NORMENT study published in Nature Neuroscience:

Early signs of mental illness in the developing brain

 
Tobias Kaufmann (left) and Lars T. Westlye
Tobias Kaufmann (left) and Lars T. Westlye

Like a fingerprint, the connections of the human brain render us distinct from one another. In a study published in the February 20th issue of Nature Neuroscience (journal impact factor 16.7), entitled "Delayed stabilization and individualization in connectome development are related to psychiatric disorders", researchers at NORMENT reveal that such a unique, fingerprint-like pattern evolves during development and is sensitive to mental health. First and last authors are Tobias Kaufmann and Lars T. Westlye (photo).
The study has already gained attention, and the results have been discussed in articles published in Science Daily and Medical News Today.

 
 

Breakfast lecture in Oslo Wednesday March 1st:

Arne Klungland talks about embryo research

 
Arne Klungland
Arne Klungland

Professor Arne Klungland, section head at the Department of Microbiology, will hold a lecture on the subject of embryonic development during a breakfast meeting held by the The Norwegian Biotechnology Advisory Board (Bioteknologirådet).

Klungland is the leader of several research projects aiming at understanding the first few days during embryonic development, and gain insight into the early development of various diseases.

Time: March 1st 8.15-9.30 AM (breakfast from 8.15, lecture starts 8.30)
Place: Håndverkeren, Galleriet (1st floor)

 
 

Invitation to seminar March 2nd 12:00

Thon Awards seminars 2017

 
From left: Amiry-Moghaddam, Zetterberg, Hoeijmakers and Bogdanovic
From left: Amiry-Moghaddam, Zetterberg, Hoeijmakers and Bogdanovic

This is a unique seminar with the Olav Thon Foundation's International Research Awardees for Mathematics and Natural Science and Medicine 2017.

The first talk will be held by International Research Prize winner Jan Hoeijmakers from Erasmus University Rotterdam, who is one of the most significant scientists in molecular genetics of our time. 

Further talks will be held by Research Awardee Mahmood Amiry-Moghaddam on Parkinson's disease, and by Research Awardees Henrik Zetterberg and Nenad Bogdanovic on Alzheimer research.

Time and place: March 2nd, 2017 12:00 PM - 03:00 PM, Runde Auditorium R-105 at Domus Medica, Gaustad

Deadline for registration: February 23rd

 
 

Critical article on doping and drug testing published in EMBO reports

 
First author Erik Boye (left) and Tore Skotland
First author Erik Boye (left) and Tore Skotland

Sports play an important role in our society. Four Norwegian researchers, two from OUS, have published an article in EMBO reports where they discuss problems occurring in the testing of athletes for doping.
The authors (E. Boye and T. Skotland from OUS (photo), J. Nissen-Meyer from UiO and B. Østerud, UiTø) describe how the World Antidoping Agency (WADA) pretends never to make mistakes and is resistant to any form of discussion with other scientists. This attitude creates false positives and athletes are being sanctioned while innocent, with dramatic consequences for the individual. It is argued that both the technological, ethical and legal procedures should be revised and an independent body should monitor the function of WADA.

 
 

OUH research seminar, Monday, February 6th 14:30

Early phase drug development: From idea to concept

 

Welcome to the next Oslo University Hospital research seminar entitled "Early phase drug development: From idea to concept".

Time: Monday, February 6th, 2017, at 14:30 – 16:00.
Place: Blue Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

 
 

"Science" article from Johanna Olweus's group highlighted by editorial in New England Journal of Medicine

 
Figure from the editorial
Figure from the editorial

The article "Targeting of cancer neoantigens with donor-derived T cell receptor repertoires" by Erlend Strønen et al, published in Science in June 2016, is highlighted by an editorial in the "Clinical Implications of Basic Research" section in the Feb 2nd edition of New England Journal of Medicine.

The editorial is entitled "The Antigenicity of the Tumor Cell — Context Matters".

 
 

Oslo Kongressenter, February 09-10 2017

6th National Conference on Stroke

 

Every year 16.000 Norwegians are stricken with stroke, and more than 60.000 have previously had one or more strokes. It is therefore important that the foremost Norwegian experts in the field gather in order and be updated on what is new within preventive, acute treatment and rehabilitation from stroke.

