Genom stability in yeast

 
Group leader<br>Ingrun Alseth
Group leader
Ingrun Alseth

Challenges
Every day all cells in all organisms are challenged with agents that damage the DNA may leading to mutations or cell death. To protect against such treats, cells express hundreds of proteins that are engaged in detection and removal of DNA damage. Defects in these processes are associated with cancer, neurological disease and premature aging. During the last years, the role of DNA repair in disease progression has been more and more acknowledged, however a complete picture has not yet been drawn. Our aim is to increase the knowledge of processes that are involved in keeping our genetic material error free by the use of simple model organisms as bacteria and yeast in addition to higher eukaryotic systems. Results obtained in such organisms are often directly transferable to mammalian organisms.

Projects

  • Identification and characterization of new DNA repair genes
  • Molecular mechanisms of DNA repair
  • Impact of DNA deamination on genom stability
  • Processing of modified RNA

 

 
 
 

Contact information

Dr. Ingrun Alseth - Department of Microbiology Oslo University Hospital, Rikshospitalet PO Box 4950 Nydalen NO-0424 Oslo, Norway - Tel: +47 23074069 Fax: +47 23074061 E-mail: Ingrun.alseth@rr-research.no