present research they support regularly, in a popular science form, and they have recently published a feature article on late effects after cancer treatment.
Cecilie Kiserud, head of the National Advisory Unit on Late Effects after Cancer Treatment at the Department of Oncology, has been interviewed about their research activites and new insight into life after cancer, a field that has gained more attention the recent years.

 
 

OUH research seminar, Tuesday, April 25th 10:00 - 15:45

Immunotherapy for Cancer

 

Welcome to the next Oslo University Hospital research seminar entitled "Immunotherapy for Cancer".

Time: Tuesday, April 25th, 2017, at 10:00-15:45.
Place: Store Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

Note that there is a limited number of seats. Please sign up at: 
http://norwegianimmunology.org/day-of-immunology-2/

 
 

Study on replication fork stability from Skarstad group published in Nucleic Acids Research

 
First authors Ida B. Pedersen (left) and Emily Helgesen
First authors Ida B. Pedersen (left) and Emily Helgesen

Replication forks must be stabilized in order to avoid DNA breakage and recombination. In a study recently published in Nucleic Acids Research (journal impact factor 9.2), entitled “SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms“, researchers in the Skarstad group show that double strand breaks are generated in the absence of fork-trailing SeqA structures and that cells then have lost the ability to perform direct (RecA-independent) restart of replication forks.
The two first authors are Ida Benedikte Pedersen and Emily Helgesen (photo).

 
 

OUH research seminar, Monday, April 3rd 14:30

Innovation to Finance Research

 

Welcome to the next Oslo University Hospital research seminar entitled "Innovation to Finance Research".

Time: Monday, April 3rd, 2017, at 14:30 – 16:00.
Place: Green Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

 
 

NORMENT researchers contribute to PLOS Medicine article on genetic assessment of age-associated Alzheimer's disease risk

 
Ole Andreassen, Centre Director NORMENT
Ole Andreassen, Centre Director NORMENT

Researchers from the NORMENT KG Jebsen Centre for Psychosis Research at OUS and UiO have participated in a large international consortium to develop a novel tool for genetic risk prediction in Alzheimer’s disease. This is based on a long standing collaboration between the statistical genetics team at NORMENT and the University of California San Diego (UCSD) Center for Translational Imaging and Precision Medicine. The scientists are now working to improve the method for mental illness applications.
The results have recently been published in Plos Medicine (journal impact factor 13.6). The study has received widespread attention, including articles in major international newspapers.

 
 

The AACR-WICR Friend Lectureship presented to Anne-Lise Børresen-Dale

 
A-L. Børresen-Dale
A-L. Børresen-Dale

The American Association for Cancer Research (AACR) - Women in Cancer Research (WICR) Charlotte Friend Memorial Lectureship was established in 1998 in honour of renowned virologist and discoverer of the Friend virus, Dr. Charlotte Friend. The WICR Friend Lectureship is presented to an outstanding scientist who has made meritorious contributions to the field of cancer research and who has, through leadership or by example, furthered the advancement of women in science.
Anne-Lise Børresen-Dale, professor emerita at the Department of Cancer Genetics at the Institute for Cancer Research, OUH, has been chosen as the 20th Annual Award Recipient. Her award lecture will be held on April 3rd in the Washington Convention Center.

 
 

CanCell – a new Centre of Excellence – will reprogram cancer cells

 

“Centre for Cancer Cell Reprogramming”, affiliated with the Institute of Clinical Medicine at University of Oslo, has been funded by the Research Council of Norway as a new Centre of Excellence.

 
 

New group leader at the Institute for Cancer Research:

Jørgen Wesche appointed group leader for the Mesenchymal Cancer Biology Group at the Department of Tumor Biology

 
Jørgen Wesche
Jørgen Wesche

Jørgen Wesche earned his PhD in Sjur Olsnes's group in 2001, studying intracellular transport and membrane translocation. During his postdoctoral training, spending some time at Institute Curie in Paris, he has changed his focus towards problems with more translational relevance, specializing in live cell imaging, fibroblast growth factor receptor (FGFR) signaling and importance of FGFR in cell migration/invasion. Aberrations in FGFR signaling are found in several types of sarcoma and that´s the main reason way Jørgen started to get interested in sarcoma biology and treatment. He has several exciting ideas on how to further develop his research into more translational/clinical relevance.

 
 

King Olav V´s Cancer Research Prize to Per O. Seglen

Prestigious research prize from the Norwegian Cancer Society to pioneer in autophagy research

 
Per O. Seglen (left) and 2016 Nobel laureate Yoshinori Ohsumi
Per O. Seglen (left) and 2016 Nobel laureate Yoshinori Ohsumi

Professor Per Ottar Seglen, formerly head of the Proteomics & Mammalian Cell Biology Section at the Institute for Cancer Research, OUH, currently a guest researcher at NCMM, has been awarded the prestigious King Olav V’s prize for Cancer Research 2017.

