ERC Starting Grant 2017 to Kyrre Eeg Emblem

 

The European Research Council (ERC) has awarded a Starting Grant 2017 to Kyrre Eeg Emblem from Department of Diagnostic Physics at the Divsion of Radiology & Nuclear Medicine. This is the seventh ERC Starting Grant awarded to Norway in the main panel Life Sciences (LS), and the first time Oslo University Hospital is the host institution.

 
 

Tone Rustøen "Researcher of the Month" for July

 
Tone Rustøen
Tone Rustøen

The South-Eastern Norway Regional Health Authority (Helse Sør-Øst) has appointed Tone Rustøen from the Nursing Research Group at the Division of Emergencies and Critical Care at Oslo University Hospital as "Researcher of the month" for the month of July.

 
 

Håvard Danielsen appointed "Scientist of the Month" by "Helse Sør-Øst" for June 2017

 
Håvard Danielsen
Håvard Danielsen

The South-Eastern Norway Regional Health Authority (Helse Sør-Øst) aims to profile ongoing excellent research in the region by calling special attention to a "Scientist of the Month".

For the month of June 2017, this honour went to professor Håvard Danielsen, head of the Institute for Cancer Genetics and Informatics at OUH.

 
 

OUH scientists involved in sequencing study of osteosarcoma that has identified mutations in IGF signalling genes

 
From left: Zaikova, Bjerkehagen and Myklebost
From left: Zaikova, Bjerkehagen and Myklebost

A portion of bone cancers may respond to existing insulin-like growth factor 1 receptor inhibitors because they carry mutations in IGF signaling genes, a study recently published in Nature Communications suggests. The sarcoma team at the Norwegian Radium Hospital at Oslo University Hospital was represented in this study by Bodil Bjerkehagen, the sarcoma reference pathologist, Olga Zaikova, on behalf of the orthopedists, and Ola Myklebost, PI in the ICGC Bone Cancer Project. This study is a side branch from their previous participation in the European Network of Excellence on Bone Tumours, and is carried out by the International Cancer Genomics Consortium at the Sanger Centre in Hinxton outside Cambridge.

 
 

Øyvind S. Bruland appointed "Innovator of the Month" by Helse Sør-Øst

 
Øyvind S. Bruland
Øyvind S. Bruland

Professor Øyvind Sverre Bruland, senior consultant oncologist at the Department of Oncology at the Division of Cancer Medicine, has been interviewed in connection with being appointed "Innovator of the Month" by South-Eastern Norway Regional Health Authority (Helse Sør-Øst). His clinical experience and research are mainly devoted to primary bone and soft tissue cancers (sarcomas) and skeletal metastases from prostate cancer and breast cancer. In particular, targeted radionuclide therapy, e.g. Alpharadin (Algeta), based on Radium-223, is currently at center stage.

 
 

Lars Tjelta Westlye appointed "Scientist of the Month" by "Helse Sør-Øst" for May 2017

 
Lars T. Westlye
Lars T. Westlye

The South-Eastern Norway Regional Health Authority (Helse Sør-Øst) aims to profile ongoing excellent research in the region by calling special attention to a "Scientist of the Month".

For the month of May 2017, this honour went to Lars Tjelta Westlye, senior scientist at the The Norwegian Centre for Mental Disorders Research (NORMENT). The centre is based on a collaboration between the University of Oslo (host institution), the University of Bergen and Oslo University Hospital, where Westlye has a position at the psychosis research section at the Division of Mental Health and Addiction.

 
 

Call for applications 2018

Annuncement of research funding from South-East Norway regional health authority for 2018

 

The South-Eastern Norway Regional Health Authority hereby announces a call for applications for research projects and research activities starting in 2018.

The total funding available for this call is approximately 100 million Norwegian kroner.

Application deadline is Tuesday, September 5th 2017 kl. 16:00.

 
 

Oslo University Hospital has awarded 6 excellent articles for the second half-year of 2016

 
Award winners during the ceremony (photo Marethe Falch)
Award winners during the ceremony (photo Marethe Falch)

Six research groups were awarded for their excellent papers published during the second half-year of 2016 during a ceremony June 16th. Each group received NOK 50.000 for use in further research. The prize winners gave short presentations of the main findings in their respective articles.

