Magnar Bjørås' group

Cellular responses to DNA damage

 
Magnar Bjørås<br>Group leader
Magnar Bjørås
Group leader

The Laboratory for Molecular Biology investigates basic biological processes associated with cellular responses to DNA damage including DNA repair pathways and mechanism for tolerance, scavenging and adaptation. Focus has been on the repair of endogenous DNA damage and mechanisms for removal of base damage to DNA. At the cellular and organismal level, the aim is to understand mechanisms for genome maintenance in mammalian as well as microbial cells and to develop new interventions for preventing cancer and neurological disease associated with genome instability caused by DNA damage.

Challenges

Cellular genomes are continuously challenged by physical, chemical and biological agents that introduce changes of the chemical structure of the DNA. Intracellular reactive metabolites such as reactive oxygen species and alkylating compounds are important inducers of such changes. Nevertheless, mutation frequencies are low because of very efficient pathways for DNA repair and DNA recombination, which remove DNA damage and conserve at least one functional copy of the genome. Nevertheless, in humans, DNA damage will induce genome instability that is associated with disease and degenerative disorders. Challenges are to understand the mechanisms for cellular protection against DNA damage and its role in cancer, ageing and neurological disease.

Projects

  • Molecular mechanisms of DNA base repair
  • Genome stability in stem cells
  • Impact of oxidative DNA damage on brain function
  • Impact of oxidative DNA damage on cancer development
  • RNA genes and small peptides in biological responses to DNA damage

Contact information:
Professor Magnar Bjørås Department of Microbiology Oslo University Hospital Rikshospitalet PO Box 4950 Nydalen NO-0424 Oslo, Norway Tel: +47 23074059 Fax: +47 23074061 E-mail: magnar.bjoras@rr-research.no