David Russell from the Department of Neurology at the Division of Surgery and Clinical Neuroscience at Oslo University Hospital welcomes participants to the 6th national conference on stroke - "den 6. Nasjonale konferanse om Hjerneslag".

 
 

Theis Tønnessen appointed "Scientist of the Month" by "Helse Sør-Øst" for January 2017

 
Theis Tønnessen
Theis Tønnessen

The South-Eastern Norway Regional Health Authority (Helse Sør-Øst) aims to profile ongoing excellent research in the region by calling special attention to a "Scientist of the Month".

For the month of January 2017, this honour went to Theis Tønnessen, leader of the "Genetics of autoimmunity and cancer" group at the Department of Medical Genetics at the Division of Diagnostics and Intervention, Oslo University Hospital.

 
 

OUH research seminar, Thursday, January 26th

Sepsis: New definitions and future research

 

Welcome to the next Oslo University Hospital research seminar entitled "Sepsis: New definitions and future research".

Time: Monday, Thursday, January 26th, 2017, at 13:45 – 15:15.
Place: Red Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

 
 

Announcement: Nominating outstanding scientists, closing date March 1st:

Excellent Researcher Award and Early Career Award 2017

 
From the 2016 ceremony: Pål Aukrust (Excellent Researcher Award) flanked by Therese Seierstad og Espen Melum (both Early Career Awards)
From the 2016 ceremony: Pål Aukrust (Excellent Researcher Award) flanked by Therese Seierstad og Espen Melum (both Early Career Awards)

 Oslo University Hospital hereby announce research awards in the following two catagories for 2017:

  • Excellent Researcher Award (one prize, 300.000 NOK)
  • Early Career Award (two prizes of 150.000 NOK each)

The candidate must be employed by Oslo University Hospital or University of Oslo, and be a member of a research group at Oslo University Hospital/University of Oslo.

 
 

OUH research seminar, Monday, January 16th

Antimicrobial resistance - how bad is the situation in the world of virus, fungus and mycoplasma?

 

Welcome to the next Oslo University Hospital research seminar entitled "Antimicrobial resistance - how bad is the situation in the world of virus, fungus and mycoplasma?".

Time: Monday, January 16th, 2017, at 14:30 – 16:00.
Place: Blue Auditorium, Rikshospitalet, Sognsvannsveien 20

 
 

Updated: honoured with "Preview" article in Developmental Cell

Findings from Rusten group published in Nature on microenvironmental autophagy draw nationwide attention

 
First author Nadja Katheder and senior author Tor Erik Rusten
First author Nadja Katheder and senior author Tor Erik Rusten

Nadja Katheder and collaborators in the lab of Tor Erik Rusten, the Department of Molecular Cell Biology, and CCB has published an article entitled "Microenvironmental autophagy supports tumor growth", in an advanced online publication 11th of January in the journal Nature (journal impact factor 41.46). 
The findings have been subject to news coverage by the Norwegian national broadcasting corporation (NRK).
The prestigious journal "Developmental Cell" has recently published an article in their "Previews" section, entitled "Breaking Down Neighbors to Fuel Tumorigenesis". Here, the authors discuss how the work of Katheder and colleagues "opens new avenues for understanding and manipulating cancers through cell-cell communication."

 
 

Commentary article from Arne Klungland in Nature Methods on epitranscriptome analysis

 
Arne Klungland
Arne Klungland

In the Nature Methods (journal impact factor 25.3) January 2017 issue “Epitranscriptome analysis” is presented as the method of the year. In recent years, it has become clear that RNA molecules, including mRNAs, can be dynamically modified. Thus, this allows for a new strategy for gene regulation with vital biological consequences. Epitranscriptome analysis relates to methods that can profile RNA modifications in a sequence specific manner. In a commentary to this discovery, Klungland and co-workers from Department of Microbiology and Department of Gynecology, OUS, discuss the role of such modifications for the maturation of sperm and egg (meiosis) and pluripotent cells.

 
 

Research funding from South-Eastern Norway Regional Health Authority for 2017

 

The board of the South-Eastern Norway Regional Health Authority (Helse Sør-Øst) has distributed financial resources to new research projects for 2017. Of the in total 568 incoming applications 121 new projects were granted support.
A substantial amount of the resources goes to young researchers. Support is given to a number og doctoral and post doctoral stipendiates, as well as to researcher grants and career grants. The latter category is for young outstanding researchers planning to establish an independent research group.