The six selected articles are of especially high quality, and they present important finding on both-short and long-term scales. The works reflect the good quality and the interdisciplinarity that characterises several research environments at Oslo University Hospital. The research is a fundamental condition for the institution to maintain and strenghten the quality in the patient treatment.

 
 

Clinically important genetic heterogeneity in colorectal cancers with microsatellite instability

 
First authors Anita Sveen, Torstein Tengs and Bjarne Johannessen (contributed equally)
First authors Anita Sveen, Torstein Tengs and Bjarne Johannessen (contributed equally)

Microsatellite instability (MSI) defines a small subgroup of approximately 15% of colorectal cancers (CRC) which currently receives much attention due to its overall good response to immune-checkpoint inhibition. In the latest issue of Genome Medicine, scientist Anita Sveen and colleagues publish the largest multilevel genetic analysis of this tumor type reported to date, describing substantial inter- and intra-tumor heterogeneity. The clinical importance of these results, in particular with respect to the optimized use of immunotherapeutics for treatment of human cancers, was emphasized in a Research Highlight in the same issue of the journal.

 
 

Per O. Seglen awarded King Olav V's cancer research prize for 2017

 
Per Ottar Seglen received the award from H.M. King Harald V and was congratulated by Anne Lise Ryel and Gunn-Elin Aa. Bjørneboe
Per Ottar Seglen received the award from H.M. King Harald V and was congratulated by Anne Lise Ryel and Gunn-Elin Aa. Bjørneboe

King Olav V's cancer research prize for 2017 was on June 6th given to professor Per O. Seglen, formerly head of the Proteomics & Mammalian Cell Biology Section at the Institute for Cancer Research, OUH, currently a guest researcher at NCMM.

The prestigious prize is distributed annually by the Norwegian Cancer Society, and the winner receives NOK 1.000.000.

 
 

New mechanism for rare skin disorder discovered

 
Jan C. Sitek
Jan C. Sitek

Norwegian scientists have found the genetic cause of the skin disease KWE (keratolytic winter erythema) - a rare autosomal-dominant skin disorder characterized by recurrent episodes of palmoplantar erythema and epidermal peeling, usually triggered by cold weather, moisture, or stress.
In an article recently published in the American Journal of Human Genetics (journal impact factor 10.8) it is concluded that KWE is caused by tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB, a gene encoding cathepsin B, resulting in upregulation of the protein in affected individuals.
The article was selected as "Editors choice" in AJHG for the month of May.
Head physician  and 2nd author of the paper Jan Cezary Sitek (photo) from the Dermatology Research Group at Oslo University Hospital initiated the research project six years ago, and treats several patients with KWE.

 
 

Less expensive medicine results in treatment for more patients

Norwegian research with international impact

 
Lancet article Norwegian co-authors
Lancet article Norwegian co-authors

A Norwegian randomized clinical trial shows that it is safe to change from expensive originator medicine to a less expensive biosimilar product. The effect is the same but the costs are reduced more than 50% in Norway. This means that more patients can receive this important treatment. The results of the study are now published in one of the world’s most recognised medical journals, The Lancet (journal impact factor 44.0). The findings have been covered by the Norwegian Broadcasting Corporation (NRK).
Scientists participating in the study affiliated to Oslo University Hospital were Merete Lorentzen (shared first authorship), Knut Lundin and Nils Bolstad.

 
 

The 2017 Excellent Research Awards to Kirsten Sandvig, Johannes Espolin Roksund Hov and Tor Paaske Utheim

 
From left: Johannes Espolin Roksund Hov, Kirsten Sandvig and Tor Paaske Utheim.
From left: Johannes Espolin Roksund Hov, Kirsten Sandvig and Tor Paaske Utheim.

Three scientists received awards for their outstanding research at a ceremony taking place at Oslo University Hospital May 5th.

