Department of Molecular Oncology
|Ragnhild A. Lothe||Rolf I. Skotheim||Guro E. Lind|
A Norwegian Centre of Excellence funded by the Research Council of Norway.
|Norwegian Cancer Genomics Consortium|
20 young scientists have been selected from 160 applicants to become the founding members of the Young Academy of Norway. Read more at the YA web site and by following the links below.
Overveldende respons for ungt akademi
Norge får akademi for unge forskere
From The Norwegian Academy of Science and Letters:
Akademiet for yngre forskere etableres
Akademiet for yngre forskere etableres (including blog)
Review article in Oncogene on alternative splicing in cancer
Dr. Anita Sveen and co-workers recently published a review article about alternative splicing in cancer in the journal Oncogene. In this article, an overview of known aberrant splicing events in cancer-critical genes and their potential as cancer biomarkers is given. The article also discusses cancer-associated patterns of splicing on a genome-wide scale. Furthermore, the genes encoding splicing factors are found to be enriched for cancer-critical somatic mutations and to have dysregulated expression patterns. Several novel cancer-critical splicing factors are proposed. Sveen has previously investigated the biomarker potential of aberrant splicing events in cancer (Sveen et al., Int J Cancer 2012;131:1479-85) and identified transcriptome instability, TIN, in colorectal cancer as a splicing-related molecular feature that is associated with splicing factor gene expression levels and poor patient survival (Sveen et al., Genome Med 2011;3:32 and BMC Genomics 2014;15:672). Sveen is currently a post doc in the Lothe group, working with genomics of colorectal cancer in a translational research perspective.
Link to the Genetics Group in the Department of Molecular Oncology: http://www.ous-research.no/lothe/
Link to the K.G. Jebsen Colorectal Cancer Research Centre: http://colorectal.no/
Department of Molecular Oncology, Institute for Cancer Research
Oslo University Hospital HE - Norwegian Radium Hospital
Mail address: P. O. Box 4953 Nydalen, NO-0424 Oslo, Norway
Street address: Norwegian Radium Hospital, Montebello
Phone: +47 2278 1728, Switchboard: +47 2293 4000, Fax: +47 2278 1745
Sep 30, 2015
Dept of Molecular Oncology
Novel RNA variants in colorectal cancers
Oncotarget, 6 (34), 36587-602