 
 

Educating future cancer researchers from Ullern high school

 
Photo: Åsmund H. Eikenes
Photo: Åsmund H. Eikenes

As part of the collaboration between Oslo Cancer Cluster and Ullern high shool, a total of 40 students visited six different laboratories at the Oslo University Hospital and the National Institute for Public Health last week. A journalist from Framtida.no interviewed the six students who visited the Department for Tumor biologi. Researchers Siri Tveito and Karen-Marie Heintz guided them through immunoflourescence, PCR, gel electrophoresis and other techniques in the lab, and the students were eager to learn about the life of a cancer researcher.

 
 

Novel cancer immunotherapy published in Cancer Research, with cover illustration

 
Dec. 1 issue of Cancer Research. <br>First author Kristina Berg Lorvik and senior author Alexandre Corthay
Dec. 1 issue of Cancer Research.
First author Kristina Berg Lorvik and senior author Alexandre Corthay

Collaborative efforts by researchers at the Department of Immunology and the Department of Pathology revealed the unexpected potential of tumor-specific Th2 cells for cancer immunotherapy by adoptive cell transfer (ACT) in mice.
The study was published in the December 1st 2016 issue of Cancer Research, the flagship journal of the American Association for Cancer Research. An immunofluorescence microscopy image from the paper was selected to illustrate the journal cover.

 
 

Monday, November 21st, 2016, at 14:30 – 16:10

Oslo University Hospital research seminar: Exercise and Brain Energy

 

Welcome to the next Oslo University Hospital (OUH) research seminar entitled "Exercise and Brain Energy".
Time: Monday, November 21st, 2016, at 14:30 – 16:10
Place: Green Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

Speakers: Linda Hildegard Bergersen, Cecilie Morland, Krister Andresson, Lauritz H. Kennedy, Mahdi Olive Hasan, Johanne Egge Ringholm

 
 

Thursday November 17th at 10:00-15:00

Oslo University Hospital research seminar: The World of Immunology

 

Welcome to the next Oslo University Hospital (OUH) research seminar entitled "The World of Immunology".

Time: Thursday November 17th at 10:00-15:00.
Place: Red Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.

Speakers: Inger Sandlie, Roland Jonsson, Bart N. Lambrecht, Frode Jahnsen and Erlend Strønen.

 
 

Results of Open Call 2016:

Oslo University Hospital researchers receive 77.3 mill NOK from the Norwegian Cancer Society

 

The Norwegian Cancer Society has recently distributed in total 179 million NOK to Norwegian cancer researchers. The 34 projects that will receive funding are distributed among seven research institutions in Tromsø, Trondheim, Bergen and Oslo. Twelve research groups are affiliated to Oslo University Hospital. OUH project leaders being supported are Svein Dueland, Jon Amund Kyte, Heidi Lyng, Eirik Malinen, Johanna Olweus, Mouldy Sioud, Erlend Bremertun Smeland, Harald Stenmark, Bjørn Atle Bjørnbeth, Magnar Bjørås, Alexandre Corthay and Jorrit Enserink, and these will altogether receive 77.3 million NOK.

 
 

Human lung macrophages are self-maintained for several years

 
First author Ibon Eguiluz-Gracia (left) and senior author Espen Bækkevold
First author Ibon Eguiluz-Gracia (left) and senior author Espen Bækkevold

The classical view of tissue macrophages is that they are continuously replaced by blood monocytes, but a paper first-authored by Ibon Eguiluz-Gracia (photo) from Frode Jahnsen's group at the Department of Pathology at OUH and the Centre for Immune Regulation at UiO, recently published in Thorax (journal impact factor 8.3), show that human alveolar macrophages are self-maintained within the lungs for many years. This may be important for development of chronic graft rejection, which is a common complication after lung transplantation and remains the major obstacle to better long-term outcomes.
Furthermore, as pointed out in the accompanying Editorial in Thorax, this study has potential implications for treatment of patients with alveolar proteinosis and COPD. 