The award, formally announced by the Norwegian Cancer Society today, is recognized as one of the Norwegian cancer research community’s most respected prizes. Professor Seglen has been awarded the prize in recognition of his ground-breaking research into autophagic-lysosomal protein degradation and its relationship to cancer.

The prize will be officially presented by King Harald V, on behalf of the Cancer Society, at a special ceremony on 6 June 2017. The prize is NOK 1 million.

 
Previous news articles
 Health after transplantation OUH research seminar, Monday, March 6th 14:30 
 Early signs of mental illness in the developing brain NORMENT study published in Nature Neuroscience: 
 Arne Klungland talks about embryo research Breakfast lecture in Oslo Wednesday March 1st: 
 Thon Awards seminars 2017 Invitation to seminar March 2nd 12:00 
 Critical article on doping and drug testing published in EMBO reports  
 Early phase drug development: From idea to concept OUH research seminar, Monday, February 6th 14:30 
 "Science" article from Johanna Olweus's group highlighted by editorial in New England Journal of Medicine  
 6th National Conference on Stroke Oslo Kongressenter, February 09-10 2017 
 Theis Tønnessen appointed "Scientist of the Month" by "Helse Sør-Øst" for January 2017  
 Sepsis: New definitions and future research OUH research seminar, Thursday, January 26th 
 Excellent Researcher Award and Early Career Award 2017 Announcement: Nominating outstanding scientists, closing date March 1st: 
 Antimicrobial resistance - how bad is the situation in the world of virus, fungus and mycoplasma? OUH research seminar, Monday, January 16th 
 Findings from Rusten group published in Nature on microenvironmental autophagy draw nationwide attention Updated: honoured with "Preview" article in Developmental Cell  
 Commentary article from Arne Klungland in Nature Methods on epitranscriptome analysis  
 Research funding from South-Eastern Norway Regional Health Authority for 2017  
 Educating future cancer researchers from Ullern high school  
 Novel cancer immunotherapy published in Cancer Research, with cover illustration  
 Oslo University Hospital has awarded 6 excellent articles for the first half-year of 2016  
 Oslo University Hospital research seminar: Exercise and Brain Energy Monday, November 21st, 2016, at 14:30 – 16:10 
 Oslo University Hospital research seminar: The World of Immunology Thursday November 17th at 10:00-15:00 
 Oslo University Hospital researchers receive 77.3 mill NOK from the Norwegian Cancer Society Results of Open Call 2016: 
 Human lung macrophages are self-maintained for several years  
 Announcement of research funding from the Norwegian Cancer Society Gathering Friday October 28th 10-12 at UiO: 
 Dag Berild awarded the "Akademikerprisen" for his work on antibiotic resistance  
 50 years anniversary Institute for Surgical Research Thursday 13 October 2016 at 10.15 AM 
 Making therapeutic antibodies from scratch  
 Lina Prasmickaite's work presented in popularised form  
 Medical imaging in cardiac research Oslo University Hospital research seminar Monday October 10th 
 Focus on personalized medicine and the MetAction study  
 Histone marks regulate maternal-to-zygotic transition Paper from Dahl/Klungland published in the Sep 22nd issue of Nature 
 Turning the tide of antimicrobial resistance National kick-off, Tuesday September 13th 
 Marina Vietri interviewed for major Italian research web portal  
 OUH researchers publish groundbreaking computer tools for cell biology research in Nature Methods  
 POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis  
 Clinical Cancer Research highlights biomarker paper from Lyng’s group  
 The Norwegian Cancer Genomics Consortium participates in international study of gene variants predisposing for cancer development.  
 Annuncement of research funding from South-East Norway regional health authority for 2017 Call for applications 2017 
 H.M. the King's Gold Medal to Marina Vietri  
 Oslo University Hospital has awarded 6 excellent articles for the second half-year of 2015  
 Atle Bjørnerud "Innovator of the Month" South-Eastern Norway Regional Health Authority brings attention to innovation: 
 Tomas Lindahl, Nobel Prize laureate 2015 Symposium at OUS, Rikshospitalet, 17. June 2016 13:00-15:30 
 The 2016 Excellent Research Awards to Pål Aukrust, Therese Seierstad and Espen Melum Oslo University Hospital honouring outstanding scientific work: 
 Strønen and Olweus publish article in Science on the use of donor immunity to target cancer  
 Håvard Danielsen and Erik Fosse receive Lighthouse project grants from the Norwegian Research Council  
