Department of Molecular Oncology
|Ragnhild A. Lothe||Rolf I. Skotheim||Guro E. Lind|
A Norwegian Centre of Excellence funded by the Research Council of Norway.
Norwegian Cancer Genomics Consortium
The Research Council of Norway and Norway’s research institutions are providing a total of NOK 1 billion to 46 FRIPRO Toppforsk projects (FRIPRO - "Frie prosjektmidler"). Each project will receive NOK 15–25 million over a four-to-five-year period.
FRIPRO is an open competitive arena for all research areas and disciplines, where there are no thematic guidelines and no requirements relating to the applicability or immediate utility of the research. The competition in FRIPRO is tough, and only the best researchers with particularly good projects and very well-written proposals have a chance at succeeding.
University of Oslo and Oslo University Hospital based research groups led by Ragnhild A. Lothe from the Department of Molecular Oncology and Michael Bretthauer from the Department of Transplantation Medicine are among the successful applicants.
The 2015 "Dr. Ragnar Mørk's legacy prize" went to Guro E. Lind, head of the Epigenetics Group at the Department of Molecular Oncology. This award of NOK 200.000 is annually given to scientists affiliated to the Norwegian Radium Hospital who have obtained important results within the field of cancer research. The ceremony took place on Friday November 20th in the Research Building at Montebello. Guro E. Lind gave a lecture about the research activities that has earned her the award.
Guro E. Lind receives Dr. Ragnar Mørk's prize for 2015 for her outstanding research on cancer epigenetics, which has led to identification of several novel biomarkers in colorectal cancer, bladder cancer, ovarian cancer, lymphoma and cholangiocarcinoma. These biomarkers may form the basis for diagnostic tests for early detection of cancer.
20 young scientists have been selected from 160 applicants to become the founding members of the Young Academy of Norway. Read more at the YA web site and by following the links below.
Overveldende respons for ungt akademi
Norge får akademi for unge forskere
From The Norwegian Academy of Science and Letters:
Akademiet for yngre forskere etableres
Akademiet for yngre forskere etableres (including blog)
Review article in Oncogene on alternative splicing in cancer
Dr. Anita Sveen and co-workers recently published a review article about alternative splicing in cancer in the journal Oncogene. In this article, an overview of known aberrant splicing events in cancer-critical genes and their potential as cancer biomarkers is given. The article also discusses cancer-associated patterns of splicing on a genome-wide scale. Furthermore, the genes encoding splicing factors are found to be enriched for cancer-critical somatic mutations and to have dysregulated expression patterns. Several novel cancer-critical splicing factors are proposed. Sveen has previously investigated the biomarker potential of aberrant splicing events in cancer (Sveen et al., Int J Cancer 2012;131:1479-85) and identified transcriptome instability, TIN, in colorectal cancer as a splicing-related molecular feature that is associated with splicing factor gene expression levels and poor patient survival (Sveen et al., Genome Med 2011;3:32 and BMC Genomics 2014;15:672). Sveen is currently a post doc in the Lothe group, working with genomics of colorectal cancer in a translational research perspective.
Link to the Genetics Group in the Department of Molecular Oncology: http://www.ous-research.no/lothe/
Link to the K.G. Jebsen Colorectal Cancer Research Centre: http://colorectal.no/
Department of Molecular Oncology, Institute for Cancer Research
Oslo University Hospital HE - Norwegian Radium Hospital
Mail address: P. O. Box 4953 Nydalen, NO-0424 Oslo, Norway
Street address: Norwegian Radium Hospital, Montebello
Phone: +47 2278 1728, Switchboard: +47 2293 4000, Fax: +47 2278 1745
Sep 30, 2015
Dept of Molecular Oncology
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Nat Rev Gastroenterol Hepatol, 13 (5), 261-80
Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
Biochim Biophys Acta, 1865 (2), 133-146 (in press)