 
Previous news articles
 Announcement of research funding from the Norwegian Cancer Society Gathering Friday October 28th 10-12 at UiO: 
 Dag Berild awarded the "Akademikerprisen" for his work on antibiotic resistance  
 50 years anniversary Institute for Surgical Research Thursday 13 October 2016 at 10.15 AM 
 Making therapeutic antibodies from scratch  
 Lina Prasmickaite's work presented in popularised form  
 Medical imaging in cardiac research Oslo University Hospital research seminar Monday October 10th 
 Focus on personalized medicine and the MetAction study  
 Histone marks regulate maternal-to-zygotic transition Paper from Dahl/Klungland published in the Sep 22nd issue of Nature 
 Turning the tide of antimicrobial resistance National kick-off, Tuesday September 13th 
 Marina Vietri interviewed for major Italian research web portal  
 OUH researchers publish groundbreaking computer tools for cell biology research in Nature Methods  
 POLE proofreading domain mutations identify a subset of immunogenic colorectal cancers with excellent prognosis  
 Clinical Cancer Research highlights biomarker paper from Lyng’s group  
 The Norwegian Cancer Genomics Consortium participates in international study of gene variants predisposing for cancer development.  
 Annuncement of research funding from South-East Norway regional health authority for 2017 Call for applications 2017 
 H.M. the King's Gold Medal to Marina Vietri  
 Oslo University Hospital has awarded 6 excellent articles for the second half-year of 2015  
 Atle Bjørnerud "Innovator of the Month" South-Eastern Norway Regional Health Authority brings attention to innovation: 
 Tomas Lindahl, Nobel Prize laureate 2015 Symposium at OUS, Rikshospitalet, 17. June 2016 13:00-15:30 
 The 2016 Excellent Research Awards to Pål Aukrust, Therese Seierstad and Espen Melum Oslo University Hospital honouring outstanding scientific work: 
 Strønen and Olweus publish article in Science on the use of donor immunity to target cancer  
 Håvard Danielsen and Erik Fosse receive Lighthouse project grants from the Norwegian Research Council  
 "Intelligent needle tracking using ultrasound imaging for improved minimally invasive interventions" supported by EU OUS scientists partners in project funded by HORIZON 2020 FAST TRACK TO INNOVATION 
 Discovery of biologically active small molecular compounds Oslo University Hospital research seminar Monday May 9th 
 Mapping somatic mutations in breast cancer whole genomes OUS scientists co-author Nature article: 
 Same, but different? Genetic analysis of five immune mediated diseases reveals molecular taxonomy of chronic inflammation  
 Immunotherapy for Cancer Day of Immunology Conference 2016 April 29 
 New guidelines for "Helse Sør-Øst" and "Kreftforeningen" applications Information meeting, Radiumhospitalet, Friday April 22nd 
 Ståle Nygård – Dept. of Core Facilities Institute seminar April 6th 
 Article published in Science Translational Medicine showing that cyclodextrin may reduce atherosclerosis attracts worldwide attention  
 The Fridtjof Nansen Award for Young Scientists for 2016 to Kyrre Eeg Emblem  
 Theodossiou and Berg funded by the Future and Emerging Technology (FET) program  
 King Olav V's cancer research prize for 2016 to Kjetil Taskén  
 Morgendagens medisin The Norwegian Inflammation Network seminar Wednesday March 16th 
 Microbiome Oslo University Hospital research seminar Monday March 14th 
 Liliane Christ identifies mechanism for regulation of daughter cell separation  
 NoPSC study of PSC gut microbiota published in Gut  
 Olav Thon Foundation's International Prize and Research Awardees 2016 Invitation to seminar March 3rd 12:00 
 Stephen H. Friend Norsk Hydro's Fond guest lecture March 10th 
 Ragnhild A. Lothe and Michael Bretthauer substantially supported by FRIPRO  
 Filming live cancer cells Camilla Raiborg's work presented in popularised form on forskning.no: 
 Elderly patients benefit from an early invasive strategy Heart study results recently published in Lancet attract attention: 
 Lorenz et al. published an extensive study investigating the genomic chaos in osteosarcoma  
 Personalized Cancer Care Symposium, Oslo, May 18-20, 2016 
 Åslaug Helland’s research on lung cancer presented by the Norwegian Cancer Society  
 Innovation projects funded by the Norwegian Cancer Society and Research Council  
 Medical imaging in cancer biology and personalized therapy Oslo University Hospital research seminar January 11th 