 "Intelligent needle tracking using ultrasound imaging for improved minimally invasive interventions" supported by EU OUS scientists partners in project funded by HORIZON 2020 FAST TRACK TO INNOVATION 
 Discovery of biologically active small molecular compounds Oslo University Hospital research seminar Monday May 9th 
 Mapping somatic mutations in breast cancer whole genomes OUS scientists co-author Nature article: 
 Same, but different? Genetic analysis of five immune mediated diseases reveals molecular taxonomy of chronic inflammation  
 Immunotherapy for Cancer Day of Immunology Conference 2016 April 29 
 New guidelines for "Helse Sør-Øst" and "Kreftforeningen" applications Information meeting, Radiumhospitalet, Friday April 22nd 
 Ståle Nygård – Dept. of Core Facilities Institute seminar April 6th 
 Article published in Science Translational Medicine showing that cyclodextrin may reduce atherosclerosis attracts worldwide attention  
 The Fridtjof Nansen Award for Young Scientists for 2016 to Kyrre Eeg Emblem  
 Theodossiou and Berg funded by the Future and Emerging Technology (FET) program  
 King Olav V's cancer research prize for 2016 to Kjetil Taskén  
 Morgendagens medisin The Norwegian Inflammation Network seminar Wednesday March 16th 
 Microbiome Oslo University Hospital research seminar Monday March 14th 
 Liliane Christ identifies mechanism for regulation of daughter cell separation  
 NoPSC study of PSC gut microbiota published in Gut  
 Olav Thon Foundation's International Prize and Research Awardees 2016 Invitation to seminar March 3rd 12:00 
 Stephen H. Friend Norsk Hydro's Fond guest lecture March 10th 
 Ragnhild A. Lothe and Michael Bretthauer substantially supported by FRIPRO  
 Filming live cancer cells Camilla Raiborg's work presented in popularised form on forskning.no: 
 Elderly patients benefit from an early invasive strategy Heart study results recently published in Lancet attract attention: 
 Lorenz et al. published an extensive study investigating the genomic chaos in osteosarcoma  
 Personalized Cancer Care Symposium, Oslo, May 18-20, 2016 
 Åslaug Helland’s research on lung cancer presented by the Norwegian Cancer Society  
 Innovation projects funded by the Norwegian Cancer Society and Research Council  
 Medical imaging in cancer biology and personalized therapy Oslo University Hospital research seminar January 11th 
 Sandvig received INNO INDIGO grant for work with biodegradable nanoparticles  
 Work from Bjørås' group published in "Cell Report"  
 Research funding from South-Eastern Norway Regional Health Authority for 2016  
 AACR Recognizes Dr. Anne-Lise Børresen-Dale With 2015 Distinguished Lectureship in Breast Cancer Research  
 Erik Boye - an internationally renowned scientist retires  
 Oslo University Hospital has awarded 6 excellent articles for the first half-year of 2015  
 New PhD Andreas Hoff publishes testis cancer fusion genes in Cancer Research  
 Asta Juzeniene - Dept. of Radiation Biology Institute Seminar Wednesday 9th of December at 12:00 
 Findings regarding a novel non-genomic tamoxifen cytotoxic action published in ACS Chemical Biology  
 Tor Espen Thorvaldsen with cover story in Molecular Cancer Research  
 Oslo University Hospital researchers receive 92 mill NOK from the Norwegian Cancer Society  
 Ragnar Mørk legacy prize 2015 to Guro E. Lind Ceremony Friday November 20th 
 The first-in-man Phase I clinical trial of the EpCAM-targeting immunotoxin MOC31PE  
 Research on sonoactivatable nanoparticles funded by EuroNanoMed II ERA-NET program  
 Research on nanoparticle radiosensitizers funded by Euronanomed II ERA-NET program  
 PCI research funded by Euronanomed II ERA-NET program  
 Jørgen Wesche – Dept. of Molecular Cell Biology Institute Seminar Wednesday 4th of November at 12:00 
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 The Wonder of Stem Cells in Eye and Oral Regeneration Oslo University Hospital research seminar October 19th 
 Presenting the Young Academy of Norway  
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 Review article from Sveen and co-workers on alternative splicing published in Oncogene  
 The Anders Jahre Senior Medical Prize to Ludvig Sollid  
 Award winner Erik Fosse presented in Uniforum The UiO Innovation Prize: 
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 Kaisa Haglund receives the Jahre prize for young medical researchers Recognition of outstanding scientific work: 
 Oslo Cancer Cluster Innovation Park officially opened  
 New English version of "The Research Handbook- from idea to publication" is available  
 Chronicle on personalised cancer medicine in Aftenposten  
 Preparing for the upcoming health calls for Horizon 2020 Training course August 25: 
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