Department of Molecular Oncology
|Ragnhild A. Lothe||Rolf I. Skotheim||Guro E. Lind|
A Norwegian Centre of Excellence funded by the Research Council of Norway.
Norwegian Cancer Genomics Consortium
The Norwegian Cancer Society calls attention to collaborative study on relevance of genetic heterogeneity
The Norwegian Cancer Society has recently presented a research project on their home page where researchers from Oslo and Bergen have performed genetic analyses on cancer cells that have spread from the gut to the liver. The results show that the degree of genetic heterogenenity between the tumors in the gut and in the liver respectively may reveal important prognostic information. The study led by Ragnhild A. Lothe from the Department of Moleceular Oncology at OUS and Per Eystein Lønning from Haukeland University Hospital.
Clinical relevance of genetic heterogeneity among distinct liver metastatic deposits identified in patients with colorectal cancer
In this collaborative study with Dept Oncology, Haukeland University Hospital and Dept Computer Science, University of Oslo, scientist Anita Sveen (photo) and colleagues in the Lothe group show that patients with a low level of heterogeneity, based on DNA copy number analyses of multiple metastases per patient, have a 4.6X and 3.6X longer three-year progression free and overall survival rate than patients with a high heterogeneity level.
Department of Molecular Oncology, Institute for Cancer Research
Oslo University Hospital HE - Norwegian Radium Hospital
Mail address: P. O. Box 4953 Nydalen, NO-0424 Oslo, Norway
Street address: Norwegian Radium Hospital, Montebello
Phone: +47 2278 1728, Switchboard: +47 2293 4000, Fax: +47 2278 1745
Aug 25, 2016
Aug 11, 2016
Aug 3, 2016
Jun 29, 2016
Dept of Molecular Oncology
PBX3 is a putative biomarker of aggressive prostate cancer
Int J Cancer, 139 (8), 1810-20
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Nat Rev Gastroenterol Hepatol, 13 (5), 261-80