Department of Molecular Oncology


Department head: Ragnhild A. Lothe, Professor
Department administrative consultants: Mona Hagen and Linda Uv Mjøen
Lab manager: Guro E. Lind

Research groups:

GeneticsGenome BiologyEpigenetics

Ragnhild A. LotheRolf I. SkotheimGuro E. Lind

Project group:

Cell signalling


Edward Leithe


Centre for Cancer Biomedicine  

Centre for Cancer Biomedicine

A Norwegian Centre of Excellence funded by the Research Council of Norway.


The K.G. Jebsen Colorectal Cancer Research Centre.




Norwegian Cancer Genomics Consortium


Latest News


The Norwegian Cancer Society calls attention to collaborative study on relevance of genetic heterogeneity

Anita Sveen is heavily involved in the study (photo Terje Heiestad)

The Norwegian Cancer Society has recently presented a research project on their home page where researchers from Oslo and Bergen have performed genetic analyses on cancer cells that have spread from the gut to the liver. The results show that the degree of genetic heterogenenity between the tumors in the gut and in the liver respectively may reveal important prognostic information. The study led by Ragnhild A. Lothe from the Department of Moleceular Oncology at OUS and Per Eystein Lønning from Haukeland University Hospital.


Clinical relevance of genetic heterogeneity among distinct liver metastatic deposits identified in patients with colorectal cancer

Anita Sveen (first author)
Anita Sveen (first author)

In this collaborative study with Dept Oncology, Haukeland University Hospital and Dept Computer Science, University of Oslo, scientist Anita Sveen (photo) and colleagues in the Lothe group show that patients with a low level of heterogeneity, based on DNA copy number analyses of multiple metastases per patient, have a 4.6X and 3.6X longer three-year progression free and overall survival rate than patients with a high heterogeneity level.


Contact information

Department of Molecular Oncology, Institute for Cancer Research
Oslo University Hospital HE - Norwegian Radium Hospital
Mail address: P. O. Box 4953 Nydalen, NO-0424 Oslo, Norway
Street address: Norwegian Radium Hospital, Montebello
Phone: +47 2278 1728, Switchboard: +47 2293 4000, Fax: +47 2278 1745