 Sandvig received INNO INDIGO grant for work with biodegradable nanoparticles  
 Work from Bjørås' group published in "Cell Report"  
 Research funding from South-Eastern Norway Regional Health Authority for 2016  
 AACR Recognizes Dr. Anne-Lise Børresen-Dale With 2015 Distinguished Lectureship in Breast Cancer Research  
 Erik Boye - an internationally renowned scientist retires  
 Oslo University Hospital has awarded 6 excellent articles for the first half-year of 2015  
 New PhD Andreas Hoff publishes testis cancer fusion genes in Cancer Research  
 Asta Juzeniene - Dept. of Radiation Biology Institute Seminar Wednesday 9th of December at 12:00 
 Findings regarding a novel non-genomic tamoxifen cytotoxic action published in ACS Chemical Biology  
 Tor Espen Thorvaldsen with cover story in Molecular Cancer Research  
 Oslo University Hospital researchers receive 92 mill NOK from the Norwegian Cancer Society  
 Ragnar Mørk legacy prize 2015 to Guro E. Lind Ceremony Friday November 20th 
 The first-in-man Phase I clinical trial of the EpCAM-targeting immunotoxin MOC31PE  
 Research on sonoactivatable nanoparticles funded by EuroNanoMed II ERA-NET program  
 Research on nanoparticle radiosensitizers funded by Euronanomed II ERA-NET program  
 PCI research funded by Euronanomed II ERA-NET program  
 Jørgen Wesche – Dept. of Molecular Cell Biology Institute Seminar Wednesday 4th of November at 12:00 
 New gold-standard for miRNA annotations published in Annual Reviews of Genetics  
 The Wonder of Stem Cells in Eye and Oral Regeneration Oslo University Hospital research seminar October 19th 
 Presenting the Young Academy of Norway  
 Prestigious award from the Research Council of Norway to Harald A. Stenmark Møbius 2015: 
 Review article from Sveen and co-workers on alternative splicing published in Oncogene  
 The Anders Jahre Senior Medical Prize to Ludvig Sollid  
 Award winner Erik Fosse presented in Uniforum The UiO Innovation Prize: 
 Two studies of PARP inhibition in malignant lymphocytes reveal differential phenotypical responses, DNA damage induction and repair during the cell cycle  
 Kaisa Haglund receives the Jahre prize for young medical researchers Recognition of outstanding scientific work: 
 Oslo Cancer Cluster Innovation Park officially opened  
 New English version of "The Research Handbook- from idea to publication" is available  
 Chronicle on personalised cancer medicine in Aftenposten  
 Preparing for the upcoming health calls for Horizon 2020 Training course August 25: 
 Novel method reveals new knowledge about G1-phase  
 H.M. The Kings Gold Medal to Sigrid Bratlie Thoresen  
 Llorente and coworkers report promising prostate cancer biomarkers in urinary exosomes  
 Microscopy infrastructure funded by the Norwegian Research Council  
 Innovation prize to Erik Fosse  
 Cover article on personalized cancer medicine and big data in META  
 Paper from OUS/CCB researchers dedicated commentary articles in both Nature and Science  
 What is the cost of a cancer patient's life? OUS research blog June 16th: 
 Annuncement of research funding from South-East Norway regional health authority for 2016 Call for applications 2016 
 The Department of Pathology receives funding for melanoma research through Horizon 2020 project.  
 Findings from the Skarstad group published in PLOS Genetics  
 A cancer cell on the move OUS research blog about endocytosis: 
 William Louch appointed "Scientist of the Month" by "Helse Sør-Øst" for May 2015  
 The long road to success Article about work in the Stenmark group on www.nrk.no: 
 Sealing holes in the nuclear envelope as a mechanism to protect the genome Nature article from Marina Vietri: 
 Non-Homologous functions of the AlkB Homologs – an update of the present knowledge Review article in J Mol Cell Biol: 
 New EU H2020- MARIE Sklodowska-CURIE ACTIONS project coordinated by The Intervention Centre WiBEC (Wireless In-Body Environment Communications) selected for funding by EU 
 Improved methods for the treatment of metabolic diseases affecting children's nervous system OUS research blog: 
 Many OUS teams in the Holmenkollstafetten 2015 Public health improvement: 
 Åsmund Eikenes publishes careers column in Nature  
 Oslo University Hospital honouring excellent research  (27.04.2015 11:16)
 More precise cancer treatment by use of RNA biomarkers OUS research blog from Anja Nilsen: (27.04.2015 11:16)
 Oslo University Hospital has awarded 6 excellent articles for the second half-year of 2014  (27.04.2015 11:16)