The major prize - the "Excellent Researcher Award" - went to professor Kirsten Sandvig.
Johannes Espolin Roksund Hov and Tor Paaske Utheim both received the "Early Career Award".

The prize money - 300.000 and 150.000 NOK respectively - is earmarked for research activities. This prize is distributed anually in order to honour excellent scientific work.

 
 

OUH research seminar, Monday, May 8th 14:30 - 16:00

Organ donation for abdominal and thoracic organs

 

Welcome to the next Oslo University Hospital research seminar entitled "Organ donation for abdominal and thoracic organs".

Time: Monday, May 8th, 2017, at 14:30 – 16:00.
Place: Red Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

Speakers: Pål Dag Line, Arnt Fiane, Stein Foss and Jan E. Brinchmann

 
 

Program Info - workshops held May 8-9th:

Placing my research in an H2020 project

 

The objective of the workshop is to familiarize the participants with the prospective calls in the future EU thematic 2018-2020 health programme: Societal Challenge 1: Health, Demographic Change and Well-being.

After a presentation of the work programme content, resource personnel will be available for discussions to identify the calls that fit the participants' long-term scientific interests.

The workshop will last 2 hours.

It will be arranged
Rikshospitalet: Seminarrom 3 B1.1017, Monday 8th May at 9:00 – 11:00
Radiumhospitalet: Seminarrom 1 FOBY, Monday 8th May at 13:00 – 15:00
Ullevål: Rom 390 at Søsterhjemmet, Tuesday 9th May at 13:00 – 15:00

 
 

New insight into late effects after cancer treatment presented by the Norwegian Cancer Society

 
Cecilie Kiserud
Cecilie Kiserud

The Norwegian Cancer Society present research they support regularly, in a popular science form, and they have recently published a feature article on late effects after cancer treatment.
Cecilie Kiserud, head of the National Advisory Unit on Late Effects after Cancer Treatment at the Department of Oncology, has been interviewed about their research activites and new insight into life after cancer, a field that has gained more attention the recent years.

 
 

OUH research seminar, Tuesday, April 25th 10:00 - 15:45

Immunotherapy for Cancer

 

Welcome to the next Oslo University Hospital research seminar entitled "Immunotherapy for Cancer".

Time: Tuesday, April 25th, 2017, at 10:00-15:45.
Place: Store Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

Note that there is a limited number of seats. Please sign up at: 
http://norwegianimmunology.org/day-of-immunology-2/

 
 

Study on replication fork stability from Skarstad group published in Nucleic Acids Research

 
First authors Ida B. Pedersen (left) and Emily Helgesen
First authors Ida B. Pedersen (left) and Emily Helgesen

Replication forks must be stabilized in order to avoid DNA breakage and recombination. In a study recently published in Nucleic Acids Research (journal impact factor 9.2), entitled “SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms“, researchers in the Skarstad group show that double strand breaks are generated in the absence of fork-trailing SeqA structures and that cells then have lost the ability to perform direct (RecA-independent) restart of replication forks.
The two first authors are Ida Benedikte Pedersen and Emily Helgesen (photo).

 
 

OUH research seminar, Monday, April 3rd 14:30

Innovation to Finance Research

 

Welcome to the next Oslo University Hospital research seminar entitled "Innovation to Finance Research".

Time: Monday, April 3rd, 2017, at 14:30 – 16:00.
Place: Green Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

 
 

NORMENT researchers contribute to PLOS Medicine article on genetic assessment of age-associated Alzheimer's disease risk

 
Ole Andreassen, Centre Director NORMENT
Ole Andreassen, Centre Director NORMENT

Researchers from the NORMENT KG Jebsen Centre for Psychosis Research at OUS and UiO have participated in a large international consortium to develop a novel tool for genetic risk prediction in Alzheimer’s disease. This is based on a long standing collaboration between the statistical genetics team at NORMENT and the University of California San Diego (UCSD) Center for Translational Imaging and Precision Medicine. The scientists are now working to improve the method for mental illness applications.
The results have recently been published in Plos Medicine (journal impact factor 13.6). The study has received widespread attention, including articles in major international newspapers.

 
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